Toxicology, Год журнала: 2024, Номер unknown, С. 154044 - 154044
Опубликована: Дек. 1, 2024
Язык: Английский
Autoimmunity, Год журнала: 2024, Номер 57(1)
Опубликована: Фев. 8, 2024
Type 2 inflammation related diseases, such as atopic dermatitis, asthma, and allergic rhinitis, are diverse affect multiple systems in the human body. It is common for individuals to have co-existing type which can impose a significant financial living burden on patients. However, exact pathogenesis of these diseases still unclear. The NLRP3 inflammasome protein complex composed protein, ASC, Caspase-1, activated through various mechanisms, including NF-κB pathway, ion channels, lysosomal damage. plays role immune response pathogens cellular Recent studies indicated strong correlation between abnormal activation onset inflammation. Additionally, it has been demonstrated that suppressing expression effectively diminishes inflammatory response, highlighting its promising therapeutic applications. Therefore, this article reviews development therapy diseases.
Язык: Английский
Процитировано
23
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Янв. 29, 2024
Spinal cord injury is a severe neurological trauma that can frequently lead to neuropathic pain. During the initial stages following spinal injury, inflammation plays critical role; however, excessive exacerbate Regulatory T cells (Treg cells) have crucial function in regulating and alleviating Treg release suppressor cytokines modulate of other immune suppress inflammatory response. Simultaneously, impedes cell activity, further intensifying Therefore, suppressing response while enhancing regulatory may provide novel therapeutic avenues for treating pain resulting from injury. This review comprehensively describes mechanisms underlying regulation subsequent with specific focus on exploring potential through which regulate The insights gained this aim new concepts rationale prospects direction therapy injury-related conditions.
Язык: Английский
Процитировано
11
Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 670 - 670
Опубликована: Май 22, 2024
Given the ongoing rise in occurrence of allergic disorders, alterations dietary patterns have been proposed as a possible factor contributing to emergence and progression these conditions. Currently, there is significant focus on development therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols plant metabolites intensively researched due their well-documented anti-inflammatory, antioxidant, immunomodulatory characteristics, making them one most prominent bioactive chemicals. This study seeks discuss in-depth mechanisms by which molecules may exert anti-allergic effects, namely through capacity diminish allergenicity proteins, modulate immune responses, modify composition gut microbiota. However, further investigation required fully understand effects. paper examines existing evidence from experimental clinical studies supports idea different polyphenols, such catechins, resveratrol, curcumin, quercetin, others, can reduce inflammation, relieve symptoms food allergy, asthma, atopic dermatitis, rhinitis, prevent response. In summary, possess properties be utilized for developing both preventative therapeutic strategies targeting The also discusses constraints investigating broad usage well potential avenues future research.
Язык: Английский
Процитировано
8
Nutrients, Год журнала: 2023, Номер 15(22), С. 4823 - 4823
Опубликована: Ноя. 17, 2023
In light of the constantly increasing prevalence allergic diseases, changes in dietary patterns have been suggested as a plausible environmental explanation for development and progression these diseases. Nowadays, much attention has paid to interventions using natural substances with anti-allergy activities. this respect, polyphenols studied extensively one most prominent bioactive compounds well-documented anti-inflammatory, antioxidant, immunomodulatory properties. This review aims discuss mechanisms underlying potential anti-allergic actions related their ability reduce protein allergenicity, regulate immune response, gut microbiome modification; however, issues need be elucidated detail. paper reviews current evidence from experimental clinical studies confirming that various such quercetin, curcumin, resveratrol, catechins, many others could attenuate inflammation, alleviate symptoms food allergy, asthma, rhinitis, prevent response. Conclusively, are endowed great therefore used either preventive approaches or therapeutic relation Limitations studying widespread use well future research directions also discussed.
Язык: Английский
Процитировано
17
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12091 - 12091
Опубликована: Ноя. 11, 2024
The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.
