Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

ACS Chemical Neuroscience, Год журнала: 2023, Номер 15(1), С. 1 - 30

Опубликована: Дек. 14, 2023

Aging is a dynamic, time-dependent process that characterized by gradual accumulation of cell damage. Continual functional decline in the intrinsic ability living organisms to accurately regulate homeostasis leads increased susceptibility and vulnerability diseases. Many efforts have been put forth understand prevent effects aging. Thus, major cellular molecular hallmarks aging identified, their relationships age-related diseases malfunctions explored. Here, we use data from CAS Content Collection analyze publication landscape recent aging-related research. We review advances knowledge delineate trends research advancements on factors attributes across time geography. also current concepts related molecular, cellular, organismic level, age-associated diseases, with attention brain health, as well biochemical processes associated Major outlined, correlations features are hope this will be helpful for apprehending field mechanisms progression, an effort further solve remaining challenges fulfill its potential.

Язык: Английский

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Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 18, 2025

Язык: Английский

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Bridging gap in the treatment of Alzheimer’s disease via postbiotics: Current practices and future prospects

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102689 - 102689

Опубликована: Фев. 1, 2025

Язык: Английский

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Inflamm-ageing: how cytokines and nutrition shape the trajectory of ageing

Cytokine & Growth Factor Reviews, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Population ageing is increasing in prevalence most developed countries. Ageing the decline of functional properties at cellular, tissue, and organ level. Biochemical changes that occur all organisms experience biological are referred to as "Hallmarks ageing". Inflammation a common denominator hallmarks ageing, being mechanistically involved age-related health consequences. Inflamm-ageing refers inflammatory immune systems which somehow drive process towards healthy or unhealthy ageing. Current evidences, support that, reversing pro-inflammatory status inflamm-ageing, able modulate associated with increased levels molecules (e.g. cytokines, chemokines), ultimately producing chronic low-grade state typically observed older individuals. It commonly accepted balance between pro- anti-inflammatory cytokines/chemokines one factors determining whether occurs. Malnutrition nutritional imbalances, highly prevalent elderly, playing role driving immunoactive molecules. In particular, malnutrition major risk factor for sarcopenia, phenomenon characterized by loss muscle mass, often basis frailty. Given close relationship there also evidence link Indeed, cytokine/chemokine elderly patients were demonstrated. The demonstration specific cytokines play modulating appetite nutrient sensing taste reception, provided further existence nutrition shaping trajectory present review will overview current supporting circulating chemokines inflammation, malnutrition.

Язык: Английский

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Does Lifelong Exercise Counteract Low-Grade Inflammation Associated with Aging? A Systematic Review and Meta-Analysis

Sports Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Background Aging is associated with sustained low-grade inflammation, which has been linked to age-related diseases and mortality. Long-term exercise programs have shown be effective for attenuating this process; however, subsequent detraining might negate some of these benefits. Master athletes, as a model lifelong consistent practice, suggested present similar inflammatory profiles untrained young adults. Nonetheless, it unclear whether maintaining training habits throughout life can completely counteract inflammation aging. Objectives We aimed systematically evaluate comparisons baseline in middle-aged older adults, individuals elucidate Methods A systematic review was conducted following the Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) statement, protocol prospectively registered PROSPERO (CRD42024521339). Studies reporting systemic levels proinflammatory anti-inflammatory markers athletes controls were eligible inclusion. total six databases (PubMed [MEDLINE], Embase, Cochrane Central Register Controlled Trials [CENTRAL], Scopus, SPORTDiscus, Web Science [WoS]) searched September 2024, studies independently screened by two reviewers. Risk bias assessed using an adapted version Joanna Briggs Institute Critical Appraisal tool cross-sectional trials, random-effect meta-analyses standardized mean differences (SMDs) between age-matched adults well subjects. Subgroup analyses performed based on intensity type, participants’ sex. Results 17 ( n = 649 participants) included both qualitative quantitative synthesis. Lifelong appears attenuate increases C-reactive protein, elevate interleukin (IL)-10 compared (C-reactive protein: SMD − 0.71, 95% confidence interval 0.97, 0.45, I 2 0%, p 0.78; IL-10: 1.44, 0.55, 2.32, 87%, < 0.00001). Statistical significance maintained protein IL-10 sub-analyses. No difference tumor necrosis factor-α observed (SMD 0.40, 0.15, 0.96, 72%, 0.0008). trend towards decreased IL-6 pooled comparing rendered statistically significant However, indicated that still elevated IL-6, along IL-10. Conclusions exhibit more profile denoted circulating and, potentially, increased healthy peers. insufficient changes factor-α, IL-10,

Язык: Английский

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Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

