2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension

Journal of Hypertension, Год журнала: 2023, Номер 41(12), С. 1874 - 2071

Опубликована: Июнь 24, 2023

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering Sang Hyun Ihm (South Korea), Uday Jadhav (India), Manolis Kallistratos Kazuomi Kario (Japan), Vasilios Kotsis Adi Leiba (Israel), Patricio López-Jaramillo (Colombia), Hans-Peter Marti (Norway), Terry McCormack Paolo Mulatero Dike B. Ojji (Nigeria), Sungha Park Priit Pauklin (Estonia), Sabine Perl (Austria), Arman Postadzhian (Bulgaria), Aleksander Prejbisz Venkata Ram Ramiro Sanchez (Argentina), Markus Schlaich Alta Schutte Cristina Sekib Sokolovic (Bosnia and Herzegovina), Jonas Spaak (Sweden), Dimitrios Terentes-Printzios Bruno Trimarco Thomas Unger (The Netherlands), Bert-Jan van den Born Anna Vachulova Agostino Virdis Jiguang Wang (China), Ulrich Wenzel (Germany), Paul Whelton Jiri Widimsky (Czech Jacek Wolf Grégoire Wuerzner (Switzerland), Eugene Yang Yuqing Zhang (China).

Язык: Английский

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Targeting inflammation in atherosclerosis — from experimental insights to the clinic

Nature Reviews Drug Discovery, Год журнала: 2021, Номер 20(8), С. 589 - 610

Опубликована: Май 11, 2021

Язык: Английский

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Genomics of circadian rhythms in health and disease

Genome Medicine, Год журнала: 2019, Номер 11(1)

Опубликована: Дек. 1, 2019

Abstract Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts over myriad aspects of mammalian physiology, including the regulation sleep, metabolism, immune system. Here, we review advances in understanding genetic sleep through system, as well impact dysregulated gene expression on metabolic function. We also recent studies have begun to unravel clock’s role controlling cardiovascular nervous systems, gut microbiota, cancer, aging. Such these systems relies, part, transcriptional regulation, with evidence for genome-wide chromosome organization. These novel insights into genomic human physiology provide opportunities discovery improved treatment strategies new biological underpinnings disease.

Язык: Английский

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Circadian disruption and human health

Journal of Clinical Investigation, Год журнала: 2021, Номер 131(19)

Опубликована: Сен. 30, 2021

Circadian disruption is pervasive and can occur at multiple organizational levels, contributing to poor health outcomes individual population levels. Evidence points a bidirectional relationship, in that circadian increases disease severity many diseases disrupt rhythms. Importantly, increase the risk for expression development of neurologic, psychiatric, cardiometabolic, immune disorders. Thus, harnessing rich findings from preclinical translational research biology enhance via circadian-based approaches represents unique opportunity personalized/precision medicine overall societal well-being. In this Review, we discuss implications human using bench-to-bedside approach. science applied clinical population-based Given broad regulation health, Review focuses its discussion on selected examples metabolic, cardiovascular, allergic, immunologic disorders highlight interrelatedness between potential interventions, such as bright light therapy exogenous melatonin, well chronotherapy improve and/or modify outcomes.

Язык: Английский

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Molecular regulations of circadian rhythm and implications for physiology and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Фев. 8, 2022

The term "circadian rhythms" describes endogenous oscillations with ca. 24-h period associated the earth's daily rotation and light/dark cycle. Such rhythms reflect existence of an intrinsic circadian clock that temporally orchestrates physiological processes to adapt internal environment external cues. At molecular level, consists multiple sets transcription factors resulting in autoregulatory transcription-translation feedback loops. Notably, addition their primary role as generator rhythm, biological plays a key controlling functions almost all tissues organs. It regulates several intracellular signaling pathways, ranging from cell proliferation, DNA damage repair response, angiogenesis, metabolic redox homeostasis, inflammatory immune response. In this review, we summarize findings showing crosstalk between some describing scenario wherein reciprocal regulation impinges upon aspects mammalian physiology. Moreover, based on evidence indicating can be challenged by environmental factors, social behaviors, well pre-existing pathological conditions, discuss implications misalignment human pathologies, such cancer diseases. Accordingly, disruption rhythm has been reported affect are relevant Expanding our understanding field represents intriguing transversal medicine challenge order establish precision medicine.

