The molecular hallmarks of epigenetic control

Nature Reviews Genetics, Год журнала: 2016, Номер 17(8), С. 487 - 500

Опубликована: Июнь 27, 2016

Язык: Английский

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Epigenetic Determinants of Cancer

Cold Spring Harbor Perspectives in Biology, Год журнала: 2016, Номер 8(9), С. a019505 - a019505

Опубликована: Май 18, 2016

Stephen B. Baylin1 and Peter A. Jones2 1Cancer Biology Program, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287 2Van Andel Research Institute, Grand Rapids, Michigan 49503 Correspondence: sbaylin{at}jhmi.edu

Язык: Английский

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DNA Methylation in Mammals

Cold Spring Harbor Perspectives in Biology, Год журнала: 2014, Номер 6(5), С. a019133 - a019133

Опубликована: Май 1, 2014

En Li1 and Yi Zhang2 1China Novartis Institutes for BioMedical Research, Pudong New Area, Shanghai 201203, China 2Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115 Correspondence: en.li{at}novartis.com

Язык: Английский

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Genomic Imprinting in Mammals

Cold Spring Harbor Perspectives in Biology, Год журнала: 2014, Номер 6(2), С. a018382 - a018382

Опубликована: Фев. 1, 2014

Denise P. Barlow1 and Marisa S. Bartolomei2 1CeMM Research Center for Molecular Medicine of the Austrian Academy Sciences, CeMM, 1090 Vienna, Austria 2Department Cell Developmental Biology, University Pennsylvania Perelman School Medicine, Philadelphia, 19104-6148 Correspondence: dbarlow{at}cemm.oeaw.ac.at bartolom{at}mail.med.upenn.edu

Язык: Английский

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The interplay of epigenetic marks during stem cell differentiation and development

Nature Reviews Genetics, Год журнала: 2017, Номер 18(11), С. 643 - 658

Опубликована: Авг. 14, 2017

Язык: Английский

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Epigenetic Regulation in Plants

Cold Spring Harbor Perspectives in Biology, Год журнала: 2014, Номер 6(12), С. a019315 - a019315

Опубликована: Дек. 1, 2014

Craig S. Pikaard1 and Ortrun Mittelsten Scheid2 1Department of Biology, Department Molecular Cellular Biochemistry, Howard Hughes Medical Institute, Indiana University, Bloomington, 47405 2Gregor Mendel-Institute Plant Austrian Academy Sciences, 1030 Vienna, Austria Correspondence: ortrun.mittelsten_scheid{at}gmi.oeaw.ac.at

Язык: Английский

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Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

Trends in Biochemical Sciences, Год журнала: 2017, Номер 43(1), С. 61 - 74

Опубликована: Ноя. 24, 2017

Язык: Английский

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The genetic basis of disease

Essays in Biochemistry, Год журнала: 2018, Номер 62(5), С. 643 - 723

Опубликована: Дек. 3, 2018

Genetics plays a role, to greater or lesser extent, in all diseases. Variations our DNA and differences how that functions (alone combinations), alongside the environment (which encompasses lifestyle), contribute disease processes. This review explores genetic basis of human disease, including single gene disorders, chromosomal imbalances, epigenetics, cancer complex considers understanding technological advances can be applied provision appropriate diagnosis, management therapy for patients.

Язык: Английский

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Bioinformatics and Drug Discovery

Current Topics in Medicinal Chemistry, Год журнала: 2017, Номер 17(15), С. 1709 - 1726

Опубликована: Апрель 26, 2017

Bioinformatic analysis can not only accelerate drug target identification and candidate screening refinement, but also facilitate characterization of side effects predict resistance. High-throughput data such as genomic, epigenetic, genome architecture, cistromic, transcriptomic, proteomic, ribosome profiling have all made significant contribution to mechanismbased discovery repurposing. Accumulation protein RNA structures, well development homology modeling structure simulation, coupled with large databases small molecules metabolites, paved the way for more realistic protein-ligand docking experiments informative virtual screening. I present conceptual framework that drives collection these high-throughput data, summarize utility potential mining in discovery, outline a few inherent limitations software point out news ways refine diverse types highlight commonly used relevant discovery. Keywords: Drug target, candidate, screening, Genomics, Epigenetics, Transcriptomics, Proteomics, Structure.

Язык: Английский

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Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging

Cell, Год журнала: 2020, Номер 182(1), С. 12 - 23

Опубликована: Июль 1, 2020

Язык: Английский

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