Medicina,
Год журнала:
2025,
Номер
61(2), С. 254 - 254
Опубликована: Фев. 1, 2025
Nicotinamide
(NAM),
the
amide
form
of
vitamin
B3,
is
a
precursor
to
essential
cofactors
nicotinamide
adenine
dinucleotide
(NAD⁺)
and
NADPH.
NAD⁺
integral
numerous
cellular
processes,
including
metabolism
regulation,
ATP
production,
mitochondrial
respiration,
reactive
oxygen
species
(ROS)
management,
DNA
repair,
senescence,
aging.
NAM
supplementation
has
demonstrated
efficacy
in
restoring
energy,
repairing
damage,
inhibiting
inflammation
by
suppressing
pro-inflammatory
cytokines
release.
Due
its
natural
presence
variety
foods
excellent
safety
profile—even
at
high
doses
up
3
g/day—NAM
extensively
used
chemoprevention
non-melanoma
skin
cancers
treatment
dermatological
conditions
such
as
blistering
diseases,
atopic
dermatitis,
rosacea,
acne
vulgaris.
Recently,
anti-aging
properties
have
elevated
NAM’s
prominence
skincare
formulations.
Beyond
repair
energy
replenishment,
significantly
impacts
oxidative
stress
reduction,
cell
cycle
apoptosis
modulation.
Despite
these
multifaceted
benefits,
comprehensive
molecular
mechanisms
underlying
actions
remain
not
fully
elucidated.
This
review
consolidates
recent
research
shed
light
on
mechanisms,
emphasizing
critical
role
health
therapeutic
potential.
By
enhancing
our
understanding,
this
work
underscores
importance
continued
exploration
into
applications,
aiming
inform
future
clinical
practices
innovations.
Cancers,
Год журнала:
2024,
Номер
16(12), С. 2262 - 2262
Опубликована: Июнь 18, 2024
Melanoma,
originating
through
malignant
transformation
of
melanin-producing
melanocytes,
is
a
formidable
malignancy,
characterized
by
local
invasiveness,
recurrence,
early
metastasis,
resistance
to
therapy,
and
high
mortality
rate.
This
review
discusses
etiologic
risk
factors
for
melanoma,
diagnostic
prognostic
tools,
including
recent
advances
in
molecular
biology,
omics,
bioinformatics,
provides
an
overview
its
therapy.
Since
the
incidence
melanoma
rising
remains
unacceptably
high,
we
discuss
inherent
properties,
melanogenesis,
that
make
this
disease
resilient
treatment
propose
use
AI
solve
above
complex
multidimensional
problems.
We
provide
on
vitamin
D
anticancerogenic
report
field
can
solutions
prevention
and/or
therapy
melanoma.
Experimental
papers
clinicopathological
studies
role
status
signaling
pathways
initiated
active
metabolites
prognosis
are
reviewed.
conclude
signaling,
defined
specific
nuclear
receptors
selective
activation
hydroxyderivatives,
benefit
new
or
existing
therapeutic
approaches.
target
with
computational
biology
tools
solution
problem.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
278, С. 116429 - 116429
Опубликована: Май 7, 2024
Air
pollutants
deteriorate
the
survival
environment
and
endanger
human
health
around
world.
A
large
number
of
studies
have
confirmed
that
air
pollution
jeopardizes
multiple
organs,
such
as
cardiovascular,
respiratory,
central
nervous
systems.
Skin
is
largest
organ
first
barrier
protects
us
from
outside
particulate
matter
(PM),
polycyclic
aromatic
hydrocarbons
(PAHs),
volatile
organic
compounds
(VOCs)
will
affect
structure
function
skin
bring
about
development
inflammatory
diseases
(atopic
dermatitis
(AD),
psoriasis),
accessory
(acne,
alopecia),
auto-immune
(cutaneous
lupus
erythematosus(CLE)
scleroderma),
even
tumors
(melanoma,
basal
cell
carcinoma
(BCC),
squamous-cell
(SCC)).
Oxidative
stress,
damage,
microbiome
dysbiosis,
inflammation
are
pathogenesis
stimulation.
In
this
review,
we
summarize
current
evidence
on
effects
possible
mechanisms
to
provide
strategies
for
future
research.
Biomedicines,
Год журнала:
2024,
Номер
12(5), С. 1023 - 1023
Опубликована: Май 7, 2024
The
synergic
role
of
vitamin
D
and
the
intestinal
microbiota
in
regulation
immune
system
has
been
thoroughly
described
literature.
Vitamin
deficiency
dysbiosis
have
shown
a
pathogenetic
development
numerous
immune-mediated
allergic
diseases.
physiological
processes
underlying
aging
sex
proven
to
be
capable
having
negative
influence
both
on
values
biodiversity
microbiome.
This
leads
global
increase
levels
systemic
inflammatory
markers,
with
potential
implications
for
all
diseases
conditions.
Our
review
aims
collect
analyze
relationship
between
microbiome
associated
it,
emphasizing
effect
mediated
by
sexual
hormones
aging.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 4101 - 4101
Опубликована: Апрель 7, 2024
Skin
aging
is
a
complex
process
involving
structural
and
functional
changes
characterized
by
decrease
in
collagen
content,
reduced
skin
thickness,
dryness,
the
formation
of
wrinkles.
This
underpinned
multiple
mechanisms
including
free
radical
theory,
inflammation
photoaging
metabolic
theory.
The
immune
system,
an
indispensable
part
body’s
defense
mechanism,
comprises
macrophages,
lymphocytes,
dendritic
cells,
mast
cells.
