Recent advances in spheroid-based microfluidic models to mimic the tumour microenvironment DOI
Jooyoung Ro, Junyoung Kim, Yoon‐Kyoung Cho

и другие.

The Analyst, Год журнала: 2022, Номер 147(10), С. 2023 - 2034

Опубликована: Янв. 1, 2022

Microfluidic platforms with 3D tumour spheroid culture provide to study the multi-cellular interactions and external stimuli in complex microenvironment.

Язык: Английский

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation DOI Creative Commons
Sara Gimondi, Helena Ferreira, Rui L. Reis

и другие.

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14205 - 14228

Опубликована: Июль 27, 2023

The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment diseases which conventional therapies present serious limitations. Additionally, NPs can drastically improve early diagnosis and follow-up many disorders. However, to harness their full capabilities, they must be precisely designed, produced, tested relevant models. Microfluidic systems simulate dynamic fluid flows, gradients, specific microenvironments, multiorgan complexes, providing an efficient cost-effective approach both synthesis screening. technologies allow under controlled conditions, enhancing batch-to-batch reproducibility. Moreover, due versatility microfluidic devices, it is possible generate customize endless platforms rapid vitro vivo screening NPs' performance. Indeed, devices show potential as advanced small organism manipulation immobilization. In this review, first we summarize major that synthesis. Next, will discuss most innovative enable mimicking environments well give insights into organism-on-a-chip promising application We conclude review with a critical assessment current challenges future directions impact field nanomedicine.

Язык: Английский

Процитировано

125

Biomedical Applications of Microfluidic Devices: A Review DOI Creative Commons
Ghazaleh Gharib, İsmail Bütün, Zülâl Muganlı

и другие.

Biosensors, Год журнала: 2022, Номер 12(11), С. 1023 - 1023

Опубликована: Ноя. 16, 2022

Both passive and active microfluidic chips are used in many biomedical chemical applications to support fluid mixing, particle manipulations, signal detection. Passive devices geometry-dependent, their uses rather limited. Active include sensors or detectors that transduce chemical, biological, physical changes into electrical optical signals. Also, they transduction detect biological applications, highly versatile tools for disease diagnosis organ modeling. This review provides a comprehensive overview of the significant advances have been made development microfluidics devices. We will discuss function as micromixers sorters cells substances (e.g., microfiltration, flow displacement, trapping). Microfluidic fabricated using range techniques, including molding, etching, three-dimensional printing, nanofabrication. Their broad utility lies detection diagnostic biomarkers organ-on-chip approaches permit modeling cancer, well neurological, cardiovascular, hepatic, pulmonary diseases. Biosensor allow point-of-care testing, assays based on enzymes, nanozymes, antibodies, nucleic acids (DNA RNA). An anticipated field includes optimization techniques fabrication biocompatible materials. These developments increase versatility, reduce costs, accelerate time technology.

Язык: Английский

Процитировано

105

Advances and challenges in portable optical biosensors for onsite detection and point-of-care diagnostics DOI
Sufian Rasheed,

Tehreem Kanwal,

Naseer Ahmad

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 173, С. 117640 - 117640

Опубликована: Март 8, 2024

Язык: Английский

Процитировано

71

Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology DOI Creative Commons

Lucie Thorel,

Marion Perréard,

Romane Florent

и другие.

Experimental & Molecular Medicine, Год журнала: 2024, Номер 56(7), С. 1531 - 1551

Опубликована: Июль 1, 2024

Over the past decade, emergence of patient-derived tumor organoids (PDTOs) has broadened repertoire preclinical models and progressively revolutionized three-dimensional cell culture in oncology. PDTO can be grown from patient samples with high efficiency faithfully recapitulates histological molecular characteristics original tumor. Therefore, PDTOs serve as invaluable tools oncology research, their translation to clinical practice is exciting for future precision medicine In this review, we provide an overview methods establishing various applications cancer starting basic research ending identification new targets validation anticancer compounds medicine. Finally, highlight challenges associated implementation PDTO, such its representativeness, success rate, assay speed, lack a microenvironment. Technological developments autologous cocultures stromal cells are currently ongoing meet these optimally exploit full potential models. The use standard could lead era coming decade.

