Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Сен. 23, 2022
Over
the
past
two
decades,
there
has
been
a
tendency
toward
early
diagnosis
of
prostate
cancer
due
to
raised
awareness
among
general
public
and
professionals,
as
well
promotion
prostate-specific
antigen
(PSA)
screening.
As
result,
patients
with
are
detected
at
an
earlier
stage.
Due
risks
urine
incontinence,
erectile
dysfunction,
etc.,
surgery
is
not
advised
because
tumor
so
small
this
Doctors
typically
only
advise
active
surveillance.
However,
it
will
bring
negative
psychological
effects
on
patients,
such
anxiety.
And
higher
chance
progression.
Focal
therapy
received
increasing
attention
alternative
option
between
monitoring
radical
therapy.
its
minimally
invasive,
oncological
safety,
low
toxicity,
minimal
functional
outcomes
support
by
level
1
evidence
from
RCT
within
focal
literature,
photodynamic
treatment
(PDT)
holds
significant
promise
choice
over
other
modalities
for
men
localized
cancer.
still
numerous
obstacles
that
prevent
further
advancement.
The
review
follows
provides
overview
preclinical
clinical
published
research
PDT
1999
present.
It
focuses
applications
innovative
techniques
technologies
address
current
problems,
especially
use
nanoparticle
photosensitizers
in
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(15), С. 8669 - 8742
Опубликована: Янв. 1, 2021
Inorganic
nanomaterials
that
have
inherently
exceptional
physicochemical
properties
(e.g.,
catalytic,
optical,
thermal,
electrical,
or
magnetic
performance)
can
provide
desirable
functionality
drug
delivery,
diagnostics,
imaging,
therapy)
considerable
potential
for
application
in
the
field
of
biomedicine.
However,
toxicity
be
caused
by
long-term,
non-specific
accumulation
these
inorganic
healthy
tissues,
preventing
their
large-scale
clinical
utilization.
Over
past
several
decades,
emergence
biodegradable
and
clearable
has
offered
to
prevent
such
long-term
toxicity.
In
addition,
a
comprehensive
understanding
design
metabolic
pathways
within
body
is
essential
enabling
expansion
theranostic
applications
various
diseases
advancing
trials.
Thus,
it
critical
importance
develop
biomedical
applications.
This
review
systematically
summarizes
recent
progress
nanomaterials,
particularly
cancer
theranostics
other
disease
therapies.
The
future
prospects
opportunities
this
rapidly
growing
are
also
discussed.
We
believe
timely
will
stimulate
guide
additional
in-depth
studies
area
nanomedicine,
as
rapid
vivo
clearance
degradation
likely
prerequisite
translation
with
unique
functionality.
Sonodynamic
therapy
(SDT)
has
considerably
revolutionized
the
healthcare
sector
as
a
viable
noninvasive
therapeutic
procedure.
It
employs
combination
of
low-intensity
ultrasound
and
chemical
entities,
known
sonosensitizer,
to
produce
cytotoxic
reactive
oxygen
species
(ROS)
for
cancer
antimicrobial
therapies.
With
nanotechnology,
several
unique
nanoplatforms
are
introduced
sonosensitizers,
including,
titanium-based
nanomaterials,
thanks
their
high
biocompatibility,
catalytic
efficiency,
customizable
physicochemical
features.
Additionally,
developing
sonosensitizers
facilitates
integration
SDT
with
other
treatment
modalities
(for
example,
chemotherapy,
chemodynamic
therapy,
photodynamic
photothermal
immunotherapy),
hence
increasing
overall
results.
This
review
summarizes
most
recent
developments
in
tissue
engineering
using
titanium
mediated
SDT.
The
synthesis
strategies
biosafety
aspects
Titanium-based
also
discussed.
Finally,
various
challenges
prospects
its
further
development
potential
clinical
translation
highlighted.
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(12), С. 5649 - 5656
Опубликована: Март 2, 2020
Pd
nanosheets
(Pd
NSs)
have
attracted
extensive
attention
due
to
their
promising
application
in
photothermal
therapy.
