Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

Nano-Micro Letters, Год журнала: 2023, Номер 16(1)

Опубликована: Ноя. 21, 2023

Since the discovery of enzyme-like activity Fe

Язык: Английский

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Год журнала: 2023, Номер 32, С. 66 - 97

Опубликована: Сен. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Язык: Английский

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Light-Triggered Nanozymes Remodel the Tumor Hypoxic and Immunosuppressive Microenvironment for Ferroptosis-Enhanced Antitumor Immunity

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12261 - 12275

Опубликована: Апрель 29, 2024

Cancer immunotherapy holds significant promise for addressing diverse malignancies. Nevertheless, its efficacy remains constrained by the intricate tumor immunosuppressive microenvironment. Herein, a light-triggered nanozyme Fe-TCPP-R848-PEG (Fe-MOF-RP) was designed remodeling The Fe-TCPP-MOFs were utilized not only as core catalysis component against destruction but also biocompatible delivery vector of an immunologic agonist, improving long circulation and enrichment. Concurrently, it catalyzes decomposition H2O2 within tumor, yielding oxygen to augment photodynamic therapy. induced ferroptosis, in synergy with therapy, prompts liberation tumor-associated antigens from cells inducing immunogenic cell death. Phototriggered on-demand release R848 agonists stimulated maturation dendritic reverted tumor-promoting M2 phenotypes into adoptive M1 macrophages, which further reshaped Notably, effectively restrains well-established tumors, such B16F10 melanoma. Moreover, demonstrates distal tumor-inhibiting effect upon situ light treatment. What is more, lung metastasis model, elicits robust immune memory, conferring enduring protection rechallenge. Our study presents straightforward broadly applicable strategy crafting nanozymes potential thwart cancer recurrence metastasis.

Язык: Английский

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Genetically Edited Cascade Nanozymes for Cancer Immunotherapy

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12295 - 12310

Опубликована: Май 2, 2024

Immune checkpoint blockade (ICB) has brought tremendous clinical progress, but its therapeutic outcome can be limited due to insufficient activation of dendritic cells (DCs) and infiltration cytotoxic T lymphocytes (CTLs). Evoking immunogenic cell death (ICD) is one promising strategy promote DC maturation elicit T-cell immunity, whereas low levels ICD induction solid tumors restrict durable antitumor efficacy. Herein, we report a genetically edited membrane-coated cascade nanozyme (gCM@MnAu) for enhanced cancer immunotherapy by inducing activating the stimulator interferon genes (STING) pathway. In tumor microenvironment (TME), gCM@MnAu initiates reaction generates abundant hydroxyl (•OH), resulting in improved chemodynamic therapy (CDT) boosted activation. addition, released Mn

Язык: Английский

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Gas-Amplified Metalloimmunotherapy with Dual Activation of Pyroptosis and the STING Pathway for Remodeling the Immunosuppressive Cervical Cancer Microenvironment

ACS Nano, Год журнала: 2024, Номер 18(20), С. 12830 - 12844

Опубликована: Май 6, 2024

The immunosuppressive microenvironment of cervical cancer significantly hampers the effectiveness immunotherapy. Herein, PEGylated manganese-doped calcium sulfide nanoparticles (MCSP) were developed to effectively enhance antitumor immune response through gas-amplified metalloimmunotherapy with dual activation pyroptosis and STING pathway. bioactive MCSP exhibited ability rapidly release Ca2+, Mn2+, H2S in tumor microenvironment. disrupted buffer system cells by interfering oxidative phosphorylation pathway, leading overload-triggered pyroptosis. On other hand, H2S-mediated mitochondrial dysfunction further promoted DNA (mtDNA), enhancing effect Mn2+ on cGAS-STING signaling axis thereby activating immunosuppressed dendritic cells. released acted as an important synergist between Ca2+ modulating mechanisms bridge innate adaptive responses. combination NPs PD-1 immunotherapy achieved synergistic effects inhibited growth. This study reveals potential collaboration gas therapy provides idea for design nanoimmunomodulators rational regulation

Язык: Английский

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Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(8), С. 3432 - 3456

Опубликована: Май 13, 2024

The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.

Язык: Английский

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Employing Piezoelectric Mg²⁺‐Doped Hydroxyapatite to Target Death Receptor‐Mediated Necroptosis: A Strategy for Amplifying Immune Activation

Advanced Science, Год журнала: 2024, Номер 11(13)

Опубликована: Янв. 22, 2024

Abstract Although immunogenic cell death (ICD) inducers evidently enhance the effectiveness of immunotherapy, their potential is increasingly restricted by development apoptosis resistance in tumor cells, poor immunogenicity, and low T‐cell immune responsiveness. In this study, for first time, piezoelectrically catalyzed Mg 2+ ‐doped hydroxyapatite (Mg‐HAP) nanoparticles, which are coated with a mesoporous silica layer loaded ONC201 as an agonist to specifically target receptor DR5 on ultimately developing Mg‐HAP@MS/ONC201 nanoparticle (MHMO NP) system, engineered. Owing its excellent piezoelectric properties, MHMO facilitates release significant amount reactive oxygen species Ca within effectively promoting upregulation expression inducing necroptosis overcome resistance. Concurrently, released microenvironment promotes CD8 + T activation response antitumor reaction induced ICD. Using RNA‐seq analysis, it elucidated that can activate NF‐κB pathway under catalysis, thus M1‐type macrophage polarization. summary, dual‐targeting therapy system targets both cells catalysis designed. This holds substantial advancements immunotherapy.

Язык: Английский

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3D‐Printed Dendritic Cell Vaccines for Post‐Surgery Cancer Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Март 31, 2024

Abstract Dendritic cell (DC) vaccines have shown promising effects in cancer management, while low activity and migration rate to lymph nodes limit their clinical application. Here, this work reports a bioink DC vaccine, synthesized by 3D printing methacryloyl gelatin encapsulate DCs tumor cellular vesicles overexpressing programmed death protein 1 (PD1‐CVs), for immunotherapy. Compared with traditional hydrogel, the porous scaffold significantly improves viability of from ∼16% ∼70% after 7 days culture increases proportion released into about fourfold. The PD1‐CVs stimulate maturation block PD ligand‐1 (PD‐L1) mature cells, synergistically boosting DC‐mediated antitumor immunity. In breast mouse models, personalized vaccine developed site‐specific filling resection suppress recurrence extend median survival time 45 days. This printed offers simple, safe, robust strategy enhanced cell‐based

Язык: Английский

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Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(26)

Опубликована: Авг. 4, 2023

Abstract The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, have found significant role improving drug delivery inhibiting the growth metastasis tumor cells. Moreover, recent studies highlighted potential modulating microenvironment (TME) enhancing activity immune cells improve therapy efficacy. Various types are currently utilized carriers, immunosuppressants, activators, immunoassay reagents, more for immunotherapy. Necessarily, used immunotherapy can be grouped into two categories: organic inorganic nanomaterials. Though both shown ability achieve purpose immunotherapy, composition properties result differences mechanisms modes action. Organic further divided polymers, cell membranes, nanoemulsion‐modified, hydrogel forms. At same time, broadly classified nonmetallic metallic current work aims explore action these different prospects promoting

Язык: Английский

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In situ formed scaffold with royal jelly-derived extracellular vesicles for wound healing

Theranostics, Год журнала: 2023, Номер 13(9), С. 2811 - 2824

Опубликована: Янв. 1, 2023

Safe and effective wound healing can be a major clinical challenge. Inflammation vascular impairment are two main causes of inadequate healing.

Язык: Английский

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