Biocatalysis as Key to Sustainable Industrial Chemistry

ChemSusChem, Год журнала: 2022, Номер 15(9)

Опубликована: Март 3, 2022

The role and power of biocatalysis in sustainable chemistry has been continuously brought forward step by to its present outstanding position. problem-solving capabilities have realized numerous substantial achievements biology, engineering. Advances breakthroughs the life sciences interdisciplinary cooperation with clearly accelerated implementation biocatalytic synthesis modern chemistry. Resource-efficient manufacturing processes already provided benefits as well customer-centric value creation pharmaceutical, food, flavor, fragrance, vitamin, agrochemical, polymer, specialty, fine chemical industries. Biocatalysis can make significant contributions not only processes, but also design completely new value-creation chains. now be considered a key enabling technology implement

Язык: Английский

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Biocatalysed synthesis planning using data-driven learning

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Фев. 18, 2022

Abstract Enzyme catalysts are an integral part of green chemistry strategies towards a more sustainable and resource-efficient chemical synthesis. However, the use biocatalysed reactions in retrosynthetic planning clashes with difficulties predicting enzymatic activity on unreported substrates enzyme-specific stereo- regioselectivity. As now, only rule-based systems support using biocatalysis, while initial data-driven approaches limited to forward predictions. Here, we extend reaction as well pathway prediction models based Molecular Transformer architecture biocatalysis. The knowledge is learned from extensive data set publicly available biochemical aid new class token scheme enzyme commission classification number, which captures catalysis patterns among different enzymes belonging same hierarchy. model (top-1 accuracy 49.6%), single-step round-trip 39.6%) curated made facilitate adoption design greener processes.

Язык: Английский

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Expanding the Synthetic Toolbox through Metal–Enzyme Cascade Reactions

Chemical Reviews, Год журнала: 2023, Номер 123(9), С. 5297 - 5346

Опубликована: Янв. 10, 2023

The combination of metal-, photo-, enzyme-, and/or organocatalysis provides multiple synthetic solutions, especially when the creation chiral centers is involved. Historically, enzymes and transition metal species have been exploited simultaneously through dynamic kinetic resolutions racemates. However, more recently, linear cascades appeared as elegant solutions for preparation valuable organic molecules combining bioprocesses metal-catalyzed transformations. Many advantages are derived from this symbiosis, although there still bottlenecks to be addressed including successful coexistence both catalyst types, need compatible reaction media mild conditions, or minimization cross-reactivities. Therefore, here also provided by means coimmobilization, compartmentalization strategies, flow chemistry, etc. A comprehensive review presented focusing on period 2015 early 2022, which has divided into two main sections that comprise first use metals independent catalysts but working in an orchestral sequential manner, later their application bionanohybrid materials coimmobilization adequate supports. Each part classified different subheadings, based catalyzed catalyst, while development nonasymmetric stereoselective processes was considered section.

Язык: Английский

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Accelerating the implementation of biocatalysis in industry

Applied Microbiology and Biotechnology, Год журнала: 2019, Номер 103(12), С. 4733 - 4739

Опубликована: Май 2, 2019

Язык: Английский

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Scalable biocatalytic C–H oxyfunctionalization reactions

Chemical Society Reviews, Год журнала: 2020, Номер 49(22), С. 8137 - 8155

Опубликована: Янв. 1, 2020

Biocatalytic methods for selective C–H oxyfunctionalization reactions are rapidly emerging and hold significant potential to streamline complex molecule synthesis. This review highlights key advances in this area developed within the past decade.

Язык: Английский

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Broadening the scope of biocatalytic C–C bond formation

Nature Reviews Chemistry, Год журнала: 2020, Номер 4(7), С. 334 - 346

Опубликована: Июнь 3, 2020

Язык: Английский

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Looking Back: A Short History of the Discovery of Enzymes and How They Became Powerful Chemical Tools

ChemCatChem, Год журнала: 2020, Номер 12(24), С. 6082 - 6102

Опубликована: Сен. 16, 2020

Enzymatic approaches to challenges in chemical synthesis are increasingly popular and very attractive industry given their green nature high efficiency compared traditional methods. In this historical review we highlight the developments across several fields that were necessary create modern field of biocatalysis, with enzyme engineering directed evolution at its core. We exemplify modular, incremental, highly unpredictable scientific discovery, driven by curiosity, showcase resulting examples cutting-edge enzymatic applications industry.

Язык: Английский

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Biokatalyse: Enzymatische Synthese für industrielle Anwendungen

Angewandte Chemie, Год журнала: 2020, Номер 133(1), С. 89 - 123

Опубликована: Июнь 18, 2020

Abstract Die Biokatalyse hat in verschiedenen Einsatzgebieten Anwendung als Alternative zur chemischen Katalyse gefunden, wobei die herausragendsten Beispiele Herstellung chiraler Verbindungen für Pharmazeutika und Riechstoff‐ Aromen‐Industrie sind. Zunehmend werden Biokatalysatoren im großen Maßstab genutzt, um Spezial‐ sogar Bulkchemikalien herzustellen. Dieser Aufsatz soll lehrreiche diesem Gebiet mit besonderem Augenmerk auf skalierbare chemische Verfahren aufzeigen. Es Möglichkeiten Grenzen enzymatischer Synthesen diskutiert, es wird ein Ausblick neu aufstrebende Enzymklassen gegeben.

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Continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients and their advanced intermediates

Green Chemistry, Год журнала: 2021, Номер 23(17), С. 6117 - 6138

Опубликована: Янв. 1, 2021

Catalytic enantioselective transformations provide well-established and direct access to stereogenic synthons that are broadly distributed among active pharmaceutical ingredients (APIs). These reactions have been demonstrated benefit considerably from the merits of continuous processing microreactor technology. Over past few years, flow catalysis has grown into a mature field found diverse applications in asymmetric synthesis pharmaceutically substances. The present review therefore surveys chemistry-based approaches for chiral APIs their advanced intermediates, covering utilization biocatalysis, organometallic metal-free organocatalysis introduce asymmetry continuously operated systems. Single-step processes, interrupted multistep syntheses, combined batch/flow processes uninterrupted one-flow syntheses discussed herein.

Язык: Английский

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Streamlining Design, Engineering, and Applications of Enzymes for Sustainable Biocatalysis

ACS Sustainable Chemistry & Engineering, Год журнала: 2021, Номер 9(24), С. 8032 - 8052

Опубликована: Июнь 9, 2021

In this Perspective we show how an expansion of the scope and impact biocatalysis in industrial organic synthesis is enabled by streamlining underpinning biocatalyst bioprocess engineering. We begin discussing underlying need for waste reduction high (enantio)selectivities fostered introduction as a sustainable technology active pharmaceutical ingredients (APIs). continue showing advances molecular biology, particular gene sequencing protein engineering, development more better enzymes, thereby broadening biocatalysis. Further process improvements are provided through engineering enzyme immobilization integration production with vivo immobilization. Finally, use immobilized enzymes continuous operation (biocatalysis flow) facilitates sequential multi-step reactions into enzymatic or chemo-enzymatic cascade processes, thus enabling complete, cost-effective, environmentally attractive APIs.

Язык: Английский

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