Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616

Published: April 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Language: Английский

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A comprehensive review on various techniques used for synthesizing nanoparticles

Journal of Materials Research and Technology, Journal Year: 2023, Volume and Issue: 27, P. 1739 - 1763

Published: Oct. 4, 2023

Nature is still the main focus of scientific and technological research, particularly in nanotechnology because its remarkable properties; has acquired much interest recent years. This review focuses on up-to-date overview classification nanoparticles, characterization, methods preparation, characterization application nanoparticles. Initial section gives insight various techniques for synthesis encompassing both bottom-up top-down approaches. Different nanoparticles are discussed details. Highlighting importance controlling shape, size, composition to develop enhance properties These include enhanced surface area, unique optical, electronic, magnetic characteristics, as well improved mechanical properties. Understanding these attributes essential harnessing different applications effectively. Broad spectrum also discussed. Additionally, have found catalysis, environmental remediation, antimicrobial coatings, contributing sustainable development protection. Overall, represent a progressive area research with tremendous potential innovation societal impact. Our evaluation will serve solid reference, assisting community comprehend topic better by showing role each technique comparable manner. As field constantly evolving, this incorporates latest developments, advancements up time publication. A comprehensive understanding their properties, decisive realizing full industrial domains.

Language: Английский

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Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 7326 - 7378

Published: March 13, 2023

Cancer thermal therapy, also known as hyperthermia has long been exploited to eradicate mass lesions that are now defined cancer. With the development of corresponding technologies and equipment, local therapies such radiofrequency ablation, microwave high-intensity focused ultrasound, have validated effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages adjacent normal tissues incomplete ablation particularly for large tumors, restricting their wide usage. Attributed versatile physiochemical properties, biomaterials specially designed potentiate treatments according unique working principles. Meanwhile, biomaterial-based delivery systems able bridge with other types treatment strategies chemotherapy, radiotherapy immunotherapy. Therefore, this review, we discuss recent progress functional reinforce by functioning sensitizers endow more efficient tumor-localized and/or vehicles synergize therapeutic modalities combined cancer treatments. Thereafter, provide a critical perspective on further biomaterial-assisted toward applications.

Language: Английский

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Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(11), P. 4391 - 4416

Published: May 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Language: Английский

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The use of RNA-based treatments in the field of cancer immunotherapy

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: July 7, 2023

Abstract Over the past several decades, mRNA vaccines have evolved from a theoretical concept to clinical reality. These offer advantages over traditional vaccine techniques, including their high potency, rapid development, low-cost manufacturing, and safe administration. However, until recently, concerns instability inefficient distribution of in vivo limited utility. Fortunately, recent technological advancements mostly resolved these concerns, resulting development numerous vaccination platforms for infectious diseases various types cancer. shown promising outcomes both animal models humans. This study highlights potential as alternative approach conventional techniques cancer treatment. review article aims provide thorough detailed examination vaccines, mechanisms action applications immunotherapy. Additionally, will analyze current state technology highlight future directions implementation this platform mainstream therapeutic option. The also discuss challenges limitations such stability distribution, suggest ways overcome issues. By providing comprehensive overview critical analysis contribute advancement innovative

Language: Английский

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The quest for nanoparticle-powered vaccines in cancer immunotherapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 14, 2024

Abstract Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role preventing illness by preparing the body's adaptive and innate immune responses combat diseases. As our understanding of malignancies their connection system improves, there has been growing interest priming fight more effectively comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which shown potentiate as vaccines and/or adjuvants. In review, we comprehensively summarized immunological mechanisms while focusing specifically on applications various types nanoparticles field immunotherapy. By exploring these breakthroughs, hope identify significant challenges obstacles making nanoparticle-based adjuvants feasible clinical application. This review serves assess breakthroughs vaccinations shed light prospects potential barriers. doing so, aim inspire future immunotherapies that harness nanotechnology deliver effective targeted treatments. Graphical abstract

