Marine Life Science & Technology,
Journal Year:
2023,
Volume and Issue:
5(1), P. 85 - 93
Published: Jan. 20, 2023
Further
insights
on
the
secondary
metabolites
of
a
soft
coral-derived
fungus
Aspergillus
versicolor
under
guidance
MS/MS-based
molecular
networking
led
to
isolation
seven
known
cycloheptapeptides,
namely,
asperversiamides
A-C
(1-3)
and
asperheptatides
A-D
(4-7)
an
unusual
pyrroloindoline-containing
new
cycloheptapeptide,
asperpyrroindotide
A
(8).
The
structure
8
was
elucidated
by
comprehensive
spectroscopic
data
analysis,
its
absolute
configuration
determined
advanced
Marfey's
method.
semisynthetic
transformation
1
into
successfully
achieved
reaction
conditions
were
optimized.
Additionally,
series
derivatives
(10-19)
asperversiamide
(1)
semi-synthesized
their
anti-tubercular
activities
evaluated
against
Mycobacterium
tuberculosis
H37Ra.
preliminary
structure-activity
relationships
revealed
that
serine
hydroxy
groups
tryptophan
residue
are
important
activity.The
online
version
contains
supplementary
material
available
at
10.1007/s42995-022-00157-8.
Marine Drugs,
Journal Year:
2021,
Volume and Issue:
19(10), P. 530 - 530
Published: Sept. 23, 2021
The
prevalence
of
antimicrobial
resistance
reduces
the
effectiveness
drugs
in
preventing
and
treating
infectious
diseases
caused
by
pathogenic
organisms,
such
as
bacteria,
fungi,
viruses.
Because
burgeoning
growth
microbes
with
antimicrobial-resistant
traits,
there
is
a
dire
need
to
identify
develop
novel
effective
agents
treat
infections
from
strains.
marine
environment
rich
ecological
biodiversity
can
be
regarded
an
untapped
resource
for
prospecting
bioactive
compounds.
Therefore,
exploring
plays
significant
role
drug
development
biomedical
research.
Several
earlier
scientific
investigations
have
proven
that
bacterial
diversity
represents
emerging
source
structurally
unique
agents.
There
are
several
reports
on
secondary
metabolites,
many
pharmacologically
enormous
promise
developing
combat
microbial
drug-resistant
pathogens.
In
this
review,
we
attempt
summarize
published
articles
last
twenty-five
years
(1996–2020)
metabolites
bacteria
evolved
environments,
sediment,
water,
fauna,
flora.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(5), P. 1643 - 1643
Published: March 2, 2022
This
review
describes
the
recent
Food
and
Drug
Administration
(FDA)-approved
drugs
(in
year
2021)
containing
at
least
one
halogen
atom
(covalently
bound).
The
structures
proposed
throughout
this
work
are
grouped
according
to
their
therapeutical
use.
Their
synthesis
is
presented
as
well.
number
of
halogenated
molecules
that
reaching
market
regularly
preserved,
14
50
approved
by
FDA
in
last
contain
halogens.
underlines
emergent
role
halogens
and,
particular,
fluorine
chlorine
preparation
for
treatment
several
diseases
such
viral
infections,
types
cancer,
cardiovascular
disease,
multiple
sclerosis,
migraine
inflammatory
vasculitis.
Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products,
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 546
Food Production Processing and Nutrition,
Journal Year:
2023,
Volume and Issue:
5(1)
Published: March 20, 2023
Abstract
Green
seaweed,
as
the
most
abundant
species
of
macroseaweeds,
is
an
important
marine
biological
resource.
It
a
rich
source
several
amino
acids,
fatty
and
dietary
fibers,
well
polysaccharides,
polyphenols,
pigments,
other
active
substances,
which
have
crucial
roles
in
various
processes
such
antioxidant
activity,
immunoregulation,
anti-inflammatory
response.
In
recent
years,
attention
to
resources
has
accelerated
exploration
utilization
green
seaweeds
for
greater
economic
value.
This
paper
elaborates
on
main
nutrients
substances
present
different
provides
review
their
activities
applications
high-value
utilization.
