Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
63(30), С. 10382 - 10411
Опубликована: Май 2, 2022
Natural
products
have
been
a
bedrock
for
drug
discovery
decades.
(−)-Epigallocatechin-3-gallate
(EGCG)
is
one
of
the
widely
studied
natural
polyphenolic
compounds
derived
from
green
tea.
It
key
component
believed
to
be
responsible
medicinal
value
Significant
studies
implemented
in
vitro,
cellulo,
and
vivo
models
suggested
its
anti-oxidant,
anti-cancer,
anti-diabetic,
anti-inflammatory,
anti-microbial,
neuroprotective
activities
etc.
Despite
having
such
wide
array
therapeutic
potential
promising
results
preclinical
studies,
applicability
humans
has
encountered
with
rather
limited
success
largely
due
poor
bioavailability,
membrane
permeability,
rapid
metabolic
clearance
lack
stability
EGCG.
Therefore,
novel
techniques
are
warranted
address
those
limitations
so
that
EGCG
or
modified
analogs
can
used
clinical
setup.
This
review
comprehensively
covers
different
strategies
as
structural
modifications,
nano-carriers
efficient
delivery
systems,
synergistic
other
bioactivities
improve
chemico-biological
aspects
(e.g.,
stability,
etc.)
enhanced
pharmacokinetics
pharmacological
properties,
eventually
enhancing
potentials.
We
think
this
article
will
serve
strong
platform
comprehensive
literature
on
development
bioavailability
it
translated
applications.
Scientific Reports,
Год журнала:
2020,
Номер
10(1)
Опубликована: Фев. 10, 2020
Blueberries
are
a
rich
source
of
polyphenols,
widely
studied
for
the
prevention
or
attenuation
metabolic
diseases.
However,
health
contribution
and
mechanisms
action
polyphenols
depend
on
their
type
structure.
Here,
we
evaluated
effects
wild
blueberry
polyphenolic
extract
(WBE)
(Vaccinium
angustifolium
Aiton)
cardiometabolic
parameters,
gut
microbiota
composition
epithelium
histology
high-fat
high-sucrose
(HFHS)
diet-induced
obese
mice
determined
which
constitutive
fractions
(BPF)
was
responsible
observed
effects.
To
do
so,
whole
separated
in
three
fractions,
F1)
Anthocyanins
phenolic
acids,
F2)
oligomeric
proanthocyanidins
(PACs),
acids
flavonols
(PACs
degree
polymerization
DP
<
4),
F3)
PACs
polymers
>
4)
supplied
at
respective
concentration
extract.
After
8
weeks,
WBE
reduced
OGTT
AUC
by
18.3%
compared
to
HFHS
treated
rodents
F3
fraction
contributed
most
this
effect.
The
anthocyanin
F1
did
not
reproduce
response.
BPF
restored
colonic
mucus
layer.
Particularly,
polymeric
PACs-rich
increased
mucin-secreting
goblet
cells
number.
caused
significant
2-fold
higher
proportion
Adlercreutzia
equolifaciens
whereas
F2
2.5-fold
Akkermansia
muciniphila.
This
study
reveals
key
role
modulating
restoring
epithelial
layer,
providing
suitable
ecological
niche
mucosa-associated
symbiotic
bacteria,
may
be
crucial
triggering
polyphenols.
Antioxidants,
Год журнала:
2020,
Номер
9(10), С. 982 - 982
Опубликована: Окт. 13, 2020
Lifestyle
factors,
especially
diet
and
nutrition,
are
currently
regarded
as
essential
avenues
to
decrease
modern-day
cardiometabolic
disorders
(CMD),
including
obesity,
metabolic
syndrome,
type
2
diabetes,
atherosclerosis.
Many
groups
around
the
world
attribute
these
trends,
at
least
partially,
bioactive
plant
polyphenols
given
their
anti-oxidant
anti-inflammatory
actions.
In
fact,
can
prevent
or
reverse
progression
of
disease
processes
through
many
distinct
mechanisms.
particular,
crosstalk
between
gut
microbiota,
recently
unveiled
thanks
DNA-based
tools
next
generation
sequencing,
unravelled
central
regulatory
role
dietary
intestinal
micro-ecology
metabolites
on
host
energy
metabolism
related
illnesses.
The
objectives
this
review
to:
(1)
provide
an
understanding
classification,
structure,
bioavailability
polyphenols;
(2)
underline
by
microbiota;
(3)
highlight
prebiotic
effects
microflora;
(4)
discuss
multifaceted
roles
in
CMD
while
shedding
light
mechanisms
action;
(5)
underscore
ability
initiate
epigenetic
regulation.
sum,
clearly
documents
whether
favorably
interact
promote
multiple
physiological
functions
human
organism.
