Which cell death modality wins the contest for photodynamic therapy of cancer?

Cell Death and Disease, Год журнала: 2022, Номер 13(5)

Опубликована: Май 13, 2022

Abstract Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed the treatment of several types cancer. Traditionally, cell death induced by categorized into three types: apoptosis, associated with autophagy, necrosis. However, discovery other regulated modalities in recent years, it has become clear that this is a rather simple understanding mechanisms action PDT. New observations revealed cancer cells exposed to can pass through various non-conventional pathways, such as paraptosis, parthanatos, mitotic catastrophe, pyroptosis, necroptosis, ferroptosis. Nowadays, immunogenic (ICD) one most promising ways eradicate tumor activation T-cell adaptive immune response induction long-term immunological memory. ICD be triggered anti-cancer methods, including In review, we critically discuss findings on Next, emphasize role contribution these PDT-induced modalities. Finally, obstacles propose areas research will help overcome challenges lead development highly effective based

Язык: Английский

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Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death

ACS Nano, Год журнала: 2022, Номер 16(3), С. 3647 - 3663

Опубликована: Март 10, 2022

The nanocatalytic activity of nanozymes provides a vision for tumor treatment. However, the glutathione (GSH)-related antioxidant defense system (ADS) formed on basis excessive GSH in microenvironment limits its catalytic activity. Here, dendritic mesoporous silica nanoparticles (DMSNs) were employed as nanocarrier; ultrasmall Fe3O4 nanoparticles, Mn2+ ions, and glutaminase inhibitor Telaglenastat (CB-839) subsequently integrated into large mesopores DMSNs, forming DMSN/Fe3O4–Mn@CB-839 (DFMC) nanomedicine. This nanomedicine exhibits peroxidase mimicking activities under acidic conditions, which catalyzes decomposition hydrogen peroxide (H2O2) hydroxyl radical (•OH). also promotes formation lipid peroxides, is required ferroptosis. Furthermore, this can effectively deplete existing GSH, thereby enhancing reactive oxygen species (ROS)-mediated therapy. Moreover, introduced CB-839 blocks endogenous synthesis further depletion performance, reduces excretion oxaliplatin (GSH-related resistance) from cells, restoring chemical sensitivity oxaliplatin. dual property significantly weakens GSH-related ADS restores oxaliplatin, leading to high DFMC-induced apoptosis ferroptosis cells. Our developed based nanotechnology clinical drug may aid development

Язык: Английский

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Recent advances and trends in nanoparticles based photothermal and photodynamic therapy

Photodiagnosis and Photodynamic Therapy, Год журнала: 2021, Номер 37, С. 102697 - 102697

Опубликована: Дек. 20, 2021

Язык: Английский

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Dual key co-activated nanoplatform for switchable MRI monitoring accurate ferroptosis-based synergistic therapy

Chem, Год журнала: 2022, Номер 8(7), С. 1956 - 1981

Опубликована: Март 28, 2022

Язык: Английский

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Regulatory pathways and drugs associated with ferroptosis in tumors

Cell Death and Disease, Год журнала: 2022, Номер 13(6)

Опубликована: Июнь 10, 2022

Abstract Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS). The accumulation lipid peroxidation primarily initiates oxidative membrane damage during ferroptosis. core molecular mechanism ferroptosis includes the regulation oxidation balance between antioxidant defense. Tumor cells usually contain large amount H 2 O , ferrous/iron ions will react with excessive in to produce hydroxyl radicals induce tumor cells. Here, we reviewed latest studies introduced tumor-related signaling pathways We paid particular attention role noncoding RNA, nanomaterials, drugs, targeted treatment using drugs for mediating process Finally, discussed currently unresolved problems future research directions prospects this emerging field. Therefore, have attempted provide reference further understanding pathogenesis proposed new targets cancer treatment.

Язык: Английский

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Ferritin‐Hijacking Nanoparticles Spatiotemporally Directing Endogenous Ferroptosis for Synergistic Anticancer Therapy

Advanced Materials, Год журнала: 2022, Номер 34(51)

Опубликована: Окт. 10, 2022

Abstract Existing ferroptosis as an iron‐dependent form of regulated cell death primarily relies on importing exogenous iron. However, the excessive employment toxic materials may cause potential adverse effects human health. Herein, a ferritin‐hijacking nanoparticle (Ce6‐PEG‐HKN 15 ) is fabricated, by conjugating ferritin‐homing peptide HKN with photosensitizer chlorin e6 (Ce6) for endogenous without introducing Fenton‐reactive metals. Once internalized, designed Ce6‐PEG‐HKN NPs can specifically accumulate around ferritin. With laser irradiation, activated Ce6 in nanoparticles potently generates reactive oxygen species (ROS) surrounding Abundant ROS not only helps to destroy iron storage protein and activate but also directly kill tumor cells. In turn, released partially interacts intracellular excess H 2 O produce , thereby enhancing photodynamic therapy further amplifying oxidative stress. Overall, this work highlights possibility via spatiotemporally destroying ferritin, offering paradigm synergistic ferroptosis–photodynamic antitumor therapy.

