New insights into bee pollen: Nutrients, phytochemicals, functions and wall-disruption

Food Research International, Journal Year: 2024, Volume and Issue: 178, P. 113934 - 113934

Published: Jan. 4, 2024

Language: Английский

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Chemical Properties and Biological Activity of Bee Pollen

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7768 - 7768

Published: Nov. 25, 2023

Pollen, a remarkably versatile natural compound collected by bees for its abundant source of proteins and nutrients, represents rich reservoir diverse bioactive compounds with noteworthy chemical therapeutic potential. Its extensive biological effects have been known exploited since ancient times. Today, there is an increased interest in finding against oxidative stress, factor that contributes to various diseases. Recent research has unraveled multitude activities associated bee pollen, ranging from antioxidant, anti-inflammatory, antimicrobial, antifungal properties potential antiviral anticancer applications. Comprehending the repertoire across pollen sources remains challenging. By investigating spectrum types their composition, this review produces updated analysis constituents prospects they offer. This emphasizes necessity further exploration standardization could contribute development innovative therapies.

Language: Английский

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New Insights into Identification, Distribution, and Health Benefits of Polyamines and Their Derivatives

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(10), P. 5089 - 5106

Published: Feb. 28, 2024

Polyamines and their derivatives are ubiquitously present in free or conjugated forms various foods from animal, plant, microbial origins. The current knowledge of polyamines contents is readily available; furthermore, generate considerable recent research interest due to potential health benefits. structural diversity results challenging qualitative quantitative analysis food. Herein, we review summarize the published on foods, including identification, sources, quantities, Particularly, facing inherent challenges isomer identification polyamines, this paper provides a comprehensive overview polyamines' characteristics, cleavage patterns characteristic ion fragments MS/MS for identification. Free all types food, while limited plant-derived foods. Spermidine renowned antiaging properties, acclaimed as vitamins. Conjugated highlight anti-inflammatory properties have emerged mainstream drugs antiprostatitis. This will likely help us gain better insight into further develop functional personalized nutraceuticals.

Language: Английский

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Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 236 - 236

Published: Aug. 22, 2024

Low molecular weight chitosan selenium nanoparticles (LCS-SeNPs), a biologically active compound derived from polysaccharides, have demonstrated potential in addressing obesity. However, the mechanism through which LCS-SeNPs alleviate high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) remains unclear. Our results elucidated that significantly inhibited fat accumulation and markedly improved intestinal barrier by increasing mucus secretion goblet cells. Moreover, reshaped flora composition abundance of mucus-associated microbiota (Bifidobacterium, Akkermansia, Muribaculaceae_unclassified) decreasing obesity-contributed bacterium (Anaerotruncus, Lachnoclostridium, Proteus). The modulation influenced several metabolic pathways, including bile acid secretion, purine metabolites, tryptophan derivation. Meanwhile, glycocholic tauro-beta-muricholic were reduced LCS-SeNP group. study suggests crucial role metabolism, providing new theoretical foundation for utilizing polysaccharides intervention HFD-induced NAFLD.

Language: Английский

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Fu Loose Tea Administration Ameliorates Obesity in High-Fat Diet-Fed C57BL/6J Mice: A Comparison with Fu Brick Tea and Orlistat

Foods, Journal Year: 2024, Volume and Issue: 13(2), P. 206 - 206

Published: Jan. 9, 2024

Fu tea is receiving increasing attention for its specific aroma, flavor, and dramatic functional benefits. Herein, we explored the effects underlying mechanisms of loose (FLT), brick (FBT), diet pills (orlistat) on a high-fat (HFD)-induced obesity. The results indicated that FLT FBT administration effectively inhibited weight gain, glucose metabolic dysregulation, fat accumulation in organs, hepatic kidney injury, oxidative stress induced by HFD. Additionally, treatments improved lipid profiles reduced production proinflammatory cytokines regulating expression levels metabolism- inflammation-related genes. Furthermore, ameliorated gut microbiota dysbiosis HFD-mice dose-dependent relationship abundance family Verrucomicrobiaceae genus

Language: Английский

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Comparison of diet and exercise on cardiometabolic factors in young adults with overweight/obesity: multiomics analysis and gut microbiota prediction, a randomized controlled trial

