The effects of time-restricted eating and Ramadan fasting on gut microbiota composition: a systematic review of human and animal studies DOI Creative Commons
Joanna Maria Pieczyńska-Zając, Anna M. Malinowska, Karolina Łagowska

et al.

Nutrition Reviews, Journal Year: 2023, Volume and Issue: 82(6), P. 777 - 793

Published: Aug. 1, 2023

Abstract Context It is well known that the microbiome undergoes cyclical diurnal rhythms. has thus been hypothesized meal timing may affect gut microbial composition, function, and host health. Objective This review aims to examine effects of time-restricted eating (TRE) Ramadan fasting (RF) on composition microbiota in animal human studies. The associations between metabolic parameters are also examined. Data Sources A search was performed PubMed, Cochrane, Scopus, Web Science databases up December 31, 2022. strategy using Medical Subject Heading (MeSH) terms “intermittent fasting” “gastrointestinal microbiome” key words “Ramadan “microbes.” Extraction Seven studies (4 TRE 3 RF) 9 (7 TRE, 2 RF-like) were retrieved. Analysis RF lead an increase community alpha-diversity. In (both RF-like), not associated with improved alpha-diversity, but enhancement fluctuation observed, compared high-fat diet ad libitum groups. Within Firmicutes Bacteroidetes phyla, no specific direction changes resulting from observed both animals human. After or RF, a greater abundance Faecalibacterium genus studies; Lactobacillus found increases Akkermansia seen humans fed feed-pellet diet. Only show beneficial correlation (HDL cholesterol) anthropometric (body mass index). Conclusions These findings support importance regimens improving composition. However, based results studies, it can be suggested remains essential factor forming microbiota’s environment. Systematic Review Registration PROSPERO registration no. CRD42021278918.

Language: Английский

The gut microbiota in obesity and weight management: microbes as friends or foe? DOI
Matthias Van Hul, Patrice D. Cani

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(5), P. 258 - 271

Published: Jan. 17, 2023

Language: Английский

Citations

159
Diets and drugs for weight loss and health in obesity – An update DOI Open Access
Jan Aaseth, Stian Ellefsen, Urban Alehagen

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 140, P. 111789 - 111789

Published: May 31, 2021

Numerous combinations of diets and pharmacological agents, including lifestyle changes, have been launched to treat obesity. There are still ambiguities regarding the efficacies different approaches despite many clinical trials use animal models study physiological mechanisms in weight management obesity comorbidities, Here, we present an update on promising aids. Literature published after year 2005 was searched PubMed, Medline Google scholar. Among recommended low-fat (LF) low-carbohydrate (LC) diets, addition Mediterranean diet intermittent fasting approach, all which presumably being optimized by adequate contents dietary fibers. A basic point for loss is adopt a that creates permanently negative acceptable energy balance, prolonged adherence crucial factor. As aids, obese patients with type 2 diabetes or insulin resistance seem benefit from LC combined GLP-1 agonist, e.g. semaglutide, may improve glycemic control, stimulate satiety, suppress appetite. The lipase inhibitor orlistat used maintain be favorable hypercholesterolemia. bupropion-naltrexone-combination appears interruption vicious cycle addictive over-eating. Successful seems almost biomarkers comorbidities. Until more support specific strategies available, clinicians should recommend adapted lifestyle, when necessary, drug combination tailored individual needs Different change hormonal secretion, gut-brain signaling, influence hunger, satiety expenditure. Further research needed clarify how such knowledge can management.

Language: Английский

Citations

128
Effect of Intermittent Fasting on Non-Alcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis DOI Creative Commons
Cong Yin, Zihan Li,

Yulin Xiang

et al.

Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8

Published: July 12, 2021

Background: Weight loss by lifestyle modification is the cornerstone therapy of non-alcoholic fatty liver disease (NAFLD). Intermittent fasting has shown favorable effects on body weight (BW) and relevant indicators NAFLD in several reports. Objective: To estimate intermittent adults with NAFLD. Materials methods: Literature searches were conducted PubMed, EMBASE, Web Science, Cochrane Library, ClinicalTrials.gov from inception to May 10, 2021. Results: A total six studies involving 417 patients included. In meta-analysis, there significant differences BW, mass index (BMI), alanine aminotransferase (ALT), aspartate transaminase (AST) between control group. Up now, no difference triglycerides (TG), cholesterol (TC), other metabolic parameters two groups. Conclusions: beneficial for management enzyme improvement, but long-term feasibility safety should be further studies.

Language: Английский

Citations

65
Seven decades of Ramadan intermittent fasting research: Bibliometrics analysis, global trends, and future directions DOI
Khaled Obaideen, Katia Abu Shihab, Mohamed Madkour

et al.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2022, Volume and Issue: 16(8), P. 102566 - 102566

Published: July 8, 2022

Language: Английский

Citations

59
Diet and the microbiota–gut–brain-axis: a primer for clinical nutrition DOI Creative Commons
Gabriela Ribeiro,

Aimone Ferri,

Gerard Clarke

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2022, Volume and Issue: 25(6), P. 443 - 450

Published: Sept. 14, 2022

Diet is an essential modulator of the microbiota - gut brain communication in health and disease. Consequently, diet-induced microbiome states can impact behaviour. The integration into clinical nutrition perspectives sparse. This review will thus focus on emerging evidence microbiome-targeted dietary approaches with potential to improve disorders.

