Oral Oncology Reports, Journal Year: 2024, Volume and Issue: 10, P. 100498 - 100498
Published: May 7, 2024
• Oral microbiome shapes tumor environment, impacting cancer progression. Dysbiotic microbes induce chronic inflammation in oral cancer. Pathogens interact with immune cells, promoting evasion. Commensal bacteria may enhance antitumor immunity Understanding microbiome-TME interplay crucial for therapy.
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7226 - 7226
Published: June 30, 2024
Breast cancer represents the most prevalent form of and leading cause cancer-related mortality among females worldwide. It has been reported that several risk factors contribute to appearance progression this disease. Despite advancements in breast treatment, a significant portion patients with distant metastases still experiences no cure. The extracellular matrix potential target for enhanced serum biomarkers cancer. Furthermore, degradation epithelial–mesenchymal transition constitute primary stages local invasion during tumorigenesis. Additionally, microbiome influence on diverse physiological processes. is emerging microbial dysbiosis element development various cancers, including Thus, better understanding interactions could provide novel alternatives treatment management. In review, we summarize current evidence regarding intricate relationship between microbiome. We discuss arising associations future perspectives field.
Language: Английский
Citations
10
Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 368 - 368
Published: Jan. 23, 2025
Fusobacterium nucleatum, a gram-negative anaerobic bacterium, has emerged as significant player in colorectal cancer (CRC) pathogenesis. The bacterium causes persistent inflammatory reaction the mucosa by stimulating release of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α, creating an environment conducive to progression. F. nucleatum binds penetrates epithelial cells through adhesins such FadA, impairing cell junctions encouraging epithelial-to-mesenchymal transition (EMT), which is associated with advancement. Additionally, modulates host immune system, suppressing activity conditions favorable for tumor growth. Its interactions gut microbiome contribute dysbiosis, further influencing carcinogenic pathways. Evidence indicates that can inflict DNA damage either directly via reactive oxygen species or indirectly environment. it triggers oncogenic pathways, especially Wnt/β-catenin signaling pathway, promotes growth longevity. Moreover, alters microenvironment, impacting behavior, metastasis, therapeutic responses. purpose this review elucidate molecular mechanisms contributes CRC. Understanding these crucial development targeted therapies diagnostic strategies CRC nucleatum.
Language: Английский
Citations
2
The American Journal of the Medical Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 9, 2024
The gut microbiome plays a significant role in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), influencing oncogenesis, immune responses, and treatment outcomes. Studies have identified microbial species like Porphyromonas gingivalis Fusobacterium nucleatum, that promote PDAC progression through various mechanisms. Additionally, affects cell activation response to immunotherapy, including checkpoint inhibitors CAR-T therapy. Specific microbes their metabolites play effectiveness (ICIs). Alterations can either enhance or diminish responses PD-1/PD-L1 CTLA-4 blockade bacterial trimethylamine N-oxide (TMAO) lipopolysaccharide (LPS) impact antitumor immunity, offering potential targets augment immunotherapy responses. Modulating fecal microbiota transplantation, probiotics, prebiotics, dietary changes, antibiotics shows promise treatment, although outcomes are highly variable. Dietary modifications, particularly high-fiber diets specific fat consumption, influence composition cancer risk. Combining microbiome-based therapies with existing treatments holds for improving therapy outcomes, but further research is needed optimize effectiveness.
Language: Английский
Citations
7
Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2997 - 2997
Published: Aug. 28, 2024
Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although oral cavity an easily accessible area for visual examination, OSCC more often detected at advanced stage. The global prevalence of around 6%, with increasing trends posing a significant health problem due to increase in morbidity mortality. microbiome has been target numerous studies, findings highlighting role dysbiosis developing OSCC. Dysbiosis can significantly pathobionts (bacteria, viruses, fungi, parasites) that trigger inflammation through their virulence pathogenicity factors. In contrast, chronic bacterial contributes development Pathobionts also have other effects, such as impact on immune system, which alter responses contribute pro-inflammatory environment. Poor hygiene carbohydrate-rich foods risk factors mechanisms are not yet fully understood remain frequent research topic. For this reason, narrative review concentrates issue potential cause OSCC, well underlying involved.
