Breast Cancer: Extracellular Matrix and Microbiome Interactions

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7226 - 7226

Опубликована: Июнь 30, 2024

Breast cancer represents the most prevalent form of and leading cause cancer-related mortality among females worldwide. It has been reported that several risk factors contribute to appearance progression this disease. Despite advancements in breast treatment, a significant portion patients with distant metastases still experiences no cure. The extracellular matrix potential target for enhanced serum biomarkers cancer. Furthermore, degradation epithelial–mesenchymal transition constitute primary stages local invasion during tumorigenesis. Additionally, microbiome influence on diverse physiological processes. is emerging microbial dysbiosis element development various cancers, including Thus, better understanding interactions could provide novel alternatives treatment management. In review, we summarize current evidence regarding intricate relationship between microbiome. We discuss arising associations future perspectives field.

Язык: Английский

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Unraveling the Role of Fusobacterium nucleatum in Colorectal Cancer: Molecular Mechanisms and Pathogenic Insights

Cancers, Год журнала: 2025, Номер 17(3), С. 368 - 368

Опубликована: Янв. 23, 2025

Fusobacterium nucleatum, a gram-negative anaerobic bacterium, has emerged as significant player in colorectal cancer (CRC) pathogenesis. The bacterium causes persistent inflammatory reaction the mucosa by stimulating release of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α, creating an environment conducive to progression. F. nucleatum binds penetrates epithelial cells through adhesins such FadA, impairing cell junctions encouraging epithelial-to-mesenchymal transition (EMT), which is associated with advancement. Additionally, modulates host immune system, suppressing activity conditions favorable for tumor growth. Its interactions gut microbiome contribute dysbiosis, further influencing carcinogenic pathways. Evidence indicates that can inflict DNA damage either directly via reactive oxygen species or indirectly environment. it triggers oncogenic pathways, especially Wnt/β-catenin signaling pathway, promotes growth longevity. Moreover, alters microenvironment, impacting behavior, metastasis, therapeutic responses. purpose this review elucidate molecular mechanisms contributes CRC. Understanding these crucial development targeted therapies diagnostic strategies CRC nucleatum.

Язык: Английский

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Carcinogenetic mechanisms employed by the oral microbiome: a narrative review

The American Journal of the Medical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Unraveling the gut microbiome’s contribution to pancreatic ductal adenocarcinoma: mechanistic insights and therapeutic perspectives

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 9, 2024

The gut microbiome plays a significant role in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), influencing oncogenesis, immune responses, and treatment outcomes. Studies have identified microbial species like Porphyromonas gingivalis Fusobacterium nucleatum, that promote PDAC progression through various mechanisms. Additionally, affects cell activation response to immunotherapy, including checkpoint inhibitors CAR-T therapy. Specific microbes their metabolites play effectiveness (ICIs). Alterations can either enhance or diminish responses PD-1/PD-L1 CTLA-4 blockade bacterial trimethylamine N-oxide (TMAO) lipopolysaccharide (LPS) impact antitumor immunity, offering potential targets augment immunotherapy responses. Modulating fecal microbiota transplantation, probiotics, prebiotics, dietary changes, antibiotics shows promise treatment, although outcomes are highly variable. Dietary modifications, particularly high-fiber diets specific fat consumption, influence composition cancer risk. Combining microbiome-based therapies with existing treatments holds for improving therapy outcomes, but further research is needed optimize effectiveness.

Язык: Английский

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The Impact of Oral Microbiome Dysbiosis on the Aetiology, Pathogenesis, and Development of Oral Cancer

Cancers, Год журнала: 2024, Номер 16(17), С. 2997 - 2997

Опубликована: Авг. 28, 2024

Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although oral cavity an easily accessible area for visual examination, OSCC more often detected at advanced stage. The global prevalence of around 6%, with increasing trends posing a significant health problem due to increase in morbidity mortality. microbiome has been target numerous studies, findings highlighting role dysbiosis developing OSCC. Dysbiosis can significantly pathobionts (bacteria, viruses, fungi, parasites) that trigger inflammation through their virulence pathogenicity factors. In contrast, chronic bacterial contributes development Pathobionts also have other effects, such as impact on immune system, which alter responses contribute pro-inflammatory environment. Poor hygiene carbohydrate-rich foods risk factors mechanisms are not yet fully understood remain frequent research topic. For this reason, narrative review concentrates issue potential cause OSCC, well underlying involved.

Язык: Английский

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Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 15, 2024

Fusobacterium nucleatum (Fn) has been extensively studied for its connection to colorectal cancer (CRC) and potential role in chemotherapy resistance. Studies indicate that Fn is commonly found CRC tissues associated with unfavorable prognosis treatment failure. It shown promotes chemoresistance by affecting autophagy, a cellular process helps cells survive under stressful conditions. Additionally, targets specific signaling pathways activate particular microRNAs modulate the response chemotherapy. Understanding current molecular mechanisms investigating importance of Fn-inducing could provide valuable insights developing novel therapies. This review surveys tumor proliferation, metastasis, CRC, focusing on effects microenvironment, gene expression, resistance conventional drugs. also discusses therapeutic implications targeting highlights need further research.

