Abstract
Organic
agents
possessing
NIR‐II
and
photoacoustic
duplex
imaging
capabilities,
coupled
with
high‐efficiency
photothermal
conversion,
offer
significant
potential
for
noninvasive
precise
phototheranostics
of
glioblastoma,
which
is
further
augmented
when
these
can
concurrently
exhibit
tumor
targeting
blood–brain
barrier
(BBB)
permeability.
This
study
reports
a
series
finely
tunable
molecular
luminophores
based
on
the
aza‐BODIPY
scaffold,
featuring
unique
twisted
rotatable
structures.
They
are
constructed
to
folate‐decorated
polymeric
nanoparticles,
exhibiting
remarkable
NIR‐II/photoacoustic
performance
superior
conversion
efficiency
(49.7%).
Folate
modification
enables
BBB
permeability
through
receptor‐mediated
transcytosis,
allowing
efficient
phototherapy
in
4T1‐/glioblastoma‐bearing
mice
after
single
intravenous
injection
irradiation.
presents
rational
engineering
approach
versatile
structural
scaffold
designing
emitters
tailored
photophysical
properties
desirable
phototherapeutic
efficacy,
thereby
offering
novel
perspectives
development
advanced
depth
probes
brain
therapeutics.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(5), С. 1795 - 1835
Опубликована: Янв. 1, 2022
The
discovery
of
a
near-infrared
(NIR,
650-900
nm)
fluorescent
chromophore
hemicyanine
dye
with
high
structural
tailorability
is
great
significance
in
the
field
detection,
bioimaging,
and
medical
therapeutic
applications.
It
exhibits
many
outstanding
advantages
including
absorption
emission
NIR
region,
tunable
spectral
properties,
photostability
as
well
large
Stokes
shift.
These
properties
are
superior
to
those
conventional
fluorogens,
such
coumarin,
fluorescein,
naphthalimides,
rhodamine,
cyanine.
Researchers
have
made
remarkable
progress
developing
activity-based
multifunctional
probes
based
on
skeletons
for
monitoring
vital
biomolecules
living
systems
through
output
fluorescence/photoacoustic
signals,
integration
diagnosis
treatment
diseases
using
chemotherapy
or
photothermal/photodynamic
therapy
combination
therapy.
achievements
prompted
researchers
develop
more
smart
fluorogen
template.
In
this
review,
we
begin
by
describing
brief
history
dyes,
synthetic
approaches,
design
strategies
functional
probes.
Then,
selected
hemicyanine-based
that
can
detect
ions,
small
biomolecules,
overexpressed
enzymes
diagnostic
reagents
systematically
highlighted.
Finally,
potential
drawbacks
outlook
future
investigation
clinical
medicine
transformation
activatable
also
discussed.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(7), С. 2322 - 2357
Опубликована: Янв. 1, 2023
Typical
PeT-based
fluorescent
probes
are
multi-component
systems
where
a
fluorophore
is
connected
to
recognition/activating
group
by
an
unconjugated
linker.
powerful
tools
for
cell
imaging
and
disease
diagnosis
due
their
low
fluorescence
background
significant
enhancement
towards
the
target.
This
review
provides
research
progress
that
target
polarity,
pH
biological
species
(reactive
oxygen
species,
biothiols,
biomacromolecules,
etc.)
over
last
five
years.
In
particular,
we
emphasise
molecular
design
strategies,
mechanisms,
application
of
these
probes.
As
such,
this
aims
provide
guidance
enable
researchers
develop
new
improved
probes,
as
well
promoting
use
sensing,
imaging,
therapy.
Journal of the American Chemical Society,
Год журнала:
2021,
Номер
143(50), С. 21143 - 21160
Опубликована: Дек. 8, 2021
Fluorescent
organic
dyes
have
been
extensively
used
as
raw
materials
for
the
development
of
versatile
imaging
tools
in
field
biomedicine.
Particularly,
solid-state
fluorophores
(SSOFs)
past
20
years
has
exhibited
an
upward
trend.
In
recent
years,
studies
on
SSOFs
focused
advanced
tools,
such
optical
contrast
agents
and
phototherapy
agents,
biomedical
applications.
However,
practical
application
these
hindered
owing
to
several
limitations.
Thus,
this
Perspective,
we
provided
insights
that
could
aid
researchers
further
develop
overcome
limitations
limited
aqueous
dispersibility,
low
biocompatibility,
uncontrolled
emission.
First,
described
inherent
photophysical
properties
fluorescence
mechanisms
conventional,
aggregation-induced
emissive,
precipitating
with
respect
their
Subsequently,
highlighted
functionalized
bioimaging,
biosensing,
theranostics.
