International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7236 - 7236
Published: June 30, 2024
Post-burn
hypertrophic
scars
often
exhibit
abnormal
pigmentation.
Exosomes
play
important
roles
in
maintaining
normal
physiological
homeostasis
and
the
pathological
development
of
diseases.
This
study
investigated
effects
exosomes
derived
from
scar
fibroblasts
(HTSFs)
on
melanocytes,
which
are
pigment-producing
cells.
Normal
(NFs)
HTSFs
were
isolated
cultured
skin
(HTS)
tissue.
Both
NF-
HTSF-exosomes
a
cell
culture
medium
purified
using
column-based
technique.
The
human
epidermal
melanocytes
treated
with
both
at
concentration
100
μg/mL
different
times.
proliferation,
melanin
content
medium,
apoptotic
factors,
transcription
synthesis
enzymes,
signaling,
signal
transduction
pathways,
activators
factors
(STAT)
1,
3,
5,
6
investigated.
Compared
Dulbecco's
phosphate-buffered
saline
(DPBS)-treated
controls
NF-exosomes,
decreased
melanocyte
proliferation
secretion.
molecular
patterns
apoptosis,
synthesis,
Smad
non-Smad
STATs
altered
by
treatment
HTSF-exosomes.
No
significant
differences
observed
between
DPBS-treated
control
NF-exosome-treated
HTSF-derived
may
role
hypopigmentation
patients
HTS.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(12), P. 2262 - 2262
Published: June 18, 2024
Melanoma,
originating
through
malignant
transformation
of
melanin-producing
melanocytes,
is
a
formidable
malignancy,
characterized
by
local
invasiveness,
recurrence,
early
metastasis,
resistance
to
therapy,
and
high
mortality
rate.
This
review
discusses
etiologic
risk
factors
for
melanoma,
diagnostic
prognostic
tools,
including
recent
advances
in
molecular
biology,
omics,
bioinformatics,
provides
an
overview
its
therapy.
Since
the
incidence
melanoma
rising
remains
unacceptably
high,
we
discuss
inherent
properties,
melanogenesis,
that
make
this
disease
resilient
treatment
propose
use
AI
solve
above
complex
multidimensional
problems.
We
provide
on
vitamin
D
anticancerogenic
report
field
can
solutions
prevention
and/or
therapy
melanoma.
Experimental
papers
clinicopathological
studies
role
status
signaling
pathways
initiated
active
metabolites
prognosis
are
reviewed.
conclude
signaling,
defined
specific
nuclear
receptors
selective
activation
hydroxyderivatives,
benefit
new
or
existing
therapeutic
approaches.
target
with
computational
biology
tools
solution
problem.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
278, P. 116429 - 116429
Published: May 7, 2024
Air
pollutants
deteriorate
the
survival
environment
and
endanger
human
health
around
world.
A
large
number
of
studies
have
confirmed
that
air
pollution
jeopardizes
multiple
organs,
such
as
cardiovascular,
respiratory,
central
nervous
systems.
Skin
is
largest
organ
first
barrier
protects
us
from
outside
particulate
matter
(PM),
polycyclic
aromatic
hydrocarbons
(PAHs),
volatile
organic
compounds
(VOCs)
will
affect
structure
function
skin
bring
about
development
inflammatory
diseases
(atopic
dermatitis
(AD),
psoriasis),
accessory
(acne,
alopecia),
auto-immune
(cutaneous
lupus
erythematosus(CLE)
scleroderma),
even
tumors
(melanoma,
basal
cell
carcinoma
(BCC),
squamous-cell
(SCC)).
Oxidative
stress,
damage,
microbiome
dysbiosis,
inflammation
are
pathogenesis
stimulation.
In
this
review,
we
summarize
current
evidence
on
effects
possible
mechanisms
to
provide
strategies
for
future
research.
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(3), P. 327 - 327
Published: Jan. 30, 2025
Wearable
devices
have
gained
increasing
attention
for
use
in
multifunctional
applications
related
to
health
monitoring,
particularly
research
of
the
circadian
rhythms
cognitive
functions
and
metabolic
processes.
In
this
comprehensive
review,
we
encompass
how
wearables
can
be
used
study
disease.