Language: Английский

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Deformable nanocarriers for enhanced drug delivery and cancer therapy

Exploration, Journal Year: 2024, Volume and Issue: 4(5)

Published: March 15, 2024

Abstract Recently, the field of nanomedicine has witnessed substantial advancements in development nanocarriers for targeted drug delivery, emerges as promising platforms to enhance therapeutic efficacy and minimize adverse effects associated with conventional chemotherapy. Notably, deformable have garnered considerable attention due their unique capabilities size changeable, tumor‐specific aggregation, stimuli‐triggered disintegration, morphological transformations. These present significant opportunities revolutionizing delivery strategies, by responding specific stimuli or environmental cues, enabling achieved various functions at tumor site, including size‐shrinkage penetration, aggregative retention effect, disintegrating enable controlled release, shape‐changing improve cellular uptake, allowing personalized treatment approaches combination therapies. This review provides an overview recent developments applications enhancing therapy, underscores diverse design strategies employed create elucidates remarkable potential therapy.

Language: Английский

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Polymer and Nanocomposite Fillers as Advanced Materials in Biomedical Applications

Nano Trends, Journal Year: 2025, Volume and Issue: unknown, P. 100087 - 100087

Published: Feb. 1, 2025

Language: Английский

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Lipid‐based nanoparticles as drug delivery systems for cancer immunotherapy

MedComm, Journal Year: 2023, Volume and Issue: 4(4)

Published: Aug. 1, 2023

Abstract Immune checkpoint inhibitors (ICIs) have shown remarkable success in cancer treatment. However, patients without sufficient antitumor immunity, numerous data indicate that blocking the negative signals elicited by immune checkpoints is ineffective. Drugs stimulate activation‐related pathways are emerging as another route for improving immunotherapy. In addition, development of nanotechnology presents a promising platform tissue and cell type‐specific delivery improved uptake immunomodulatory agents, ultimately leading to enhanced immunotherapy reduced side effects. this review, we summarize discuss latest developments nanoparticles (NPs) immuno‐oncology therapy with focus on lipid‐based NPs (lipid‐NPs), including characteristics advantages various types. Using agonists targeting stimulation interferon genes (STING) transmembrane protein an exemplar, review potential lipid‐NPs augment STING agonist therapy. Furthermore, present recent findings underlying mechanisms how pathway activation fosters immunity regulates tumor microenvironment provide summary distinct preclinical studies clinical trials. Ultimately, conduct critical assessment obstacles future directions utilization enhance

Language: Английский

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Dual-Targeted Nanodiscs Revealing the Cross-Talk between Osteogenic Differentiation of Mesenchymal Stem Cells and Macrophages

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 3153 - 3167

Published: Jan. 30, 2023

Ongoing research has highlighted the significance of cross-play macrophages and mesenchymal stem cells (MSCs). Lysine-specific demethylase 6B (KDM6B) been shown to control osteogenic differentiation MSCs by depleting trimethylated histone 3 lysine 27 (H3K27me3). However, date, role KDM6B in bone marrow-derived (BMDMs) remains controversial. Here, a chromatin immunoprecipitation assay (ChIP) proved that derived from osteogenic-induced BMSCs could bind promoter region BMDMs' brain muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 (BMAL1) gene coculture system activate BMAL1. Transcriptome sequencing experiments vitro showed overexpression BMAL1 BMDM inhibit TLR2/NF-κB signaling pathway, reduce pyroptosis, decrease M1/M2 ratio, thereby promoting BMSCs. Furthermore, macrophage dual-targeted GSK-J4 (KDM6B inhibitor)-loaded nanodiscs were synthesized via binding SDSSD-apoA-1 peptide analogs (APA) peptide, which indirectly critical osteogenesis vivo. Overall, we demonstrated serves as positive circulation trigger during decreasing ratio both Collectively, these results provide insight into basic field osteoporosis repair.

Language: Английский

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