Small tissue chips with big opportunities for space medicine DOI Creative Commons
Xuan Mu,

Weishen He,

Victoria Abril Manjarrez Rivera

et al.

Life Sciences in Space Research, Journal Year: 2022, Volume and Issue: 35, P. 150 - 157

Published: Sept. 8, 2022

Language: Английский

Advancement of organ-on-chip towards next generation medical technology DOI Creative Commons
Garima Singh, Annu Mishra, Ashish Mathur

et al.

Biosensors and Bioelectronics X, Journal Year: 2024, Volume and Issue: 18, P. 100480 - 100480

Published: April 25, 2024

Organ-on-a-Chip, or OOC, is a widely discussed topic in science due to its many unique advantages the biomedical field. Nevertheless, there still much learn about OOC's various aspects of conception and significance for advancement medical technology future. A platform organs-on-a-chip must go through fabrication process. Various manufacturing processes were also used depending on required disease modelling drug screening. Organs chip included Brain-On-Chip, Kidney-On-Chip, Liver-On-Chip, Heart-On-Chip. In order provide new beginnings with thorough understanding we have studied most recent developments organ-on-a-chip expertise critically assessed relevant features this research.

Language: Английский

Citations

8
Intestinal organ chips for disease modelling and personalized medicine DOI
Aliçan Özkan, Nina LoGrande, Jéssica F. Feitor

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(11), P. 751 - 773

Published: Aug. 27, 2024

Language: Английский

Citations

8
Advances in the Model Structure of In Vitro Vascularized Organ-on-a-Chip DOI Creative Commons

Hongze Yin,

Yue Wang, Na Liu

et al.

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Microvasculature plays a crucial role in human physiology and is closely related to various diseases. Building vitro vascular networks essential for studying tissue behavior with repeatable morphology signaling conditions. Engineered 3D microvascular network models, developed through advanced microfluidic-based techniques, provide accurate reproducible platforms the microvasculature vitro, an component designing organ-on-chips achieve greater biological relevance. By optimizing microstructure of microfluidic devices mimic vivo microenvironment, organ-specific models healthy pathological tissues can be created. This review summarizes recent advancements strategies constructing devices. It discusses static vascularization chips’ classification, structural characteristics, techniques used build them: growing blood vessels on chips either or dynamic, grown microchannels, elastic membranes, hydrogels. Finally, paper application scenarios key technical issues existing chips. also explores potential novel organoid chip approach that combines organoids organ generate better

Language: Английский

Citations

7
What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology? DOI
Haiqing Bai, Donald E. Ingber

Physiology, Journal Year: 2022, Volume and Issue: 37(5), P. 242 - 252

Published: June 6, 2022

The intertwined relationship between structure and function has been key to understanding human organ physiology disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells tissues that recapitulates organ-level functions in vitro. This accomplished recreating organ-specific tissue-tissue interfaces microenvironmental biochemical mechanical cues while providing dynamic perfusion through endothelium-lined vascular channels. In this review, we discuss how emerging technology contributed the of lung structure-function relationships at cell, tissue, levels.

Language: Английский

Citations

27
Small tissue chips with big opportunities for space medicine DOI Creative Commons
Xuan Mu,

Weishen He,

Victoria Abril Manjarrez Rivera

et al.

Life Sciences in Space Research, Journal Year: 2022, Volume and Issue: 35, P. 150 - 157

Published: Sept. 8, 2022

Language: Английский

Citations

25