Finally,
elucidated
potential
prospects
current
SSOF-based
associated
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 10, 2023
Rapid
advancements
in
materials
science
and
nanotechnology,
intertwined
with
oncology,
have
positioned
photothermal
therapy
(PTT)
as
a
promising
noninvasive
treatment
strategy
for
cancer.
The
breast's
superficial
anatomical
location
aesthetic
significance
render
breast
cancer
particularly
pertinent
candidate
the
clinical
application
of
PTT
following
melanoma.
This
review
comprehensively
explores
research
conducted
on
various
types
nanoparticles
employed
elaborates
their
specific
roles
mechanisms
action.
integration
existing
therapies
is
scrutinized,
underscoring
its
potential
synergistic
outcomes.
Additionally,
underlying
consequential
modifications
to
tumor
microenvironment
after
are
elaborated
from
medical
perspective.
Future
directions
suggested,
an
emphasis
development
integrative
platforms
that
combine
multiple
therapeutic
approaches
optimization
nanoparticle
synthesis
enhanced
efficacy.
goal
push
boundaries
toward
comprehensive,
clinically
applicable
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Апрель 3, 2023
Abstract
J-aggregation,
an
effective
strategy
to
extend
wavelength,
has
been
considered
as
a
promising
method
for
constructing
NIR-II
fluorophores.
However,
due
weak
intermolecular
interactions,
conventional
J-aggregates
are
easily
decomposed
into
monomers
in
the
biological
environment.
Although
adding
external
carriers
could
help
stabilize,
such
methods
still
suffer
from
high-concentration
dependence
and
unsuitable
activatable
probes
design.
Besides,
these
carriers-assisted
nanoparticles
risky
of
disassembly
lipophilic
Herein,
by
fusing
precipitated
dye
(HPQ)
which
orderly
self-assembly
structure,
onto
simple
hemi-cyanine
conjugated
system,
we
construct
series
activatable,
high-stability
NIR-II-J-aggregates
overcome
carrier’s
situ
vivo.
Further,
employ
probe
HPQ-Zzh-B
achieve
long-term
imaging
tumor
precise
resection
navigation
reducing
lung
metastasis.
We
believe
this
will
advance
development
controllable
bioimaging
Analytical Chemistry,
Год журнала:
2022,
Номер
94(30), С. 10676 - 10684
Опубликована: Июль 19, 2022
Lipid
droplets
(LDs)
containing
cytosolic
and
nuclear
LDs
have
recently
received
increasing
attention
because
of
their
diverse
biological
roles
in
living
systems.
However,
developing
fluorescent
probes
for
super-resolution
visualization
these
subcellular
still
remains
challenging
due
to
insufficient
fluorescence
brightness
poor
membrane
permeability.
Herein,
we
rationally
synthesized
a
series
ultrabright
solvatochromic
based
on
benzoboranils
(BBAs)
LD-specific
imaging
using
structured
illumination
microscopy
(SIM).
The
rigidly
exhibit
ultrahigh
quantum
yields
up
99.9%
low-polar
solvents.
They
also
show
more
significant
enhancements
lipid
environments
than
commercial
LD
probes.
Owing
excellent
merits,
our
lipophilic
can
specifically
light
at
ultralow
concentrations
down
10
nM.
Further
use
BBA-CF3
SIM
fusion
process
was
successfully
achieved.
unprecedented
spatial
resolution
with
an
FWHM
value
142
nm
acquired.
Collectively,
hold
tremendous
potential
unveil
the
mysterious
research
SIM.
Chemical & Biomedical Imaging,
Год журнала:
2023,
Номер
1(3), С. 220 - 233
Опубликована: Май 18, 2023
Organic
polymethine
fluorophores
with
emission
in
the
NIR-II
window
(1000–1700
nm)
are
receiving
enormous
attention
biomolecular
medicine
and
bioimaging,
attributed
to
high
absorption
coefficients,
bright
emission,
excellent
biocompatibility,
molecule
adjustability.
Recently,
researchers
have
devoted
significant
effort
designing
improving
making
notable
progress
fluorescence
imaging
performance.
This
review
summarizes
recent
developments
molecular
engineering
design
mentality
of
probes
highlights
their
extensive
bioimaging
biosensing
applications.
Furthermore,
we
elucidate
potential
challenges
perspectives
these
dyes
chemical
biomedicine
imaging,
which
may
stimulate
further
development
high-performance
dye
contrast
agents
for
future
clinical
