Nanomaterials,
Год журнала:
2024,
Номер
14(3), С. 244 - 244
Опубликована: Янв. 23, 2024
A
nanozyme
is
a
nanoscale
material
having
enzyme-like
properties.
It
exhibits
several
superior
properties,
including
low
preparation
cost,
robust
catalytic
activity,
and
long-term
storage
at
ambient
temperatures.
Moreover,
high
stability
enables
repetitive
use
in
multiple
reactions.
Hence,
it
considered
potential
replacement
for
natural
enzymes.
Enormous
research
interest
nanozymes
the
past
two
decades
has
made
imperative
to
look
better
enzyme-mimicking
materials
biomedical
applications.
Given
this,
on
metal–organic
frameworks
(MOFs)
as
gained
momentum.
MOFs
are
advanced
hybrid
of
inorganic
metal
ions
organic
ligands.
Their
distinct
composition,
adaptable
pore
size,
structural
diversity,
ease
tunability
physicochemical
properties
enable
mimic
activities
act
promising
candidates.
This
review
aims
discuss
recent
advances
development
MOF-based
(MOF-NZs)
highlight
their
applications
field
biomedicine.
Firstly,
different
enzyme-mimetic
exhibited
by
discussed,
insights
given
into
various
strategies
achieve
them.
Modification
functionalization
deliberated
obtain
MOF-NZs
with
enhanced
activity.
Subsequently,
biosensing
therapeutics
domain
discussed.
Finally,
concluded
giving
challenges
encountered
possible
directions
overcome
them
future.
With
this
review,
we
aim
encourage
consolidated
efforts
across
enzyme
engineering,
nanotechnology,
science,
biomedicine
disciplines
inspire
exciting
innovations
emerging
yet
field.
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(31)
Опубликована: Май 13, 2021
Abstract
In
human
systems,
reactive
oxygen
species
(ROS)
significantly
affect
different
physiological
activities
and
play
critical
roles
in
diverse
living
processes.
It
is
widely
known
that
excessive
ROS
generation
inflammatory
tissues
can
further
deteriorate
the
localized
tissue
injury
cause
chronic
diseases.
Though
promising
for
reducing
levels,
many
antioxidant
molecules
natural
enzymes
suffer
from
abundant
intrinsic
limitations.
Recently,
a
series
of
biocatalytic
or
nanostructures
have
been
designed
with
distinctive
scavenging
capabilities,
which
show
to
overcome
these
kernel
challenges.
this
timely
review,
most
recent
advances
engineering
are
summarized.
First,
principles
corresponding
methods
testing
various
enzymatic
carefully
concluded.
Subsequently,
rationally
high
efficiencies
comprehensively
discussed,
especially
on
catalytic
activities,
mechanisms,
structure‐function
relationships.
After
that,
representative
applications
biotherapeutics
summarized
detail.
At
last,
primary
challenges
future
perspectives
emerging
research
frontier
also
outlined.
believed
progress
review
will
offer
cutting‐edge
understanding
guidance
high‐performance
broad
biotherapeutic
applications.
Materials Today Bio,
Год журнала:
2021,
Номер
11, С. 100124 - 100124
Опубликована: Июнь 1, 2021
Reactive
oxygen
species
(ROS)
mediate
multiple
physiological
functions;
however,
the
over-accumulation
of
ROS
causes
premature
aging
and/or
death
and
is
associated
with
various
inflammatory
conditions.
Nevertheless,
there
are
limited
clinical
treatment
options
that
currently
available.
The
good
news
owing
to
considerable
advances
in
nanoscience,
types
nanomaterials
unique
ROS-scavenging
abilities
influence
temporospatial
dynamic
behaviors
biological
systems
have
been
developed.
This
has
led
emergence
next-generation
nanomaterial-controlled
strategies
aimed
at
ameliorating
ROS-related
Accordingly,
herein
we
reviewed
recent
progress
research
on
nanotherapy
based
scavenging.
underlying
mechanisms
employed
emphasized.
Furthermore,
important
issues
developing
cross-disciplinary
nanomedicine-based
for
ROS-based
conditions
discussed.
Our
review
this
increasing
interdisciplinary
field
will
benefit
ongoing
studies
applications
nanomedicine
ACS Omega,
Год журнала:
2022,
Номер
7(35), С. 30657 - 30672
Опубликована: Авг. 24, 2022
Reactive
oxygen
species
(ROS)
is
considered
a
double-edged
sword.
The
slightly
elevated
level
of
ROS
helps
in
wound
healing
by
inhibiting
microbial
infection.
In
contrast,
excessive
levels
the
site
show
deleterious
effects
on
extending
inflammation
phase.
Understanding
ROS-mediated
molecular
and
biomolecular
mechanisms
their
effect
cellular
homeostasis
thus
substantially
improves
possibility
exogenously
augmenting
manipulating
with
emerging
antioxidant
therapeutics.
This
review
comprehensively
delves
into
relationship
between
critical
phases
processes
underpinning
therapies.
manuscript
also
discusses
cutting-edge
therapeutics
that
act
via
scavenging
to
enhance
chronic
healing.
