Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 27, 2024
Making
the
utmost
of
differences
and
advantages
multiple
disciplines,
interdisciplinary
integration
breaks
science
boundaries
accelerates
progress
in
mutual
quests.
As
an
organic
connection
material
science,
enzymology,
biomedicine,
nanozyme-related
research
is
further
supported
by
computer
technology,
which
injects
new
vitality,
contributes
to
in-depth
understanding,
unprecedented
insights,
broadened
application
possibilities.
Utilizing
computer-aided
first-principles
method,
high-speed
high-throughput
mathematic,
physic,
chemic
models
are
introduced
perform
atomic-level
kinetic
analysis
for
nanocatalytic
reaction
process,
theoretically
illustrate
underlying
nanozymetic
mechanism
structure-function
relationship.
On
this
basis,
nanozymes
with
desirable
properties
can
be
designed
demand-oriented
synthesized
without
repeated
trial-and-error
experiments.
Besides
that,
computational
device
also
play
indispensable
role
nanozyme-based
detecting
methods
realize
automatic
readouts
improved
accuracy
reproducibility.
Here,
work
focuses
on
crossing
nanocatalysis
inspire
nanozyme
field
a
greater
extent.
ACS Nano,
Год журнала:
2024,
Номер
18(4), С. 2533 - 2540
Опубликована: Янв. 12, 2024
Nanozymes,
nanomaterials
exhibiting
enzyme-like
activities,
have
emerged
as
a
prominent
interdisciplinary
field
over
the
past
decade.
To
date,
1200
different
been
identified
nanozymes,
covering
four
catalytic
categories:
oxidoreductases,
hydrolases,
isomerases,
and
lyases.
Catalytic
activity
specificity
are
two
pivotal
benchmarks
for
evaluating
enzymatic
performance.
Despite
substantial
progress
being
made
in
quantifying
optimizing
of
there
is
still
lack
in-depth
research
on
preventing
formation
consensual
knowledge
impeding
more
refined
systematic
classification
nanozymes.
Recently,
debates
regarding
whether
nanozymes
could
possess
similar
to
that
enzymes.
This
Perspective
discusses
by
referring
enzymes,
highlights
gap
between
concludes
offering
our
perspective
future
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(24)
Опубликована: Фев. 15, 2024
Abstract
Thanks
to
their
properties,
stability,
and
multifunctionality,
nanozymes
are
increasingly
impacting
several
fields,
including
medicine,
diagnostics,
environmental
science.
However,
clear
information
about
catalytic
properties
mechanisms
is
still
lacking.
Several
critical
issues
currently
under
discussions,
such
as
the
absence
of
univocally
accepted
mechanisms,
standardized
protocols
for
directly
comparing
versus
enzymes,
a
comprehensive
characterization
performance
in
different
chemical/biological
environments.
All
these
strongly
limit
advancement
field.
Herein,
metrology
analysis
both
methodological
procedures
attempted,
taking
platinum
case
study
thanks
multifunctional
features.
The
oxidoreductase
activities
Pt‐nanozymes
(i.e.,
peroxidase‐,
oxidase‐,
catalase‐like
reactions)
critically
investigated
physical/chemical
environments,
clarifying
fundamental
aspects
providing
general
guidelines
nanozyme
characterization.
Furthermore,
PtNP
compared
with
natural
enzymes
conditions,
behavior
evaluated
by
calculating
turnover
frequency
(TOF)
normalization
strategies.
results
highlight
that
efficient
catalysts,
exhibiting
outstanding
activity.
This
work
clarifies
key
points
concerning
Pt‐nanozyme
metrological
issues,
workflow
can
become
reference
characterizations.
Biomaterials Science,
Год журнала:
2024,
Номер
12(9), С. 2229 - 2243
Опубликована: Янв. 1, 2024
Nanozymes,
a
distinctive
class
of
nanomaterials
with
enzyme-like
activity
and
kinetics
akin
to
enzyme-catalysed
reactions,
present
several
advantages
over
natural
enzymes,
including
cost-effectiveness,
heightened
stability,
adjustable
activity.
Nanoscale,
Год журнала:
2024,
Номер
16(16), С. 7786 - 7824
Опубликована: Янв. 1, 2024
The
therapeutic
efficacy
of
nanozymes,
which
have
wide
applications
in
cancer
treatment,
can
be
enhanced
by
various
biomimetic
design
strategies,
from
structural
and
process
mimicry
to
advanced
functional
biomimicry.
ACS Sensors,
Год журнала:
2024,
Номер
9(8), С. 3840 - 3847
Опубликована: Июль 31, 2024
Single-atom
nanozymes
(SANs)
have
become
a
breakthrough
in
atomically
precise
catalysis,
which
relies
on
the
catalytic
active
site
formed
by
single-atom
itself.
From
this
angle,
SANs
and
their
advantages
compared
to
natural
enzymes
as
well
spaces
for
application
are
emphasized.
The
outstanding
control
over
activities;
is
with
bulk
materials
enzymes.
structure
of
has
very
promising
potential
next
generation
biosensing
biomedical
devices
environmental
remediation.
Although
capabilities
high,
difficulties
still
arise.
specificity,
scalability,
biosafety,
catalysis
mechanisms
raise
additional
issues
that
require
further
research.
We
build
up
vision
perspectives
better
implementation
SANs,
designed
diagnostic
purposes,
improving
industrial
technologies,
creating
new
sustainable
technologies
food
processing
industry.
AI
machine
learning
systems
may
clarify
structure–performance
relationship
improved
material
process
selectivity.
future
promising,
addressing
these
challenges
leveraging
advancements
artificial
intelligence
science,
powerful
tools
future.