These
cells
play
pivotal
role
maintaining
homeostasis
responding
to
injury
or
infection.
As
age
advances,
along
with
various
internal
external
environmental
stimuli,
may
undergo
senescence
accelerated
aging,
cell
division
capability,
increased
mortality,
gene
expression
patterns
signaling
pathways,
altered
functions.
collectively
impact
overall
function
system.
review
summarizes
relationship
between
immunity
explores
characteristics
composition
effects
these
on
aging.
Immune
dysfunction
plays
significant
suggesting
that
immunoregulation
become
one
important
strategies
for
prevention
treatment
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4483 - 4483
Опубликована: Апрель 19, 2024
Photobiomodulation
(PBM)
is
a
procedure
that
uses
light
to
modulate
cellular
functions
and
biological
processes.
Over
the
past
decades,
PBM
has
gained
considerable
attention
for
its
potential
in
various
medical
applications
due
non-invasive
nature
minimal
side
effects.
We
conducted
narrative
review
including
articles
about
photobiomodulation,
LED
therapy
or
low-level
laser
their
on
dermatology
published
over
last
6
years,
encompassing
research
studies,
clinical
trials,
technological
developments.
This
highlights
mechanisms
of
action
underlying
PBM,
interaction
with
chromophores
activation
intracellular
signaling
pathways.
The
evidence
from
trials
experimental
studies
evaluate
efficacy
practice
summarized
special
emphasis
dermatology.
Furthermore,
advancements
technology,
such
as
novel
sources
treatment
protocols,
are
discussed
context
optimizing
therapeutic
outcomes
improving
patient
care.
underscores
promising
role
approach
broad
applicability.
Despite
need
further
develop
standard
holds
great
addressing
wide
range
conditions
enhancing
modern
healthcare
practice.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8224 - 8224
Опубликована: Июль 27, 2024
Polynucleotides,
complex
molecules
composed
of
nucleotides,
have
gained
attention
in
aesthetic
medicine
for
their
potential
to
regulate
gene
expression
and
promote
tissue
regeneration.
This
review
aims
provide
an
overview
the
current
practices
perceived
effectiveness
polynucleotides
medicine.
A
comprehensive
search
literature
was
conducted
using
keywords
related
polynucleotides,
cosmetic
application,
application.
Studies
were
selected
based
on
relevance
inclusion
human
subjects.
The
found
that
been
used
improve
skin
texture,
reduce
wrinkle
depth,
enhance
facial
appearance.
studies
reported
varying
degrees
efficacy
safety,
with
some
demonstrating
significant
improvements
elasticity
hydration.
However,
others
limited
or
no
benefits.
also
highlighted
need
further
research
establish
optimal
use
While
existing
suggests
may
benefits
medicine,
more
is
needed
fully
understand
mechanisms
action
use.
Clinicians
should
be
aware
limitations
risks
associated
Diagnostics,
Год журнала:
2025,
Номер
15(3), С. 327 - 327
Опубликована: Янв. 30, 2025
Wearable
devices
have
gained
increasing
attention
for
use
in
multifunctional
applications
related
to
health
monitoring,
particularly
research
of
the
circadian
rhythms
cognitive
functions
and
metabolic
processes.
In
this
comprehensive
review,
we
encompass
how
wearables
can
be
used
study
disease.
We
highlight
importance
these
as
markers
well-being
potential
predictors
outcomes.
focus
on
wearable
technologies
sleep
research,
medicine,
chronomedicine
beyond
domain
emphasize
actigraphy
a
validated
tool
monitoring
sleep,
activity,
light
exposure.
discuss
various
mathematical
methods
currently
analyze
actigraphic
data,
such
parametric
non-parametric
approaches,
linear,
non-linear,
neural
network-based
applied
quantify
non-circadian
variability.
also
introduce
novel
actigraphy-derived
markers,
which
personalized
proxies
status,
assisting
discriminating
between
disease,
offering
insights
into
neurobehavioral
status.
lifestyle
factors
physical
activity
exposure
modulate
brain
health.
establishing
reference
standards
measures
further
refine
data
interpretation
improve
clinical
The
review
calls
existing
tools
methods,
deepen
our
understanding
health,
develop
healthcare
strategies.
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1762 - 1762
Опубликована: Июнь 4, 2024
Autoimmune
thyroid
diseases
(AITD)
are
among
the
most
frequent
autoimmune
disorders,
with
a
multifactorial
etiology
in
which
both
genetic
and
environmental
determinants
probably
involved.
Celiac
disease
(CeD)
also
represents
public
concern,
given
its
increasing
prevalence
due
to
recent
improvement
of
screening
programs,
leading
detection
silent
subtypes.
The
two
conditions
may
be
closely
associated
common
risk
factors,
including
setting,
changes
composition
diversity
gut
microbiota,
deficiency
nutrients
like
vitamin
D.
This
comprehensive
review
discussed
current
evidence
on
pivotal
role
D
modulating
microbiota
dysbiosis
immune
system
dysfunction,
shedding
light
possible
relevance
an
adequate
intake
this
nutrient
primary
prevention
AITD
CeD.
While
future
technology-based
strategies
for
proper
supplementation
could
attractive
context
personalized
medicine,
several
issues
remain
defined,
standardized
assays
determination,
timely
recommendations
functioning,
longitudinal
studies
randomized
controlled
trials
definitely
establish
causal
relationship
between
serum
levels
onset