Graphical
abstract
Natural Products and Bioprospecting,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 24, 2025
Abstract
Marine
natural
products
have
long
been
recognized
as
a
vast
and
diverse
source
of
bioactive
compounds
with
potential
therapeutic
applications,
particularly
in
oncology.
This
review
provides
an
updated
overview
the
significant
advances
made
discovery
development
marine-derived
anticancer
drugs
between
2019
2023.
With
focus
on
recent
research
findings,
explores
rich
biodiversity
marine
organisms,
including
sponges,
corals,
algae,
microorganisms,
which
yielded
numerous
exhibiting
promising
properties.
Emphasizing
multifaceted
mechanisms
action,
discusses
molecular
targets
pathways
targeted
by
these
compounds,
such
cell
cycle
regulation,
apoptosis
induction,
angiogenesis
inhibition,
modulation
signaling
pathways.
Additionally,
highlights
innovative
strategies
employed
isolation,
structural
elucidation,
chemical
modification
to
enhance
their
potency,
selectivity,
pharmacological
Furthermore,
it
addresses
challenges
opportunities
associated
drugs,
issues
related
supply,
sustainability,
synthesis,
clinical
translation.
Finally,
underscores
immense
valuable
reservoir
novel
agents
advocates
for
continued
exploration
exploitation
environment
address
unmet
medical
needs
cancer
therapy
Graphical
Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(9), P. 1431 - 1431
Published: Sept. 8, 2021
Reactive
oxygen
species
(ROS)
attack
biological
molecules,
such
as
lipids,
proteins,
enzymes,
DNA,
and
RNA,
causing
cellular
tissue
damage.
Hence,
the
disturbance
of
antioxidant
homeostasis
can
lead
to
oxidative
stress
onset
a
plethora
diseases.
Macroalgae,
growing
in
stressful
conditions
under
intense
exposure
UV
radiation,
have
developed
protective
mechanisms
been
recognized
an
important
source
secondary
metabolites
macromolecules
with
activity.
In
parallel,
fact
that
many
algae
be
cultivated
coastal
areas
ensures
provision
sufficient
quantities
fine
chemicals
biopolymers
for
commercial
utilization,
rendering
them
viable
antioxidants.
This
review
focuses
on
progress
made
concerning
discovery
compounds
derived
from
marine
macroalgae,
covering
literature
up
December
2020.
The
present
report
presents
potential
biogenetic
origin
301
macroalgal
metabolites,
categorized
according
their
chemical
classes,
highlighting
antioxidative
action
when
known.
RSC Advances,
Journal Year:
2021,
Volume and Issue:
11(50), P. 31339 - 31363
Published: Jan. 1, 2021
Since
its
first
report
in
December
2019,
the
novel
coronavirus
virus,
SARS-CoV-2,
has
caused
an
unprecedented
global
health
crisis
and
economic
loss
imposing
a
tremendous
burden
on
worldwide
finance,
healthcare
system,
even
daily
life.
Even
with
introduction
of
different
preventive
vaccines,
there
is
still
dire
need
for
effective
antiviral
therapeutics.
Nature
been
considered
as
historical
trove
drug
discovery
development,
particularly
cases
crises.
Herein,
comprehensive
Natural Product Reports,
Journal Year:
2021,
Volume and Issue:
39(1), P. 7 - 19
Published: Oct. 16, 2021
Covering:
1877
to
2020A
key
challenge
in
natural
products
research
is
the
selection
of
biodiversity
yield
novel
chemistry.
Recently,
marine
microorganisms
have
become
a
preferred
source.
But
how
are
microorganism
compared
those
reported
from
terrestrial
microbes?
Cluster
analysis
chemical
fingerprints
and
molecular
scaffold
55
817
compounds
microorganisms,
macro-organisms
showed
that
76.7%
isolated
closely
related
microorganisms.
Only
14.3%
unique
when
macro-organism
also
considered.
Studies
targeting
specific
understudied
microbial
phyla
result
higher
likelihood
finding
compounds,
whereas
depth
geographic
location
collection
little
influence.
We
recommend
targeted
strain
isolation,
incorporating
early
use
genomic
sequencing
guide
selection,
innovation
culture
media
cultivation
techniques
application
cheminformatics
tools
focus
on
product
diversity,
rather
than
dereplication
known
compounds.
