Sensors and Actuators B Chemical, Год журнала: 2024, Номер unknown, С. 136952 - 136952
Опубликована: Ноя. 1, 2024
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(34)
Опубликована: Июнь 11, 2024
The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.
Язык: Английский
Процитировано
48
Science China Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
10
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 27, 2024
Abstract Efficient type II photodynamic therapy (PDT) requires stable and biocompatible photosensitizers (PS) that present low dark cytotoxicity, are photo‐excitable in deep tissue regions, can efficiently penetrate kill cells via situ singlet oxygen production. Here, heavy‐metal‐free organic PS combined with near‐infrared (NIR)‐excitable small (<20 nm) upconversion nanoparticles (UCNPs) into UCNP‐PS nanohybrids for accomplishing such advanced PDT conditions. UCNP‐to‐PS energy transfer efficiencies between 11% 42% 1 O 2 generation quantum yields 74% 86% resulted efficient NIR‐sensitized PDT. HeLa incubated be destroyed 808 nm laser irradiance at 140 mW cm −2 3 min (<30% cell viability) or 3.2 W 6 (<10% viability). Theranostic functionality of is demonstrated live imaging intracellular UCNP‐PS‐mediated production, which death, most probably apoptosis. Preliminary vivo experiments also performed the consequences a detailed study toward clinical translation discussed. The deep‐tissue properties nanomolecular large potential future implementation theranostics.
Язык: Английский
Процитировано
8
Chemistry - A European Journal, Год журнала: 2024, Номер 30(27)
Опубликована: Март 18, 2024
Controlling the formation of photoexcited triplet states is critical for many (photo)chemical and physical applications. Here, we demonstrate that a permanent out-of-plane distortion benzothioxanthene imide (BTI) dye promotes intersystem crossing by increasing spin-orbit coupling. This manipulation was achieved through subtle chemical modification, specifically bay-area methylation. Consequently, this simple yet efficient approach expands catalog known molecular engineering strategies synthesizing heavy atom-free, dual redox-active, still emissive synthetically accessible photosensitizers.
Язык: Английский
Процитировано
5
Nanoscale Horizons, Год журнала: 2024, Номер 9(9), С. 1390 - 1416
Опубликована: Янв. 1, 2024
Molecular disassembly is pioneering a new route to refined diagnostic and therapeutic solutions. This approach breaks down self-assembled molecules, offering enhanced precision efficiency in various bio-oriented applications.
Язык: Английский
Процитировано
5
Angewandte Chemie International Edition, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).
Язык: Английский
Процитировано
0
Angewandte Chemie, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).
Язык: Английский
Процитировано
0
ChemPhotoChem, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
Phototherapy, encompassing photodynamic therapy (PDT) and photothermal (PTT), presents a promising cancer treatment strategy with high spatial specificity minimal invasiveness. Optimizing these techniques hinges on the design of high‐performance photosensitizers (PSs) agents (PTAs). Single‐atom chalcogen substitution, at both endocyclic exocyclic positions in conventional organic chromophores, has proven to be novel for enhancing their photophysical photochemical properties. Ideal PSs/PTAs exhibit biocompatibility, visible‐to‐near‐infrared (vis–NIR) absorption, efficient triplet state harvesting, feasible heat energy transfer efficiency. Moreover, chalcogen‐based show promise synergistic multimodal therapies, integrating imaging treatment. This review comprehensively examines recent advancements (within last five years) utilizing substitution robust PDT/PTT. It provides holistic perspective spectroscopic characterization computational analyses, singlet‐oxygen/triplet quantum yields, generation efficiency, vitro/in vivo biological evaluations chalcogen‐substituted PSs/PTAs. is anticipated that this will stimulate further research endeavors area.
Язык: Английский
Процитировано
0
Nucleic Acids Research, Год журнала: 2023, Номер 52(D1), С. D72 - D80
Опубликована: Окт. 30, 2023
Abstract G-quadruplexes (G4s) are non-canonical four-stranded structures and emerging as novel genetic regulatory elements. However, a comprehensive genomic annotation of endogenous G4s (eG4s) systematic characterization their network still lacking, posing major challenges for eG4 research. Here, we present EndoQuad (https://EndoQuad.chenzxlab.cn/) to address these pressing issues by integrating high-throughput experimental data. First, based on high-quality genome-wide eG4s mapping datasets (human: 1181; mouse: 24; chicken: 2) generated G4 ChIP-seq/CUT&Tag, generate reference set eG4s. Our multi-omics analyses show that most identified in one or few cell types. The with higher occurrences across samples more structurally stable, evolutionarily conserved, enriched promoter regions, mark highly expressed genes associate complex programs, demonstrating confidence level further experiments. Finally, integrate millions functional variants prioritize functions disease cancer contexts. These efforts have culminated the interactive database experimentally validated DNA As such, enables users easily access, download repurpose data own will become one-stop resource research lay foundation future studies.
Язык: Английский
Процитировано
11
ChemSusChem, Год журнала: 2024, Номер unknown
Опубликована: Июнь 13, 2024
The sulfoxide moiety is one of the most commonly utilized groups in pharmaceutical and industrial chemistry. need for sustainability easy accessibility to moieties deemed necessary, due its ubiquity natural products potentially pharmaceutically active compounds. In this context, we report herein a sustainable, aerobic environmentally friendly photochemical protocol based on use benzothioxathene imide as photocatalyst selectively oxidize sulfides under mild irradiation (456 nm), very low catalyst loading (0.01 mol %) water. addition, demonstrate compatibility our with wide scope substrates, latter was successfully applied synthesis biologically-active Sulforaphane Modafinil.
Язык: Английский
Процитировано
4