Melatonin and Its Role in the Epithelial-to-Mesenchymal Transition (EMT) in Cancer
Cancers,
Год журнала:
2024,
Номер
16(5), С. 956 - 956
Опубликована: Фев. 27, 2024
The
epithelial-to-mesenchymal
transition
(EMT)
is
a
cell-biological
program
that
occurs
during
the
progression
of
several
physiological
processes
and
can
also
take
place
pathological
situations
such
as
carcinogenesis.
EMT
consists
sequential
activation
number
intracellular
signaling
pathways
aimed
at
driving
epithelial
cells
toward
acquisition
series
intermediate
phenotypic
states
arrayed
along
epithelial–mesenchymal
axis.
These
features
include
changes
in
motility,
conformation,
polarity
functionality
cancer
cells,
ultimately
leading
to
stemness,
increased
invasiveness,
chemo-
radioresistance
formation
metastasis.
Amongst
different
existing
types
EMT,
type
3
directly
involved
A
neoplastic
have
previously
acquired
genetic
epigenetic
alterations,
specifically
affecting
genes
promoting
clonal
outgrowth
invasion.
Markers
E-cadherin;
N-cadherin;
vimentin;
transcription
factors
(TFs)
like
Twist,
Snail
ZEB
are
considered
key
molecules
transition.
process
regulated
by
microRNA
expression.
Many
miRNAs
been
reported
repress
EMT-TFs.
Thus,
1
repressed
miR-29,
miR-30a
miR-34a;
miR-200b
downregulates
Slug;
ZEB1
ZEB2
miR-200
miR-205,
respectively.
Occasionally,
some
target
act
downstream
master
TFs;
thus,
Twist1
upregulates
levels
miR-10b.
Melatonin
an
endogenously
produced
hormone
released
mainly
pineal
gland.
It
widely
accepted
melatonin
exerts
oncostatic
actions
large
variety
tumors,
inhibiting
initiation,
invasion
phases
tumorigenesis.
molecular
mechanisms
underlying
these
inhibitory
complex
involve
great
processes.
In
this
review,
we
will
focus
our
attention
on
ability
regulate
EMT-related
markers,
micro-RNAs,
summarizing
multiple
ways
which
EMT.
Since
has
no
known
toxic
side
effects
help
overcome
drug
resistance,
it
good
candidate
be
adjuvant
conventional
therapies.
Язык: Английский
Forces at play: exploring factors affecting the cancer metastasis
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 1, 2024
Metastatic
disease,
a
leading
and
lethal
indication
of
deaths
associated
with
tumors,
results
from
the
dissemination
metastatic
tumor
cells
site
primary
origin
to
distant
organ.
Dispersion
during
development
tumors
at
organs
leads
failure
comply
conventional
treatments,
ultimately
instigating
abrupt
tissue
homeostasis
organ
failure.
Increasing
evidence
indicates
that
microenvironment
(TME)
is
crucial
factor
in
cancer
progression
process
secondary
sites.
TME
comprises
several
factors
contributing
initiation
cascade.
Among
these,
various
cell
types
TME,
such
as
mesenchymal
stem
(MSCs),
lymphatic
endothelial
(LECs),
cancer-associated
fibroblasts
(CAFs),
myeloid-derived
suppressor
(MDSCs),
T
cells,
tumor-associated
macrophages
(TAMs),
are
significant
players
participating
metastasis.
Besides,
other
factors,
extracellular
matrix
(ECM),
gut
microbiota,
circadian
rhythm,
hypoxia,
also
shape
impact
A
thorough
understanding
functions
components
metastasis
necessary
discover
new
therapeutic
strategies
targeting
TME.
Therefore,
we
reviewed
these
pivotal
highlighted
background
knowledge
on
how
disrupted
influence
cascade
establish
premetastatic
niche.
This
review
will
help
researchers
identify
altered
components’
molecular
patterns
design
an
optimized,
targeted
therapy
treat
solid
restrict
Язык: Английский
Therapeutic Effects of Melatonin in the Regulation of Ferroptosis: A Review of Current Evidence
Current Drug Targets,
Год журнала:
2024,
Номер
25(8), С. 543 - 557
Опубликована: Май 6, 2024
Ferroptosis
is
implicated
in
the
pathogenesis
of
multiple
diseases,
including
neurodegenerative
cardiovascular
kidney
pathologies,
ischemia-reperfusion
injury,
and
cancer.
The
current
review
article
highlights
involvement
ferroptosis
traumatic
brain
acute
damage,
ethanol-induced
liver
PM2.5-induced
lung
injury.
Melatonin,
a
molecule
produced
by
pineal
gland
many
other
organs,
well
known
for
its
anti-
aging,
anti-inflammatory,
anticancer
properties
used
treatment
different
diseases.