However,
photodynamic
properties
rarely
been
reported.
Herein,
holey
NSs
(H-Pd
with
intrinsic
and
hypoxia-resistant
capacities
are
fabricated
for
the
first
time
using
an
anisotropic
oxidative
etching
strategy,
which
introduces
one-dimensional
nanoholes
active
(100)
facets
on
hole
walls.
Gradual
degradation
of
H-Pd
is
observed
simulated
physiological
media
etching.
In
vitro
vivo
studies
indicate
that
single-component
can
act
as
a
photothermal/photodynamic
agent
imaging-guided
hypoxic
tumor
therapy,
high
inhibition
rate
99.7%.
This
work
provides
ideas
introducing
metallic
pore
walls,
broadening
design
biodegradable
noble
metal
nanotheranostic
agents
cancer
ACS Nano,
Год журнала:
2020,
Номер
14(2), С. 2126 - 2136
Опубликована: Фев. 6, 2020
Similar
to
translated
thermal
ablative
techniques
in
clinic,
the
occurrence
of
cellular
necrosis
during
tumor
photothermal
therapy
(PTT)
would
induce
inflammatory
responses
that
are
detrimental
therapeutic
outcomes.
Inspired
by
well-known
colorimetric
Folin-Ciocalteu
assay,
monodispersed
and
renal-clearable
tungsten
(W)-based
polyoxometalate
nanoclusters
(W-POM
NCs,
average
diameter
around
2.0
nm)
were
successfully
obtained
here
through
a
facile
redox
reaction
with
natural
gallic
acid
alkaline
aqueous
solution.
Apart
from
excellent
stability
form
freeze-dried
powder,
as-prepared
W-POM
NCs
occupied
considerable
biocompatibility
toward
normal
cells/tissues
both
vitro
vivo,
since
no
obvious
toxicities
observed
treating
female
Balb/c
mice
concentrated
30
day
post-treatment
period.
More
importantly,
exhibited
not
only
near-infrared
(NIR)
light
absorption
(coloration
effect
originated
existence
electron-trapped
W5+)
for
efficient
PTT
but
also
impressive
anti-inflammatory
ability
(eliminating
inflammation-related
reactive
oxygen
species
oxidation
W5+
into
W6+
state)
achieve
better
Thus,
our
study
pioneers
application
POMs
non-inflammatory
expected
safety
efficiency.
Applied Physics Reviews,
Год журнала:
2020,
Номер
7(4)
Опубликована: Дек. 1, 2020
Sonodynamic
therapy,
with
advantages
in
large
tissue
penetration
depth
and
great
controllability,
is
a
promising
type
of
non-invasive
cancer
treatment
method.
Developing
sonosensitizers
high
reactive
oxygen
species
(ROS)
quantum
yield
the
ability
to
regulate
tumor
microenvironment
achieve
enhanced
performances
sonodynamic
therapy
would
thus
be
rather
attractive.
Herein,
vanadium
(V)
doped
TiO2
(V-TiO2)
nanospindles
glutathione-depleting
properties
are
fabricated
for
therapy.
Due
doping
V
element,
bandgap
V-TiO2
reduced,
increasing
efficiency
ultrasound-triggered
ROS
production
compared
that
pure
nanoparticles.
More
interestingly,
also
makes
an
effective
Fenton-like
agent,
which
can
catalyze
generation
highly
toxic
hydroxyl
radicals
(•OH)
from
endogenous
H2O2
tumor,
enabling
cancer-killing
through
chemodynamic
In
addition,
endows
function
glutathione
depletion,
further
amplifying
oxidative
stress
generated
by
chemodynamic-sonodynamic
vitro
cell
experiments
vivo
animal
demonstrate
effectively
kill
combined
significantly
improving
outcomes.
Importantly,
ultrasmall
spindle
morphology
quickly
excreted
body,
without
causing
any
long-term
toxicity.
This
work
illustrates
other
special
elements
meaningful
strategy
fabricate
nanostructures
interesting
functions
useful
biomedicine.
