Physiology,
Год журнала:
2022,
Номер
37(5), С. 242 - 252
Опубликована: Июнь 6, 2022
The
intertwined
relationship
between
structure
and
function
has
been
key
to
understanding
human
organ
physiology
disease
pathogenesis.
An
organ-on-a-chip
(organ
chip)
is
a
bioengineered
microfluidic
cell
culture
device
lined
by
living
cells
tissues
that
recapitulates
organ-level
functions
in
vitro.
This
accomplished
recreating
organ-specific
tissue-tissue
interfaces
microenvironmental
biochemical
mechanical
cues
while
providing
dynamic
perfusion
through
endothelium-lined
vascular
channels.
In
this
review,
we
discuss
how
emerging
technology
contributed
the
of
lung
structure-function
relationships
at
cell,
tissue,
levels.
Sensors,
Год журнала:
2024,
Номер
24(13), С. 4350 - 4350
Опубликована: Июль 4, 2024
Water
pollution
greatly
impacts
humans
and
ecosystems,
so
a
series
of
policies
have
been
enacted
to
control
it.
The
first
step
in
performing
is
detect
contaminants
the
water.
Various
methods
proposed
for
water
quality
testing,
such
as
spectroscopy,
chromatography,
electrochemical
techniques.
However,
traditional
testing
require
utilization
laboratory
equipment,
which
large
not
suitable
real-time
field.
Microfluidic
devices
can
overcome
limitations
instruments
become
an
efficient
convenient
tool
analysis.
At
same
time,
artificial
intelligence
ideal
means
recognizing,
classifying,
predicting
data
obtained
from
microfluidic
systems.
based
on
machine
learning
are
being
developed
with
great
significance
next
generation
monitoring
This
review
begins
brief
introduction
algorithms
involved
materials
used
fabrication
detection
techniques
platforms.
Then,
latest
research
development
combining
two
pollutant
bodies,
including
heavy
metals,
pesticides,
micro-
nanoplastics,
microalgae,
mainly
introduced.
Finally,
challenges
encountered
future
directions
industrial
chips
discussed.
Cyborg and Bionic Systems,
Год журнала:
2024,
Номер
5
Опубликована: Янв. 1, 2024
Microvasculature
plays
a
crucial
role
in
human
physiology
and
is
closely
related
to
various
diseases.
Building
vitro
vascular
networks
essential
for
studying
tissue
behavior
with
repeatable
morphology
signaling
conditions.
Engineered
3D
microvascular
network
models,
developed
through
advanced
microfluidic-based
techniques,
provide
accurate
reproducible
platforms
the
microvasculature
vitro,
an
component
designing
organ-on-chips
achieve
greater
biological
relevance.
By
optimizing
microstructure
of
microfluidic
devices
mimic
vivo
microenvironment,
organ-specific
models
healthy
pathological
tissues
can
be
created.
This
review
summarizes
recent
advancements
strategies
constructing
devices.
It
discusses
static
vascularization
chips’
classification,
structural
characteristics,
techniques
used
build
them:
growing
blood
vessels
on
chips
either
or
dynamic,
grown
microchannels,
elastic
membranes,
hydrogels.
Finally,
paper
application
scenarios
key
technical
issues
existing
chips.
also
explores
potential
novel
organoid
chip
approach
that
combines
organoids
organ
generate
better
Biosensors and Bioelectronics X,
Год журнала:
2024,
Номер
18, С. 100480 - 100480
Опубликована: Апрель 25, 2024
Organ-on-a-Chip,
or
OOC,
is
a
widely
discussed
topic
in
science
due
to
its
many
unique
advantages
the
biomedical
field.
Nevertheless,
there
still
much
learn
about
OOC's
various
aspects
of
conception
and
significance
for
advancement
medical
technology
future.
A
platform
organs-on-a-chip
must
go
through
fabrication
process.
Various
manufacturing
processes
were
also
used
depending
on
required
disease
modelling
drug
screening.
Organs
chip
included
Brain-On-Chip,
Kidney-On-Chip,
Liver-On-Chip,
Heart-On-Chip.
In
order
provide
new
beginnings
with
thorough
understanding
we
have
studied
most
recent
developments
organ-on-a-chip
expertise
critically
assessed
relevant
features
this
research.
Physiology,
Год журнала:
2022,
Номер
37(5), С. 242 - 252
Опубликована: Июнь 6, 2022
The
intertwined
relationship
between
structure
and
function
has
been
key
to
understanding
human
organ
physiology
disease
pathogenesis.
An
organ-on-a-chip
(organ
chip)
is
a
bioengineered
microfluidic
cell
culture
device
lined
by
living
cells
tissues
that
recapitulates
organ-level
functions
in
vitro.
This
accomplished
recreating
organ-specific
tissue-tissue
interfaces
microenvironmental
biochemical
mechanical
cues
while
providing
dynamic
perfusion
through
endothelium-lined
vascular
channels.
In
this
review,
we
discuss
how
emerging
technology
contributed
the
of
lung
structure-function
relationships
at
cell,
tissue,
levels.