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Abstract The optimal strategy for improving cardiometabolic factors (CMFs) in young obese individuals through diet and exercise remains unclear, as do the potential mechanisms. We conducted an 8‐week randomized controlled trial to compare effects of different interventions youth with overweight/obesity. Gut microbes serum metabolites were examined identify regulating A total 129 undergraduates randomly assigned fiber‐rich (FR) diet, rope‐skipping (RS), combined FR–RS control groups. results showed that single effective weight, waist circumference, body fat, lipid profile compared group. Notably, FR group further reduced low‐density lipoprotein (LDL‐C) uric acid (UA) (all p < 0.05). Mediation analysis revealed four gut microbiota–metabolite–host axes CMFs. Additionally, we used machine learning algorithms predict individual responses based on baseline microbiota composition, specific microbial genera guiding targeted intervention selection. In conclusion, and/or RS CMFs, particular effectiveness reducing LDL‐C UA levels. These benefits may drive by microbiome–metabolite–host interactions. Moreover, predictability composition supports making decisions selecting interventions. Trial Registration: NCT04834687.

Language: Английский

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Anti-obesity effects of luteoloside on high fat diet induced obese mice: Modulation of white adipose tissue, gut microbiota, and PPAR signaling pathways

Food Research International, Journal Year: 2025, Volume and Issue: 203, P. 115892 - 115892

Published: Jan. 31, 2025

Language: Английский

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Di-p-coumaroyl spermidine from bee pollen alleviates chronic non- bacterial prostatitis

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Bee pollen and its extracts have been used for decades as therapeutic agents or health food supplements to alleviate chronic non-bacterial prostatitis (CNP). However, functional compounds in bee on anti-CNP remain still unclear. In this study, we evaluated the properties of six principal phenolamides pollen. Our results provide compelling evidence that property may be ascribed abundance phenolamides. Particularly, di-p-Coumaroyl spermidine can CNP by upregulating autophagy via AMPK/mTOR signaling pathway regulating gut microbiota, based cellular rat models. Additionally, our finding a novel insight into gut-prostate axis spermidine. This is first report possesses anti-prostatitis function. paper will likely helpful further develop foods, personalized nutraceuticals, medicine from

Language: Английский

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Apricot Bee Pollen Alleviates Deoxynivalenol-Induced Cellular Toxicity in Bovine Granulosa Cells

Animals, Journal Year: 2025, Volume and Issue: 15(11), P. 1580 - 1580

Published: May 28, 2025

Apricot bee pollen is an important natural product that exhibits antioxidant, anti-inflammatory, and antimicrobial properties. Deoxynivalenol (DON), one of the most prevalent mycotoxins produced by Fusarium fungi, poses risks to both human animal reproductive systems. We observed exposure DON inhibited cell proliferation induced apoptosis in bovine granulosa cells (bGCs), accompanied a significant downregulation PCNA expression upregulation BAX expression. RNA sequencing analysis revealed differentially expressed genes (DEGs) were primarily enriched oxidation-reduction process, oxidoreductase activity, steroid biosynthesis. further confirmed production estrogen progesterone decreasing protein levels CYP19A1 StAR. Additionally, increased reactive oxygen species (ROS) malondialdehyde (MDA) dose-dependent manner, suggesting oxidative stress bGCs. Importantly, we demonstrated apricot ethanol extract (ABPE) viability bGCs alleviated effects DON-induced reduction dysfunction. Furthermore, ABPE attenuated increase ROS upregulated antioxidant-related gene heme oxygenase-1 (HO-1). These results reveal protective against reduction, disorder, stress, providing new insights into potential as promising agent improve mycotoxin contamination.

Language: Английский

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Chemical Properties and Biological Activity of Bee Pollen

Published: Oct. 19, 2023

Pollen, a remarkably versatile natural compound collected by bees for its abundant source of proteins and nutrients, represents rich reservoir diverse bioactive compounds with noteworthy chemical therapeutic potential. Its large range biological effects has been known exploited since ancient times. Today, there is an increased interest in finding agaisnt oxidative stress, factor that contributes to various diseases. Recent research unraveled multitude activities associated bee pollen, ranging from antioxidant, anti-inflammatory, antimicrobial, antifungal properties potential antiviral anticancer applications. Comprehending the extensive repertoire across pollen sources remains challenge. By investigating spectrum types their composition, this review produces updated analysis constituents prospects they offer. The findings emphasize necessity further exploration standardization could contribute development innovative therapies.

Language: Английский

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