Broadening the scope: Multiple functional connectivity networks underlying threat conditioning and extinction DOI Creative Commons
Cody A. Cushing, Yujia Peng, Zachary Anderson

и другие.

Imaging Neuroscience, Год журнала: 2024, Номер 2, С. 1 - 15

Опубликована: Янв. 1, 2024

Abstract Threat learning processes are thought to be foundational anxiety and fear-related disorders. However, the study of these in human brain has largely focused on specific regions, owing partly ease translating between regions nonhuman animals. Moving beyond analyzing focal interest whole-brain dynamics connectivity during threat is essential for understanding neuropathology disorders humans. In this study, 223 participants completed a 2-day Pavlovian conditioning paradigm while undergoing fMRI. Participants acquisition extinction. Extinction recall was assessed 48 hours later. Using data-driven group independent component analysis (ICA), we examined large-scale functional networks each phase learning. Connectivity were tested see how they responded conditioned stimuli early late phases extinction as well trials recall. A network overlapping with default mode involving hippocampus, ventromedial prefrontal cortex (vmPFC), posterior cingulate implicated Another salience dorsal anterior (dACC), mPFC, inferior frontal gyrus both Other parts salience, somatomotor, visual, frontoparietal involved or learned responses. These findings help support cooperation model-free fashion introducing new spatially safety Rather than being single process core involves multiple operating parallel performing different functions at timescales. Understanding nature interplay will critical comprehensive that may play

Язык: Английский

The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery DOI Creative Commons
Shannon E. Grogans, Eliza Bliss‐Moreau, Kristin A. Buss

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 151, С. 105237 - 105237

Опубликована: Май 18, 2023

Язык: Английский

Процитировано

45
Temporally and anatomically specific contributions of the human amygdala to threat and safety learning DOI Creative Commons

Zhenfu Wen,

Candace M. Raio, Edward F. Pace‐Schott

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(26)

Опубликована: Июнь 21, 2022

Neural plasticity in subareas of the rodent amygdala is widely known to be essential for Pavlovian threat conditioning and safety learning. However, less consistent results have been observed human neuroimaging studies. Here, we identify test three important factors that may contribute these discrepancies: temporal profile response conditioning, anatomical specificity responses during learning, insufficient power responses. We combined data across multiple studies using a well-validated paradigm examine involvement In 601 humans, show two subregions tracked conditioned stimulus with aversive shock early while only one demonstrated delayed responding not paired shock. Our findings cross-species similarities temporal- anatomical-specific contributions affirm associative learning highlight future research humans.

Язык: Английский

Процитировано

47
Sensing fear: fast and precise threat evaluation in human sensory cortex DOI Creative Commons
Wen Li, Andreas Keil

Trends in Cognitive Sciences, Год журнала: 2023, Номер 27(4), С. 341 - 352

Опубликована: Фев. 1, 2023

Язык: Английский

Процитировано

28
Distributed neural representations of conditioned threat in the human brain DOI Creative Commons

Zhenfu Wen,

Edward F. Pace‐Schott, Sara W. Lazar

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Март 12, 2024

Abstract Detecting and responding to threat engages several neural nodes including the amygdala, hippocampus, insular cortex, medial prefrontal cortices. Recent propositions call for integration of more distributed that process sensory cognitive facets related threat. Integrative, sensitive, reproducible decoders detection response safety have yet be established. We combine functional MRI data across varying conditioning negative affect paradigms from 1465 participants with multivariate pattern analysis investigate representations safety. The trained sensitively specifically distinguish between cues multiple datasets. further show many dynamically shift Our results establish integrate circuits, merging well-characterized ‘threat circuit’ nodes, discriminating regardless experimental designs or acquisition parameters.

Язык: Английский

Процитировано

9
Fear extinction retention in children, adolescents, and adults DOI Creative Commons
Ebba Widegren, Johan Vegelius, Matilda A. Frick

и другие.

Developmental Cognitive Neuroscience, Год журнала: 2025, Номер 71, С. 101509 - 101509

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Threat and Reward Imminence Processing in the Human Brain DOI Creative Commons
Dinavahi V. P. S. Murty, Songtao Song, Srinivas Govinda Surampudi

и другие.

Journal of Neuroscience, Год журнала: 2023, Номер 43(16), С. 2973 - 2987

Опубликована: Март 16, 2023

In the human brain, aversive and appetitive processing have been studied with controlled stimuli in rather static settings. addition, extent to which aversive-related appetitive-related engage distinct or overlapping circuits remains poorly understood. Here, we sought investigate dynamics of while male female participants engaged comparable trials involving threat avoidance reward seeking. A central goal was characterize temporal evolution responses during periods imminence. For example, domain, predicted that bed nucleus stria terminalis (BST), but not amygdala, would exhibit anticipatory given role former anxious apprehension. We also periaqueductal gray (PAG) threat-proximity based on its involvement proximal-threat processes, ventral striatum threat-imminence escape rodents. Overall, uncovered imminence-related temporally increasing ("ramping") multiple brain regions, including BST, PAG, striatum, subcortically, dorsal anterior insula midcingulate, cortically. Whereas generated proximity as expected, it exhibited threat-related imminence responses. fact, across observed a main effect arousal. other words, extensive evolving, both suggesting distributed are dynamically biologically relevant information regardless valence, findings further supported by network analysis.

