New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(47), P. 19742 - 19745
Published: Jan. 1, 2024
Regio-selective C–H alkenylation reaction with acrylates by a rhodium-catalyzed of PMS (phenylmethyl sulfoximine) directed 2-oxo-2 H -chromene-3-carboxylic acid derivatives.
Language: Английский
Organic Letters, Journal Year: 2024, Volume and Issue: 26(35), P. 7425 - 7430
Published: Aug. 22, 2024
Presented herein is an atom- and step-economical method enabling the precise assembly of a heptacyclic scaffold containing both azocine indoline units through cascade reactions indolin-1-yl(aryl)methanimines with diazo indanediones. The formation products involves C–H bond activation double carbene insertion followed by intramolecular condensation, retro-[2 + 2] cycloaddition, recyclization. This reaction not only provided concise straightforward strategy for synthesis otherwise difficult to obtain compounds from readily available substrates but also disclosed unprecedented mode derivatives compounds. In general, this novel synthetic protocol has advantages, such as easily obtainable substrates, structurally sophisticated products, procedure, good compatibility diverse functional groups, ready scalability. Moreover, thus obtained showed decent antiproliferative activity against three human cancer cell lines.
Language: Английский
Citations
8
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(8), P. 5434 - 5441
Published: April 6, 2024
A mild method for the C–H/S–H coupling of pyrazol-5-amines and thiophenols was developed via electrochemistry, giving diverse amino pyrazole thioether derivatives in 37–98% yields. This electrochemical reaction is sustainable an atom-efficient approach with good functional group tolerance scalability by avoiding metal external chemical oxidants.
Language: Английский
Citations
4
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(51), P. 6560 - 6563
Published: Jan. 1, 2024
A Rh( iii )-catalyzed C–H/N–H [4+2] annulation of oxadiazolones with iodonium ylides was developed, which afforded a series fused-isoquinolines and fused-pyridines.
Language: Английский
Citations
4
Organic Letters, Journal Year: 2024, Volume and Issue: 26(20), P. 4205 - 4211
Published: May 14, 2024
An unprecedented base-controlled selective skeletal rearrangement reaction of hexahydro-4
Language: Английский
Citations
3
New Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Oxadiazolone-fused isoquinolines were synthesized via Rh( iii )-catalyzed [4+2] annulation and C–H activation, followed by acymethylation products with antidiabetic anti-inflammatory potential.
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
A divergent [5 + 1] cyclization reaction of o-aminobenzamides with vinylene carbonate has been developed, rapidly generating three types cyclic molecules including quinazolinones, 2-methylquinazolinones, and 2,3-dihydroquinazolinones high chemoselectivity. In this discovery, blooms as a multifunctional reagent to participate in cyclization. The potential new finding is further emphasized by assembling the benzothiazole heteroarene via [4 version tolerating bioactive units well.
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 29, 2025
Iridium(III)-catalyzed regioselective cyclization of substituted oximes with iodonium ylides has been described. This methodology offered multisubstituted heterocyclic N-oxides under mild reaction conditions in a redox-neutral manner. The was also compatible vinyl oximes. Additionally, substrate diversification carried out to illustrate the synthetic application protocol. A possible mechanism involving C-H bond activation proposed as well supported by isolation key five-membered iridacycle intermediate.
Language: Английский
Citations
0
Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3567 - 3567
Published: July 29, 2024
Transition-metal-catalyzed directed C-H functionalization with various carbene precursors has been widely employed for constructing a wide range of complex and diverse active molecules through metal migratory insertion processes. Among precursors, iodonium ylides serve as novel emerging precursor features including easy accessibility, thermal stability high activity, which have attracted great attention from organic chemists achieved tremendous success in transformation. In this review, recent progress on the application multifunctional coupling characteristics bond activation reactions is summarized, potential discussed.
Language: Английский
Citations
2
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 14, 2024
A solvent-controlled Rh(III)-catalyzed mono- and dual-C-H bond activation/carbene migratory insertion with diazo compounds as a single coupling partner was demonstrated. The reaction proceeded under mild conditions, yielding products in good to excellent yields. These results are significant for the development of domino multiple functionalization C(sp
Language: Английский
Citations
2
Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 4, 2024
Comprehensive Summary Herein, an unprecedented nickel‐catalyzed regioselective hydroalkynylation of unsymmetrical internal alkynes was realized with steric hindered resistance selectivity via the cyano‐directing group strategy. Significantly, resulting 1,3‐enyne products could be effectively employed in synthesis novel nitrogen‐containing tricyclics compounds, that provided potential candidate compound 8a (IC 50 = 2.6—6.1 μmol/L) for anti‐tumor cell proliferation activity. Therefore, this work not only improves transition‐metal‐ catalyzed strategy alkynes, but also exhibits versatility 1,3‐enynes construction complex bioactive chemical space.
Language: Английский
Citations
1