Язык: Английский

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Nutrition Intervention and Microbiome Modulation in the Management of Breast Cancer

Nutrients, Год журнала: 2024, Номер 16(16), С. 2644 - 2644

Опубликована: Авг. 10, 2024

Breast cancer (BC) is one of the most common cancers worldwide and a leading cause cancer-related deaths among women. The escalating incidence BC underscores necessity multi-level treatment. complex heterogeneous disease involving many genetic, lifestyle, environmental factors. Growing evidence suggests that nutrition intervention an evolving effective prevention treatment strategy for BC. In addition, human microbiota, particularly gut now widely recognized as significant player contributing to health or status. It also associated with risk development This review will focus on in BC, including dietary patterns, bioactive compounds, nutrients affect therapeutic responses both animal studies. Additionally, this paper examines impacts these interventions modulating composition functionality microbiome, highlighting microbiome-mediated mechanisms combination factors microbes discussed. Insights from emphasize comprehensive management focuses nutrition–microbiome axis.

Язык: Английский

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Elucidating the Intricate Roles of Gut and Breast Microbiomes in Breast Cancer Metastasis to the Bone

Cancer Reports, Год журнала: 2024, Номер 7(8)

Опубликована: Авг. 1, 2024

ABSTRACT Background Breast cancer is the most predominant and heterogeneous in women. Moreover, breast has a high prevalence to metastasize distant organs, such as brain, lungs, bones. Patients with metastasis bones have poor overall relapse‐free survival. treatment using chemotherapy immunotherapy ineffective preventing or reducing metastasis. Recent Findings Microorganisms residing gut breast, termed resident microbiome, significant influence on formation progression of cancer. studies identified some microorganisms that induce bone. These organisms utilize multiple mechanisms, including induction epithelial–mesenchymal transition, steroid hormone metabolism, immune modification, bone remodeling, secretion microbial products alter tumor microenvironment, enhance propensity cells metastasize. However, their involvement makes these suitable novel therapeutic targets. Thus, are underway prevent reduce bone, chemotherapeutic immunotherapeutic drugs, along probiotics, antibiotics fecal microbiota transplantation. Conclusions The present review describes association microbiomes metastases. We elaborated mechanisms utilized by metastasis, especially also highlights current options may target both for Finally, we specified necessity maintaining diverse microbiome dysbiosis, which otherwise carcinogenesis facilitate more detailed investigations causal associations between potential described promote discussions research modes improve survival patients targeting microbiomes.

Язык: Английский

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Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer

Biomolecules, Год журнала: 2024, Номер 14(8), С. 917 - 917

Опубликована: Июль 27, 2024

Gastrointestinal (GI) cancers impose a substantial global health burden, highlighting the necessity for deeper understanding of their intricate pathogenesis and treatment strategies. This review explores interplay between intratumoral microbiota, tumor metabolism, major types GI (including esophageal, gastric, liver, pancreatic, colorectal cancers), summarizing recent studies elucidating clinical implications future directions. Recent research revealed altered microbial signatures within tumors, impacting progression, immune responses, outcomes. Dysbiosis-induced alterations in including glycolysis, fatty acid amino play critical roles cancer progression therapeutic resistance. The integration molecular mechanisms potential biomarkers into this further enhances prognostic significance microbiota composition opportunities targeting microbiota-mediated metabolism. Despite advancements, challenges remain dynamic interactions microenvironment (TME). Future directions, advanced omics technologies prospective studies, offer promising avenues precision oncology personalized interventions cancer. Overall, integrating microbiota-based approaches management holds promise improving patient outcomes survival.

Язык: Английский

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Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk

Annals of Clinical Microbiology and Antimicrobials, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 29, 2025

Highly frequent colorectal cancer (CRC) is predicted to have 3.2 million novel cases by 2040. Tumor microenvironment (TME) bacteriome and metabolites are proposed be involved in CRC development. In this regard, we aimed investigate the of healthy, adenomatous polyp, tissues. Sixty samples including healthy (H), polyps (AP), polyps-adjacent (APA), tumor (CT), tumor-adjacent (CA) tissues were collected analyzed 16 S rRNA sequencing 1H NMR spectroscopy. Our results revealed that H, AP, CT groups significantly different. We observed Lachnospiraceae family depleted concomitant with acetoacetate beta-hydroxybutyric acid (BHB) accumulations AP addition, some bacterial species Gemella morbillorum, Morganella morganii enriched compared H group. Furthermore, fumarate was accumulated Aeromonas enteropelogenes, veronii, Fusobacterium nucleatum subsp. animalis increased abundance These beneficial bacteria depletion cross-talk BHB followed an driver G. M. may reprogram polyp leading initiation. Consequently, passenger accumulation like A. A.veronii, F. cross-talking TME aggravate So, knowledge might help prevention, early diagnosis, a good prognosis.

Язык: Английский

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