Antioxidants,
Год журнала:
2019,
Номер
8(6), С. 166 - 166
Опубликована: Июнь 6, 2019
Cardiovascular
diseases
(CVDs)
are
critical
global
public
health
issues
with
high
morbidity
and
mortality.
Epidemiological
studies
have
revealed
that
regular
tea
drinking
is
inversely
associated
the
risk
of
CVDs.
Additionally,
substantial
in
vitro
vivo
experimental
shown
its
bioactive
compounds
effective
protecting
against
The
relevant
mechanisms
include
reducing
blood
lipid,
alleviating
ischemia/reperfusion
injury,
inhibiting
oxidative
stress,
enhancing
endothelial
function,
attenuating
inflammation,
cardiomyocyte
function.
Moreover,
some
clinical
trials
also
proved
protective
role
In
order
to
provide
a
better
understanding
relationship
between
CVDs,
this
review
summarizes
effects
CVDs
discusses
potential
action
based
on
evidence
from
epidemiological,
experimental,
studies.
animal,
Год журнала:
2019,
Номер
14(1), С. 95 - 107
Опубликована: Окт. 1, 2019
In
addition
to
a
multifactorial
etiology
of
nutritional,
social
and
environmental
stressors,
post-weaning
diarrhea
(PWD)
in
pigs
is
often
related
infection
with
specific
pathogens
such
as
enterotoxigenic
Escherichia
coli
(ETEC).
swine
farming
operations,
the
incidence
PWD
global
concern
associated
an
unbalanced
gut
status,
resulting
poor
performance
high
antimicrobial
consumption
via
prophylaxis
metaphylaxis.
Increases
resistance
are
reinforcing
already-urgent
need
for
sustainable,
alternative
solutions
maintaining
optimal
health
livestock.
Tannin-rich
plants
extracts
contain
bioactive
compounds
that
could
be
great
interest
this
respect.
This
review
describes
how
use
tannins
around
weaning
beneficial
pigs,
special
emphasis
on
reduction
ETEC-related
PWD.
An
overview
broad
chemical
diversity
presented
together
their
physicochemical
biological
properties,
well
they
may
metabolized
digestive
tract.
The
pharmacological
effects
exerted
by
summarized;
more
precisely,
possible
mechanisms
which
can
disrupt
different
steps
pathogenesis
highlighted.
factors
affecting
bioactivity
also
discussed,
shedding
light
importance
structure
among
tannins.
Microorganisms,
Год журнала:
2020,
Номер
8(2), С. 199 - 199
Опубликована: Янв. 31, 2020
Polyphenolic
antioxidants,
including
dietary
plant
lignans,
modulate
the
gut–brain
axis,
which
involves
transformation
of
these
polyphenolic
compounds
into
physiologically
active
and
neuroprotector
(called
human
lignans)
through
gut
bacterial
metabolism.
These
metabolites
exert
their
neuroprotective
effects
in
various
neurodegenerative
diseases,
such
as
Alzheimer’s
disease
(AD)
Parkinson’s
(PD),
also
have
protective
against
other
cardiovascular
cancer,
diabetes.
For
example,
enterolactone
enterodiol,
therapeutically
relevant
polyphenols,
are
formed
secondary
non-flavonoid
found
plant-based
foods.
acetylcholinesterase
inhibitors,
thereby
potential
applications
therapeutics
AD
neurological
diseases.
Polyphenols
advanced
glycation
end
product
(AGE)
inhibitors
(antiglycating
agents),
cases
AD.
Thus,
metabolism
lignans
results
formation
polyphenols—some
enhanced
blood–brain
barrier
permeability.
It
is
hypothesized
that
metabolism-derived
when
combined
with
nanoparticle-based
(BBB)-targeted
drug
delivery,
may
prove
to
be
effective
for
disorders,
traumatic
brain
injury
(TBI),
AD,
PD.
This
mini-review
addresses
role
focusing
on
American Journal of Clinical Nutrition,
Год журнала:
2020,
Номер
112(4), С. 1051 - 1068
Опубликована: Июль 1, 2020
There
is
a
lack
of
focus
on
the
protective
health
effects
phytochemicals
in
dietary
guidelines.
Although
number
chemical
libraries
and
databases
contain
belonging
to
plant
metabolome,
they
are
not
entirely
relevant
human
because
many
constituents
extensively
metabolized
within
body
following
ingestion.