Язык: Английский
Процитировано
7
Journal of Functional Foods, Год журнала: 2024, Номер 116, С. 106152 - 106152
Опубликована: Апрель 5, 2024
The crucial roles of innate and acquired immunity in the pathogenesis allergic diseases have been well highlighted based on molecular mechanisms. Thus, modulation unregulated unabated inflammatory responses is a therapeutic strategy diseases. One most important natural compounds with high immune anti-inflammation potency quercetin, found various fruits vegetables, namely onions, shallots, apples, berry crops. Therefore, this study, we reviewed influences quercetin against conditions, including asthma, rhinitis, atopic dermatitis, conjunctivitis, anaphylaxis. Scientific databases, PubMed, Scopus, Web Sciences, EMBASE, were searched English until March 2024. Quercetin's beneficial effects attributed to its anti-cancer, anti-viral, anti-oxidant, anti-inflammatory activities, also decrease pro-inflammatory cytokines, leukotrienes production, inhibition histamine release, suppression interleukin IL-4 production. It can reduce production antigen-specific IgE antibodies improve Th1/Th2 balance. These qualities be used as treat According findings these investigations, may influence allergy illnesses.
Язык: Английский
Процитировано
5
Pharmacological Research - Natural Products, Год журнала: 2025, Номер unknown, С. 100159 - 100159
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Янв. 31, 2025
Scoparone (SCO), also known as 6,7-Dimethoxycoumarin, is a naturally occurring bioactive ingredient originally derived from Chinese herb Artemisiae Scopariae Herba (Yin-Chen-Hao). Previous studies have shown that it effective in treating some of the liver diseases. Beyond its hepatoprotective effects, an expanding body research has underscored immunoregulatory properties SCO, indicating potential therapeutic benefits for autoimmune and other inflammatory Over past decade, significant advances been made understanding mechanistic insights into effects on immune-mediated diseases well SCO impact various immune cells, including mast monocytes, macrophages, neutrophils T affects broad range intracellular signaling pathways, TLR4/Myd88/NFκB, TGFβR/Smad3 JNK/Sab/SHP-1 etc. Therefore, this review not only summarizes immunomodulatory immune-based (IMIDs), such bowel disease, osteoarthritis, allergic rhinitis, acute lung injury, type 1 diabetes neuroinflammatory etc., but provides comprehensive summary hepatic diseases, non-alcoholic steatohepatitis, fulminant failure fibrosis. In review, we include impacts TGFβR/Smad3, Nrf2/P38, JAK2/STAT3 Further researches may help understand in-depth mechanisms action pave way development novel drugs to prevent treat disorders thereby significantly advancing innovations pharmaceutical applications.
Язык: Английский
Процитировано
0
International Journal of General Medicine, Год журнала: 2025, Номер Volume 18, С. 529 - 565
Опубликована: Фев. 1, 2025
Abstract: Allergic rhinitis (AR) is a prevalent allergic disease that imposes significant economic burdens and life pressures on individuals, families, society, particularly in the context of accelerating globalization increasing pathogenic factors. Current clinical therapies for AR include antihistamines, glucocorticoids administered via various routes, leukotriene receptor antagonists, immunotherapy, several decongestants. These treatments have demonstrated efficacy alleviating symptoms pathological states. However, with growing awareness rising expectations improvements quality life, these become associated higher incidence side effects an elevated risk drug resistance. Furthermore, development intricately dysregulation immune system, yet underlying pathogenetic mechanisms remain incompletely understood. In contrast, widely available natural plant molecules offer multiple targeting pathways uniquely modify typical pathophysiology through immunomodulatory processes. This review presents comprehensive analysis both vivo vitro studies modulate immunity treating AR. Additionally, we examine their specific action animal models to provide new insights developing safe effective targeted while guiding experimental applications against Keywords: molecules, rhinitis, immunomodulation, therapeutic mechanism, research progress
Язык: Английский
Процитировано
0
Redox Report, Год журнала: 2025, Номер 30(1)
Опубликована: Фев. 2, 2025
Oxidative stress, characterized by an imbalance between excessive reactive oxygen species (ROS) production and impaired antioxidant defenses, is closely linked to the pathogenesis of various otorhinolaryngological disorders. Mitochondria, as primary site cellular energy production, play a crucial role in modulating oxidative stress. Mitochondrial dysfunction exacerbates ROS generation, leading damage inflammatory responses. In diseases, stress strongly associated with conditions such hearing loss, allergic rhinitis, chronic sinusitis, where tissue inflammation are key pathological features. Recent studies have highlighted potential therapies mitigate restore homeostasis, offering promising avenues for alleviating symptoms these diseases. However, despite encouraging results from early-stage research, clinical efficacy interventions remains be fully established. This review provides overview diseases evaluates therapeutic strategies.
Язык: Английский
Процитировано
0