Recent Progress and Prospect of Metal–Organic Framework-Based Nanozymes in Biomedical Application DOI Creative Commons
Anupriya Baranwal, Shakil Ahmed Polash, Vijay Kumar Aralappanavar

и другие.

Nanomaterials, Год журнала: 2024, Номер 14(3), С. 244 - 244

Опубликована: Янв. 23, 2024

A nanozyme is a nanoscale material having enzyme-like properties. It exhibits several superior properties, including low preparation cost, robust catalytic activity, and long-term storage at ambient temperatures. Moreover, high stability enables repetitive use in multiple reactions. Hence, it considered potential replacement for natural enzymes. Enormous research interest nanozymes the past two decades has made imperative to look better enzyme-mimicking materials biomedical applications. Given this, on metal–organic frameworks (MOFs) as gained momentum. MOFs are advanced hybrid of inorganic metal ions organic ligands. Their distinct composition, adaptable pore size, structural diversity, ease tunability physicochemical properties enable mimic activities act promising candidates. This review aims discuss recent advances development MOF-based (MOF-NZs) highlight their applications field biomedicine. Firstly, different enzyme-mimetic exhibited by discussed, insights given into various strategies achieve them. Modification functionalization deliberated obtain MOF-NZs with enhanced activity. Subsequently, biosensing therapeutics domain discussed. Finally, concluded giving challenges encountered possible directions overcome them future. With this review, we aim encourage consolidated efforts across enzyme engineering, nanotechnology, science, biomedicine disciplines inspire exciting innovations emerging yet field.

Язык: Английский

Copper-based metal–organic frameworks for biomedical applications DOI

Ju‐E Cun,

Fan Xi, Qingqing Pan

и другие.

Advances in Colloid and Interface Science, Год журнала: 2022, Номер 305, С. 102686 - 102686

Опубликована: Апрель 29, 2022

Язык: Английский

Процитировано

152

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics DOI
Liyun Wang, Bihui Zhu, Yuting Deng

и другие.

Advanced Functional Materials, Год журнала: 2021, Номер 31(31)

Опубликована: Май 13, 2021

Abstract In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation inflammatory tissues can further deteriorate the localized tissue injury cause chronic diseases. Though promising for reducing levels, many antioxidant molecules natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or nanostructures have been designed with distinctive scavenging capabilities, which show to overcome these kernel challenges. this timely review, most recent advances engineering are summarized. First, principles corresponding methods testing various enzymatic carefully concluded. Subsequently, rationally high efficiencies comprehensively discussed, especially on catalytic activities, mechanisms, structure‐function relationships. After that, representative applications biotherapeutics summarized detail. At last, primary challenges future perspectives emerging research frontier also outlined. believed progress review will offer cutting‐edge understanding guidance high‐performance broad biotherapeutic applications.

Язык: Английский

Процитировано

148

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation DOI Creative Commons
Xue Huang, Dongyang He,

Zheng Pan

и другие.

Materials Today Bio, Год журнала: 2021, Номер 11, С. 100124 - 100124

Опубликована: Июнь 1, 2021

Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that currently available. The good news owing to considerable advances in nanoscience, types nanomaterials unique ROS-scavenging abilities influence temporospatial dynamic behaviors biological systems have been developed. This has led emergence next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related Accordingly, herein we reviewed recent progress research on nanotherapy based scavenging. underlying mechanisms employed emphasized. Furthermore, important issues developing cross-disciplinary nanomedicine-based for ROS-based conditions discussed. Our review this increasing interdisciplinary field will benefit ongoing studies applications nanomedicine

Язык: Английский

Процитировано

124

Multi-enzyme activity nanozymes for biosensing and disease treatment DOI
Su Li,

Sainan Qin,

Zhongjian Xie

и другие.

Coordination Chemistry Reviews, Год журнала: 2022, Номер 473, С. 214784 - 214784

Опубликована: Сен. 13, 2022

Язык: Английский

Процитировано

97

Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process DOI Creative Commons
Suryanarayana Polaka, Pratik Katare,

Bhakti Pawar

и другие.

ACS Omega, Год журнала: 2022, Номер 7(35), С. 30657 - 30672

Опубликована: Авг. 24, 2022

Reactive oxygen species (ROS) is considered a double-edged sword. The slightly elevated level of ROS helps in wound healing by inhibiting microbial infection. In contrast, excessive levels the site show deleterious effects on extending inflammation phase. Understanding ROS-mediated molecular and biomolecular mechanisms their effect cellular homeostasis thus substantially improves possibility exogenously augmenting manipulating with emerging antioxidant therapeutics. This review comprehensively delves into relationship between critical phases processes underpinning therapies. manuscript also discusses cutting-edge therapeutics that act via scavenging to enhance chronic healing.

