Copper-based metal–organic frameworks for biomedical applications

Advances in Colloid and Interface Science, Год журнала: 2022, Номер 305, С. 102686 - 102686

Опубликована: Апрель 29, 2022

Язык: Английский

---

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Advanced Functional Materials, Год журнала: 2021, Номер 31(31)

Опубликована: Май 13, 2021

Abstract In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation inflammatory tissues can further deteriorate the localized tissue injury cause chronic diseases. Though promising for reducing levels, many antioxidant molecules natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or nanostructures have been designed with distinctive scavenging capabilities, which show to overcome these kernel challenges. this timely review, most recent advances engineering are summarized. First, principles corresponding methods testing various enzymatic carefully concluded. Subsequently, rationally high efficiencies comprehensively discussed, especially on catalytic activities, mechanisms, structure‐function relationships. After that, representative applications biotherapeutics summarized detail. At last, primary challenges future perspectives emerging research frontier also outlined. believed progress review will offer cutting‐edge understanding guidance high‐performance broad biotherapeutic applications.

Язык: Английский

---

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Materials Today Bio, Год журнала: 2021, Номер 11, С. 100124 - 100124

Опубликована: Июнь 1, 2021

Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that currently available. The good news owing to considerable advances in nanoscience, types nanomaterials unique ROS-scavenging abilities influence temporospatial dynamic behaviors biological systems have been developed. This has led emergence next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related Accordingly, herein we reviewed recent progress research on nanotherapy based scavenging. underlying mechanisms employed emphasized. Furthermore, important issues developing cross-disciplinary nanomedicine-based for ROS-based conditions discussed. Our review this increasing interdisciplinary field will benefit ongoing studies applications nanomedicine

Язык: Английский

---

Multi-enzyme activity nanozymes for biosensing and disease treatment

Coordination Chemistry Reviews, Год журнала: 2022, Номер 473, С. 214784 - 214784

Опубликована: Сен. 13, 2022

Язык: Английский

---

Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process

ACS Omega, Год журнала: 2022, Номер 7(35), С. 30657 - 30672

Опубликована: Авг. 24, 2022

Reactive oxygen species (ROS) is considered a double-edged sword. The slightly elevated level of ROS helps in wound healing by inhibiting microbial infection. In contrast, excessive levels the site show deleterious effects on extending inflammation phase. Understanding ROS-mediated molecular and biomolecular mechanisms their effect cellular homeostasis thus substantially improves possibility exogenously augmenting manipulating with emerging antioxidant therapeutics. This review comprehensively delves into relationship between critical phases processes underpinning therapies. manuscript also discusses cutting-edge therapeutics that act via scavenging to enhance chronic healing.

Язык: Английский

---

Engineering Antioxidative Cascade Metal-Phenolic Nanozymes for Alleviating Oxidative Stress during Extracorporeal Blood Purification

ACS Nano, Год журнала: 2022, Номер 16(11), С. 18329 - 18343

Опубликована: Ноя. 10, 2022

Oxidative stress is a compelling risk factor in chronic kidney diseases and further aggravated for individuals during extracorporeal blood purification, ultimately leading to multiple complications. Herein, antioxidative cascade metal-phenolic nanozymes (metal-tannic acid nanozymes, M-TA NMs) are synthesized via metal ions-mediated oxidative coupling of polyphenols; then NMs engineered hemoperfusion microspheres (Cu-TAn@PMS) constructed alleviating stress. show adjustable broad-spectrum activities toward reactive nitrogen oxygen species (RNOS) due the catalytic active centers. Importantly, could mimic processes superoxide dismutase catalase maintain intracellular redox balance. Detailed structural spectral analyses reveal that existence transition decrease electronic energy band gaps offer better electron transfers RNOS scavenging. Notably, dynamic experiments demonstrate Cu-TAn@PMS serve as an antioxidant defense system scavenge (ROS) effectively even complex environment protect endogenous enzymes molecules. In general, this work developed with excellent therapeutic efficacy treatment stress-related diseases, which exhibited potential clinical purification extended biomedical applications nanozymes.

