Targeting apoptosis in cancer therapy

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(7), P. 395 - 417

Published: March 23, 2020

Language: Английский

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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

Genes & Diseases, Journal Year: 2018, Volume and Issue: 5(2), P. 77 - 106

Published: May 12, 2018

As the most commonly occurring cancer in women worldwide, breast poses a formidable public health challenge on global scale. Breast consists of group biologically and molecularly heterogeneous diseases originated from breast. While risk factors associated with this varies respect to other cancers, genetic predisposition, notably mutations

Language: Английский

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Cell Death Signaling

Cold Spring Harbor Perspectives in Biology, Journal Year: 2015, Volume and Issue: 7(12), P. a006080 - a006080

Published: Dec. 1, 2015

Douglas R. Green and Fabien Llambi Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105 Correspondence: douglas.green{at}stjude.org

Language: Английский

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Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Seminars in Cancer Biology, Journal Year: 2019, Volume and Issue: 80, P. 1 - 17

Published: Dec. 19, 2019

Language: Английский

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The lingering mysteries of metastatic recurrence in breast cancer

British Journal of Cancer, Journal Year: 2020, Volume and Issue: 124(1), P. 13 - 26

Published: Nov. 26, 2020

Despite being the hallmark of cancer that is responsible for highest number deaths, very little known about biology metastasis. Metastatic disease typically manifests after a protracted period undetectable following surgery or systemic therapy, owing to relapse recurrence. In case breast cancer, metastatic can occur months decades initial diagnosis and treatment. this review, we provide an overview key factors influence recurrence, with goal highlighting critical unanswered questions still need be addressed make difference in mortality patients.

Language: Английский

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Signaling Networks that Regulate Cell Migration

Cold Spring Harbor Perspectives in Biology, Journal Year: 2015, Volume and Issue: 7(8), P. a005959 - a005959

Published: Aug. 1, 2015

Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in metazoans cyclic AMP Dictyostelium, activate signaling pathways control organization of the actin cytoskeleton adhesion complexes. The Rho-family GTPases are a key convergence point these pathways. Their effectors include regulators formins, members WASP/WAVE family Arp2/3 complex, myosin II motor protein. Pathways link to Rho Ras GTPases, TorC2, PI3K. Many molecules involved form gradients within cells, which define front rear migrating also established related cellular behaviors neuronal cone extension cytokinesis. regulate migration can be integrated provide model network function. displays biochemical excitability seen spontaneous waves activation propagate along cortex. These events coordinate movement biased by external cues bring about directed migration.

Language: Английский

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Liquid–liquid phase separation drives cellular function and dysfunction in cancer

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(4), P. 239 - 252

Published: Feb. 11, 2022

Language: Английский

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Biomolecular Condensates and Cancer

Cancer Cell, Journal Year: 2021, Volume and Issue: 39(2), P. 174 - 192

Published: Jan. 9, 2021

Language: Английский

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Natural products: An upcoming therapeutic approach to cancer

Food and Chemical Toxicology, Journal Year: 2019, Volume and Issue: 128, P. 240 - 255

Published: April 13, 2019

Language: Английский

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Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 113054 - 113054

Published: April 30, 2022

Cancer is one of the leading causes death and significantly burdens healthcare system. Due to its prevalence, there undoubtedly an unmet need discover novel anticancer drugs. The use natural products as agents acceptable therapeutic approach due accessibility, applicability, reduced cytotoxicity. Natural have been incomparable source drugs in modern era drug discovery. Along with their derivatives analogs, play a major role cancer treatment by modulating microenvironment different signaling pathways. These compounds are effective against several pathways, mainly cell pathways (apoptosis autophagy) embryonic developmental (Notch pathway, Wnt Hedgehog pathway). historical record strong, but investigate current discovery development determine possibility being important future agents. Many target-specific failed provide successful results, which accounts for multi-target characteristics achieve better outcomes. potential be promising makes them area research. This review explores significance inhibiting various that serve drivers carcinogenesis thus pave way developing discovering

Language: Английский

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