Nature Microbiology, Год журнала: 2024, Номер 9(11), С. 2785 - 2794
Опубликована: Окт. 30, 2024
Язык: Английский
Nature Reviews Endocrinology, Год журнала: 2023, Номер 19(5), С. 258 - 271
Опубликована: Янв. 17, 2023
Язык: Английский
Процитировано
165
Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 140, С. 111789 - 111789
Опубликована: Май 31, 2021
Numerous combinations of diets and pharmacological agents, including lifestyle changes, have been launched to treat obesity. There are still ambiguities regarding the efficacies different approaches despite many clinical trials use animal models study physiological mechanisms in weight management obesity comorbidities, Here, we present an update on promising aids. Literature published after year 2005 was searched PubMed, Medline Google scholar. Among recommended low-fat (LF) low-carbohydrate (LC) diets, addition Mediterranean diet intermittent fasting approach, all which presumably being optimized by adequate contents dietary fibers. A basic point for loss is adopt a that creates permanently negative acceptable energy balance, prolonged adherence crucial factor. As aids, obese patients with type 2 diabetes or insulin resistance seem benefit from LC combined GLP-1 agonist, e.g. semaglutide, may improve glycemic control, stimulate satiety, suppress appetite. The lipase inhibitor orlistat used maintain be favorable hypercholesterolemia. bupropion-naltrexone-combination appears interruption vicious cycle addictive over-eating. Successful seems almost biomarkers comorbidities. Until more support specific strategies available, clinicians should recommend adapted lifestyle, when necessary, drug combination tailored individual needs Different change hormonal secretion, gut-brain signaling, influence hunger, satiety expenditure. Further research needed clarify how such knowledge can management.
Язык: Английский
Процитировано
129
Frontiers in Nutrition, Год журнала: 2021, Номер 8
Опубликована: Июль 12, 2021
Background: Weight loss by lifestyle modification is the cornerstone therapy of non-alcoholic fatty liver disease (NAFLD). Intermittent fasting has shown favorable effects on body weight (BW) and relevant indicators NAFLD in several reports. Objective: To estimate intermittent adults with NAFLD. Materials methods: Literature searches were conducted PubMed, EMBASE, Web Science, Cochrane Library, ClinicalTrials.gov from inception to May 10, 2021. Results: A total six studies involving 417 patients included. In meta-analysis, there significant differences BW, mass index (BMI), alanine aminotransferase (ALT), aspartate transaminase (AST) between control group. Up now, no difference triglycerides (TG), cholesterol (TC), other metabolic parameters two groups. Conclusions: beneficial for management enzyme improvement, but long-term feasibility safety should be further studies.
Язык: Английский
Процитировано
65
Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2022, Номер 16(8), С. 102566 - 102566
Опубликована: Июль 8, 2022
Язык: Английский
Процитировано
59
Advanced Science, Год журнала: 2023, Номер 10(9)
Опубликована: Фев. 3, 2023
Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.
Язык: Английский
Процитировано
44
Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2022, Номер 25(6), С. 443 - 450
Опубликована: Сен. 14, 2022
Diet is an essential modulator of the microbiota - gut brain communication in health and disease. Consequently, diet-induced microbiome states can impact behaviour. The integration into clinical nutrition perspectives sparse. This review will thus focus on emerging evidence microbiome-targeted dietary approaches with potential to improve disorders.
Язык: Английский
Процитировано
43
Nutrients, Год журнала: 2023, Номер 15(2), С. 259 - 259
Опубликована: Янв. 4, 2023
Each individual has a unique gut microbiota; therefore, the genes in our microbiome outnumber genome by about 150 to 1. Perturbation host nutritional status influences composition and vice versa. The can help producing vitamins, hormones, other active metabolites that support immune system; harvest energy from food; aid digestion; protect against pathogens; improve transit function; send signals brain organs; oscillate circadian rhythm; coordinate with metabolism through multiple cellular pathways. Gut microbiota be influenced genetics, medications, diet, lifestyle factors preterm aging. Aligning precision nutrition, identifying personalized mandates provision of right nutrients at time patient. Thus, before prescribing treatment, it is crucial monitor count flora as focused biomarker. Many approaches have been developed maintaining restoring an optimal such specific diet therapy, nutrition interventions, customized eating patterns. One these time-restricted feeding/eating (TRF/E), type intermittent fasting (IF) which subject abstains food intake for window. Such dietary modification might alter restore proper alignment molecular pathways throughout lifespan. In this review, we highlighted would targeted biomarker TRF/E approach gut-microbiome-associated hormonal signaling, system, metabolic regulators, neural responses, immune-inflammatory Consequently, modulation could contribute utilization availability way confer protection diseases harnessing human health.
Язык: Английский
Процитировано
30
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Фев. 12, 2024
Background Intermittent fasting (IF) has gained popularity in interventions targeting overweight, obesity and metabolic syndrome. IF may affect the gut microbiome composition therefore have various effects on mediated functions humans. Research of human is limited. Therefore, objective this systematic review was to determine how different types microbiome. Methods A literature search conducted for studies investigating association microbiota richness, alpha beta diversity, subjects. Databases included Cochrane Library (RRID:SCR_013000), PubMed (RRID:SCR_004846), Scopus (RRID:SCR_022559) Web Science (RRID:SCR_022706). total 1,332 were retrieved, which 940 remained after removing duplicates. Ultimately, a 8 review. The randomized controlled trials, quasi-experimental pilot implementing an intervention (time-restricted eating, alternate day or 5:2 diet) healthy subjects with any disease. Results Most found between diversity compositional changes. There heterogeneity results, bacteria be statistically significantly affected by varied widely depending study. Conclusion findings suggest that influences microbiota. It seems possible can improve richness diversity. Due substantial more research required validate these clarify whether changes might beneficial health. Systematic Review Registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42021241619.
Язык: Английский
Процитировано
13
Cell Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
2
Reviews in Endocrine and Metabolic Disorders, Год журнала: 2023, Номер 24(5), С. 839 - 870
Опубликована: Апрель 29, 2023
Obesity has reached epidemic proportion worldwide and in all ages. Available evidence points to a multifactorial pathogenesis involving gene predisposition environmental factors. Gut microbiota plays critical role as major interface between external factors, i.e., diet, lifestyle, toxic chemicals, internal mechanisms regulating energy metabolic homeostasis, fat production storage. A shift composition is linked with overweight obesity, pathogenic bacterial products metabolites (mainly endocannabinoid-related mediators, short-chain fatty acids, bile catabolites of tryptophan, lipopolysaccharides) subsequent alterations gut barrier, altered insulin resistance chronic, low-grade inflammation. Although animal studies point the links an "obesogenic" development different obesity phenotypes, translational value these results humans still limited by heterogeneity among studies, high variation over time lack robust longitudinal adequately considering inter-individual confounders. Nevertheless, available underscores existence several genera predisposing or, conversely, lean metabolically health phenotype (e.g., Akkermansia muciniphila, species from Faecalibacterium, Alistipes, Roseburia). Further using metagenomics, transcriptomics, proteomics, metabolomics exact characterization confounders are needed this field. Results must confirm that distinct specific microbial-derived represent effective precision interventions against long-term.
Язык: Английский
Процитировано
20