Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107533 - 107533
Опубликована: Ноя. 1, 2024
Язык: Английский
Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Май 31, 2024
Abstract The neuroscience community has largely accepted the notion that functional neurons can be generated from neural stem cells in adult brain, especially two brain regions: subventricular zone of lateral ventricles and subgranular dentate gyrus hippocampus. However, impaired neurogenesis been observed some neurodegenerative diseases, particularly Alzheimer’s, Parkinson’s, Huntington’s also Lewy Body dementia. Therefore, restoration neurogenic function diseases emerges as a potential therapeutic strategy to counteract, or at least delay, disease progression. Considering this, present study summarizes different neuronal niches, provides collection pro-neurogenic strategies pre-clinical clinical research, providing details about their possible modes action, guide future research practice.
Язык: Английский
Процитировано
5
Nutrients, Год журнала: 2024, Номер 16(19), С. 3380 - 3380
Опубликована: Окт. 4, 2024
Background: Tryptophan is widely present in foods such as peanuts, milk, and bananas, playing a crucial role maintaining metabolic homeostasis health disease. metabolism involved the development progression of immune, nervous, digestive system diseases. Although some excellent reviews on tryptophan exist, there has been no systematic scientometric study yet. Methods: This review provides summarizes research hotspots potential future directions by analyzing annual publications, topics, keywords, highly cited papers sourced from Web Science spanning 1964 to 2022. Results: overview disorder-triggered diseases, mechanisms, therapeutic strategies. Conclusions: The gut microbiota regulates permeability, inflammation, host immunity directly converting indole its derivatives. Gut microbial metabolites regulate activating specific receptors or enzymes. Additionally, kynurenine (KYN) pathway, activated indoleamine-2, 3-dioxygenase (IDO) 2, 3-dioxygenase, affects migration invasion glioma cells COVID-19 depression. IDO inhibitors help improve effectiveness immunotherapy. markers are used for disease therapy, guiding clinical decision-making. serve targets provide new promising strategy neuroprotective/neurotoxic imbalance affecting brain structure function. In summary, this valuable guidance basic application metabolism.
Язык: Английский
Процитировано
5
Nutrition Reviews, Год журнала: 2024, Номер unknown
Опубликована: Июнь 25, 2024
Abstract The elderly population is increasing worldwide every day. Age a significant factor in the progression of neurological diseases, which can also cause cognitive decline and memory disorders. Inflammation oxidative stress are primary drivers senescence disorders, particularly those associated with aging neurodegenerative diseases. Bioactive phytochemicals considered promising therapeutic strategy combating age-related pathological conditions. One diverse biological properties encompassing antioxidant, anti-inflammatory, antibacterial, antiviral, anticancer, antifungal, antidepressant, anti-allergic, anti-aging curcumin. Curcumin, polyphenolic structure distinct orange hue unique chemical properties, derived from roots Curcuma longa, member Zingiberaceae family, commonly known as turmeric. It has been noted that incidence diseases low societies consume curcumin widely. Therefore, this review investigates effect on Alzheimer Parkinson disease, most prevalent
Язык: Английский
Процитировано
4
Nutritional Neuroscience, Год журнала: 2025, Номер unknown, С. 1 - 14
Опубликована: Янв. 29, 2025
Oxidative stress is recognized as a critical contributor to the advancement of neurological diseases, thereby rendering alleviation oxidative pivotal strategy in therapeutic management such conditions. Sesamol, principal constituent sesame oil, has been subject extensive research due its significant antioxidant properties, especially ability effectively counteract within central nervous system and confer neuroprotection. While sesamol demonstrates potential treatment prevention modulation complex not yet fully understood. This review delves into neuroprotective effects arising from sesamol's analyzing how antioxidative capabilities impact diseases. It provides theoretical foundation unveils novel applications disorders through stress.