Melatonin's
ability
to
activate
anti-ferroptosis
pathways
sirtuin
(SIRT)6/p-
nuclear
factor
erythroid
2-related
2
(Nrf2),
Nrf2/
antioxidant
responsive
element
(ARE)/
heme
oxygenase
(HO-1)/SLC7A11/glutathione
peroxidase
(GPX4)/
prostaglandin-endoperoxide
synthase
(PTGS2),
extracellular
signal-regulated
kinase
(ERK)/Nrf2,
ferroportin
(FPN),
Hippo/
Yes-associated
protein
(YAP),
Phosphoinositide
3-kinase
(PI3K)/
B
(AKT)/
mammalian
target
rapamycin
(mTOR)
SIRT6/
receptor
coactivator
4
(NCOA4)/
ferritin
heavy
chain
1
(FTH1)
signaling
suggests
that
it
could
serve
as
valuable
therapeutic
agent
preventing
cell
death
associated
with
various
Further
research
needed
fully
understand
precise
mechanisms
which
melatonin
regulates
potential
target.
Язык: Английский
Melatonin as a natural anti-inflammatory and anti-oxidant therapy in the testis: a focus on infertility and aging
Biology of Reproduction,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 12, 2024
Abstract
Melatonin
is
a
pineal
hormone
that
regulates
testicular
activity
(i.e.,
steroidogenesis
and
spermatogenesis)
through
two
complementary
mechanisms,
indirect
effects
exerted
via
the
hypothalamic–adenohypophyseal
axis
direct
actions
take
place
on
different
cell
populations
of
male
gonad.
The
increased
age
testis
general
mechanisms
involved
in
pathology
leading
to
infertility
are
still
only
poorly
understood.
However,
there
growing
evidence
link
aging
idiopathic
local
inflammatory
oxidative
stress
events.
Because
literature
data
strongly
indicate
melatonin
exhibits
anti-inflammatory
anti-oxidant
properties,
this
review
focuses
potential
benefits
by
indoleamine
at
level
reproductive
fertility
aging.
Taking
into
account
supplementation
function
currently
being
investigated,
overview
covers
not
promising
prospects
but
also
many
questions
concerning
future
therapeutic
value
as
an
anti-aging
drug
well
management
cases
for
which
no
medical
treatments
available.
Язык: Английский
Melatonin attenuates inflammatory bone loss by alleviating mitophagy and lactate production
APOPTOSIS,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Язык: Английский
The interactions between melatonin and the renin–angiotensin system (RAS) in vascular attenuation in diabetic and non-diabetic conditions
Acta Diabetologica,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Язык: Английский
UBC4: A Repurposed Drug Regimen for Adjunctive Use During Bladder Cancer Treatment
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 706 - 706
Опубликована: Март 13, 2025
After
it
has
metastasized,
bladder
cancer,
the
malignant
transformation
of
urothelium,
continues
to
be
a
common
cause
death
after
maximal
use
all
currently
available
standard
treatments.
To
address
this
problem
in
2025,
drug
repurposing
movement
within
oncology
aims
identify
medicines
general
medical
care
that
have
data
indicating
they
can
interfere
or
inhibit
growth
driving
element
been
identified
cancer.
This
paper
now
outlines
extensive
preclinical
showing
four
drugs
from
practice
meet
these
criteria—the
melatonergic
ramelteon,
antidepressant
fluoxetine,
antibiotic
dapsone,
and
analgesic
celecoxib.
is
UBC4
regimen,
meant
as
possible
adjunct
added
treatments
metastatic
Three
factors
justify
clinical
pilot
trial
UBC4:
(1)
are
usually
well
tolerated
carry
low
risk
harm,
(2)
commonly
fatal
outcome
cancer
once
widely
plus
(3)
strong
database
UBC
inhibition
by
each
individual
outlined
paper.
Язык: Английский
Melatonin and cisplatin co-treatment against cancer: A mechanistic review of their synergistic effects and melatonin’s protective actions
Pathology - Research and Practice,
Год журнала:
2023,
Номер
253, С. 155031 - 155031
Опубликована: Дек. 12, 2023
Язык: Английский
Unraveling the impact of melatonin treatment: Oxidative stress, metabolic responses, and morphological changes in HuH7.5 hepatocellular carcinoma cells
Pathology - Research and Practice,
Год журнала:
2023,
Номер
253, С. 155056 - 155056
Опубликована: Дек. 21, 2023
Язык: Английский
Melatonin mitigates vincristine-induced peripheral neuropathy by inhibiting TNF-α/astrocytes/microglial cells activation in the spinal cord of rats, while preserving vincristine's chemotherapeutic efficacy in lymphoma cells
Toxicology and Applied Pharmacology,
Год журнала:
2024,
Номер
492, С. 117134 - 117134
Опубликована: Окт. 25, 2024
Язык: Английский