Green Chemistry,
Год журнала:
2023,
Номер
26(1), С. 513 - 519
Опубликована: Ноя. 24, 2023
We
report
a
visible
light-promoted
intramolecular
radical
cascade
reaction
to
construct
fluorenol
and
naphthalene-fused
cyclopropyl
carbaldehyde
derivatives.
Green Chemistry,
Год журнала:
2023,
Номер
25(20), С. 7983 - 7987
Опубликована: Янв. 1, 2023
An
atom-
and
step-economical,
efficient
eco-friendly
method
for
constructing
naphthoselenazol-2-amines
through
a
visible-light
photocatalytic
multi-component
reaction
under
aqueous
phase
conditions
is
reported.
ACS Catalysis,
Год журнала:
2024,
Номер
14(8), С. 6247 - 6258
Опубликована: Апрель 10, 2024
Aryl-substituted
bicyclo[1.1.1]pentane
(BCP-aryl)
derivatives
represent
the
most
important
bioisosteres
of
biaryl
scaffolds
and
widely
exist
in
numerous
complex
pharmaceutical
molecules.
The
current
synthetic
method
limitations
using
only
tertiary
radical
precursors,
prefunctionalized
heteroarenes,
toxic
transition
metals,
expensive
photocatalysts
make
it
urgent
to
develop
a
more
simple
practical
protocol.
To
confront
enrich
Minisci-type
chemistry,
herein,
we
disclose
photocatalytic
multicomponent
reaction
for
synthesis
various
(halo)alkyl
BCP-aryls
[1.1.1]propellane,
alkyl
halides,
unfunctionalized
heteroarenes
as
starting
materials.
Diverse
kinds
radicals
(primary,
secondary,
carbons)
derived
from
chlorides,
bromides,
fluoroalkyl
iodides
are
very
compatible
this
transformation.
practicability
is
additionally
boosted
by
product
derivatizations
late-stage
functionalization
pharmaceutically
relevant
mechanistic
studies
demonstrate
that
relay
mechanism
initiated
consecutive
photoinduced
electron
transfer
(ConPET)
process
operation.
We
anticipate
methodology
would
act
useful
tool
biaryl-type
drug
derivatives,
ultimately
resulting
great
utility
discovery
program.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(18), С. 5122 - 5129
Опубликована: Янв. 1, 2024
This
study
demonstrates
a
strategy
involving
photoinduced
energy
transfer
for
decarboxylative
Minisci
C–H
(amino)alkylation
of
heteroarenes
employing
diverse
oxime
esters
(from
carboxylic
acids)
as
(amino)alkylating
reagents.
Green Chemistry,
Год журнала:
2024,
Номер
26(7), С. 4199 - 4208
Опубликована: Янв. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(10), С. 4926 - 4975
Опубликована: Янв. 1, 2024
In
search
for
the
perfect
wave(length).
This
review
is
dedicated
to
recent
efforts
in
development
of
visible
light
driven
photochemical
strategies
occurring
coloured
organic
compounds.
Organic Letters,
Год журнала:
2024,
Номер
26(15), С. 3014 - 3019
Опубликована: Март 28, 2024
The
radical
relay
provides
an
effective
paradigm
for
intermolecular
assembly
to
achieve
functionalization
across
remote
chemical
bonds.
Herein,
we
report
the
first
1,3-carbocarbonylation
of
α-carbonyl
alkyl
bromides
two
separate
C═C
reaction
is
highly
chemo-
and
regioselective,
with
C(sp3)–C(sp3)
bonds
one
C═O
bond
formed
in
a
single
orchestrated
operation.
In
addition,
synthesis
method
under
mild
conditions
using
inexpensive
copper
as
catalyst
allows
facile
access
structurally
diverse
products.
plausible
mechanism
investigated
through
series
control
experiments,
including
trapping,
clock
critical
intermediate
18O
labeling
experiment.
Organic Letters,
Год журнала:
2023,
Номер
25(36), С. 6773 - 6778
Опубликована: Сен. 1, 2023
A
visible-light-driven
desaturative
β-alkoxyoxalyation
of
N-aryl
cyclic
amines
with
difluoromethyl
bromides
and
H2O
has
been
reported.
This
tandem
reaction
is
triggered
by
homolysis
the
C–Br
bond
to
produce
difuoroalkyl
radical,
which
undergoes
subsequent
defluorinated
β-alkoxyoxalylation
cascades
afford
a
wide
range
β-ketoester/ketoamides
substituted
enamines.
The
prominent
feature
this
contains
photocatalyst-free,
transition-metal
free,
mild
conditions.
18O
labeling
experiment
disclosed
that
oxygen
source
carbonyl
unit.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(19), С. 4758 - 4763
Опубликована: Янв. 1, 2023
A
photocatalytic
method
for
desaturative
C(sp
3
)–H
amidation
of
N
-phenylpiperidine
under
external
photocatalyst-
and
transition
metal-free
conditions.