A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning

Nature Neuroscience, Год журнала: 2017, Номер 20(4), С. 559 - 570

Опубликована: Март 6, 2017

Язык: Английский

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Associative Learning in Invertebrates

Cold Spring Harbor Perspectives in Biology, Год журнала: 2015, Номер 7(5), С. a021709 - a021709

Опубликована: Апрель 15, 2015

Robert D. Hawkins1,2 and John H. Byrne3 1Department of Neuroscience, Columbia University, New York, York 10032 2New State Psychiatric Institute, 3Department Neurobiology Anatomy, The University Texas Medical School at Houston, 77030 Correspondence: rdh1{at}columbia.edu

Язык: Английский

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A brainwide atlas of synapses across the mouse life span

Science, Год журнала: 2020, Номер 369(6501), С. 270 - 275

Опубликована: Июнь 11, 2020

Brain synapses through the life span Excitatory connect neurons in brain to build circuits that enable behavior. Cizeron et al. surveyed mouse from birth old age and present data as a community resource, Mouse Lifespan Synaptome Atlas (see Perspective by Micheva ). Molecular morphological features defined 37 subtypes of synapses. Although synapse density generally increased early development declined age, details differed different areas. Science this issue p. 270 ; see also 253

Язык: Английский

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High-throughput sequencing of single neuron projections reveals spatial organization in the olfactory cortex

Cell, Год журнала: 2022, Номер 185(22), С. 4117 - 4134.e28

Опубликована: Окт. 1, 2022

Язык: Английский

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Terahertz Photons Improve Cognitive Functions in Posttraumatic Stress Disorder

Research, Год журнала: 2023, Номер 6

Опубликована: Янв. 1, 2023

Posttraumatic stress disorder (PTSD) is a serious psychosis leading to cognitive impairment. To restore functions for patients, the main treatments are based on medication or rehabilitation training but with limited effectiveness and strong side effects. Here, we demonstrate new treatment approach PTSD by using terahertz (THz) photons stimulating hippocampal CA3 subregion. We verified that this method can nonthermally function in rats vivo. After THz photon irradiation, rats’ recognitive index improved about 10% novel object recognition test, accuracy 100% shuttler box numbers identify target was 5 times lower Barnes maze rate of staying arm increased approximately 40% Y-maze test. Further experimental studies found (34.5 THz) irradiation could improve expression NR2B (increased nearly 40%) phosphorylated 50%). In addition, molecular dynamics simulations showed at frequency 34.5 mainly absorbed pocket glutamate receptors rather than molecules. Moreover, binding between molecules photons. This study offers nondrug, nonthermal regulate excitatory neurotransmitter (glutamate) NR2B. By increasing synaptic plasticity, it effectively improves animals PTSD, providing promising strategy NR2B-related disorders.

Язык: Английский

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The cognitive impact of light: illuminating ipRGC circuit mechanisms

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(3), С. 159 - 175

Опубликована: Янв. 26, 2024

Язык: Английский

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Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation

Neuron, Год журнала: 2018, Номер 98(5), С. 992 - 1004.e4

Опубликована: Май 10, 2018

Язык: Английский

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Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus

Proceedings of the National Academy of Sciences, Год журнала: 2020, Номер 118(1)

Опубликована: Дек. 23, 2020

Significance Synaptic plasticity in the hippocampus is important for learning and memory formation. In particular, homeostatic synaptic enables neurons to restore their activity levels response chronic neuronal changes. While astrocytes modulate functions via secretion of factors, underlying molecular mechanisms remain unclear. Here, we show that suppression hippocampal increases cytokine IL-33 release from CA1 region. Activation its ST2 receptor complex promotes functional excitatory synapse Moreover, IL-33/ST2 signaling blockade-induced increase synapses vivo spatial This study suggests astrocyte-secreted acts as a negative feedback control signal regulate plasticity.

Язык: Английский

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Effects of acute alcohol on excitability in the CNS

Neuropharmacology, Год журнала: 2017, Номер 122, С. 36 - 45

Опубликована: Май 4, 2017

Язык: Английский

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Integration of Plasticity Mechanisms within a Single Sensory Neuron of C. elegans Actuates a Memory

Neuron, Год журнала: 2018, Номер 97(2), С. 356 - 367.e4

Опубликована: Янв. 1, 2018

Язык: Английский

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