This
especially
apparent
for
highly
abundant
(poly)phenols,
which
situation
compounded
by
confusion
regarding
their
bioavailability
metabolism,
partially
variety
nomenclatures
trivial
names
used
describe
compounds
arising
from
microbial
catabolism
gastrointestinal
tract.
confusion,
perpetuated
online
chemical/metabolite
databases,
will
hinder
future
discovery
bioactivities
affect
establishment
guidelines
if
steps
taken
overcome
these
issues.
In
order
resolve
this
situation,
nomenclature
system
phenolic
catabolites
phase
II
metabolites
proposed
article
basis
its
format
outlined.
Previous
literature
cited
along
with
recommended
nomenclature,
International
Union
Pure
Applied
Chemistry
terminology,
and,
where
appropriate,
Chemical
Abstracts
Service
numbers,
InChIKey,
accurate
mass.
Journal of Agricultural and Food Chemistry,
Год журнала:
2020,
Номер
68(36), С. 9804 - 9815
Опубликована: Авг. 18, 2020
Interaction
of
tea
phenolics
with
gut
microbiota
may
play
an
integral
role
in
the
health
benefits
these
bioactive
compounds,
yet
this
interaction
is
not
fully
understood.
Here,
metabolic
fate
epigallocatechin-3-gallate
(EGCG)
and
its
impact
on
were
integrally
investigated
via
vitro
fermentation.
As
revealed
by
ultrahigh
performance
liquid
chromatography
hybrid
quadrupole
Orbitrap
mass
spectrometry
(UHPLC-Q-Orbitrap-MS),
EGCG
was
promptly
degraded
into
a
series
metabolites,
including
4-phenylbutyric
acid,
3-(3′,4′-dihydroxyphenyl)propionic
3-(4′-hydroxyphenyl)propionic
through
consecutive
ester
hydrolysis,
C-ring
opening,
A-ring
fission,
dehydroxylation,
aliphatic
chain
shortening.
Microbiome
profiling
indicated
that,
compared
to
blank,
treatment
resulted
stimulation
beneficial
bacteria
Bacteroides,
Christensenellaceae,
Bifidobacterium.
Additionally,
pathogenic
Fusobacterium
varium,
Bilophila,
Enterobacteriaceae
inhibited.
Furthermore,
changes
concentrations
acid
phenylacetic
strongly
correlated
abundance
specific
microbiota.
These
reciprocal
interactions
between
collectively
contribute
EGCG.
Nutrients,
Год журнала:
2020,
Номер
12(1), С. 130 - 130
Опубликована: Янв. 2, 2020
The
intestinal
barrier
is
constantly
exposed
to
potentially
harmful
environmental
factors,
including
food
components
and
bacterial
endotoxins.
When
function
immune
homeostasis
are
compromised
(intestinal
dysfunction),
inflammatory
conditions
may
develop
impact
overall
health.
Evidence
from
experimental
animal
cell
culture
studies
suggests
that
exposure
of
mucosa
proanthocyanidin
(PAC)-rich
plant
products,
such
as
grape
seeds,
contribute
maintaining
the
ameliorating
pathological
inflammation
present
in
diet-induced
obesity
bowel
disease.
In
this
review,
we
aim
update
current
knowledge
on
bioactivity
PACs
models
dysfunction
humans,
provide
insights
into
underlying
biochemical
molecular
mechanisms.
Journal of Agricultural and Food Chemistry,
Год журнала:
2019,
Номер
68(7), С. 1790 - 1807
Опубликована: Июнь 26, 2019
Age-associated
pathophysiological
changes
such
as
neurodegenerative
diseases
are
multifactorial
conditions
with
increasing
incidence
and
no
existing
cure.
The
possibility
of
altering
the
progression
development
these
through
diet
is
an
attractive
approach
supporting
data.
Epidemiological
clinical
studies
have
highlighted
health
potential
diets
rich
in
fruits
vegetables.
Such
food
sources
(poly)phenols,
natural
compounds
increasingly
associated
benefits,
having
to
prevent
or
retard
various
diseases.
However,
absorption
blood
concentration
(poly)phenols
very
low
when
compared
their
corresponding
(poly)phenolic
metabolites.
Therefore,
serum-bioavailable
metabolites
much
more
promising
candidates
overcome
cellular
barriers
reach
target
tissues,
brain.
Bearing
this
mind,
it
will
be
reviewed
that
molecular
mechanisms
underlying
effects,
range
from
0.1
<50
μM
role
on
neuroinflammation,
a
central
hallmark