Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216549 - 216549
Published: Feb. 27, 2025
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215677 - 215677
Published: Jan. 31, 2024
Language: Английский
Citations
46
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215907 - 215907
Published: May 12, 2024
Language: Английский
Citations
33
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)
Published: March 29, 2024
Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.
Language: Английский
Citations
27
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)
Published: Jan. 4, 2024
Abstract Second near‐infrared (NIR‐II) bioimaging technology shows broad application prospects in the field of biomedical due to its significant superiority deep tissue penetration and high signal‐to‐background ratio. Among them, organic small molecule fluorophores have received progressively more consideration their low biotoxicity, biocompatibility, rapid clearance, good modification properties. As key acceptor core, 2, 1, 3‐benzothiadiazole (BTD) derivative plays an essential role construction donor‐acceptor‐donor type NIR‐II fluorophores. This mini‐review summarizes research development based on BTD derivatives bioimaging, focusing molecular design photophysical properties, introduces a part applications biological field. Furthermore, challenges BTD‐based future are discussed .
Language: Английский
Citations
23
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215719 - 215719
Published: Feb. 24, 2024
Language: Английский
Citations
23
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated
Language: Английский
Citations
5
Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)
Published: Aug. 6, 2023
Prostate cancer (PCa) is a frustrating immunogenic "cold" tumor and generally receives unsatisfied immunotherapy outcomes in the clinic. Pyroptosis an excellent cell death form that can effectively activate antitumor immune response, promote cytotoxic T-lymphocyte infiltration, convert tumors from to "hot." However, vivo application of pyroptosis drugs seriously limited, upregulation PD-L1 caused by photo-immunotherapy further promotes escape. Herein, new nano-photosensitizer (YBS-BMS NPs-RKC) with pH-response integrating induction checkpoint blockade developed. The pH-responsive polymer equipped membrane anchoring peptide RKC used as carrier encapsulated near-infrared-activated semiconductor photosensitizer YBS PD-1/PD-L1 complex small molecule inhibitor BMS-202. pH-driven membrane-anchoring activation YBS-BMS NPs-RKC clearly demonstrated. In vitro studies have shown this dual-pronged therapy stimulates powerful response suppress primary progression evokes long-term memory inhibit relapse metastasis. This work provides effective self-synergistic platform for PCa idea developing more biocompatible photo-controlled inducers.
Language: Английский
Citations
44
Small, Journal Year: 2024, Volume and Issue: 20(26)
Published: Feb. 17, 2024
Abstract Photothermal therapy (PTT) is a new treatment modality for tumors. However, the efficient delivery of photothermal agents into tumors remains difficult, especially in hypoxic tumor regions. In this study, an approach to deliver melanin, natural agent, using genetically engineered bacteria image‐guided and immune developed. An Escherichia coli MG1655 transformed with recombinant plasmid harboring tyrosinase gene produce melanin nanoparticles. Melanin‐producing (MG1655‐M) are systemically administered 4T1 tumor‐bearing mice. The tumor‐targeting properties MG1655‐M environment integrate hypoxia targeting, photoacoustic imaging, therapeutic “all‐in‐one” manner. This eliminates need post‐modification achieve hypoxia‐targeted cancer therapy. Tumor growth significantly suppressed by irradiating 808 nm laser. Furthermore, strong antitumor immunity triggered PTT, thereby producing long‐term memory effects that effectively inhibit metastasis recurrence. work proposes guided melanin‐producing bacteria, which can offer broad potential applications treatment.
Language: Английский
Citations
15
Journal of Photochemistry and Photobiology C Photochemistry Reviews, Journal Year: 2024, Volume and Issue: 58, P. 100652 - 100652
Published: Jan. 14, 2024
Language: Английский
Citations
10
Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5501 - 5544
Published: Jan. 1, 2023
Photodynamic Therapy (PDT) is an approved treatment modality, which presently receiving great attention due to its limited invasiveness, high selectivity and susceptibility drug resistance.Another related research area currently expanding rapidly the development of novel theranostic agents based on combination PDT with different imaging technologies, allows for both therapy diagnosis.This can help address issues suboptimal biodistribution through regional imaging, while therapeutic enable effective personalized therapy.In this review, we describe compounds, whose structures combine photosensitizers probes -including examples near-infrared optical magnetic resonance (MRI) nuclear (PET or SPECT), generating candidates.We have intentionally focused our already been investigated preclinically in vivo order demonstrate potential such clinical applications.
Language: Английский
Citations
22