Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1810 - 1810
Published: May 25, 2022
The
use
of
nanomaterials
has
been
increasing
in
recent
times,
and
they
are
widely
used
industries
such
as
cosmetics,
drugs,
food,
water
treatment,
agriculture.
rapid
development
new
demands
a
set
approaches
to
evaluate
the
potential
toxicity
risks
related
them.
In
this
regard,
nanosafety
using
adapting
already
existing
methods
(toxicological
approach),
but
unique
characteristics
demand
(nanotoxicology)
fully
understand
toxicity,
immunotoxicity,
(epi)genotoxicity.
addition,
technologies,
organs-on-chips
sophisticated
sensors,
under
and/or
adaptation.
All
information
generated
is
develop
silico
trying
predict
effects
newly
developed
materials.
overall
evaluation
from
their
production
final
disposal
chain
completed
life
cycle
assessment
(LCA),
which
becoming
an
important
element
considering
sustainability
environmental
impact.
review,
we
give
overview
all
these
elements
nanosafety.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(15), P. 14205 - 14228
Published: July 27, 2023
The
use
of
nanoparticles
(NPs)
in
nanomedicine
holds
great
promise
for
the
treatment
diseases
which
conventional
therapies
present
serious
limitations.
Additionally,
NPs
can
drastically
improve
early
diagnosis
and
follow-up
many
disorders.
However,
to
harness
their
full
capabilities,
they
must
be
precisely
designed,
produced,
tested
relevant
models.
Microfluidic
systems
simulate
dynamic
fluid
flows,
gradients,
specific
microenvironments,
multiorgan
complexes,
providing
an
efficient
cost-effective
approach
both
synthesis
screening.
technologies
allow
under
controlled
conditions,
enhancing
batch-to-batch
reproducibility.
Moreover,
due
versatility
microfluidic
devices,
it
is
possible
generate
customize
endless
platforms
rapid
vitro
vivo
screening
NPs'
performance.
Indeed,
devices
show
potential
as
advanced
small
organism
manipulation
immobilization.
In
this
review,
first
we
summarize
major
that
synthesis.
Next,
will
discuss
most
innovative
enable
mimicking
environments
well
give
insights
into
organism-on-a-chip
promising
application
We
conclude
review
with
a
critical
assessment
current
challenges
future
directions
impact
field
nanomedicine.
Biosensors,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1023 - 1023
Published: Nov. 16, 2022
Both
passive
and
active
microfluidic
chips
are
used
in
many
biomedical
chemical
applications
to
support
fluid
mixing,
particle
manipulations,
signal
detection.
Passive
devices
geometry-dependent,
their
uses
rather
limited.
Active
include
sensors
or
detectors
that
transduce
chemical,
biological,
physical
changes
into
electrical
optical
signals.
Also,
they
transduction
detect
biological
applications,
highly
versatile
tools
for
disease
diagnosis
organ
modeling.
This
review
provides
a
comprehensive
overview
of
the
significant
advances
have
been
made
development
microfluidics
devices.
We
will
discuss
function
as
micromixers
sorters
cells
substances
(e.g.,
microfiltration,
flow
displacement,
trapping).
Microfluidic
fabricated
using
range
techniques,
including
molding,
etching,
three-dimensional
printing,
nanofabrication.
Their
broad
utility
lies
detection
diagnostic
biomarkers
organ-on-chip
approaches
permit
modeling
cancer,
well
neurological,
cardiovascular,
hepatic,
pulmonary
diseases.
Biosensor
allow
point-of-care
testing,
assays
based
on
enzymes,
nanozymes,
antibodies,
nucleic
acids
(DNA
RNA).
An
anticipated
field
includes
optimization
techniques
fabrication
biocompatible
materials.
These
developments
increase
versatility,
reduce
costs,
accelerate
time
technology.
Experimental & Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
56(7), P. 1531 - 1551
Published: July 1, 2024
Over
the
past
decade,
emergence
of
patient-derived
tumor
organoids
(PDTOs)
has
broadened
repertoire
preclinical
models
and
progressively
revolutionized
three-dimensional
cell
culture
in
oncology.
PDTO
can
be
grown
from
patient
samples
with
high
efficiency
faithfully
recapitulates
histological
molecular
characteristics
original
tumor.
Therefore,
PDTOs
serve
as
invaluable
tools
oncology
research,
their
translation
to
clinical
practice
is
exciting
for
future
precision
medicine
In
this
review,
we
provide
an
overview
methods
establishing
various
applications
cancer
starting
basic
research
ending
identification
new
targets
validation
anticancer
compounds
medicine.