Language: Английский

Citations

42
Fasting: From Physiology to Pathology DOI Creative Commons
Dongmei Tang,

Qiuyan Tang,

Wei Huang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(9)

Published: Feb. 3, 2023

Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.

Language: Английский

Citations

39
Gut Microbiota and Time-Restricted Feeding/Eating: A Targeted Biomarker and Approach in Precision Nutrition DOI Open Access
Falak Zeb, Tareq M. Osaili, Reyad S. Obaid

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 259 - 259

Published: Jan. 4, 2023

Each individual has a unique gut microbiota; therefore, the genes in our microbiome outnumber genome by about 150 to 1. Perturbation host nutritional status influences composition and vice versa. The can help producing vitamins, hormones, other active metabolites that support immune system; harvest energy from food; aid digestion; protect against pathogens; improve transit function; send signals brain organs; oscillate circadian rhythm; coordinate with metabolism through multiple cellular pathways. Gut microbiota be influenced genetics, medications, diet, lifestyle factors preterm aging. Aligning precision nutrition, identifying personalized mandates provision of right nutrients at time patient. Thus, before prescribing treatment, it is crucial monitor count flora as focused biomarker. Many approaches have been developed maintaining restoring an optimal such specific diet therapy, nutrition interventions, customized eating patterns. One these time-restricted feeding/eating (TRF/E), type intermittent fasting (IF) which subject abstains food intake for window. Such dietary modification might alter restore proper alignment molecular pathways throughout lifespan. In this review, we highlighted would targeted biomarker TRF/E approach gut-microbiome-associated hormonal signaling, system, metabolic regulators, neural responses, immune-inflammatory Consequently, modulation could contribute utilization availability way confer protection diseases harnessing human health.

Language: Английский

Citations

28
The impact of intermittent fasting on gut microbiota: a systematic review of human studies DOI Creative Commons
Isa Paukkonen,

Elli-Noora Törrönen,

Johnson Lok

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 12, 2024

Background Intermittent fasting (IF) has gained popularity in interventions targeting overweight, obesity and metabolic syndrome. IF may affect the gut microbiome composition therefore have various effects on mediated functions humans. Research of human is limited. Therefore, objective this systematic review was to determine how different types microbiome. Methods A literature search conducted for studies investigating association microbiota richness, alpha beta diversity, subjects. Databases included Cochrane Library (RRID:SCR_013000), PubMed (RRID:SCR_004846), Scopus (RRID:SCR_022559) Web Science (RRID:SCR_022706). total 1,332 were retrieved, which 940 remained after removing duplicates. Ultimately, a 8 review. The randomized controlled trials, quasi-experimental pilot implementing an intervention (time-restricted eating, alternate day or 5:2 diet) healthy subjects with any disease. Results Most found between diversity compositional changes. There heterogeneity results, bacteria be statistically significantly affected by varied widely depending study. Conclusion findings suggest that influences microbiota. It seems possible can improve richness diversity. Due substantial more research required validate these clarify whether changes might beneficial health. Systematic Review Registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42021241619.

Language: Английский

Citations

11
Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders DOI Creative Commons
Shihan Zhang, Shasha Tang, Yalei Liu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, cardiovascular diseases, leading to multi-organ dysfunction higher incidence of endpoints. Traditional approaches managing CKM risk are inadequate in these patients, necessitating strategies targeting specific factors. Increasing evidence suggests that addressing uremic toxins and/or pathways induced may reduce treat the disease. This review explores heart, kidney, context underscores significant role as potential therapeutic targets pathophysiology diseases. Strategies aimed at regulating offer avenues for reversing syndrome, providing new insights its diagnosis treatment.

Language: Английский

Citations

1
Dietary Restrictions and Cancer Prevention: State of the Art DOI Open Access
Greta Caprara, Rani Pallavi,

S. Sanyal

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 503 - 503

Published: Jan. 29, 2025

Worldwide, almost 10 million cancer deaths occurred in 2022, a number that is expected to rise 16.3 by 2040. Primary prevention has long been acknowledged as crucial approach reducing incidence. In fact, between 30 and 50 percent of all tumors are known be preventable eating healthy diet, staying active, avoiding alcohol, smoking, being overweight. Accordingly, many international organizations have created tumor guidelines, which underlie the importance following diet emphasizes plant-based foods while minimizing consumption red/processed meat, sugars, processed foods, alcohol. However, further research needed define relationship effect specific diets or nutritional components on prevention. Interestingly, reductions food intake dietetic restrictions can extend lifespan yeast, nematodes, flies, rodents. Despite controversial results humans, those approaches potential ameliorate health via direct indirect effects signaling pathways involved onset. Here, we describe latest knowledge cancer-preventive dietary biochemical processes involved. Molecular, preclinical, clinical studies evaluating different fasting strategies will also reviewed.

Language: Английский

Citations

1