The sleep–circadian interface: A window into mental disorders

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 23, 2024

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances alleviate psychopathology. Conversely, poor disrupt clock-controlled processes. Despite progress elucidating underlying mechanisms, a cohesive approach integrates dynamic interactions between disorder with both processes is lacking. This review synthesizes recent evidence for dysfunction as transdiagnostic contributor range disorders, an emphasis on biological mechanisms. We highlight observations from adolescent young adults, who at greatest risk developing whom early detection intervention promise benefit. In particular, we aim a) integrate factors implicated pathophysiology treatment mood, anxiety, psychosis spectrum perspective; b) need reframe existing knowledge adopt integrated which recognizes interaction factors; c) identify important gaps opportunities further research.

Language: Английский

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Causal dynamics of sleep, circadian rhythm, and mood symptoms in patients with major depression and bipolar disorder: insights from longitudinal wearable device data

EBioMedicine, Journal Year: 2024, Volume and Issue: 103, P. 105094 - 105094

Published: April 4, 2024

Sleep and circadian rhythm disruptions are common in patients with mood disorders. The intricate relationship between these has been investigated, but their causal dynamics remain unknown.

Language: Английский

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Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi‐disciplinary literature review and agenda for future research from the ISBD task force on chronobiology

Bipolar Disorders, Journal Year: 2021, Volume and Issue: 24(3), P. 232 - 263

Published: Dec. 1, 2021

Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many these processes are regulated by circadian function, rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence neurobiological behavioral mechanisms pertinent BD.Drawing upon expertise animal models, biomarkers, physiology, behavior, CTF analyzed the relevant cross-disciplinary literature precisely frame discussion around disruption BD, highlight key findings, first time integrate findings across levels analysis develop an internally consistent, coherent theoretical framework.Evidence from multiple sources implicates system mood regulation, with corresponding associations BD diagnoses mood-related traits reported genetic, cellular, physiological, domains. However, does not appear be specific is present variety high-risk, prodromal, syndromic psychiatric disorders. Substantial variability ambiguity among definitions, concepts assumptions research have limited replication emergence consensus findings.Future rhythms its role warranted. Well-powered studies that carefully define between BD-related chronobiologically-related constructs, will most illuminating.

Language: Английский

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Circadian rhythms and mood disorders: Time to see the light

Neuron, Journal Year: 2023, Volume and Issue: 112(1), P. 25 - 40

Published: Oct. 18, 2023

Language: Английский

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Day and night light exposure are associated with psychiatric disorders: an objective light study in >85,000 people

Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(11), P. 853 - 862

Published: Oct. 9, 2023

Language: Английский

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Circadian biology to advance therapeutics for mood disorders

Trends in Pharmacological Sciences, Journal Year: 2023, Volume and Issue: 44(10), P. 689 - 704

Published: Aug. 28, 2023

Mood disorders account for a significant global disease burden, and pharmacological innovation is needed as existing medications are suboptimal. A wide range of evidence implicates circadian sleep dysfunction in the pathogenesis mood disorders, there growing interest these chronobiological pathways focus treatment innovation. We review contemporary three promising areas circadian-clock-based therapeutics disorders: targeting system informed by mechanistic molecular advances; time-tailoring medications; personalizing using parameters. also consider limitations challenges accelerating development new circadian-informed pharmacotherapies disorders.

Language: Английский

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Screen time and manic symptoms in early adolescents: prospective findings from the Adolescent Brain Cognitive Development Study

Social Psychiatry and Psychiatric Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

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Cyberbullying Victimisation Was Associated With Greater Manic Symptoms in Early Adolescence: A Prospective Cohort Study

Acta Paediatrica, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Cyberbullying has been linked to various adverse psychological outcomes, but prospective associations with manic symptoms in early adolescents remain unexplored. We examined the relationship between cyberbullying victimisation and a diverse cohort of American children adolescents. analysed data from Adolescent Brain Cognitive Development study period 2 follow-up (2018-2020) 3 (2019-2021). Linear regression models estimated (lifetime past 12 months) symptoms. adjusted for age, sex, race ethnicity, household income, parental education, symptoms, anxiety, depression, total screen time, site. The average age our 9095 (51.3% male) was 12.0 ± 0.7 years. prevalence 9.2% lifetime 6.1% months. Adjusting covariates, associated 0.41 higher symptom sum score (95% CI 0.18-0.65, p = 0.001), 12-month 0.38 0.11-0.66, 0.007). These findings highlight need identification intervention experiencing mitigate its effects on mental health.