Aging Cell, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases. It has long been speculated that “rejuvenation molecules” exist in their blood promote extended lifespan. We unexpectedly discovered longevity exhibit erythrocyte oxygen release function similar young individuals, whereas most elderly show reduced capacity. Untargeted metabolomics profiling revealed are characterized by youth‐like metabolic reprogramming these metabolites effectively differentiate the from elderly. Quantification analyses led us identify multiple novel longevity‐related within erythrocytes including adenosine, sphingosine‐1‐phosphate (S1P), glutathione (GSH) related amino acids. Mechanistically, we increased bisphosphoglycerate mutase (BPGM) MFSD2B protein levels of collaboratively work together induce elevation intracellular S1P, glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) membrane cytosol, thereby orchestrate glucose toward Rapoport–Luebering Shunt 2,3‐BPG production trigger delivery. Furthermore, glutamine glutamate transporter expression coupled with enhanced metabolism underlie elevated GSH higher anti‐oxidative stress capacity individuals. As such, displayed less systemic hypoxia‐related more antioxidative anti‐inflammatory plasma, healthier clinical outcomes inflammation parameters as well better glucose–lipid metabolism, liver kidney function. Overall, identified youthful enable counteract peripheral tissue thus maintaining healthspan.

Язык: Английский

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Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds

Nutrients, Год журнала: 2023, Номер 15(21), С. 4607 - 4607

Опубликована: Окт. 30, 2023

Pentadecanoic acid (C15:0) is an essential odd-chain saturated fatty with broad activities relevant to protecting cardiometabolic, immune, and liver health. C15:0 activates AMPK inhibits mTOR, both of which are core components the human longevity pathway. To assess potential for enhance processes associated healthspan, we used cell-based molecular phenotyping assays compare three longevity-enhancing candidates: acarbose, metformin, rapamycin. (n = 36 in 10 12 cell systems) rapamycin 32 had most clinically relevant, dose-dependent activities. At their optimal doses, (17 µM) (9 shared 24 across systems, including anti-inflammatory (e.g., lowered MCP-1, TNFα, IL-10, IL-17A/F), antifibrotic, anticancer activities, further supported by previously published vitro vivo studies. Paired prior demonstrated abilities target pathways, hallmarks aging, aging rate biomarkers, type 2 diabetes, heart disease, cancer, nonalcoholic our results support as nutrient equivalent to, or surpassing, leading candidate compounds.

Язык: Английский

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Ultra-processed foods, unprocessed/minimally processed foods and risk of frailty in a cohort of U.S. females

American Journal of Clinical Nutrition, Год журнала: 2024, Номер 120(1), С. 232 - 239

Опубликована: Май 14, 2024

Язык: Английский

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Integrating Machine Learning with Multi-Omics Technologies in Geroscience: Towards Personalized Medicine

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(9), С. 931 - 931

Опубликована: Авг. 31, 2024

Aging is a fundamental biological process characterized by progressive decline in physiological functions and an increased susceptibility to diseases. Understanding aging at the molecular level crucial for developing interventions that could delay or reverse its effects. This review explores integration of machine learning (ML) with multi-omics technologies-including genomics, transcriptomics, epigenomics, proteomics, metabolomics-in studying hallmarks develop personalized medicine interventions. These include genomic instability, telomere attrition, epigenetic alterations, loss proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, dysbiosis. Using ML analyze big complex datasets helps uncover detailed interactions pathways play role aging. The advances can facilitate discovery biomarkers therapeutic targets, offering insights into anti-aging strategies. With these developments, future points toward better understanding process, aiming ultimately promote healthy extend life expectancy.

Язык: Английский

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Postbiotics as Molecules Targeting Cellular Events of Aging Brain—The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases

Nutrients, Год журнала: 2024, Номер 16(14), С. 2244 - 2244

Опубликована: Июль 12, 2024

Aging is the most prominent risk factor for neurodegeneration occurrence. The common neurodegenerative diseases (NDs), Alzheimer’s (AD) and Parkinson’s (PD) diseases, are characterized by incidence of proteinopathy, abnormal activation glial cells, oxidative stress, neuroinflammation, impaired autophagy cellular senescence excessive patient’s age. Moreover, mitochondrial disfunction, epigenetic alterations neurogenesis inhibition, together with increased blood–brain barrier permeability gut dysbiosis, have been linked to ND pathogenesis. Since NDs still lack curative treatment, recent research has sought therapeutic options in restoring microbiota supplementing probiotic bacteria-derived metabolites beneficial action host—so called postbiotics. current review focuses on literature explaining mechanisms involved pathogenesis addressing impact that postbiotics as a whole mixture particular metabolites, such short-chain fatty acids (SCFAs), lactate, polyamines, polyphenols, tryptophan exopolysaccharides bacterial extracellular vesicles, ageing-associated processes underlying also discusses issue implementing into prophylaxis therapy, depicting them compounds senescence-triggered dysfunctions worth translating from bench pharmaceutical market response “silver consumers” demands.

Язык: Английский

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