Theranostics,
Год журнала:
2023,
Номер
13(8), С. 2721 - 2733
Опубликована: Янв. 1, 2023
Rationale:
Myocardial
injury
triggers
intense
oxidative
stress,
inflammatory
response,
and
cytokine
release,
which
are
essential
for
myocardial
repair
remodeling.Excess
reactive
oxygen
species
(ROS)
scavenging
inflammation
elimination
have
long
been
considered
to
reverse
injuries.However,
the
efficacy
of
traditional
treatments
(antioxidant,
anti-inflammatory
drugs
natural
enzymes)
is
still
poor
due
their
intrinsic
defects
such
as
unfavorable
pharmacokinetics
bioavailability,
low
biological
stability,
potential
side
effects.Nanozyme
represents
a
candidate
effectively
modulate
redox
homeostasis
treatment
ROS
related
diseases.Methods:
We
develop
an
integrated
bimetallic
nanozyme
derived
from
metal-organic
framework
(MOF)
eliminate
alleviate
inflammation.The
(Cu-TCPP-Mn)
synthesized
by
embedding
manganese
copper
into
porphyrin
followed
sonication,
could
mimic
cascade
activities
superoxide
dismutase
(SOD)
catalase
(CAT)
transform
radicals
hydrogen
peroxide,
catalysis
peroxide
water.Enzyme
kinetic
analysis
oxygen-production
velocities
were
performed
evaluate
enzymatic
Cu-TCPP-Mn.We
also
established
infarction
(MI)
ischemia-reperfusion
(I/R)
animal
models
verify
anti-inflammation
effect
Cu-TCPP-Mn.Results:
As
demonstrated
analysis,
Cu-TCPP-Mn
possesses
good
performance
in
both
SOD-and
CAT-like
achieve
synergistic
provide
protection
injury.In
MI
I/R
models,
this
promising
reliable
technology
protect
heart
tissue
stress
inflammation-induced
injury,
enables
function
recover
otherwise
severe
damage.Conclusions:
This
research
provides
facile
applicable
method
MOF
nanozyme,
alternative
injuries.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Апрель 21, 2024
Abstract
Persistent
oxidative
stress
and
bacterial
infection
are
significant
challenges
that
impede
diabetic
wound
healing.
By
combining
diagnosis
treatment,
pH
variation
on
the
tissue
can
be
monitored
in
real
time,
precise
treatment
carried
out
promptly
to
promote
In
this
study,
a
lipoic
acid‐modified
chitosa
(LAMC)
hydrogel
is
constructed
via
an
amidation
reaction,
ceria
oxide‐molybdenum
disulfide
nanoparticles
with
polydopamine
layer
(C@M@P),
along
carbon
quantum
dots
(CDs)
synthesized
by
hydrothermal
method,
loaded
into
hydrogel,
thus
developing
diagnostic
therapeutic
(LAMC/CD‐C@M@P).
incorporating
CDs,
exhibits
high
sensitivity
reversibility
under
ultraviolet
light.
Furthermore,
images
of
hydrogels
collected
using
smartphones
converted
signals,
providing
means
for
early
detection
infection.
Notably,
LAMC/CD‐C@M@P
excellent
photothermal
antibacterial
capability
against
Staphylococcus
aureus
Escherichia
coli
remarkable
antioxidant
anti‐inflammatory
abilities
alleviate
reactive
oxygen
species
relieve
inflammation
response.
summary,
multifunctional
offers
great
potential
as
innovative
dressing
platform,
representing
advancement
chronic
management.
Chemical Society Reviews,
Год журнала:
2023,
Номер
53(1), С. 137 - 162
Опубликована: Ноя. 29, 2023
Natural
metalloenzymes
with
astonishing
reaction
activity
and
specificity
underpin
essential
life
transformations.
Nevertheless,
enzymes
only
operate
under
mild
conditions
to
keep
sophisticated
structures
active,
limiting
their
potential
applications.
Artificial
that
recapitulate
the
catalytic
of
can
not
circumvent
enzymatic
fragility
but
also
bring
versatile
functions
into
practice.
Among
them,
metal-organic
frameworks
(MOFs)
featuring
diverse
site-isolated
metal
sites
supramolecular
have
emerged
as
promising
candidates
for
move
toward
unparalleled
properties
behaviour
enzymes.
In
this
review,
we
systematically
summarize
significant
advances
in
MOF-based
metalloenzyme
mimics
a
special
emphasis
on
active
pocket
engineering
at
atomic
level,
including
primary
secondary
coordination
spheres.
Then,
deep
understanding
mechanisms
advanced
applications
are
discussed.
Finally,
perspective
emerging
frontier
research
is
provided
advance
bioinspired
catalysis.
ACS Nano,
Год журнала:
2024,
Номер
18(19), С. 12049 - 12095
Опубликована: Май 2, 2024
Cancer,
as
one
of
the
leading
causes
death
worldwide,
drives
advancement
cutting-edge
technologies
for
cancer
treatment.
Transition-metal-based
nanozymes
emerge
promising
therapeutic
nanodrugs
that
provide
a
reference
therapy.
In
this
review,
we
present
recent
breakthrough
First,
comprehensively
outline
preparation
strategies
involved
in
creating
transition-metal-based
nanozymes,
including
hydrothermal
method,
solvothermal
chemical
reduction
biomimetic
mineralization
and
sol–gel
method.
Subsequently,
elucidate
catalytic
mechanisms
(catalase
(CAT)-like
activities),
peroxidase
(POD)-like
oxidase
(OXD)-like
activities)
superoxide
dismutase
(SOD)-like
along
with
their
activity
regulation
such
morphology
control,
size
manipulation,
modulation,
composition
adjustment
surface
modification
under
environmental
stimulation.
Furthermore,
elaborate
on
diverse
applications
anticancer
therapies
encompassing
radiotherapy
(RT),
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
photothermal
(PTT),
sonodynamic
(SDT),
immunotherapy,
synergistic
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
The
purpose
review
is
to
offer
scientific
guidance
will
enhance
clinical
based
transition
metals.