Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(49)
Опубликована: Авг. 23, 2024
Abstract
Molecular
spherical
nucleic
acids
(m‐SNAs)
are
a
second
generation
of
(SNAs),
which
significance
in
potential
application
targeted
delivery
or
gene
regulation
due
to
their
defined
molecular
structures.
Nevertheless,
m‐SNAs
typically
involve
single
DNA
sequence
greatly
limits
its
functions
as
either
targeting
purpose
regulation.
In
response,
we
proposed
here
third
generation,
supramolecular
(Supra‐SNAs)
with
two
different
sequences
achieve
both
above‐mentioned
functions.
Specifically,
constructed
series
self‐assembly
structures
by
coupling
cell
membrane
receptor
(i.e.,
nucleolin)‐recognizing
aptamer
(AS1411)‐modified
adamantine
probe
and
human
epithelial
growth
factor
2
(HER2)
antisense‐functionalized
β‐cyclodextrin
specifically
inhibit
the
overexpression
HER2
proteins
for
regulations.
comparison
m‐SNA
precursors,
such
Supra‐SNA
exhibited
enhanced
levels
resistance
nuclease
degradation,
cellular
uptake,
capabilities
tumor
retention
capacity.
We
demonstrated
that
Supra‐SNAs
optimal
suppression
rates
apoptosis
via
phosphatidylinositol
3‐kinase/protein
kinase
B
signaling
pathway.
The
well‐defined
provide
an
attractive
platform
investigating
interrelationship
between
structure
property
at
level.
Advanced Materials,
Год журнала:
2024,
Номер
36(27)
Опубликована: Март 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(16)
Опубликована: Янв. 4, 2024
Abstract
Second
near‐infrared
(NIR‐II)
bioimaging
technology
shows
broad
application
prospects
in
the
field
of
biomedical
due
to
its
significant
superiority
deep
tissue
penetration
and
high
signal‐to‐background
ratio.
Among
them,
organic
small
molecule
fluorophores
have
received
progressively
more
consideration
their
low
biotoxicity,
biocompatibility,
rapid
clearance,
good
modification
properties.
As
key
acceptor
core,
2,
1,
3‐benzothiadiazole
(BTD)
derivative
plays
an
essential
role
construction
donor‐acceptor‐donor
type
NIR‐II
fluorophores.
This
mini‐review
summarizes
research
development
based
on
BTD
derivatives
bioimaging,
focusing
molecular
design
photophysical
properties,
introduces
a
part
applications
biological
field.
Furthermore,
challenges
BTD‐based
future
are
discussed
.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
emerged
as
promising
treatment
options,
showcasing
immense
potential
in
addressing
both
oncologic
nononcologic
diseases.
Single‐component
organic
phototherapeutic
agents
(SCOPAs)
offer
advantages
compared
to
inorganic
or
multicomponent
nanomedicine,
including
better
biosafety,
lower
toxicity,
simpler
synthesis,
enhanced
reproducibility.
Nonetheless,
how
further
improve
the
therapeutic
effectiveness
of
SCOPAs
remains
a
challenging
research
area.
This
review
delves
deeply
into
strategies
performance
PDT
PTT
by
optimizing
structural
design
SCOPAs.
These
encompass
augmenting
reactive
oxygen
species
(ROS)
generation,
mitigating
dependence,
elevating
light
absorption
capacity,
broadening
region,
enhancing
conversion
efficiency
(PCE).
Additionally,
this
also
underscores
ideal
for
developing
with
balanced
PTT.
Furthermore,
synergies
are
highlighted
between
other
modalities
such
ferroptosis,
gas
therapy,
chemotherapy,
immunotherapy.
By
providing
comprehensive
analysis
these
strategies,
aspires
serve
valuable
resource
clinicians
researchers,
facilitating
wider
application
advancement
SCOPAs‐mediated
Prostate
cancer
(PCa)
is
a
frustrating
immunogenic
"cold"
tumor
and
generally
receives
unsatisfied
immunotherapy
outcomes
in
the
clinic.
