Science China Chemistry, Год журнала: 2024, Номер 67(5), С. 1397 - 1441
Опубликована: Март 22, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2022, Номер 13, С. 100197 - 100197
Опубликована: Янв. 1, 2022
Photothermal (PT)-enhanced Fenton-based chemodynamic therapy (CDT) has attracted a significant amount of research attention over the last five years as highly effective, safe, and tumor-specific nanomedicine-based therapy. CDT is new emerging nanocatalyst-based therapeutic strategy for in situ treatment tumors via Fenton reaction or Fenton-like reaction, which got fast progress recent because its high specificity activation by endogenous substances. A variety multifunctional nanomaterials such metal-, metal oxide-, metal-sulfide-based nanocatalysts have been designed constructed to trigger within tumor microenvironment (TME) generate cytotoxic hydroxyl radicals (•OH), efficient killing cells. However, still required enhance curative outcomes minimize side effects. Specifically, efficiency certain CDTs hindered TME, including low levels hydrogen peroxide (H2O2), overexpression reduced glutathione (GSH), catalytic efficacy reactions (pH 5.6-6.8), makes it difficult completely cure cancer using monotherapy. For this reason, photothermal (PTT) utilized combination with efficacy. More interestingly, heating during PTT not only causes damage cells but can also accelerate generation •OH reactions, thus enhancing efficacy, providing more effective when compared Currently, synergistic PT-enhanced both PT properties made enormous theranostics. there no comprehensive review on subject published date. In review, we first summarize treatment. We then discuss potential challenges future development nanocatalytic clinical application.
Язык: Английский
Процитировано
109
Advanced Materials, Год журнала: 2023, Номер 36(21)
Опубликована: Июль 21, 2023
Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward
Язык: Английский
Процитировано
101
Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)
Опубликована: Март 24, 2022
Presently, nanocarriers (NCs) have gained huge attention for their structural ability, good biocompatibility, and biodegradability. The development of effective NCs with stimuli-responsive properties has acquired a interest among scientists. When developing drug delivery NCs, the fundamental goal is to tackle delivery-related problems associated standard chemotherapy carry medicines intended sites action while avoiding undesirable side effects. These were able delivering drugs tumors through regulating pH, temperature, enzyme responsiveness. With use nanocarriers, chemotherapeutic could be supplied more accurately that can equally encapsulate deliver them. Material carriers are discussed in this review keeping viewpoint targeting methods make these therapeutically effective, addition metabolic pathways triggered by drug-loaded NCs. Largely, countering endogenous exogenous stimuli tumor regions understanding mechanisms would encourage progress therapy precision diagnosis future.
Язык: Английский
Процитировано
99
Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4392 - 4442
Опубликована: Янв. 1, 2023
Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.
Язык: Английский
Процитировано
93
Chemosphere, Год журнала: 2022, Номер 302, С. 134826 - 134826
Опубликована: Май 4, 2022
Язык: Английский
Процитировано
85
Advanced Functional Materials, Год журнала: 2023, Номер 33(29)
Опубликована: Июнь 9, 2023
Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.
Язык: Английский
Процитировано
61
ACS Nano, Год журнала: 2023, Номер 17(4), С. 3225 - 3258
Опубликована: Фев. 6, 2023
The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer treatment, while low response rates and systemic toxicity limit its clinical outcomes. With rapid advances in nanotechnology materials science, various types biomaterials have been developed to maximize therapeutic efficacy minimizing side effects by increasing tumor antigenicity, reversing immunosuppressive microenvironment, amplifying antitumor response, reducing extratumoral distribution inhibitors as well enhancing their retention within target sites. In this review, we reviewed current design strategies for different augment ICB effectively then discussed present representative biomaterial-assisted modulation targeted delivery boost therapy. Current challenges future development prospects expanding with were also summarized. We anticipate review will be helpful developing emerging promoting application
Язык: Английский
Процитировано
59
ACS Nano, Год журнала: 2023, Номер 18(1), С. 713 - 727
Опубликована: Дек. 20, 2023
Porphyrins and their derivatives are widely used as photosensitizers sonosensitizers in tumor treatment. Nevertheless, poor water solubility low chemical stability reduce singlet oxygen (1O2) yield and, consequently, photodynamic therapy (PDT) sonodynamic (SDT) efficiency. Although strategies for porphyrin molecule assembly have been developed to augment 1O2 generation, there is scope further improving PDT SDT efficiencies. Herein, we synthesized ordered manganese (SM) nanoparticles with well-defined self-assembled metalloporphyrin networks that enabled efficient energy transfer enhanced photocatalytic sonocatalytic activity production. Subsequently, Au were grown situ on the SM surface by anchoring terminal alkynyl of form plasmonic SMA heterostructures, which showed excellent near-infrared-II (NIR-II) region absorption photothermal properties, facilitated electron–hole pair separation transfer. With modification hyaluronic acid (HA), SMAH heterostructure nanocomposites exhibited good actively targeted cancer cells. Under NIR-II light ultrasound (US) irradiation, generates hyperthermia, a large amount 1O2, inducing cell damage. Both vitro vivo studies confirmed effectively suppressed growth decreasing GSH levels SDT-augmented PDT/PTT. Moreover, utilizing strong window, can achieve photoacoustic imaging-guided combined This work provides paradigm enhancing metalloporphyrins improve synergistic therapeutic effect SDT/PDT/PTT.
Язык: Английский
Процитировано
58
Chemical Society Reviews, Год журнала: 2023, Номер 52(17), С. 6075 - 6119
Опубликована: Янв. 1, 2023
The adsorptive separation based on nonporous adaptive crystals (NACs) is an attractive green technology. Herein, we comprehensively summarize recent advances in various supramolecular hosts-based NACs for hydrocarbon separation.
Язык: Английский
Процитировано
55
Journal of Photochemistry and Photobiology B Biology, Год журнала: 2023, Номер 248, С. 112796 - 112796
Опубликована: Окт. 4, 2023
Язык: Английский
Процитировано
47