Язык: Английский

Процитировано

21
The impact of poverty and socioeconomic status on brain, behaviour, and development: a unified framework DOI Creative Commons
Eid Abo Hamza, Richard Tindle,

Simon Pawlak

и другие.

Reviews in the Neurosciences, Год журнала: 2024, Номер 35(6), С. 597 - 617

Опубликована: Апрель 12, 2024

In this article, we, for the first time, provide a comprehensive overview and unified framework of impact poverty low socioeconomic status (SES) on brain behaviour. While there are many studies SES (including cortex, hippocampus, amygdala, even neurotransmitters) behaviours educational attainment, language development, development psychopathological disorders), prior did not integrate behavioural, educational, neural findings in one framework. Here, we argue that behaviour interrelated. Specifically, based studies, due to lack resources, associated with poor nutrition, high levels stress caregivers their children, exposure socio-environmental hazards. These psychological physical injuries normal several areas neurotransmitters. Impaired functioning amygdala can lead disorders, while impaired hippocampus cortex functions delay learning as well academic performance. This turn perpetuates leading vicious cycle psychological/physical impairments. addition providing economic aid economically disadvantaged families, interventions should aim tackle abnormalities caused by early childhood. Importantly, acknowledging childhood help increase equity. current study, list future understand brain.

Язык: Английский

Процитировано

7
Prefrontal Regulation of Safety Learning during Ethologically Relevant Thermal Threat DOI Creative Commons

Ada C. Felix‐Ortiz,

Jaelyn M. Terrell,

María Carolina González

и другие.

eNeuro, Год журнала: 2024, Номер 11(2), С. ENEURO.0140 - 23.2024

Опубликована: Янв. 25, 2024

Learning and adaptation during sources of threat safety are critical mechanisms for survival. The prelimbic (PL) infralimbic (IL) subregions the medial prefrontal cortex (mPFC) have been broadly implicated in processing safety. However, how these regions regulate naturalistic conditions involving thermal challenge still remains elusive. To examine this issue, we developed a novel paradigm which adult mice learned that particular zone was identified with visuospatial cues associated either noxious cold temperature (“threat zone”) or pleasant warm (“safety zone”). This led to rapid development avoidance behavior when paired approach During long-term test without further reinforcement, continued exhibit robust interest, indicating enduring spatial-based memories were formed represent zones. Optogenetic experiments revealed neural activity PL IL not essential establishing memory zone. bidirectionally regulated formation While promoted normal conditions, suppressed especially after stress pretreatment. Therefore, working model is proposed balanced between favorable formation, whereas unbalanced brain detrimental stress.

Язык: Английский

Процитировано

6
Ultra-high field imaging of the amygdala – A narrative review DOI
Cedric Fabian Kirstein, Onur Güntürkün, Sebastian Ocklenburg

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 152, С. 105245 - 105245

Опубликована: Май 24, 2023

Язык: Английский

Процитировано

15
Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder DOI Creative Commons
Haang Jeung-Maarse, Mike M. Schmitgen,

Ruth Schmitt

и другие.

Neuropsychopharmacology, Год журнала: 2023, Номер 48(6), С. 946 - 953

Опубликована: Март 20, 2023

Abstract The amygdala is a key region in current neurocircuitry models of reactive aggression as it crucially involved detecting social threat and provocation. An increased reactivity to angry faces has been reported aggression-prone individuals the neuropeptide oxytocin (OT) could dampen anger-related number mental disorders. One example antisocial personality disorder (ASPD) which so far only studied limited numbers. To address question whether OT can normalize hyperreactivity emotional faces, we conducted functional magnetic resonance imaging experiment with 20 men 18 women ASPD male female healthy control (HC) participants double-blind, randomized, placebo (PLC)-controlled within-subject design. Participants were exposed an emotion classification task (fearful, angry, happy faces) after receiving intranasal dose (24 IU) synthetic or PLC. We found attenuate right hyperactivity such extent that intensity activity group condition decreased level PLC HC group. There was also trend effects generally larger than men. These findings suggest differentially modulates following threatening provoking cues dependence psychopathology (ASPD vs. HC) sex (male female). Particularly patients benefit from treatment aggression.

Язык: Английский

Процитировано

14