What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology? DOI
Haiqing Bai, Donald E. Ingber

Physiology, Год журнала: 2022, Номер 37(5), С. 242 - 252

Опубликована: Июнь 6, 2022

The intertwined relationship between structure and function has been key to understanding human organ physiology disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells tissues that recapitulates organ-level functions in vitro. This accomplished recreating organ-specific tissue-tissue interfaces microenvironmental biochemical mechanical cues while providing dynamic perfusion through endothelium-lined vascular channels. In this review, we discuss how emerging technology contributed the of lung structure-function relationships at cell, tissue, levels.

Язык: Английский

Artificial Intelligence-Based Microfluidic Platform for Detecting Contaminants in Water: A Review DOI Creative Commons
Yihao Zhang, Jiaxuan Li, Zhou Yu

и другие.

Sensors, Год журнала: 2024, Номер 24(13), С. 4350 - 4350

Опубликована: Июль 4, 2024

Water pollution greatly impacts humans and ecosystems, so a series of policies have been enacted to control it. The first step in performing is detect contaminants the water. Various methods proposed for water quality testing, such as spectroscopy, chromatography, electrochemical techniques. However, traditional testing require utilization laboratory equipment, which large not suitable real-time field. Microfluidic devices can overcome limitations instruments become an efficient convenient tool analysis. At same time, artificial intelligence ideal means recognizing, classifying, predicting data obtained from microfluidic systems. based on machine learning are being developed with great significance next generation monitoring This review begins brief introduction algorithms involved materials used fabrication detection techniques platforms. Then, latest research development combining two pollutant bodies, including heavy metals, pesticides, micro- nanoplastics, microalgae, mainly introduced. Finally, challenges encountered future directions industrial chips discussed.

Язык: Английский

Процитировано

9

Advances in the Model Structure of In Vitro Vascularized Organ-on-a-Chip DOI Creative Commons

Hongze Yin,

Yue Wang, Na Liu

и другие.

Cyborg and Bionic Systems, Год журнала: 2024, Номер 5

Опубликована: Янв. 1, 2024

Microvasculature plays a crucial role in human physiology and is closely related to various diseases. Building vitro vascular networks essential for studying tissue behavior with repeatable morphology signaling conditions. Engineered 3D microvascular network models, developed through advanced microfluidic-based techniques, provide accurate reproducible platforms the microvasculature vitro, an component designing organ-on-chips achieve greater biological relevance. By optimizing microstructure of microfluidic devices mimic vivo microenvironment, organ-specific models healthy pathological tissues can be created. This review summarizes recent advancements strategies constructing devices. It discusses static vascularization chips’ classification, structural characteristics, techniques used build them: growing blood vessels on chips either or dynamic, grown microchannels, elastic membranes, hydrogels. Finally, paper application scenarios key technical issues existing chips. also explores potential novel organoid chip approach that combines organoids organ generate better

Язык: Английский

Процитировано

8

Advancement of organ-on-chip towards next generation medical technology DOI Creative Commons
Garima Singh, Annu Mishra, Ashish Mathur

и другие.

Biosensors and Bioelectronics X, Год журнала: 2024, Номер 18, С. 100480 - 100480

Опубликована: Апрель 25, 2024

Organ-on-a-Chip, or OOC, is a widely discussed topic in science due to its many unique advantages the biomedical field. Nevertheless, there still much learn about OOC's various aspects of conception and significance for advancement medical technology future. A platform organs-on-a-chip must go through fabrication process. Various manufacturing processes were also used depending on required disease modelling drug screening. Organs chip included Brain-On-Chip, Kidney-On-Chip, Liver-On-Chip, Heart-On-Chip. In order provide new beginnings with thorough understanding we have studied most recent developments organ-on-a-chip expertise critically assessed relevant features this research.

Язык: Английский

Процитировано

8

Intestinal organ chips for disease modelling and personalized medicine DOI
Aliçan Özkan, Nina LoGrande, Jéssica F. Feitor

и другие.

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2024, Номер 21(11), С. 751 - 773

Опубликована: Авг. 27, 2024

Язык: Английский

Процитировано

8

What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology? DOI
Haiqing Bai, Donald E. Ingber

Physiology, Год журнала: 2022, Номер 37(5), С. 242 - 252

Опубликована: Июнь 6, 2022

The intertwined relationship between structure and function has been key to understanding human organ physiology disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells tissues that recapitulates organ-level functions in vitro. This accomplished recreating organ-specific tissue-tissue interfaces microenvironmental biochemical mechanical cues while providing dynamic perfusion through endothelium-lined vascular channels. In this review, we discuss how emerging technology contributed the of lung structure-function relationships at cell, tissue, levels.

Язык: Английский

Процитировано

27