Язык: Английский

Процитировано

94

MOF-derived bimetallic nanozyme to catalyze ROS scavenging for protection of myocardial injury DOI Creative Commons

Kaiyan Xiang,

Haoguang Wu,

Yu Liu

и другие.

Theranostics, Год журнала: 2023, Номер 13(8), С. 2721 - 2733

Опубликована: Янв. 1, 2023

Rationale: Myocardial injury triggers intense oxidative stress, inflammatory response, and cytokine release, which are essential for myocardial repair remodeling.Excess reactive oxygen species (ROS) scavenging inflammation elimination have long been considered to reverse injuries.However, the efficacy of traditional treatments (antioxidant, anti-inflammatory drugs natural enzymes) is still poor due their intrinsic defects such as unfavorable pharmacokinetics bioavailability, low biological stability, potential side effects.Nanozyme represents a candidate effectively modulate redox homeostasis treatment ROS related diseases.Methods: We develop an integrated bimetallic nanozyme derived from metal-organic framework (MOF) eliminate alleviate inflammation.The (Cu-TCPP-Mn) synthesized by embedding manganese copper into porphyrin followed sonication, could mimic cascade activities superoxide dismutase (SOD) catalase (CAT) transform radicals hydrogen peroxide, catalysis peroxide water.Enzyme kinetic analysis oxygen-production velocities were performed evaluate enzymatic Cu-TCPP-Mn.We also established infarction (MI) ischemia-reperfusion (I/R) animal models verify anti-inflammation effect Cu-TCPP-Mn.Results: As demonstrated analysis, Cu-TCPP-Mn possesses good performance in both SOD-and CAT-like achieve synergistic provide protection injury.In MI I/R models, this promising reliable technology protect heart tissue stress inflammation-induced injury, enables function recover otherwise severe damage.Conclusions: This research provides facile applicable method MOF nanozyme, alternative injuries.

Язык: Английский

Процитировано

64

A Multifunctional Hydrogel with Photothermal Antibacterial and AntiOxidant Activity for Smart Monitoring and Promotion of Diabetic Wound Healing DOI
Yue Wang, Kun Liu, Wenying Wei

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(38)

Опубликована: Апрель 21, 2024

Abstract Persistent oxidative stress and bacterial infection are significant challenges that impede diabetic wound healing. By combining diagnosis treatment, pH variation on the tissue can be monitored in real time, precise treatment carried out promptly to promote In this study, a lipoic acid‐modified chitosa (LAMC) hydrogel is constructed via an amidation reaction, ceria oxide‐molybdenum disulfide nanoparticles with polydopamine layer (C@M@P), along carbon quantum dots (CDs) synthesized by hydrothermal method, loaded into hydrogel, thus developing diagnostic therapeutic (LAMC/CD‐C@M@P). incorporating CDs, exhibits high sensitivity reversibility under ultraviolet light. Furthermore, images of hydrogels collected using smartphones converted signals, providing means for early detection infection. Notably, LAMC/CD‐C@M@P excellent photothermal antibacterial capability against Staphylococcus aureus Escherichia coli remarkable antioxidant anti‐inflammatory abilities alleviate reactive oxygen species relieve inflammation response. summary, multifunctional offers great potential as innovative dressing platform, representing advancement chronic management.

Язык: Английский

Процитировано

62

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis DOI
Weiqing Xu, Yu Wu, Wenling Gu

и другие.

Chemical Society Reviews, Год журнала: 2023, Номер 53(1), С. 137 - 162

Опубликована: Ноя. 29, 2023

Natural metalloenzymes with astonishing reaction activity and specificity underpin essential life transformations. Nevertheless, enzymes only operate under mild conditions to keep sophisticated structures active, limiting their potential applications. Artificial that recapitulate the catalytic of can not circumvent enzymatic fragility but also bring versatile functions into practice. Among them, metal-organic frameworks (MOFs) featuring diverse site-isolated metal sites supramolecular have emerged as promising candidates for move toward unparalleled properties behaviour enzymes. In this review, we systematically summarize significant advances in MOF-based metalloenzyme mimics a special emphasis on active pocket engineering at atomic level, including primary secondary coordination spheres. Then, deep understanding mechanisms advanced applications are discussed. Finally, perspective emerging frontier research is provided advance bioinspired catalysis.

Язык: Английский

Процитировано

61

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment DOI
Qinrui Fu,

Chuang Wei,

Mengzhen Wang

и другие.

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

Процитировано

61

Recent progress in MOFs-based nanozymes for biosensing DOI

Imamdin Chandio,

Yongjian Ai, Lei Wu

и другие.

Nano Research, Год журнала: 2023, Номер 17(1), С. 39 - 64

Опубликована: Июль 6, 2023

Язык: Английский

Процитировано

51