Язык: Английский

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Ferroptosis Nanomedicine: Clinical Challenges and Opportunities for Modulating Tumor Metabolic and Immunological Landscape

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15328 - 15353

Опубликована: Авг. 13, 2023

Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid peroxidation, has captured much attention in the field nanomedicine since it was coined 2012. Compared with other modes such as apoptosis and pyroptosis, ferroptosis many distinct features molecular mechanisms cellular morphology, representing promising strategy for treating cancers that are resistant to conventional therapeutic modalities. Moreover, recent insights collectively reveal is tightly connected maintenance tumor immune microenvironment (TIME), suggesting potential application therapies evoking robust antitumor immunity. From biochemical perspective, intricately multiple metabolic pathways, including iron metabolism, lipid redox etc., highlighting importance elucidate relationship between metabolism developing therapies. In this review, we provide comprehensive discussion on current understanding ferroptosis-inducing thoroughly discuss various traits tumors, which offer opportunities direct inhibition through nanointegrated approach. Extending from complex impact TIME, also discussed those important considerations development ferroptosis-based immunotherapy, challenges strategies enhance ferroptosis-enabled immunostimulatory effects while avoiding side effects. We envision study may facilitate translation nanomedicines treatment.

Язык: Английский

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Год журнала: 2023, Номер 32, С. 66 - 97

Опубликована: Сен. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Язык: Английский

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Clustered Cobalt Nanodots Initiate Ferroptosis by Upregulating Heme Oxygenase 1 for Radiotherapy Sensitization

Small, Год журнала: 2023, Номер 19(10)

Опубликована: Янв. 10, 2023

Abstract High cobalt (Co) levels in tumors are associated with good clinical prognosis. An anticancer regimen that increases intratumoral Co through targeted nanomaterial delivery is proposed this study. Bovine serum albumin and dichloride applied to prepare cobaltous oxide nanodots using a facile biomineralization strategy. After iRGD peptide conjugation, the loaded into dendritic mesoporous silica nanoparticles, generating biocompatible product iCoDMSN. This nanocomposite accumulates after intravenous injection by deep tissue penetration can be used for photoacoustic imaging. Proteomics research molecular biology experiments reveal iCoDMSN potent ferroptosis inducer cancer cells. Mechanistically, iCoDMSNs upregulate heme oxygenase 1 (HMOX1), which transferrin receptors reduces solute carrier family 40 member (SLC40A1), resulting Fe 2+ accumulation initiation. Furthermore, upregulated nuclear factor erythroid 2‐related 2 (NRF2), arising from reduction Kelch‐like ECH‐associated protein (KEAP1) expression, responsible HMOX1 enhancement treatment. Owing intensified ferroptosis, acts as an efficient radiotherapy enhancer eliminate cells vitro vivo. study demonstrates versatile Co‐based primes expanding labile iron pool cells, providing promising tumor sensitizer.

Язык: Английский

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Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials

Cancers, Год журнала: 2024, Номер 16(3), С. 512 - 512

Опубликована: Янв. 24, 2024

Iron (Fe) and copper (Cu), essential transition metals, play pivotal roles in various cellular processes critical to cancer biology, including cell proliferation, mitochondrial respiration, distant metastases, oxidative stress. The emergence of ferroptosis cuproptosis as distinct forms non-apoptotic death has heightened their significance, particularly connection with these metal ions. While initially studied separately, recent evidence underscores the interdependence cuproptosis. Studies reveal a link between accumulation induction. This interconnected relationship presents promising strategy, especially for addressing refractory cancers marked by drug tolerance. Harnessing toxicity iron clinical settings becomes crucial. Simultaneous targeting cuproptosis, exemplified combination sorafenib elesclomol-Cu, represents an intriguing approach. Strategies mitochondria further enhance precision approaches, providing hope improving treatment outcomes drug-resistant cancers. Moreover, chelators copper-lowering agents established therapeutic modalities exhibits synergy that holds promise augmentation anti-tumor efficacy malignancies. review elaborates on complex interplay underlying mechanisms, explores potential druggable targets both research settings.

Язык: Английский

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