Regioselective Synthesis of 3-Trifluoromethylpyrroles by [3 + 2] Cycloaddition of N-Acyl α-Amino Acids and 2-Bromo-3,3,3-trifluoropropene DOI
Weidi Zeng, Hui Li, Duozhi Wang

и другие.

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(19), С. 14088 - 14095

Опубликована: Сен. 12, 2023

A mild and concise method for the synthesis of 3-trifluoromethylpyrroles via base-mediated [3 + 2] cycloaddition N-acyl α-amino acids 2-bromo-3,3,3-trifluoropropene is described. N-Acyl serve as 1,3-dipole precursors without additional activating agents directly. high level regioselectivity was observed, regardless electronic nature size substituents on 1,3-dipoles.

Язык: Английский

One-Pot Photocascade Catalysis: Access to Pyrrole Derivatives from N-Arylglycines and Morita–Baylis–Hillman (MBH) Acetates DOI

Jie Huang,

S.-L. You,

Ling-Zhi Hu

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

The step-economical synthesis of pyrrole derivatives has posed a challenge in the field

Язык: Английский

Процитировано

1
Protecting Group-Dependent Synthesis of Densely Substituted Dihydropyrroles v/s Pyrroles via 5-Exo-trig Cascade Radical Cyclization to Alkynyl Vinylogous Carbamates DOI
Santosh J. Gharpure, Sanyog Kumari

The Journal of Organic Chemistry, Год журнала: 2022, Номер 87(10), С. 6781 - 6793

Опубликована: Май 11, 2022

Densely substituted dihydropyrroles could be synthesized with excellent diastereoselectivity via 5-exo-trig cascade radical cyclization to alkynyl vinylogous carbamates. N-Alkyl/acyl protected carbamates upon using thiophenol gave pyrroles as against dihydropyrroles, which were formed N-sulfonyl protecting groups. This enabled a rare example wherein both dihydropyrrole and pyrrole rings are assembled in the same reaction. strategy used for synthesis of an unprecedented adjacent polyheterocyclic system having furan-thiophene-pyrrole motif. When carbamate is embedded isoindole moiety, pyridoisoindole derivative was diastereoselectivity, instead expected pyrroloisoindole product.

Язык: Английский

Процитировано

6
Photoredox Catalytic Cascade Radical Addition to Construct 1,4- Diketone-Functionalized Quinoxalin-2(1H)-one Derivatives DOI Open Access
Xin Sun,

Chaofan Qu,

Chaorui Ma

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2022, Номер 42(5), С. 1396 - 1396

Опубликована: Янв. 1, 2022

a,b ( a 河南大学 河南省手性化学国际联合基地 开封 475004) b 河南师范大学化学化工学院 新乡 453007) c 中国烟草总公司郑州烟草研究院 烟草香料基础研究重点实验室 郑州 450001) 摘要 喹喔啉-2(1H)-酮的生物学重要性激发了开发高效简便合成方法学的持续追求.其中, 对其 C3-H 官能团化已成

Процитировано

6
Iron-catalyzed radical intermolecular addition of unactivated alkenes to alkenyl N-heteroarenes DOI
Wen‐Dao Chu, Chunmei Wang, Shu Li

и другие.

Organic Chemistry Frontiers, Год журнала: 2022, Номер 9(24), С. 6973 - 6978

Опубликована: Янв. 1, 2022

The intermolecular reductive radical coupling of olefins with alkenyl N-heteroarenes, employing an iron( iii )-catalyzed hydrogen atom transfer strategy, is described.

Язык: Английский

Процитировано

6
Regioselective Synthesis of 3-Trifluoromethylpyrroles by [3 + 2] Cycloaddition of N-Acyl α-Amino Acids and 2-Bromo-3,3,3-trifluoropropene DOI
Weidi Zeng, Hui Li, Duozhi Wang

и другие.

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(19), С. 14088 - 14095

Опубликована: Сен. 12, 2023

A mild and concise method for the synthesis of 3-trifluoromethylpyrroles via base-mediated [3 + 2] cycloaddition N-acyl α-amino acids 2-bromo-3,3,3-trifluoropropene is described. N-Acyl serve as 1,3-dipole precursors without additional activating agents directly. high level regioselectivity was observed, regardless electronic nature size substituents on 1,3-dipoles.

Язык: Английский

Процитировано

2