Cell Biochemistry and Function,
Год журнала:
2025,
Номер
43(3)
Опубликована: Фев. 26, 2025
ABSTRACT
Aging
is
considered
the
contributory
accumulation
of
abruptions
occurring
through
cell
signaling
cascades,
which
ultimately
cause
changes
in
physical
functions,
fate,
and
damage
across
all
organ
systems.
DNA
response
(DDR)
also
occurs
telomere
shortening,
tumor
formation,
mitochondrial
dysfunction,
so
forth.
Cellular
aging
cycle
arrest,
result
extended
DDR
cascade
networks
via
MDC1,
53BP1,
H2AX,
ATM,
ARF,
P53,
P13‐Akt,
BRAF,
Sirtuins,
NAD
+
,
These
persistent
arrests
initiated
by
other
associated
stress‐induced
signals
promote
a
permanent
state
arrest
called
senescence‐associated
secretory
phenotype
(SASP).
However,
cellular
gets
accelerated
with
faulty
repair
systems,
produced
senescent
cells
further
generate
various
promoting
contributors
to
age‐related
dysfunctional
diseases
including
SASP.
Any
these
factors
contribute
disease
development.
Therefore,
this
review
explores
anti‐aging
targeting
SASP
regulation
their
detailed
networks.
In
addition,
it
allows
researchers
identify
targets
therapeutic
strategies
based
on
identified
nonidentified
targets.
Science,
Год журнала:
2023,
Номер
380(6641), С. 158 - 163
Опубликована: Апрель 13, 2023
Reproduction
involves
a
wide
range
of
biological
processes,
including
organ
formation
and
development,
neuroendocrine
regulation,
hormone
production,
meiosis
mitosis.
Infertility,
the
failure
reproduction,
has
become
major
issue
for
human
reproductive
health
affects
up
to
one
in
seven
couples
worldwide.
Here,
we
review
various
aspects
infertility,
etiology,
mechanisms,
treatments,
with
particular
emphasis
on
genetics.
We
focus
gamete
production
quality,
which
is
core
successful
reproduction.
also
discuss
future
research
opportunities
challenges
further
expand
our
understanding
infertility
improve
patient
care
by
providing
precision
diagnosis
personalized
treatments.
Human Reproduction Update,
Год журнала:
2023,
Номер
29(6), С. 773 - 793
Опубликована: Июль 19, 2023
Abstract
BACKGROUND
Modern
lifestyle
has
led
to
an
increase
in
the
age
at
conception.
Advanced
is
one
of
critical
risk
factors
for
female-related
infertility.
It
well
known
that
maternal
positively
correlates
with
deterioration
oocyte
quality
and
chromosomal
abnormalities
oocytes
embryos.
The
effect
on
endometrial
function
may
be
equally
important
factor
influencing
implantation
rate,
pregnancy
overall
female
fertility.
However,
there
are
only
a
few
published
studies
this
topic,
suggesting
area
been
under-explored.
Improving
our
knowledge
aging
from
biological
(cellular,
molecular,
histological)
clinical
perspectives
would
broaden
understanding
risks
age-related
OBJECTIVE
AND
RATIONALE
objective
narrative
review
critically
evaluate
existing
literature
focus
synthesizing
evidence
impact
conception
success.
This
provide
insights
into
gaps
application
research
findings
promote
development
treatment
options
field.
SEARCH
METHODS
was
prepared
using
PubMed
(Medline)
until
February
2023
keywords
such
as
‘endometrial
aging’,
‘receptivity’,
‘decidualization’,
‘hormone’,
‘senescence’,
‘cellular’,
‘molecular’,
‘methylation’,
‘biological
age’,
‘epigenetic’,
‘oocyte
recipient’,
donation’,
‘embryo
transfer’,
‘pregnancy
rate’.
Articles
language
other
than
English
were
excluded.
OUTCOMES
In
endometrium,
alterations
occur
cellular,
histological
levels
negative
biology
impair
receptivity.
Additionally,
advanced
influences
cellular
senescence,
which
plays
role
during
initial
phase
major
obstacle
suitable
senolytic
agents
aging.
Aging
also
accountable
chronic
conditions
associated
inflammaging,
eventually
can
lead
increased
pro-inflammation
tissue
fibrosis.
