Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 409 - 409
Опубликована: Март 25, 2025
Colorectal
cancer
poses
a
significant
threat
to
human
health
due
its
high
aggressiveness
and
poor
prognosis.
Key
factors
impacting
patient
outcomes
include
post-surgical
recurrence,
chemotherapeutic
drug
resistance,
insensitivity
immunotherapy.
Consequently,
early
diagnosis
the
development
of
effective
targeted
therapies
are
essential
for
improving
prevention
treatment
strategies.
Inorganic
nanomaterials
have
gained
prominence
in
colorectal
owing
their
unique
size,
advantageous
properties,
modifiability.
Various
types
inorganic
nanomaterials—such
as
metal-based,
metal
oxide,
quantum
dots,
magnetic
nanoparticles,
carbon-based,
rare-earth
nanomaterials—have
demonstrated
potential
enhancing
multimodal
imaging,
delivery,
synergistic
therapies.
These
advancements
underscore
critical
role
therapeutic
outcomes.
This
review
highlights
properties
nanomaterials,
summarizes
recent
applications
progress
treatment,
discusses
challenges
translating
these
materials
into
clinical
use.
It
aims
provide
valuable
insights
future
research
application
management.
Abstract
Atherosclerosis,
a
multifaceted
chronic
inflammatory
disease,
has
profound
impact
on
cardiovascular
health.
However,
the
critical
limitations
of
atherosclerosis
management
include
delayed
detection
advanced
stages,
intricate
assessment
plaque
stability,
and
absence
efficacious
therapeutic
strategies.
Nanotheranostic
based
nanotechnology
offers
novel
paradigm
for
addressing
these
challenges
by
amalgamating
imaging
capabilities
with
targeted
interventions.
Meanwhile,
iron
oxide
nanoparticles
have
emerged
as
compelling
candidates
theranostic
applications
in
due
to
their
magnetic
resonance
capability
biosafety.
This
review
delineates
current
state
prospects
nanoparticle‐based
nanotheranostics
realm
atherosclerosis,
including
pivotal
aspects
development,
pertinent
targeting
strategies
involved
disease
pathogenesis,
diagnostic
roles
nanoparticles.
Furthermore,
this
provides
comprehensive
overview
nanomedicine
approaches
employing
nanoparticles,
encompassing
chemical
therapy,
physical
stimulation
biological
therapy.
Finally,
proposes
discusses
associated
translating
innovative
into
clinically
viable
anti‐atherosclerosis
In
conclusion,
new
insights
future
theranostic,
showcasing
remarkable
potential
oxide‐based
versatile
tools
battle
against
atherosclerosis.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 1001 - 1001
Опубликована: Янв. 13, 2024
Globally,
cardiovascular
diseases
(CVDs)
are
the
leading
cause
of
death
and
disability.
While
there
many
therapeutic
alternatives
available
for
management
CVDs,
majority
classic
strategies
were
found
to
be
ineffective
at
stopping
or
significantly/additionally
slowing
progression
these
diseases,
they
had
unfavorable
side
effects.
Numerous
metal-based
nanoparticles
(NPs)
have
been
created
overcome
limitations,
demonstrating
encouraging
possibilities
in
treatment
CVDs
due
advancements
nanotechnology.
Metallic
nanomaterials,
including
gold,
silver,
iron,
come
various
shapes,
sizes,
geometries.
NPs
generally
smaller
more
specialized
physical,
chemical,
biological
properties.
Metal-based
may
forms,
such
as
nanoshells,
nanorods,
nanospheres,
studied
most.
Massive
potential
applications
metal
nanomaterial
structures
include
supporting
molecular
imaging,
serving
drug
delivery
systems,
enhancing
radiation-based
anticancer
therapy,
supplying
photothermal
transforming
effects
thermal
being
compounds
with
bactericidal,
fungicidal,
antiviral
qualities
that
helpful
diseases.
In
this
context,
present
paper
aims
review
relevant
oxide
creating
an
up-to-date
framework
aids
researchers
developing
efficient
strategies.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
Applied Sciences,
Год журнала:
2024,
Номер
14(3), С. 1132 - 1132
Опубликована: Янв. 29, 2024
Magnetite-based
nanoparticles
are
of
constant
interest
in
the
scientific
community
as
potential
systems
for
biomedical
applications.
Over
years,
ability
to
synthesize
diverse
based
on
iron
(II,
III)
oxide
has
been
mastered
maximize
their
effectiveness
targeted
delivery
active
substances
cancer
therapy.
The
present
review
explores
recent
literature
findings
that
detail
various
magnetic
nanosystems.
These
encompass
straightforward
designs
featuring
a
polymer
coating
core
and
more
intricate
matrices
delivering
chemotherapeutic
drugs.
This
paper
emphasizes
novel
synthetic
approaches
impact
efficacy
progress
anticancer
investigations,
specifically
targeting
particular
type.
research
also
delves
into
combinations
with
alternative
treatment
methods
diagnostic
approaches.
Additionally,
it
highlights
critical
aspect—the
interaction
cells—identifying
least
developed
aspect
current
these
systems.
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1030 - 1030
Опубликована: Фев. 27, 2024
The
use
of
conventional
methods
for
the
treatment
cancer,
such
as
chemotherapy
or
radiotherapy,
and
approaches
brachytherapy
in
conjunction
with
unique
properties
nanoparticles
could
enable
development
novel
theranostic
agents.
aim
our
current
study
was
to
evaluate
potential
iron
oxide
nanoparticles,
coated
alginic
acid
polyethylene
glycol,
functionalized
chemotherapeutic
agent
doxorubicin
monoclonal
antibody
bevacizumab,
serve
a
nanoradiopharmaceutical
against
breast
cancer.
Direct
radiolabeling
therapeutic
isotope
Lutetium-177
(177Lu)
resulted
an
additional
effect.
Functionalization
accomplished
at
high
percentages
robust.
cytotoxic
effect
radiolabeled
non-radiolabeled
nanostructures
proven
vitro
five
different
cancer
cell
lines.
ex
vivo
biodistribution
tumor-bearing
mice
investigated
three
ways
administration.
intratumoral
administration
radionanoconjugates
showed
tumor
accumulation
retention
site.
Finally,
efficacy
performed
over
50-day
period
aggressive
triple-negative
line
(4T1)
demonstrated
enhanced
growth
retention,
thus
identifying
developed
promising
nanobrachytherapy
