Recent Advances in Anti‐Aging Therapeutic Strategies Targeting DNA Damage Response and Senescence‐Associated Secretory Phenotype‐Linked Signaling Cascade DOI

Jawad Nadeem,

Rukhsana Sultana,

Amna Parveen

et al.

Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(3)

Published: Feb. 26, 2025

ABSTRACT Aging is considered the contributory accumulation of abruptions occurring through cell signaling cascades, which ultimately cause changes in physical functions, fate, and damage across all organ systems. DNA response (DDR) also occurs telomere shortening, tumor formation, mitochondrial dysfunction, so forth. Cellular aging cycle arrest, result extended DDR cascade networks via MDC1, 53BP1, H2AX, ATM, ARF, P53, P13‐Akt, BRAF, Sirtuins, NAD + , These persistent arrests initiated by other associated stress‐induced signals promote a permanent state arrest called senescence‐associated secretory phenotype (SASP). However, cellular gets accelerated with faulty repair systems, produced senescent cells further generate various promoting contributors to age‐related dysfunctional diseases including SASP. Any these factors contribute disease development. Therefore, this review explores anti‐aging targeting SASP regulation their detailed networks. In addition, it allows researchers identify targets therapeutic strategies based on identified nonidentified targets.

Language: Английский

The landscape of aging DOI Open Access
Yusheng Cai, Wei Song, Jiaming Li

et al.

Science China Life Sciences, Journal Year: 2022, Volume and Issue: 65(12), P. 2354 - 2454

Published: Sept. 2, 2022

Language: Английский

Citations

239
Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

194
Understanding the genetics of human infertility DOI
Qing Sang, Pierre F. Ray, Lei Wang

et al.

Science, Journal Year: 2023, Volume and Issue: 380(6641), P. 158 - 163

Published: April 13, 2023

Reproduction involves a wide range of biological processes, including organ formation and development, neuroendocrine regulation, hormone production, meiosis mitosis. Infertility, the failure reproduction, has become major issue for human reproductive health affects up to one in seven couples worldwide. Here, we review various aspects infertility, etiology, mechanisms, treatments, with particular emphasis on genetics. We focus gamete production quality, which is core successful reproduction. also discuss future research opportunities challenges further expand our understanding infertility improve patient care by providing precision diagnosis personalized treatments.

Language: Английский

Citations

72
Endometrial receptivity in women of advanced age: an underrated factor in infertility DOI Creative Commons
Amruta D. S. Pathare, Marina Loid, Merli Saare

et al.

Human Reproduction Update, Journal Year: 2023, Volume and Issue: 29(6), P. 773 - 793

Published: July 19, 2023

Abstract BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced is one of critical risk factors for female-related infertility. It well known that maternal positively correlates with deterioration oocyte quality and chromosomal abnormalities oocytes embryos. The effect on endometrial function may be equally important factor influencing implantation rate, pregnancy overall female fertility. However, there are only a few published studies this topic, suggesting area been under-explored. Improving our knowledge aging from biological (cellular, molecular, histological) clinical perspectives would broaden understanding risks age-related OBJECTIVE AND RATIONALE objective narrative review critically evaluate existing literature focus synthesizing evidence impact conception success. This provide insights into gaps application research findings promote development treatment options field. SEARCH METHODS was prepared using PubMed (Medline) until February 2023 keywords such as ‘endometrial aging’, ‘receptivity’, ‘decidualization’, ‘hormone’, ‘senescence’, ‘cellular’, ‘molecular’, ‘methylation’, ‘biological age’, ‘epigenetic’, ‘oocyte recipient’, donation’, ‘embryo transfer’, ‘pregnancy rate’. Articles language other than English were excluded. OUTCOMES In endometrium, alterations occur cellular, histological levels negative biology impair receptivity. Additionally, advanced influences cellular senescence, which plays role during initial phase major obstacle suitable senolytic agents aging. Aging also accountable chronic conditions associated inflammaging, eventually can lead increased pro-inflammation tissue fibrosis. Furthermore, epigenetic regulation thus altering relation between its chronological age. donation cycles determine receptivity respect rates implantation, pregnancy, miscarriage, live birth have revealed contradictory inferences indicating need future mechanisms corresponding causal effects women’s WIDER IMPLICATIONS Increasing infertility IVF failures. Based complied observations synthesized conclusions review, shown functioning. information recommendations focusing molecular composition, transcriptomic changes further prospective needed explore newly emerging therapeutic options, target without affecting decidualization. Moreover, trial protocols, cycles, beneficial direct implications outcomes.