Язык: Английский
Процитировано
0
European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177646 - 177646
Опубликована: Апрель 1, 2025
Neurogenesis is a complex process by which the neurons and supporting cells of central nervous system (CNS) are generated neural stem cells. Adult hippocampal neurogenesis (AHN) in human brain an active during life plays critical role regulation memory, cognition, mood. It has been shown that epilepsy linked with dysregulation AHN. Of note, AHN very sensitive to pathological electrical stimuli epileptic seizures, result induction acute inhibition chronic epilepsy. Epileptic seizure-induced neurodegeneration activates mobilization substitute for loss temporal lobe (TLE), most refractory type Moreover, recurrent seizures TLE trigger certain regions. However, transient seizure terminated 1-4 weeks following status epilepticus (SE). Nevertheless, adult dramatically reduced associated development cognitive impairment TLE. These findings indicate severity seizures. Hence, activators may attenuate pathogenesis Therefore, this review aims discuss explain beneficial how could be effective management
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2023, Номер 9(7), С. e17874 - e17874
Опубликована: Июль 1, 2023
Oxidative stress is essential in brain injury after intracerebral hemorrhage (ICH). Ferroptosis, iron-dependent oxidative cell death, overwhelms the antioxidant system. Recently, Olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) hold great potential for treating ferroptosis-mediated damage ICH. However, massive grafted possibly caused by a hostile host microenvironment, lessens effectiveness of OM-MSCs. Therefore, it necessary to develop strategies upregulate therapeutic efficacy OM-MSCs Curcumin, well-established traditional herbal substance, has potent property. In present study, curcumin preconditioning might enhance anti-oxidative activity OM-MSCs, thereby augmenting vitro model ICH, we demonstrated that curcumin-preconditioned co-culture more effective attenuating injury, stress, and ferroptosis neuronal compared native treatment. vivo transplantation also showed better neuroprotective effects. Moreover, pretreatment promoted survival under conditioned medium from hemin-insulted neurons improving capacities Collectively, our investigation suggested effectively enhanced effects ICH upregulating Curcumin-preconditioned be taken as novel strategy
Язык: Английский
Процитировано
7
Frontiers in Endocrinology, Год журнала: 2023, Номер 14
Опубликована: Июль 19, 2023
Introduction This study aimed to systematically review research on cinacalcet and secondary hyperparathyroidism (SHPT) using machine learning-based statistical analyses. Methods Publications indexed in the Web of Science Core Collection database Cinacalcet SHPT published between 2000 2022 were retrieved. The R package “Bibliometrix,” VOSviewer, CiteSpace, meta, latent Dirichlet allocation (LDA) Python used generate bibliometric meta-analytical results. Results A total 959 articles included our analysis. In total, 3753 scholars from 54 countries contributed this field research. United States, Japan, China found be among three most productive worldwide. Three Japanese institutions (Showa University, Tokai Kobe University) SHPT. Fukagawa, M.; Chertow, G.M.; Goodman W.G. authors who field. Most Nephrology Dialysis Transplantation , Kidney International Therapeutic Apheresis . Research has mainly topics: 1) comparative effects various treatments, 2) safety efficacy cinacalcet, 3) fibroblast growth factor-23 (FGF-23). Integrated use pediatric chronic kidney disease, new therapeutic targets are emerging hotspots. Through a meta-analysis, we confirmed reducing serum PTH ( SMD = -0.56, 95% CI -0.76 -0.37, p 0.001) calcium -0.93, -1.21to -0.64, improving phosphate 0.17, -0.33 -0.01, 0.033) calcium-phosphate product levels -0.49, -0.71 -0.28, 0.001); no difference all-cause mortality RR 0.97, 0.90 1.05, 0.47), cardiovascular 0.69, 0.36 1.31, 0.25), parathyroidectomy 0.36, 0.09 1.35, 0.13) non-Cinacalcet users. Moreover, was associated with an increased risk nausea 2.29, 1.73 3.05, 0.001), hypocalcemia 4.05, 2.33 7.04, vomiting 1.90, 1.70 2.11, 0.001). Discussion number publications rapidly over past 22 years. Literature distribution, topics, trends analyzed review. findings meta-analysis provide valuable insights into for treatment SHPT, which will interest both clinical researchers.
Язык: Английский
Процитировано
7
Neurochemical Research, Год журнала: 2024, Номер unknown
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
2
Biomedicines, Год журнала: 2022, Номер 10(12), С. 3180 - 3180
Опубликована: Дек. 8, 2022
The rhizomatous plant turmeric, which is frequently used as a spice and coloring ingredient, yields curcumin, bioactive compound. Curcumin inhibits platelet activation aggregation improves count. Platelets dysfunction results in several disorders, including inflammation, atherothrombosis, thromboembolism. Several studies have proved the beneficial role of curcumin on platelets hence it an important candidate for treatment aforementioned diseases. Moreover, also employed anti-inflammatory agent conventional medicine. In arthritic patients, has been shown to reduce generation pro-inflammatory eicosanoids edema, morning stiffness, other symptoms. taken orally reduced rats’ acute inflammation brought by carrageenan. proven prevent atherosclerosis aggregation, well angiogenesis adipose tissue. cerebral microcirculation, significantly lowered leukocyte adhesion. It largely modulated endothelium Additionally, P-selectin expression mice survival after cecal ligation puncture were improved altered adhesion blood–brain barrier dysfunction. Through regulating many processes involved curcuminoids collectively demonstrated detectable antiplatelet activity. Curcuminoids may therefore be able disorders linked possible therapeutic agents. This review article proposes highlight discuss regulatory effects platelets.
Язык: Английский
Процитировано
11
Clinical Nutrition ESPEN, Год журнала: 2024, Номер 62, С. 253 - 259
Опубликована: Июнь 3, 2024
Язык: Английский
Процитировано
2