We
highlight
importance
these
as
markers
well-being
potential
predictors
outcomes.
focus
on
wearable
technologies
sleep
research,
medicine,
chronomedicine
beyond
domain
emphasize
actigraphy
a
validated
tool
monitoring
sleep,
activity,
light
exposure.
discuss
various
mathematical
methods
currently
analyze
actigraphic
data,
such
parametric
non-parametric
approaches,
linear,
non-linear,
neural
network-based
applied
quantify
non-circadian
variability.
also
introduce
novel
actigraphy-derived
markers,
which
personalized
proxies
status,
assisting
discriminating
between
disease,
offering
insights
into
neurobehavioral
status.
lifestyle
factors
physical
activity
exposure
modulate
brain
health.
establishing
reference
standards
measures
further
refine
data
interpretation
improve
clinical
The
review
calls
existing
tools
methods,
deepen
our
understanding
health,
develop
healthcare
strategies.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4483 - 4483
Published: April 19, 2024
Photobiomodulation
(PBM)
is
a
procedure
that
uses
light
to
modulate
cellular
functions
and
biological
processes.
Over
the
past
decades,
PBM
has
gained
considerable
attention
for
its
potential
in
various
medical
applications
due
non-invasive
nature
minimal
side
effects.
We
conducted
narrative
review
including
articles
about
photobiomodulation,
LED
therapy
or
low-level
laser
their
on
dermatology
published
over
last
6
years,
encompassing
research
studies,
clinical
trials,
technological
developments.
This
highlights
mechanisms
of
action
underlying
PBM,
interaction
with
chromophores
activation
intracellular
signaling
pathways.
The
evidence
from
trials
experimental
studies
evaluate
efficacy
practice
summarized
special
emphasis
dermatology.
Furthermore,
advancements
technology,
such
as
novel
sources
treatment
protocols,
are
discussed
context
optimizing
therapeutic
outcomes
improving
patient
care.
underscores
promising
role
approach
broad
applicability.
Despite
need
further
develop
standard
holds
great
addressing
wide
range
conditions
enhancing
modern
healthcare
practice.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(5), P. 1023 - 1023
Published: May 7, 2024
The
synergic
role
of
vitamin
D
and
the
intestinal
microbiota
in
regulation
immune
system
has
been
thoroughly
described
literature.
Vitamin
deficiency
dysbiosis
have
shown
a
pathogenetic
development
numerous
immune-mediated
allergic
diseases.
physiological
processes
underlying
aging
sex
proven
to
be
capable
having
negative
influence
both
on
values
biodiversity
microbiome.
This
leads
global
increase
levels
systemic
inflammatory
markers,
with
potential
implications
for
all
diseases
conditions.
Our
review
aims
collect
analyze
relationship
between
microbiome
associated
it,
emphasizing
effect
mediated
by
sexual
hormones
aging.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 4101 - 4101
Published: April 7, 2024
Skin
aging
is
a
complex
process
involving
structural
and
functional
changes
characterized
by
decrease
in
collagen
content,
reduced
skin
thickness,
dryness,
the
formation
of
wrinkles.
This
underpinned
multiple
mechanisms
including
free
radical
theory,
inflammation
photoaging
metabolic
theory.
The
immune
system,
an
indispensable
part
body’s
defense
mechanism,
comprises
macrophages,
lymphocytes,
dendritic
cells,
mast
cells.
These
cells
play
pivotal
role
maintaining
homeostasis
responding
to
injury
or
infection.
As
age
advances,
along
with
various
internal
external
environmental
stimuli,
may
undergo
senescence
accelerated
aging,
cell
division
capability,
increased
mortality,
gene
expression
patterns
signaling
pathways,
altered
functions.
collectively
impact
overall
function
system.
review
summarizes
relationship
between
immunity
explores
characteristics
composition
effects
these
on
aging.
Immune
dysfunction
plays
significant
suggesting
that
immunoregulation
become
one
important
strategies
for
prevention
treatment
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8224 - 8224
Published: July 27, 2024
Polynucleotides,
complex
molecules
composed
of
nucleotides,
have
gained
attention
in
aesthetic
medicine
for
their
potential
to
regulate
gene
expression
and
promote
tissue
regeneration.
This
review
aims
provide
an
overview
the
current
practices
perceived
effectiveness
polynucleotides
medicine.
A
comprehensive
search
literature
was
conducted
using
keywords
related
polynucleotides,
cosmetic
application,
application.
Studies
were
selected
based
on
relevance
inclusion
human
subjects.
The
found
that
been
used
improve
skin
texture,
reduce
wrinkle
depth,
enhance
facial
appearance.
studies
reported
varying
degrees
efficacy
safety,
with
some
demonstrating
significant
improvements
elasticity
hydration.
However,
others
limited
or
no
benefits.
also
highlighted
need
further
research
establish
optimal
use
While
existing
suggests
may
benefits
medicine,
more
is
needed
fully
understand
mechanisms
action
use.
Clinicians
should
be
aware
limitations
risks
associated