Язык: Английский

---

MOF-derived bimetallic nanozyme to catalyze ROS scavenging for protection of myocardial injury

Theranostics, Год журнала: 2023, Номер 13(8), С. 2721 - 2733

Опубликована: Янв. 1, 2023

Rationale: Myocardial injury triggers intense oxidative stress, inflammatory response, and cytokine release, which are essential for myocardial repair remodeling.Excess reactive oxygen species (ROS) scavenging inflammation elimination have long been considered to reverse injuries.However, the efficacy of traditional treatments (antioxidant, anti-inflammatory drugs natural enzymes) is still poor due their intrinsic defects such as unfavorable pharmacokinetics bioavailability, low biological stability, potential side effects.Nanozyme represents a candidate effectively modulate redox homeostasis treatment ROS related diseases.Methods: We develop an integrated bimetallic nanozyme derived from metal-organic framework (MOF) eliminate alleviate inflammation.The (Cu-TCPP-Mn) synthesized by embedding manganese copper into porphyrin followed sonication, could mimic cascade activities superoxide dismutase (SOD) catalase (CAT) transform radicals hydrogen peroxide, catalysis peroxide water.Enzyme kinetic analysis oxygen-production velocities were performed evaluate enzymatic Cu-TCPP-Mn.We also established infarction (MI) ischemia-reperfusion (I/R) animal models verify anti-inflammation effect Cu-TCPP-Mn.Results: As demonstrated analysis, Cu-TCPP-Mn possesses good performance in both SOD-and CAT-like achieve synergistic provide protection injury.In MI I/R models, this promising reliable technology protect heart tissue stress inflammation-induced injury, enables function recover otherwise severe damage.Conclusions: This research provides facile applicable method MOF nanozyme, alternative injuries.

Язык: Английский

---

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

---

A Multifunctional Hydrogel with Photothermal Antibacterial and AntiOxidant Activity for Smart Monitoring and Promotion of Diabetic Wound Healing

Advanced Functional Materials, Год журнала: 2024, Номер 34(38)

Опубликована: Апрель 21, 2024

Abstract Persistent oxidative stress and bacterial infection are significant challenges that impede diabetic wound healing. By combining diagnosis treatment, pH variation on the tissue can be monitored in real time, precise treatment carried out promptly to promote In this study, a lipoic acid‐modified chitosa (LAMC) hydrogel is constructed via an amidation reaction, ceria oxide‐molybdenum disulfide nanoparticles with polydopamine layer (C@M@P), along carbon quantum dots (CDs) synthesized by hydrothermal method, loaded into hydrogel, thus developing diagnostic therapeutic (LAMC/CD‐C@M@P). incorporating CDs, exhibits high sensitivity reversibility under ultraviolet light. Furthermore, images of hydrogels collected using smartphones converted signals, providing means for early detection infection. Notably, LAMC/CD‐C@M@P excellent photothermal antibacterial capability against Staphylococcus aureus Escherichia coli remarkable antioxidant anti‐inflammatory abilities alleviate reactive oxygen species relieve inflammation response. summary, multifunctional offers great potential as innovative dressing platform, representing advancement chronic management.

Язык: Английский

---

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

Chemical Society Reviews, Год журнала: 2023, Номер 53(1), С. 137 - 162

Опубликована: Ноя. 29, 2023

Natural metalloenzymes with astonishing reaction activity and specificity underpin essential life transformations. Nevertheless, enzymes only operate under mild conditions to keep sophisticated structures active, limiting their potential applications. Artificial that recapitulate the catalytic of can not circumvent enzymatic fragility but also bring versatile functions into practice. Among them, metal-organic frameworks (MOFs) featuring diverse site-isolated metal sites supramolecular have emerged as promising candidates for move toward unparalleled properties behaviour enzymes. In this review, we systematically summarize significant advances in MOF-based metalloenzyme mimics a special emphasis on active pocket engineering at atomic level, including primary secondary coordination spheres. Then, deep understanding mechanisms advanced applications are discussed. Finally, perspective emerging frontier research is provided advance bioinspired catalysis.

Язык: Английский

---