Talanta, Год журнала: 2025, Номер unknown, С. 128052 - 128052
Опубликована: Апрель 1, 2025
Язык: Английский
Neuron, Год журнала: 2023, Номер 112(1), С. 25 - 40
Опубликована: Окт. 18, 2023
Язык: Английский
Процитировано
47
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(9)
Опубликована: Фев. 23, 2024
Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances alleviate psychopathology. Conversely, poor disrupt clock-controlled processes. Despite progress elucidating underlying mechanisms, a cohesive approach integrates dynamic interactions between disorder with both processes is lacking. This review synthesizes recent evidence for dysfunction as transdiagnostic contributor range disorders, an emphasis on biological mechanisms. We highlight observations from adolescent young adults, who at greatest risk developing whom early detection intervention promise benefit. In particular, we aim a) integrate factors implicated pathophysiology treatment mood, anxiety, psychosis spectrum perspective; b) need reframe existing knowledge adopt integrated which recognizes interaction factors; c) identify important gaps opportunities further research.
Язык: Английский
Процитировано
30
EBioMedicine, Год журнала: 2024, Номер 103, С. 105094 - 105094
Опубликована: Апрель 4, 2024
Sleep and circadian rhythm disruptions are common in patients with mood disorders. The intricate relationship between these has been investigated, but their causal dynamics remain unknown.
Язык: Английский
Процитировано
22
Bipolar Disorders, Год журнала: 2021, Номер 24(3), С. 232 - 263
Опубликована: Дек. 1, 2021
Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many these processes are regulated by circadian function, rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence neurobiological behavioral mechanisms pertinent BD.Drawing upon expertise animal models, biomarkers, physiology, behavior, CTF analyzed the relevant cross-disciplinary literature precisely frame discussion around disruption BD, highlight key findings, first time integrate findings across levels analysis develop an internally consistent, coherent theoretical framework.Evidence from multiple sources implicates system mood regulation, with corresponding associations BD diagnoses mood-related traits reported genetic, cellular, physiological, domains. However, does not appear be specific is present variety high-risk, prodromal, syndromic psychiatric disorders. Substantial variability ambiguity among definitions, concepts assumptions research have limited replication emergence consensus findings.Future rhythms its role warranted. Well-powered studies that carefully define between BD-related chronobiologically-related constructs, will most illuminating.
Язык: Английский
Процитировано
79
Nature Mental Health, Год журнала: 2023, Номер 1(11), С. 853 - 862
Опубликована: Окт. 9, 2023
Язык: Английский
Процитировано
39
Trends in Pharmacological Sciences, Год журнала: 2023, Номер 44(10), С. 689 - 704
Опубликована: Авг. 28, 2023
Mood disorders account for a significant global disease burden, and pharmacological innovation is needed as existing medications are suboptimal. A wide range of evidence implicates circadian sleep dysfunction in the pathogenesis mood disorders, there growing interest these chronobiological pathways focus treatment innovation. We review contemporary three promising areas circadian-clock-based therapeutics disorders: targeting system informed by mechanistic molecular advances; time-tailoring medications; personalizing using parameters. also consider limitations challenges accelerating development new circadian-informed pharmacotherapies disorders.
Язык: Английский
Процитировано
25
Social Psychiatry and Psychiatric Epidemiology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
2
Deleted Journal, Год журнала: 2025, Номер 2(1)
Опубликована: Март 13, 2025
Abstract Light is a crucial environmental factor that influences various aspects of life, including physiological and psychological processes. While light well-known for its role in enabling humans other animals to perceive their surroundings, influence extends beyond vision. Importantly, affects our internal time-keeping system, the circadian clock, which regulates daily rhythms biochemical processes, ultimately impacting mood behaviour. The 24-h availability can have profound effects on well-being, both physically mentally, as seen cases jet lag shift work. This review summarizes intricate relationships between light, mood-related behaviours, exploring underlying mechanisms implications health.