Furthermore,
epigenetic
regulation
thus
altering
relation
between
its
chronological
age.
donation
cycles
determine
receptivity
respect
rates
implantation,
pregnancy,
miscarriage,
live
birth
have
revealed
contradictory
inferences
indicating
need
future
mechanisms
corresponding
causal
effects
women’s
WIDER
IMPLICATIONS
Increasing
infertility
IVF
failures.
Based
complied
observations
synthesized
conclusions
review,
shown
functioning.
information
recommendations
focusing
molecular
composition,
transcriptomic
changes
further
prospective
needed
explore
newly
emerging
therapeutic
options,
target
without
affecting
decidualization.
Moreover,
trial
protocols,
cycles,
beneficial
direct
implications
outcomes.
Nature Aging,
Год журнала:
2024,
Номер
4(4), С. 527 - 545
Опубликована: Апрель 9, 2024
Abstract
Limited
understanding
exists
regarding
how
aging
impacts
the
cellular
and
molecular
aspects
of
human
ovary.
This
study
combines
single-cell
RNA
sequencing
spatial
transcriptomics
to
systematically
characterize
ovarian
aging.
Spatiotemporal
signatures
eight
types
cells
during
are
observed.
An
analysis
age-associated
changes
in
gene
expression
reveals
that
DNA
damage
response
may
be
a
key
biological
pathway
oocyte
Three
granulosa
subtypes
five
theca
stromal
subtypes,
as
well
their
spatiotemporal
aging,
identified.
FOXP1
emerges
regulator
declining
with
age
inhibiting
CDKN1A
transcription.
Silencing
results
premature
insufficiency
mice.
These
findings
offer
comprehensive
variability
aiding
prioritization
potential
diagnostic
biomarkers
therapeutic
strategies.
Ovarian
aging
occurs
prior
to
the
of
other
organ
systems
and
acts
as
pacemaker
process
multiple
organs.
As
life
expectancy
has
increased,
preventing
ovarian
become
an
essential
goal
for
promoting
extended
reproductive
function
improving
bone
genitourinary
conditions
related
in
women.
An
improved
understanding
may
ultimately
provide
tools
prediction
mitigation
this
process.
Recent
studies
have
suggested
a
connection
between
gut
microbiota,
alterations
composition
functional
profile
microbiota
profound
consequences
on
function.
The
interaction
ovaries
is
bidirectional.
In
review,
we
examine
current
knowledge
ovary-gut
crosstalk
further
discuss
potential
role
anti-aging
interventions.
Microbiota-based
manipulation
appealing
approach
that
offer
new
therapeutic
strategies
delay
or
reverse
aging.
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 19, 2022
Progressive
loss
of
physiological
integrity
and
accumulation
degenerative
changes
leading
to
functional
impairment
increased
susceptibility
diseases
are
the
main
features
aging.
The
ovary,
key
organ
that
maintains
female
reproductive
endocrine
function,
enters
aging
earlier
faster
than
other
organs
has
attracted
extensive
attention
from
society.
Ovarian
is
mainly
characterized
by
progressive
decline
in
number
quality
oocytes,
regulatory
mechanisms
which
have
yet
be
systematically
elucidated.
This
review
discusses
hallmarks
further
highlight
characteristics
ovarian
attempt
explore
its
clinical
symptoms
underlying
mechanisms.
Finally,
intervention
strategies
related
elaborated,
especially
potential
role
stem
cells
cryopreservation
embryos,
or
tissue
delay
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 13, 2023
The
ovarian
microenvironment
is
critical
for
follicular
development
and
oocyte
maturation.
Maternal
conditions,
including
polycystic
ovary
syndrome
(PCOS),
endometriosis,
aging,
may
compromise
the
microenvironment,
development,
quality.
Chronic
low-grade
inflammation
can
induce
oxidative
stress
tissue
fibrosis
in
ovary.
In
PCOS,
pro-inflammatory
cytokine
levels
are
often
elevated
fluids.
women
with
obesity
hyperandrogenemia
insulin
resistance
chronic
inflammation,
thereby
disrupting
by
increasing
stress.
endometrioma-derived
iron
overload
stress,
leading
to
ferroptosis
fibrosis.
inflammatory
aging
(inflammaging),
senescent
cells
secrete
senescence-associated
secretory
phenotype
factors,
causing
Therefore,
controlling
would
present
a
novel
therapeutic
strategy
improving
minimizing
dysfunction.
