The molecular hallmarks of epigenetic control

Nature Reviews Genetics, Год журнала: 2016, Номер 17(8), С. 487 - 500

Опубликована: Июнь 27, 2016

Язык: Английский

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Epigenetic Determinants of Cancer

Cold Spring Harbor Perspectives in Biology, Год журнала: 2016, Номер 8(9), С. a019505 - a019505

Опубликована: Май 18, 2016

Stephen B. Baylin1 and Peter A. Jones2 1Cancer Biology Program, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287 2Van Andel Research Institute, Grand Rapids, Michigan 49503 Correspondence: sbaylin{at}jhmi.edu

Язык: Английский

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Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition

Cold Spring Harbor Perspectives in Biology, Год журнала: 2014, Номер 6(7), С. a018762 - a018762

Опубликована: Июль 1, 2014

Ronen Marmorstein1 and Ming-Ming Zhou2 1Program in Gene Expression Regulation, Wistar Institute, Department of Chemistry, University Pennsylvania, Philadelphia, 19104 2Department Structural Chemical Biology, Icahn School Medicine at Mount Sinai, New York, York 10065 Correspondence: marmor{at}wistar.org

Язык: Английский

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Epigenetic Regulation in Plants

Cold Spring Harbor Perspectives in Biology, Год журнала: 2014, Номер 6(12), С. a019315 - a019315

Опубликована: Дек. 1, 2014

Craig S. Pikaard1 and Ortrun Mittelsten Scheid2 1Department of Biology, Department Molecular Cellular Biochemistry, Howard Hughes Medical Institute, Indiana University, Bloomington, 47405 2Gregor Mendel-Institute Plant Austrian Academy Sciences, 1030 Vienna, Austria Correspondence: ortrun.mittelsten_scheid{at}gmi.oeaw.ac.at

Язык: Английский

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Histone Variants and Epigenetics

Cold Spring Harbor Perspectives in Biology, Год журнала: 2015, Номер 7(1), С. a019364 - a019364

Опубликована: Янв. 1, 2015

Steven Henikoff1 and M. Mitchell Smith2 1Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024 2Department of Microbiology, University Virginia, Charlottesville, Virginia 22908 Correspondence: steveh{at}fhcrc.org

Язык: Английский

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Epigenetics and Human Disease

Cold Spring Harbor Perspectives in Biology, Год журнала: 2016, Номер 8(2), С. a019497 - a019497

Опубликована: Фев. 1, 2016

Huda Y. Zoghbi1,2 and Arthur L. Beaudet2 1Howard Hughes Medical Institute, Baylor College of Medicine, Jan Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, 77030 2Department Molecular Human Genetics, Correspondence: hzoghbi{at}bcm.edu

Язык: Английский

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Nucleosome Remodeling and Epigenetics

Cold Spring Harbor Perspectives in Biology, Год журнала: 2013, Номер 5(9), С. a017905 - a017905

Опубликована: Сен. 1, 2013

Peter B. Becker1 and Jerry L. Workman2 1BioMedical Center, Ludwig-Maximilians-University, D-80336 Munich, Germany 2Stowers Institute for Medical Research, Kansas City, Missouri 64110 Correspondence: pbecker{at}med.uni-muenchen.de; jlw{at}stowers.org

Язык: Английский

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Transcriptional Silencing by Polycomb-Group Proteins

Cold Spring Harbor Perspectives in Biology, Год журнала: 2014, Номер 6(11), С. a019331 - a019331

Опубликована: Ноя. 1, 2014

Ueli Grossniklaus1 and Renato Paro2 1Institute of Plant Biology Zürich-Basel Science Center, University Zürich, CH-8008 Switzerland 2Department Biosystems Engineering, ETH 4058 Basel, Correspondence: grossnik{at}botinst.uzh.ch

Язык: Английский

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Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

Molecular Cell, Год журнала: 2018, Номер 72(2), С. 239 - 249.e5

Опубликована: Авг. 23, 2018

Язык: Английский

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Pioneer transcription factors shape the epigenetic landscape

Journal of Biological Chemistry, Год журнала: 2018, Номер 293(36), С. 13795 - 13804

Опубликована: Март 5, 2018

Pioneer transcription factors have the unique and important role of unmasking chromatin domains during development to allow implementation new cellular programs. Compared with those other factors, this activity implies that pioneer can recognize their target DNA sequences in so-called compacted or "closed" heterochromatin trigger remodeling adjoining landscape provide accessibility nonpioneer factors. Recent studies identified several steps action, namely rapid but weak initial binding stabilization followed by opening loss cytosine-phosphate-guanine (CpG) methylation provides epigenetic memory. Whereas CpG demethylation depends on replication, does not. In Minireview, we highlight properties factor class challenges understanding mechanism action.

Язык: Английский

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