Язык: Английский

Процитировано

27

Emerging tumor-on-chips with electrochemical biosensors DOI
Lanjie Lei, Biao Ma, Chengtao Xu

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2022, Номер 153, С. 116640 - 116640

Опубликована: Апрель 15, 2022

Язык: Английский

Процитировано

50

Recent progress of microfluidic chips in immunoassay DOI Creative Commons
Kaimin Wu,

Xuliang He,

Jinglei Wang

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Дек. 23, 2022

Microfluidic chip technology is a platform that integrates basic operation units such as processing, separation, reaction and detection into microchannel to realize low consumption, fast efficient analysis of samples. It has the characteristics small volume need samples reagents, analysis, cost, automation, portability, high throughout, good compatibility with other techniques. In this review, concept, preparation materials fabrication microfluidic are described. The applications in immunoassay, including fluorescent, chemiluminescent, surface-enhanced Raman spectroscopy (SERS), electrochemical immunoassay reviewed. Look future, development chips lies point-of-care testing throughput equipment, there still some challenges design integration chips, well actual sample by chips.

Язык: Английский

Процитировано

42

Integrated technologies for continuous monitoring of organs-on-chips: Current challenges and potential solutions DOI
Jonathan Sabaté del Río, Jooyoung Ro, Heejeong Yoon

и другие.

Biosensors and Bioelectronics, Год журнала: 2023, Номер 224, С. 115057 - 115057

Опубликована: Янв. 2, 2023

Язык: Английский

Процитировано

26

Integration of pan-omics technologies and three-dimensional in vitro tumor models: an approach toward drug discovery and precision medicine DOI Creative Commons

Anmi Jose,

Pallavi Kulkarni,

Jaya Thilakan

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Март 9, 2024

Abstract Despite advancements in treatment protocols, cancer is one of the leading cause deaths worldwide. Therefore, there a need to identify newer and personalized therapeutic targets along with screening technologies combat cancer. With advent pan-omics technologies, such as genomics, transcriptomics, proteomics, metabolomics, lipidomics, scientific community has witnessed an improved molecular metabolomic understanding various diseases, including In addition, three-dimensional (3-D) disease models have been efficiently utilized for pathophysiology tools drug discovery. An integrated approach utilizing 3-D vitro tumor led intricate network encompassing signalling pathways cross-talk solid tumors. present review, we underscore current trends omics highlight their role genotypic-phenotypic co-relation respect models. We further discuss challenges associated provide our outlook on future applications these discovery precision medicine management Graphical

Язык: Английский

Процитировано

16

From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications DOI

Yisha Huang,

Tong Liu,

Qi Huang

и другие.

ACS Sensors, Год журнала: 2024, Номер 9(7), С. 3466 - 3488

Опубликована: Июль 11, 2024

Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and functionality of human organs on a microfluidic chip, is undergoing significant technological advancements. Despite its rapid evolution, this technology also facing notable challenges, such as lack vascularization, development multiorgan-on-a-chip systems, replication body single chip. The progress has played crucial role in steering OOC toward mimicking microenvironment, including microenvironment replication, multiorgan microphysiological systems. Additionally, advancements detection, analysis, organoid imaging technologies have enhanced efficiency Organs-on-Chips (OOCs). In particular, integration artificial intelligence revolutionized imaging, significantly enhancing high-throughput drug screening. Consequently, review covers research Human-on-a-chip, sensors OOCs, latest applications biomedical field.

Язык: Английский

Процитировано

15

Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface DOI Creative Commons
Yuwen Wang, Patrick Shu‐Hang Yung, Gang Lü

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Март 16, 2024

Nanotechnology-based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their translation requires a deep understanding complex interplay between nanotechnology MSK biology. Organ-on-a-chip (OoC) systems have emerged as an innovative versatile microphysiological platform to replicate dynamics tissue microenvironment studying nanotechnology-biology interactions. This review first covers recent advances applications OoCs ability mimic biophysical biochemical stimuli encountered by tissues. Next, integrating into OoCs, cellular responses behaviors may be investigated precisely controlling manipulating nanoscale environment. Analysis disease mechanisms, particularly bone, joint, muscle degeneration, drug screening development personalized medicine greatly facilitated using OoCs. Finally, future challenges directions outlined field, including advanced sensing technologies, integration immune-active components, enhancement biomimetic functionality. By highlighting emerging this aims advance intricate nanotechnology-MSK biology interface its significance in management, therapeutic interventional strategies.

Язык: Английский

Процитировано

14