
Pharmacological Research, Год журнала: 2024, Номер 211, С. 107550 - 107550
Опубликована: Дек. 13, 2024
Язык: Английский
Pharmacological Research, Год журнала: 2024, Номер 211, С. 107550 - 107550
Опубликована: Дек. 13, 2024
Язык: Английский
Food Research International, Год журнала: 2024, Номер 178, С. 113934 - 113934
Опубликована: Янв. 4, 2024
Язык: Английский
Процитировано
13Molecules, Год журнала: 2023, Номер 28(23), С. 7768 - 7768
Опубликована: Ноя. 25, 2023
Pollen, a remarkably versatile natural compound collected by bees for its abundant source of proteins and nutrients, represents rich reservoir diverse bioactive compounds with noteworthy chemical therapeutic potential. Its extensive biological effects have been known exploited since ancient times. Today, there is an increased interest in finding against oxidative stress, factor that contributes to various diseases. Recent research has unraveled multitude activities associated bee pollen, ranging from antioxidant, anti-inflammatory, antimicrobial, antifungal properties potential antiviral anticancer applications. Comprehending the repertoire across pollen sources remains challenging. By investigating spectrum types their composition, this review produces updated analysis constituents prospects they offer. This emphasizes necessity further exploration standardization could contribute development innovative therapies.
Язык: Английский
Процитировано
10Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(10), С. 5089 - 5106
Опубликована: Фев. 28, 2024
Polyamines and their derivatives are ubiquitously present in free or conjugated forms various foods from animal, plant, microbial origins. The current knowledge of polyamines contents is readily available; furthermore, generate considerable recent research interest due to potential health benefits. structural diversity results challenging qualitative quantitative analysis food. Herein, we review summarize the published on foods, including identification, sources, quantities, Particularly, facing inherent challenges isomer identification polyamines, this paper provides a comprehensive overview polyamines' characteristics, cleavage patterns characteristic ion fragments MS/MS for identification. Free all types food, while limited plant-derived foods. Spermidine renowned antiaging properties, acclaimed as vitamins. Conjugated highlight anti-inflammatory properties have emerged mainstream drugs antiprostatitis. This will likely help us gain better insight into further develop functional personalized nutraceuticals.
Язык: Английский
Процитировано
4Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(8), С. 236 - 236
Опубликована: Авг. 22, 2024
Low molecular weight chitosan selenium nanoparticles (LCS-SeNPs), a biologically active compound derived from polysaccharides, have demonstrated potential in addressing obesity. However, the mechanism through which LCS-SeNPs alleviate high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) remains unclear. Our results elucidated that significantly inhibited fat accumulation and markedly improved intestinal barrier by increasing mucus secretion goblet cells. Moreover, reshaped flora composition abundance of mucus-associated microbiota (Bifidobacterium, Akkermansia, Muribaculaceae_unclassified) decreasing obesity-contributed bacterium (Anaerotruncus, Lachnoclostridium, Proteus). The modulation influenced several metabolic pathways, including bile acid secretion, purine metabolites, tryptophan derivation. Meanwhile, glycocholic tauro-beta-muricholic were reduced LCS-SeNP group. study suggests crucial role metabolism, providing new theoretical foundation for utilizing polysaccharides intervention HFD-induced NAFLD.
Язык: Английский
Процитировано
4Foods, Год журнала: 2024, Номер 13(2), С. 206 - 206
Опубликована: Янв. 9, 2024
Fu tea is receiving increasing attention for its specific aroma, flavor, and dramatic functional benefits. Herein, we explored the effects underlying mechanisms of loose (FLT), brick (FBT), diet pills (orlistat) on a high-fat (HFD)-induced obesity. The results indicated that FLT FBT administration effectively inhibited weight gain, glucose metabolic dysregulation, fat accumulation in organs, hepatic kidney injury, oxidative stress induced by HFD. Additionally, treatments improved lipid profiles reduced production proinflammatory cytokines regulating expression levels metabolism- inflammation-related genes. Furthermore, ameliorated gut microbiota dysbiosis HFD-mice dose-dependent relationship abundance family Verrucomicrobiaceae genus
Язык: Английский
Процитировано
3MedComm, Год журнала: 2025, Номер 6(1)
Опубликована: Янв. 1, 2025
Abstract The optimal strategy for improving cardiometabolic factors (CMFs) in young obese individuals through diet and exercise remains unclear, as do the potential mechanisms. We conducted an 8‐week randomized controlled trial to compare effects of different interventions youth with overweight/obesity. Gut microbes serum metabolites were examined identify regulating A total 129 undergraduates randomly assigned fiber‐rich (FR) diet, rope‐skipping (RS), combined FR–RS control groups. results showed that single effective weight, waist circumference, body fat, lipid profile compared group. Notably, FR group further reduced low‐density lipoprotein (LDL‐C) uric acid (UA) (all p < 0.05). Mediation analysis revealed four gut microbiota–metabolite–host axes CMFs. Additionally, we used machine learning algorithms predict individual responses based on baseline microbiota composition, specific microbial genera guiding targeted intervention selection. In conclusion, and/or RS CMFs, particular effectiveness reducing LDL‐C UA levels. These benefits may drive by microbiome–metabolite–host interactions. Moreover, predictability composition supports making decisions selecting interventions. Trial Registration: NCT04834687.
Язык: Английский
Процитировано
0Food Research International, Год журнала: 2025, Номер 203, С. 115892 - 115892
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
0Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
0Animals, Год журнала: 2025, Номер 15(11), С. 1580 - 1580
Опубликована: Май 28, 2025
Apricot bee pollen is an important natural product that exhibits antioxidant, anti-inflammatory, and antimicrobial properties. Deoxynivalenol (DON), one of the most prevalent mycotoxins produced by Fusarium fungi, poses risks to both human animal reproductive systems. We observed exposure DON inhibited cell proliferation induced apoptosis in bovine granulosa cells (bGCs), accompanied a significant downregulation PCNA expression upregulation BAX expression. RNA sequencing analysis revealed differentially expressed genes (DEGs) were primarily enriched oxidation-reduction process, oxidoreductase activity, steroid biosynthesis. further confirmed production estrogen progesterone decreasing protein levels CYP19A1 StAR. Additionally, increased reactive oxygen species (ROS) malondialdehyde (MDA) dose-dependent manner, suggesting oxidative stress bGCs. Importantly, we demonstrated apricot ethanol extract (ABPE) viability bGCs alleviated effects DON-induced reduction dysfunction. Furthermore, ABPE attenuated increase ROS upregulated antioxidant-related gene heme oxygenase-1 (HO-1). These results reveal protective against reduction, disorder, stress, providing new insights into potential as promising agent improve mycotoxin contamination.
Язык: Английский
Процитировано
0Опубликована: Окт. 19, 2023
Pollen, a remarkably versatile natural compound collected by bees for its abundant source of proteins and nutrients, represents rich reservoir diverse bioactive compounds with noteworthy chemical therapeutic potential. Its large range biological effects has been known exploited since ancient times. Today, there is an increased interest in finding agaisnt oxidative stress, factor that contributes to various diseases. Recent research unraveled multitude activities associated bee pollen, ranging from antioxidant, anti-inflammatory, antimicrobial, antifungal properties potential antiviral anticancer applications. Comprehending the extensive repertoire across pollen sources remains challenge. By investigating spectrum types their composition, this review produces updated analysis constituents prospects they offer. The findings emphasize necessity further exploration standardization could contribute development innovative therapies.
Язык: Английский
Процитировано
7