Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
Abstract
Osteoarthritis
(OA)
is
an
inflammatory
and
progressive
joint
disease
characterized
by
angiogenesis‐mediated
sustained,
chronic,
low‐grade
synovitis.
Anti‐angiogenesis
emerging
as
a
strategy
for
attenuating
OA
progression,
but
often
compromised
poor
targeted
drug
delivery
immune
clearance.
Recent
studies
have
identified
macrophages
formed
“protective
barrier”
in
the
lining
layer
(LL)
of
synovium,
which
blocked
communication
cavity
sublining
(SL)
synovium.
Inspired
natural
mimicry,
macrophage
membrane‐camouflaged
explored
to
avoid
Based
on
single
cell
RNA
sequencing,
CD34
+
synovial
cells
are
“sentinel
cells”
synovium
angiogenesis.
Consequently,
antibody‐modified
membrane
constructed
target
new
Hence,
biomimetic
multi‐layered
nanoparticle
(NP)
developed
that
incorporates
axitinib‐loaded
poly(lactic‐co‐glycolic)
acid
(PLGA)
with
antibody
modified
(Atb@NP@Raw@CD34)
specifically
deliver
axitinib
(Atb)
SL
sustain
inhibiting
angiogenesis
without
elimination.
It
found
Atb@NP@Raw@CD34
can
pass
through
“barrier”,
targeting
cells,
continuously
releasing
Atb
anti‐angiogenesis
Furthermore,
vivo
data
demonstrated
attenuate
degeneration
In
conclusion,
local
injection
presents
promising
approach
clinically
impeding
progression.
Discover Materials,
Journal Year:
2025,
Volume and Issue:
5(1)
Published: Jan. 9, 2025
Achieving
the
ideal
replacement
for
robust
biological
tissues
requires
biocompatible
materials
with
a
nuanced
blend
of
characteristics,
including
organ
specific
toughness,
durability,
self-repairing
capability,
and
well-defined
structure.
Hydrogels,
structured
high
water
containing
3D-crosslinked
polymeric
networks,
present
promising
avenue
in
biomedical
applications
due
to
their
close
resemblance
natural
tissues.
However,
mechanical
performance
often
falls
short,
limiting
clinical
applications.
Recent
research
has
been
focused
on
developing
hydrogel
therapeutic
advancements
have
spurred
researchers
develop
hydrogels
having
acceptable
toughness.
While
it
is
now
possible
tailor
properties
synthetic
gels
mimic
those
tissues,
critical
aspects
such
as
biocompatibility
crosslinking
strategies
are
frequently
neglected.
This
review
scrutinizes
structural
techniques
designed
improve
toughness
hydrogels,
focusing
especially
innovative
efforts
integrate
these
enhancements
into
natural-based
hydrogels.
By
thoroughly
examining
methodologies,
sheds
light
complexities
strengthening
will
propose
valuable
insights
development
next-generation
tissue
substitutes.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 215 - 215
Published: Feb. 7, 2025
Conventional
drug
delivery
approaches,
including
tablets
and
capsules,
often
suffer
from
reduced
therapeutic
effectiveness,
largely
attributed
to
inadequate
bioavailability
difficulties
in
ensuring
patient
adherence.
These
challenges
have
driven
the
development
of
advanced
systems
(DDS),
with
hydrogels
especially
nanogels
emerging
as
promising
materials
overcome
these
limitations.
Hydrogels,
their
biocompatibility,
high
water
content,
stimuli-responsive
properties,
provide
controlled
targeted
release.
This
review
explores
evolution,
classifications
versus
applications
delivery,
detailing
synthesis
methods,
chemical
crosslinking,
physical
self-assembly,
techniques
such
microfluidics
3D
printing.
It
also
examines
drug-loading
mechanisms
(e.g.,
encapsulation
electrostatic
interactions)
release
strategies
diffusion,
stimuli-responsive,
enzyme-triggered).
gels
demonstrate
significant
advantages
addressing
limitations
traditional
DDS,
offering
improved
stability,
sustained
release,
specificity.
Their
adaptability
extends
various
routes
administration,
topical,
oral,
injectable
forms,
while
further
enhance
targeting
through
nanoscale
precision
stimuli
responsiveness.
Although
transformative
potential
personalized
medicine,
remain
scalable
manufacturing,
regulatory
approval,
delivery.
Future
include
integrating
biosensors
for
real-time
monitoring,
developing
dual-stimuli-responsive
systems,
optimizing
surface
functionalization
advancements
aim
establish
cornerstones
next-generation
solutions,
revolutionizing
paving
way
innovative,
patient-centered
treatments.
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(11)
Published: Feb. 24, 2024
Abstract
Hydrogels,
key
in
biomedical
research
for
their
hydrophilicity
and
versatility,
have
evolved
with
hydrogel
microspheres
(HMs)
of
micron‐scale
dimensions,
enhancing
role
minimally
invasive
therapeutic
delivery,
tissue
repair,
regeneration.
The
recent
emergence
nanomaterials
has
ushered
a
revolutionary
transformation
the
field,
which
demonstrates
tremendous
potential
targeted
therapies,
biological
imaging,
disease
diagnostics.
Consequently,
integration
advanced
nanotechnology
promises
to
trigger
new
revolution
realm
hydrogels.
HMs
loaded
combine
advantages
both
hydrogels
nanomaterials,
enables
multifaceted
functionalities
such
as
efficient
drug
sustained
release,
therapy,
lubrication,
biochemical
detection,
medical
biosensing
monitoring,
micro‐robotics.
Here,
this
review
comprehensively
expounds
upon
commonly
used
classifications.
Then,
it
provides
comprehensive
insights
into
raw
materials
preparation
methods
HMs.
Besides,
common
strategies
employed
achieve
nano‐micron
combinations
are
summarized,
latest
applications
these
combined
field
elucidated.
Finally,
valuable
future
design
development
provided.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 19, 2024
Organ-on-a-chip,
also
known
as
"tissue
chip,"
is
an
advanced
platform
based
on
microfluidic
systems
for
constructing
miniature
organ
models
in
vitro.
They
can
replicate
the
complex
physiological
and
pathological
responses
of
human
organs.
In
recent
years,
development
bone
joint-on-chip
platforms
aims
to
simulate
processes
occurring
bones
joints,
including
cell-cell
interactions,
interplay
various
biochemical
factors,
effects
mechanical
stimuli,
intricate
connections
between
multiple
future,
will
integrate
advantages
disciplines,
bringing
more
possibilities
exploring
disease
mechanisms,
drug
screening,
personalized
medicine.
This
review
explores
construction
application
Organ-on-a-chip
technology
joint
research,
proposes
a
modular
concept,
discusses
new
opportunities
future
challenges
platforms.