Language: Английский

Citations

52
Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1 DOI Creative Commons
Meng Wu, Weicheng Tang, Runsheng Chen

et al.

Nature Aging, Journal Year: 2024, Volume and Issue: 4(4), P. 527 - 545

Published: April 9, 2024

Abstract Limited understanding exists regarding how aging impacts the cellular and molecular aspects of human ovary. This study combines single-cell RNA sequencing spatial transcriptomics to systematically characterize ovarian aging. Spatiotemporal signatures eight types cells during are observed. An analysis age-associated changes in gene expression reveals that DNA damage response may be a key biological pathway oocyte Three granulosa subtypes five theca stromal subtypes, as well their spatiotemporal aging, identified. FOXP1 emerges regulator declining with age inhibiting CDKN1A transcription. Silencing results premature insufficiency mice. These findings offer comprehensive variability aiding prioritization potential diagnostic biomarkers therapeutic strategies.

Language: Английский

Citations

32
The influence of the gut microbiome on ovarian aging DOI Creative Commons
Feiling Huang, Ying Cao, Jinghui Liang

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 3, 2024

Ovarian aging occurs prior to the of other organ systems and acts as pacemaker process multiple organs. As life expectancy has increased, preventing ovarian become an essential goal for promoting extended reproductive function improving bone genitourinary conditions related in women. An improved understanding may ultimately provide tools prediction mitigation this process. Recent studies have suggested a connection between gut microbiota, alterations composition functional profile microbiota profound consequences on function. The interaction ovaries is bidirectional. In review, we examine current knowledge ovary-gut crosstalk further discuss potential role anti-aging interventions. Microbiota-based manipulation appealing approach that offer new therapeutic strategies delay or reverse aging.

Language: Английский

Citations

24
Evidence of sex differences in cellular senescence DOI
Mitchell Ng, Lili‐Naz Hazrati

Neurobiology of Aging, Journal Year: 2022, Volume and Issue: 120, P. 88 - 104

Published: Sept. 2, 2022

Language: Английский

Citations

47
Aging conundrum: A perspective for ovarian aging DOI Creative Commons
Jiachen Wu,

Yang Liu,

Yinhua Song

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 19, 2022

Progressive loss of physiological integrity and accumulation degenerative changes leading to functional impairment increased susceptibility diseases are the main features aging. The ovary, key organ that maintains female reproductive endocrine function, enters aging earlier faster than other organs has attracted extensive attention from society. Ovarian is mainly characterized by progressive decline in number quality oocytes, regulatory mechanisms which have yet be systematically elucidated. This review discusses hallmarks further highlight characteristics ovarian attempt explore its clinical symptoms underlying mechanisms. Finally, intervention strategies related elaborated, especially potential role stem cells cryopreservation embryos, or tissue delay

Language: Английский

Citations

41
Ovarian aging in humans: potential strategies for extending reproductive lifespan DOI
Marcelo Borges Cavalcante,

Olga Goiana Martins Sampaio,

Fernanda Eunice Araújo Câmara

et al.

GeroScience, Journal Year: 2023, Volume and Issue: 45(4), P. 2121 - 2133

Published: March 13, 2023

Language: Английский

Citations

34
Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging DOI Creative Commons
Makoto Orisaka, Tetsuya Mizutani, Yumiko Miyazaki

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 13, 2023

The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, aging, may compromise the microenvironment, development, quality. Chronic low-grade inflammation can induce oxidative stress tissue fibrosis in ovary. In PCOS, pro-inflammatory cytokine levels are often elevated fluids. women with obesity hyperandrogenemia insulin resistance chronic inflammation, thereby disrupting by increasing stress. endometrioma-derived iron overload stress, leading to ferroptosis fibrosis. inflammatory aging (inflammaging), senescent cells secrete senescence-associated secretory phenotype factors, causing Therefore, controlling would present a novel therapeutic strategy improving minimizing dysfunction.

Language: Английский

Citations

34