Language: Английский
Citations
6
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 15, 2024
Fusobacterium nucleatum (Fn) has been extensively studied for its connection to colorectal cancer (CRC) and potential role in chemotherapy resistance. Studies indicate that Fn is commonly found CRC tissues associated with unfavorable prognosis treatment failure. It shown promotes chemoresistance by affecting autophagy, a cellular process helps cells survive under stressful conditions. Additionally, targets specific signaling pathways activate particular microRNAs modulate the response chemotherapy. Understanding current molecular mechanisms investigating importance of Fn-inducing could provide valuable insights developing novel therapies. This review surveys tumor proliferation, metastasis, CRC, focusing on effects microenvironment, gene expression, resistance conventional drugs. also discusses therapeutic implications targeting highlights need further research.
Language: Английский
Citations
5
Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2644 - 2644
Published: Aug. 10, 2024
Breast cancer (BC) is one of the most common cancers worldwide and a leading cause cancer-related deaths among women. The escalating incidence BC underscores necessity multi-level treatment. complex heterogeneous disease involving many genetic, lifestyle, environmental factors. Growing evidence suggests that nutrition intervention an evolving effective prevention treatment strategy for BC. In addition, human microbiota, particularly gut now widely recognized as significant player contributing to health or status. It also associated with risk development This review will focus on in BC, including dietary patterns, bioactive compounds, nutrients affect therapeutic responses both animal studies. Additionally, this paper examines impacts these interventions modulating composition functionality microbiome, highlighting microbiome-mediated mechanisms combination factors microbes discussed. Insights from emphasize comprehensive management focuses nutrition–microbiome axis.
Language: Английский
Citations
4
Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 29, 2025
Highly frequent colorectal cancer (CRC) is predicted to have 3.2 million novel cases by 2040. Tumor microenvironment (TME) bacteriome and metabolites are proposed be involved in CRC development. In this regard, we aimed investigate the of healthy, adenomatous polyp, tissues. Sixty samples including healthy (H), polyps (AP), polyps-adjacent (APA), tumor (CT), tumor-adjacent (CA) tissues were collected analyzed 16 S rRNA sequencing 1H NMR spectroscopy. Our results revealed that H, AP, CT groups significantly different. We observed Lachnospiraceae family depleted concomitant with acetoacetate beta-hydroxybutyric acid (BHB) accumulations AP addition, some bacterial species Gemella morbillorum, Morganella morganii enriched compared H group. Furthermore, fumarate was accumulated Aeromonas enteropelogenes, veronii, Fusobacterium nucleatum subsp. animalis increased abundance These beneficial bacteria depletion cross-talk BHB followed an driver G. M. may reprogram polyp leading initiation. Consequently, passenger accumulation like A. A.veronii, F. cross-talking TME aggravate So, knowledge might help prevention, early diagnosis, a good prognosis.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 3, 2025
Fusobacterium nucleatum is strongly linked to colorectal cancer (CRC) progression, but its mechanisms for influencing macrophage polarization and tumor development are not well understood. We established an in vitro model of F. infection RAW264.7 macrophages investigate these processes. Macrophage was evaluated using scanning electron microscopy (SEM), real-time quantitative PCR (RT-qPCR), immunofluorescence staining. RNA sequencing (RNA-Seq) identified differentially expressed genes (DEGs) enriched pathways, focusing on the role NF-κB signaling pathway polarization. induced M2 macrophages, as confirmed by SEM analysis RT-qPCR validation. A total 2,029 DEGs were after infection, with 763 upregulated 1,266 downregulated. GO KEGG enrichment showed that cytokine-cytokine receptor interaction, TNF signaling, pathways indicating enhanced cytokine activity immune response. Key (Nfkb1, Nfkb2, Malt, Lta, Ltb, Tnf) proteins (P50, P100) upregulated, crucial This study offers evidence regarding modulating nucleatum-induced polarization, underscoring significance progression cancer.
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: May 8, 2025
Periodontitis (PD) is the most common oral infectious disease. The primary etiologic cause of onset and development PD dental plaque, which consists bacterial biofilm domiciled within a complex extracellular mass. In patients, there progressive breakdown periodontal ligament alveolar bone. more advanced stages, tooth loss occurs. progression this chronic inflammatory disease involves interactions among numerous microbial pathogens particularly, bacteria, host's immune factors, various environmental factors. Due to persistent infection by periodonto-pathogenic an impairment both innate acquired immunity, leading tissue destruction. Chronic inflammation in may be associated with several systemic diseases, including cardiovascular conditions, respiratory issues, diabetes, neurological cancer, adverse pregnancy outcomes. Antibiotic treatment one effective strategies for treating cases, although emergence some resistant strains limit effectiveness antibiotics. review study, we discussed main bacteria PD, interaction response, pathogenesis antibiotic treatment. We also outlined resistance antibiotics these pathogens.
Language: Английский
Citations
0