Finally,
highlight
challenges
associated
implementation
PDTO,
such
its
representativeness,
success
rate,
assay
speed,
lack
a
microenvironment.
Technological
developments
autologous
cocultures
stromal
cells
are
currently
ongoing
meet
these
optimally
exploit
full
potential
models.
The
use
standard
could
lead
era
coming
decade.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
10
Published: Dec. 23, 2022
Microfluidic
chip
technology
is
a
platform
that
integrates
basic
operation
units
such
as
processing,
separation,
reaction
and
detection
into
microchannel
to
realize
low
consumption,
fast
efficient
analysis
of
samples.
It
has
the
characteristics
small
volume
need
samples
reagents,
analysis,
cost,
automation,
portability,
high
throughout,
good
compatibility
with
other
techniques.
In
this
review,
concept,
preparation
materials
fabrication
microfluidic
are
described.
The
applications
in
immunoassay,
including
fluorescent,
chemiluminescent,
surface-enhanced
Raman
spectroscopy
(SERS),
electrochemical
immunoassay
reviewed.
Look
future,
development
chips
lies
point-of-care
testing
throughput
equipment,
there
still
some
challenges
design
integration
chips,
well
actual
sample
by
chips.
Biology,
Journal Year:
2023,
Volume and Issue:
12(2), P. 204 - 204
Published: Jan. 28, 2023
Today’s
research
on
the
processes
of
carcinogenesis
and
vital
activity
tumor
tissues
implies
more
attention
be
paid
to
constituents
microenvironment
their
interactions.
These
interactions
between
cells
in
can
mediated
via
different
types
protein
junctions.
Connexins
are
one
major
contributors
intercellular
communication.
They
form
gap
junctions
responsible
for
transfer
ions,
metabolites,
peptides,
miRNA,
etc.,
neighboring
as
well
stromal
cells.
Connexin
hemichannels
mediate
purinergic
signaling
bidirectional
molecular
transport
with
extracellular
environment.
Additionally,
connexins
have
been
reported
localize
tumor-derived
exosomes
facilitate
release
cargo.
A
large
body
evidence
that
role
cancer
is
multifaceted.
The
pro-
or
anti-tumorigenic
properties
determined
by
abundance,
localization,
functionality
channel
assembly
non-channel
functions.
In
this
review,
we
summarized
data
contribution
formation
initiation
progression.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: March 9, 2024
Abstract
Despite
advancements
in
treatment
protocols,
cancer
is
one
of
the
leading
cause
deaths
worldwide.
Therefore,
there
a
need
to
identify
newer
and
personalized
therapeutic
targets
along
with
screening
technologies
combat
cancer.
With
advent
pan-omics
technologies,
such
as
genomics,
transcriptomics,
proteomics,
metabolomics,
lipidomics,
scientific
community
has
witnessed
an
improved
molecular
metabolomic
understanding
various
diseases,
including
In
addition,
three-dimensional
(3-D)
disease
models
have
been
efficiently
utilized
for
pathophysiology
tools
drug
discovery.
An
integrated
approach
utilizing
3-D
vitro
tumor
led
intricate
network
encompassing
signalling
pathways
cross-talk
solid
tumors.
present
review,
we
underscore
current
trends
omics
highlight
their
role
genotypic-phenotypic
co-relation
respect
models.
We
further
discuss
challenges
associated
provide
our
outlook
on
future
applications
these
discovery
precision
medicine
management
Graphical
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(7), P. 3466 - 3488
Published: July 11, 2024
Organ-on-a-Chip
(OOC)
technology,
which
emulates
the
physiological
environment
and
functionality
of
human
organs
on
a
microfluidic
chip,
is
undergoing
significant
technological
advancements.
Despite
its
rapid
evolution,
this
technology
also
facing
notable
challenges,
such
as
lack
vascularization,
development
multiorgan-on-a-chip
systems,
replication
body
single
chip.
The
progress
has
played
crucial
role
in
steering
OOC
toward
mimicking
microenvironment,
including
microenvironment
replication,
multiorgan
microphysiological
systems.
Additionally,
advancements
detection,
analysis,
organoid
imaging
technologies
have
enhanced
efficiency
Organs-on-Chips
(OOCs).
In
particular,
integration
artificial
intelligence
revolutionized
imaging,
significantly
enhancing
high-throughput
drug
screening.
Consequently,
review
covers
research
Human-on-a-chip,
sensors
OOCs,
latest
applications
biomedical
field.
