Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
unknown, С. 1 - 19
Опубликована: Май 19, 2023
Antibiotic
resistance
is
a
significant
public
health
issue,
causing
illnesses
that
were
once
easily
treatable
with
antibiotics
to
develop
into
dangerous
infections,
leading
substantial
disability
and
even
death.
To
help
fight
this
growing
threat,
scientists
are
developing
new
methods
techniques
play
crucial
role
in
treating
infections
preventing
the
inappropriate
use
of
antibiotics.
These
effective
therapeutic
include
phage
therapies,
quorum-sensing
inhibitors,
immunotherapeutics,
predatory
bacteria,
antimicrobial
adjuvants,
haemofiltration,
nanoantibiotics,
microbiota
transplantation,
plant-derived
antimicrobials,
RNA
therapy,
vaccine
development,
probiotics.
As
result
activity
probiotics
intestine,
compounds
derived
from
structure
metabolism
these
bacteria
obtained,
called
postbiotics,
which
multiple
agents
various
applications,
especially
effects,
by
using
different
mechanisms.
have
been
chosen
particular
because
they
don't
promote
spread
antibiotic
substances
can
increase
resistance.
This
manuscript
provides
an
overview
novel
approaches
emphasis
on
postbiotic
metabolites
gut
beneficial
microbes,
their
activities,
recent
related
progressions
food
medical
fields,
as
well
concisely
giving
insight
concept
postbiotics
"hyperpostbiotic"
Foods,
Год журнала:
2022,
Номер
11(19), С. 3094 - 3094
Опубликована: Окт. 5, 2022
Postbiotics
are
non-viable
bacterial
products
or
metabolic
byproducts
produced
by
probiotic
microorganisms
that
have
biologic
activity
in
the
host.
functional
bioactive
compounds,
generated
a
matrix
during
anaerobic
fermentation
of
organic
nutrients
like
prebiotics,
for
generation
energy
form
adenosine
triphosphate.
The
this
sequence
called
postbiotics,
these
low
molecular
weight
soluble
compounds
either
secreted
live
microflora
released
after
microbial
cell
lysis.
A
few
examples
widely
studied
postbiotics
short-chain
fatty
acids,
fragments,
extracellular
polysaccharides,
lysates,
teichoic
acid,
vitamins,
etc.
Presently,
prebiotics
and
probiotics
on
market;
however,
also
gaining
great
deal
attention.
numerous
health
advantages
postbiotic
components
may
soon
lead
to
an
increase
consumer
demand
supplements.
most
recent
research
aspects
food
pharmaceutical
industries
included
review.
review
encompasses
brief
introduction,
classification,
production
technologies,
characterization,
biological
activities,
potential
applications
postbiotics.
Journal of Agriculture and Food Research,
Год журнала:
2023,
Номер
14, С. 100708 - 100708
Опубликована: Июль 11, 2023
Postbiotics
are
bioactive
substances
that
useful
and
produced
during
fermentation
in
the
matrix.
under
a
fragile
balance
our
body,
excessive
metabolities,
may
it
be
from
any
origin
has
potential
to
hamper
or
interfere
number
of
physiological
processes
body.
As
an
innovative
approach,
can
used
improve
immune
tolerance
treat
food
allergy
particularly
infants
children.
classified
on
basis
structure
(peptides,
teichoic
acis
plasmalogens),
elemental
composition
(as
carbohydrates),
proteins
(p40,
p75
molecule,
lactocepin),
vitamins
(B-group),
lipids
(butyrates,
acetate,
lactate,
propionates),
organic
acids
(such
as
3-phenyllactic
acid
propionic)
different
complex
molecules
lipoteichoic
acids,
peptidoglycan-derived
muropeptides).
Postbiotics,
mentioned
above
have
been
shown
immunological
effects
by
increasing
mucin
levels
encouraging
production
claudin
occluding.
Moreover,
studies
highlight
postbiotics
promising
remedy
for
prevention
gastrointestinal
diseases
is
also
considered
treatment
technique
with
lesser
unfavourable
side
effects,
especially
children
infants.
However,
future
head-to-head
will
necessary
determine
best
parent
cell
strains,
postbiotic
dosages,
inexpensive
comparison
other
medications.
The
source,
origin,
extraction,
synthesis,
bioactivity
mechanism
all
included
review.
antibacterial
mechanisms
discussed
this
review,
along
their
absorption
healthy
substances,
cancer,
mental
health,
therapeutic
qualities.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
64(19), С. 6455 - 6476
Опубликована: Янв. 23, 2023
Consumption
of
commercial
probiotics
for
health
improvement
and
disease
treatment
has
increased
in
popularity
among
the
public
recent
years.
The
local
shops
pharmacies
are
brimming
with
various
probiotic
products
such
as
food,
dietary
supplement
pharmaceuticals
that
herald
a
range
benefits,
from
nutraceutical
benefits
to
pharmaceutical
effects.
However,
although
market
is
expanding
rapidly,
there
increasing
evidence
challenging
it.
Emerging
insights
microbiome
research
demonstrate
several
potential
limitations
natural
properties,
regulatory
frameworks,
consequences
probiotics.
In
this
review,
we
highlight
safety
performance
issues
properties
probiotics,
genetic
level
trait
characteristics
further
probiotic-host
interaction.
Besides,
diverse
frameworks
confusing
guidelines
worldwide
have
led
product
pathogenic
contamination,
overstated
claims,
inaccurate
labeling
counterfeit
trademarks
products.
Here,
propose
plethora
available
methods
strategies
related
strain
selection
modification,
efficacy
assessment,
some
recommendations
agencies
address
these
guarantee
sustainability
progress
industry
improve
long-term
development.