Pyroptosis
an
excellent
cell
death
form
that
can
effectively
activate
antitumor
immune
response,
promote
cytotoxic
T-lymphocyte
infiltration,
convert
tumors
from
to
"hot."
However,
vivo
application
of
pyroptosis
drugs
seriously
limited,
upregulation
PD-L1
caused
by
photo-immunotherapy
further
promotes
escape.
Herein,
new
nano-photosensitizer
(YBS-BMS
NPs-RKC)
with
pH-response
integrating
induction
checkpoint
blockade
developed.
The
pH-responsive
polymer
equipped
membrane
anchoring
peptide
RKC
used
as
carrier
encapsulated
near-infrared-activated
semiconductor
photosensitizer
YBS
PD-1/PD-L1
complex
small
molecule
inhibitor
BMS-202.
pH-driven
membrane-anchoring
activation
YBS-BMS
NPs-RKC
clearly
demonstrated.
In
vitro
studies
have
shown
this
dual-pronged
therapy
stimulates
powerful
response
suppress
primary
progression
evokes
long-term
memory
inhibit
relapse
metastasis.
This
work
provides
effective
self-synergistic
platform
for
PCa
idea
developing
more
biocompatible
photo-controlled
inducers.
Abstract
Photothermal
therapy
(PTT)
is
a
new
treatment
modality
for
tumors.
However,
the
efficient
delivery
of
photothermal
agents
into
tumors
remains
difficult,
especially
in
hypoxic
tumor
regions.
In
this
study,
an
approach
to
deliver
melanin,
natural
agent,
using
genetically
engineered
bacteria
image‐guided
and
immune
developed.
An
Escherichia
coli
MG1655
transformed
with
recombinant
plasmid
harboring
tyrosinase
gene
produce
melanin
nanoparticles.
Melanin‐producing
(MG1655‐M)
are
systemically
administered
4T1
tumor‐bearing
mice.
The
tumor‐targeting
properties
MG1655‐M
environment
integrate
hypoxia
targeting,
photoacoustic
imaging,
therapeutic
“all‐in‐one”
manner.
This
eliminates
need
post‐modification
achieve
hypoxia‐targeted
cancer
therapy.
Tumor
growth
significantly
suppressed
by
irradiating
808
nm
laser.
Furthermore,
strong
antitumor
immunity
triggered
PTT,
thereby
producing
long‐term
memory
effects
that
effectively
inhibit
metastasis
recurrence.
work
proposes
guided
melanin‐producing
bacteria,
which
can
offer
broad
potential
applications
treatment.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Molecular
phototheranostic
dyes
are
of
eminent
interest
for
oncological
diagnosis
and
imaging‐guided
phototherapy.
However,
it
remains
challenging
to
develop
photosensitizers
(PSs)
that
simultaneously
integrate
high‐contrast
photoacoustic
imaging
efficient
therapeutic
capabilities.
In
this
work,
a
supramolecular
strategy
is
employed
construct
molecular
pair
agent
via
the
direct
self‐assembly
two
cyanines,
C5TNa
(anionic)
Cy‐Et
(cationic).
The
Coulombic
interactions
between
facilitate
formation
complementary
cyanine
(C5T‐ET)
creation
CT‐J‐type
aggregates
in
water.
This
results
completely
quenched
fluorescence
significantly
enhances
nonradiative
deactivation
(≈22
ps),
leading
3.3‐fold
increase
photothermal
conversion
efficiency
7.1‐fold
enhancement
response
compared
indocyanine
green
(ICG).
As
result,
J‐type
aggregate
demonstrates
high
capability
remarkable
antitumor
efficacy
vivo,
highlighting
its
potential
clinical
applications.
work
provides
strong
experimental
evidence
superior
performance
enhancing
photosensitization
response.
It
believed
will
propel
advancement
controllable
dye
J‐aggregates
contribute
practical
implementation
phototherapy
vivo.