Язык: Английский

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The relevance of daylight for humans

Biochemical Pharmacology, Год журнала: 2020, Номер 191, С. 114304 - 114304

Опубликована: Окт. 28, 2020

Daylight is ubiquitous and crucial for mammalian vision as well non-visual input to the brain via intrinsically photosensitive retinal ganglion cells (ipRGCs) that express photopigment melanopsin. The ipRGCs project circadian clock in suprachiasmatic nuclei thereby ensure entrainment 24-hour day-night cycle, changes daylength trigger appropriate seasonal behaviours. also perihabenular nucleus surrounding regions modulate mood, stress learning animals humans. Given light has strong direct effects on cognition, alertness, performance, sleep, can be considered a "drug" treat many clinical conditions. Light therapy already established winter other depressions sleep disorders. Beyond visual retina, daylight contributes prevent myopia young by its impact eye development, important Vitamin D synthesis bone health skin. sun most powerful source and, dependent dose, ultraviolet radiance toxic living organisms used disinfectant. Most research involves laboratory-based electric light, without dynamic spectral undergoes moment moment. There gap between importance of human beings amount being done this subject. taken granted an environmental factor, enjoyed or avoided, according More awareness architecture urban design beyond aesthetic values comfort may lead higher quality work environments. Although we do not yet have factual basis assumption natural overall "better" than debate mandates serious consideration sunlight just solar power but biologically necessary sustainable healthy living.

Язык: Английский

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Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

Journal of Pharmacokinetics and Pharmacodynamics, Год журнала: 2021, Номер 48(3), С. 321 - 338

Опубликована: Апрель 1, 2021

Язык: Английский

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Chronoculture, harnessing the circadian clock to improve crop yield and sustainability

Science, Год журнала: 2021, Номер 372(6541)

Опубликована: Апрель 29, 2021

The daily rhythms of agriculture Sunlight drives agriculture, and plant circadian tune the plant's response to light-dark cycles. Steed et al. discuss how agricultural productivity might be improved by consideration rhythm alters responses challenges posed its environment. Science , this issue p. eabc9141

Язык: Английский

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Effect of immunotherapy-infusion time of day on survival of patients with advanced cancers: a study-level meta-analysis

ESMO Open, Год журнала: 2024, Номер 9(2), С. 102220 - 102220

Опубликована: Янв. 21, 2024

Background

Immune checkpoint inhibitors (ICIs) have become the standard of care for numerous malignancies. Emerging evidence suggests that time day (ToD) ICI administration could impact outcomes patients with cancer. The consistency ToD effects on efficacy awaits initial evaluation.

Materials and methods

This meta-analysis integrates progression-free survival (PFS) overall (OS) data from studies a defined ‘cut-off' ToD. Hazard ratios (HRs) [95% confidence interval (CI)] an earlier progression or death according to ‘early' ‘late' ICIs were collected each report pooled.

Results

Thirteen involved 1663 (Eastern Cooperative Oncology Group performance status 0-1, 83%; males/females, 67%/33%) non-small-cell lung cancer (47%), renal cell carcinoma (24%), melanoma (20%), urothelial (5%), esophageal (4%). Most received anti-programmed protein 1 death-ligand (98%), small proportion also anti-cytotoxic T-lymphocyte-associated 4 (anti-CTLA-4) (18%). cut-offs 13:00 14:00 (i.e. median infusion time), six studies, 16:00 16:30 reported threshold weaker vaccination responses) seven studies. Pooled analyses revealed early groups had longer OS (HR 0.50, 95% CI 0.42-0.58; P < 0.00001) PFS 0.51, 0.42-0.61; compared late groups.

Conclusions

Patients selected metastatic cancers seemed largely benefit infusions, which is consistent circadian mechanisms in immune-cell functions trafficking. Prospective randomized trials are needed establish recommendations optimal timing ICI-based therapies.

Язык: Английский

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Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(7)

Опубликована: Фев. 6, 2024

Studies in shift workers and model organisms link circadian disruption to breast cancer. However, molecular rhythms noncancerous cancerous human tissues their clinical relevance are largely unknown. We reconstructed informatically, integrating locally collected, time-stamped biopsies with public datasets. For tissue, inflammatory, epithelial–mesenchymal transition (EMT), estrogen responsiveness pathways show modulation. Among tumors, clock correlation analysis demonstrates subtype-specific changes organization. Luminal A organoids informatic ordering of luminal samples exhibit continued, albeit dampened reprogrammed rhythms. CYCLOPS magnitude, a measure global rhythm strength, varied widely among samples. Cycling EMT pathway genes was markedly increased high-magnitude tumors. Surprisingly, patients tumors had reduced 5-y survival. Correspondingly, 3D cultures invasion following disruption. This study links cancer EMT, metastatic potential, prognosis.

Язык: Английский

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