Язык: Английский
Процитировано
1
World Psychiatry, Год журнала: 2024, Номер 23(1), С. 150 - 151
Опубликована: Янв. 12, 2024
The Mental Health Priority Area of the Wellcome Trust recently posited that sleep and circadian rhythm disturbances (SCRDs) are a plausible nexus for linking aspects biology, phenomenology, course treatment major mood, anxiety psychotic disorders1. This emphasis fits well with currently spreading trend to develop more effective scalable forms indicated prevention, early intervention, secondary prevention (of both primary illness progression physical illness). focus on SCRDs also aligns broader studies as why some specific periods life (e.g., adolescence, postnatal, menopause, late life), accompanied by large shifts in 24-hour patterns sleep-wake cycle, associated elevated risk mood disorders2. Along same line, several research groups have now prioritized understanding chronobiology advance management all phases disorders Chronobiology Task Force International Society Bipolar Disorders)3. Developments this area been greatly assisted increased basic biology homeostatic system – recognized Nobel Prize Medicine or Physiology 2017. Of note has delineation molecular architecture core clock, along revelation system's stability is fundamentally regulated common environmental factors, such timing, intensity spectrum light exposure4. It appears there brain circuits mammals which regulates learning activity, not wholly dependent mediation master timekeeper (the suprachiasmatic nucleus), including identified region perihabenular nucleus. discovery new light-sensitive extreme interest clinical psychiatry psychiatric epidemiology. An intriguing finding from over 80,000 adults UK Biobank was exposure artificial at night only rates depression, but an incidence other mental disorders, bipolar disorder, generalized disorder post-traumatic stress higher self-harm behavior psychosis-like experiences4. As predicted basis evidence day-time synchronizer clock mammals, success bright therapy during day lower disorders4. Triangulation animal models, experimental humans, epidemiology provided strong role daily good health. A possible causative etiology pathophysiology least may surprise those who think these epiphenomena accompany most disorders. However, recent discoveries regarding regulation many physiologic behavioral parameters system2, 3, alongside developments longitudinal epidemiology5, challenged assumption. Indeed, it strongly established across clinical, laboratory field-based settings related SCRD-relevant features, stable trait-like profiles delayed phase, long time, preference eveningness2, 3; melatonin body temperature rhythms; abnormal time relationships between phase markers cycle6. Accumulating suggests dysregulation likely be cross-diagnostic rather than disorder-specific3, especially key affective instability), impulsivity), cognitive disinhibition), immune-metabolic insulin resistance, raised C-reactive protein blood levels) phenotypes2. Empirical advances predictive significance prior first episode evident domain. SCRD-related factors eveningness social rhythms observed at-risk offspring parent disorder) youth meta-analytic prospective pre-existing SCRD 40% onset disorder7. study 2,000 adolescents young seeking help early-intervention clinics found disturbance transition earlier later stage disorders8. Studies focusing intensive measurement within- between-day dynamics motor activity appear dysregulated cross-reactive control populations highlighted need investigate biological interfaces systems, one candidate3. potentially important target personalized subgroup treatments selective serotonin reuptake inhibitors (SSRIs) increase sensitivity light, thereby destabilize individuals, concern9. requires urgent replication extension examination positive negative impacts exposures interventions, activation, restriction, stabilizers, antipsychotic agents, antidepressants. Some agents orexin antagonists, melatonin-based antidepressants) older pharmacotherapies lithium) do enhance stabilization systems models small patients disorders3. Further testing effects medications, potential treatment-relevant subtyping, highly warranted2, 9. There hurdles wider application insights. Accurate, real-time, repeated detection true timing internal its alignment external light-dark remains goal. Current measures largely limited either intensive, expensive, in-lab methods, indirect inferences wearable recordings sleep. Hence, clear development novel methods based gene expression, metabolic peripheral urinary markers. More sophisticated modelling techniques, tracking symptom clusters objective illness, then longitudinally, required unpick direction causation phenomena. Increased coordinated global investment timely, lead genuine therapeutic
Язык: Английский
Процитировано
8
Acta Paediatrica, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Cyberbullying has been linked to various adverse psychological outcomes, but prospective associations with manic symptoms in early adolescents remain unexplored. We examined the relationship between cyberbullying victimisation and a diverse cohort of American children adolescents. analysed data from Adolescent Brain Cognitive Development study period 2 follow-up (2018-2020) 3 (2019-2021). Linear regression models estimated (lifetime past 12 months) symptoms. adjusted for age, sex, race ethnicity, household income, parental education, symptoms, anxiety, depression, total screen time, site. The average age our 9095 (51.3% male) was 12.0 ± 0.7 years. prevalence 9.2% lifetime 6.1% months. Adjusting covariates, associated 0.41 higher symptom sum score (95% CI 0.18-0.65, p = 0.001), 12-month 0.38 0.11-0.66, 0.007). These findings highlight need identification intervention experiencing mitigate its effects on mental health.
Язык: Английский
Процитировано
1