International Journal of Molecular Sciences,
Год журнала:
2017,
Номер
18(10), С. 2168 - 2168
Опубликована: Окт. 17, 2017
The
circadian
timing
system
(CTS)
controls
various
biological
functions
in
mammals
including
xenobiotic
metabolism
and
detoxification,
immune
functions,
cell
cycle
events,
apoptosis
angiogenesis.
Although
the
importance
of
CTS
is
well
known
pharmacology
drugs,
it
less
appreciated
at
clinical
level.
Genome-wide
studies
highlighted
that
majority
drug
target
genes
are
controlled
by
CTS.
This
suggests
chronotherapeutic
approaches
should
be
taken
for
many
drugs
to
enhance
their
effectiveness.
Currently
successfully
applied
treatment
different
types
cancers.
chronotherapy
approach
has
improved
tolerability
antitumor
efficacy
anticancer
both
experimental
animals
cancer
patients.
Thus,
chronobiological
have
been
determining
most
appropriate
time
administration
agents
minimize
side
effects
or
toxicity
efficacy,
so
as
optimize
therapeutic
ratio.
review
focuses
on
underlying
mechanisms
i.e.,
chronopharmacokinetics
chronopharmacodynamics
with
molecular
aspects,
provides
an
overview
some
recent
advances
development
chronopharmaceutics.
Abstract
Circadian
clocks
are
endogenous
oscillators
that
control
24-h
physiological
and
behavioral
processes.
The
central
circadian
clock
exerts
over
myriad
aspects
of
mammalian
physiology,
including
the
regulation
sleep,
metabolism,
immune
system.
Here,
we
review
advances
in
understanding
genetic
sleep
through
system,
as
well
impact
dysregulated
gene
expression
on
metabolic
function.
We
also
recent
studies
have
begun
to
unravel
clock’s
role
controlling
cardiovascular
nervous
systems,
gut
microbiota,
cancer,
aging.
Such
these
systems
relies,
part,
transcriptional
regulation,
with
evidence
for
genome-wide
chromosome
organization.
These
novel
insights
into
genomic
human
physiology
provide
opportunities
discovery
improved
treatment
strategies
new
biological
underpinnings
disease.
Journal of Clinical Investigation,
Год журнала:
2018,
Номер
128(9), С. 3826 - 3839
Опубликована: Июнь 28, 2018
BACKGROUND.
The
circadian
clock
is
a
fundamental
and
pervasive
biological
program
that
coordinates
24-hour
rhythms
in
physiology,
metabolism,
behavior,
it
essential
to
health.
Whereas
therapy
adapted
time
of
day
increasingly
reported
be
highly
successful,
needs
personalized,
since
internal
different
for
each
individual.
In
addition,
not
stable
trait,
but
influenced
by
many
factors,
including
genetic
predisposition,
age,
sex,
environmental
light
levels,
season.
An
easy
convenient
diagnostic
tool
currently
missing.
Cancer Research,
Год журнала:
2019,
Номер
79(15), С. 3806 - 3814
Опубликована: Июль 12, 2019
The
circadian
clock
is
a
master
regulator
of
mammalian
physiology,
regulating
daily
oscillations
crucial
biological
processes
and
behaviors.
Notably,
disruption
has
recently
been
identified
as
an
independent
risk
factor
for
cancer
classified
carcinogen.
As
such,
it
imperative
to
discern
the
underpinning
mechanisms
by
which
alters
risk.
Emergent
data,
reviewed
herein,
demonstrate
that
regulatory
functions
play
critical
roles
in
several
hallmarks
cancer,
including
control
cell
proliferation,
death,
DNA
repair,
metabolic
alteration.
Developing
deeper
understanding
circadian-cancer
regulation
cross-talk
holds
promise
developing
new
strategies
interception,
prevention,
management.