The
advent
of
highthroughput
‘omics’
technologies
has
improved
our
knowledge
gut
microbiome
in
human
health
and
disease,
including
Alzheimer’s
disease
(AD),
a
neurodegenerative
disorder.
Frequent
bidirectional
communications
mutual
regulation
exist
between
the
gastrointestinal
tract
central
nervous
system
through
gut-brain
axis.
A
large
body
research
reported
close
association
microbiota
AD
development,
restoring
healthy
may
curb
or
even
improve
symptoms
progression.
Thus,
modulation
become
novel
paradigm
for
clinical
management
AD,
emerging
effort
focused
on
developing
potential
strategies
preventing
and/or
treating
disease.
In
this
review,
we
provide
an
overview
connection
causal
relationship
dysbiosis
mechanisms
driving
progression,
successes
challenges
implementing
available
microbiome-targeted
therapies
(including
probiotics,
prebiotics,
synbiotics,
postbiotics,
fecal
transplantation)
preventive
therapeutic
preclinical
intervention
studies
AD.
Finally,
discuss
future
directions
field.
Probiotics and Antimicrobial Proteins,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 3, 2024
Abstract
In
recent
years,
more
and
scientific
community,
food
producers,
industry
show
increased
interest
in
functional
foods
containing
probiotics,
which
is
a
big
challenge.
The
consumption
of
probiotics
the
context
balanced
diet
through
or
intake
pharmaceutical
preparations
has
proven
to
contribute
improvement
human
health,
even
contributing
prevention
diseases.
order
for
be
considered
suitable
consumption,
they
must
contain
minimum
concentration
viable
cells,
namely,
at
least
10
7
colony
forming
units
beneficial
microbes
per
gram.
Ensuring
viability
bacterial
cells
until
moment
overriding
priority
probiotic
manufacturers.
Probiotic
bacteria
are
subject
stress
conditions
not
only
during
manufacturing
but
also
gastrointestinal
passage,
limit
compromise
their
functionality.
This
paper
first
examines
all
stressful
faced
by
production
stages
related
present
bioreactor
fermentation
drying
processes
as
well
factors
matrix
storage.
situations
microorganisms
transit
especially
stomach
intestinal
residence
analyzed.
understand
adaptation
mechanisms
stress,
intrinsic
adaptive
identified
strains
response
acid
bile
addition,
strategies
multiple
tolerance
lactic
directions
dealing
with
accumulation
metabolites,
use
protectants,
regulation
technological
parameters
examined.
Finally,
definition
postbiotics,
inanimate
and/or
components
conferring
health
benefits,
introduced.
Postbiotics
include
cell
lysates,
enzymes,
wall
fragments
derived
from
may
represent
an
alternative
when
do
tolerate
conditions.
npj Science of Food,
Год журнала:
2022,
Номер
6(1)
Опубликована: Ноя. 15, 2022
Abstract
Probiotics
are
increasingly
used
as
adjunctive
therapy
to
manage
gastrointestinal
diseases,
such
ulcerative
colitis.
However,
probiotic
use
has
posed
some
safety
concerns.
Thus,
postbiotics
proposed
alternatives
probiotics
in
clinical
applications.
no
study
directly
compared
the
benefits
of
and
postbiotics.
This
beneficial
effect
derived
from
strain,
Bifidobacterium
adolescentis
B8589,
a
dextran
sulfate
sodium
(DSS)-induced
experimental
colitis
mouse
model.
Four
groups
mice
(
n
=
7
per
group)
were
included
this
work:
Control
(received
water
plus
saline),
DSS
without
postbiotic/probiotic),
Postbiotic
postbiotic),
Probiotic
probiotic).
Our
results
showed
that
intragastric
administration
both
postbiotic
ameliorated
colitis,
reflected
by
decreased
histology
scores
with
group
P
<
0.05).
The
fecal
microbiota
alpha
diversity
was
not
significantly
affected
DSS-,
postbiotic,
or
treatment.
treatment
stronger
effects
on
modulating
beta
diversity,
composition,
metagenomic
potential
than
Overall,
our
findings
suggested
had
similar
ability
improve
disease
phenotype
but
distinct
regulate
gut
metabolic
pathways
context
In
view
smaller
concern
its
modulatory
host
microbiota,
we
propose
be
considered
for
next-generation
biotherapeutics
managing
even
other
diseases.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
64(17), С. 5768 - 5792
Опубликована: Дек. 20, 2022
Postbiotics
are
defined
as
"preparation
of
inanimate
microorganisms
and/or
their
components
that
confers
a
health
benefit
on
the
host".
have
unique
advantages
over
probiotics,
such
stability,
safety,
and
wide
application.
Although
postbiotics
research
hotspots,
them
is
still
very
limited.
This
review
provides
comprehensive
information
scope
postbiotics,
preparation
methods
microorganisms,
application
mechanisms
in
metabolic
syndrome
(MetS).
Furthermore,
trends
food
industry
reviewed.
It
was
found
mainly
include
inactivated
microbial
lysates,
cell
components,
metabolites.
Thermal
treatments
main
to
prepare
while
non-thermal
treatments,
ionizing
radiation,
ultraviolet
light,
ultrasound,
supercritical
CO2,
show
great
potential
postbiotic
preparation.
could
ameliorate
MetS
through
multiple
pathways
including
modulation
gut
microbiota,
enhancement
intestinal
barrier,
regulation
inflammation
immunity,
hormone
homeostasis.
Additionally,
functional
supplements,
quality
improvers,
preservatives.
In
addition,
SWOT
analyses
showed
development
exists
both
opportunities
challenges.