Language: Английский

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Sleep and circadian rhythm disturbances: plausible pathways to major mental disorders?

World Psychiatry, Journal Year: 2024, Volume and Issue: 23(1), P. 150 - 151

Published: Jan. 12, 2024

The Mental Health Priority Area of the Wellcome Trust recently posited that sleep and circadian rhythm disturbances (SCRDs) are a plausible nexus for linking aspects biology, phenomenology, course treatment major mood, anxiety psychotic disorders1. This emphasis fits well with currently spreading trend to develop more effective scalable forms indicated prevention, early intervention, secondary prevention (of both primary illness progression physical illness). focus on SCRDs also aligns broader studies as why some specific periods life (e.g., adolescence, postnatal, menopause, late life), accompanied by large shifts in 24-hour patterns sleep-wake cycle, associated elevated risk mood disorders2. Along same line, several research groups have now prioritized understanding chronobiology advance management all phases disorders Chronobiology Task Force International Society Bipolar Disorders)3. Developments this area been greatly assisted increased basic biology homeostatic system – recognized Nobel Prize Medicine or Physiology 2017. Of note has delineation molecular architecture core clock, along revelation system's stability is fundamentally regulated common environmental factors, such timing, intensity spectrum light exposure4. It appears there brain circuits mammals which regulates learning activity, not wholly dependent mediation master timekeeper (the suprachiasmatic nucleus), including identified region perihabenular nucleus. discovery new light-sensitive extreme interest clinical psychiatry psychiatric epidemiology. An intriguing finding from over 80,000 adults UK Biobank was exposure artificial at night only rates depression, but an incidence other mental disorders, bipolar disorder, generalized disorder post-traumatic stress higher self-harm behavior psychosis-like experiences4. As predicted basis evidence day-time synchronizer clock mammals, success bright therapy during day lower disorders4. Triangulation animal models, experimental humans, epidemiology provided strong role daily good health. A possible causative etiology pathophysiology least may surprise those who think these epiphenomena accompany most disorders. However, recent discoveries regarding regulation many physiologic behavioral parameters system2, 3, alongside developments longitudinal epidemiology5, challenged assumption. Indeed, it strongly established across clinical, laboratory field-based settings related SCRD-relevant features, stable trait-like profiles delayed phase, long time, preference eveningness2, 3; melatonin body temperature rhythms; abnormal time relationships between phase markers cycle6. Accumulating suggests dysregulation likely be cross-diagnostic rather than disorder-specific3, especially key affective instability), impulsivity), cognitive disinhibition), immune-metabolic insulin resistance, raised C-reactive protein blood levels) phenotypes2. Empirical advances predictive significance prior first episode evident domain. SCRD-related factors eveningness social rhythms observed at-risk offspring parent disorder) youth meta-analytic prospective pre-existing SCRD 40% onset disorder7. study 2,000 adolescents young seeking help early-intervention clinics found disturbance transition earlier later stage disorders8. Studies focusing intensive measurement within- between-day dynamics motor activity appear dysregulated cross-reactive control populations highlighted need investigate biological interfaces systems, one candidate3. potentially important target personalized subgroup treatments selective serotonin reuptake inhibitors (SSRIs) increase sensitivity light, thereby destabilize individuals, concern9. requires urgent replication extension examination positive negative impacts exposures interventions, activation, restriction, stabilizers, antipsychotic agents, antidepressants. Some agents orexin antagonists, melatonin-based antidepressants) older pharmacotherapies lithium) do enhance stabilization systems models small patients disorders3. Further testing effects medications, potential treatment-relevant subtyping, highly warranted2, 9. There hurdles wider application insights. Accurate, real-time, repeated detection true timing internal its alignment external light-dark remains goal. Current measures largely limited either intensive, expensive, in-lab methods, indirect inferences wearable recordings sleep. Hence, clear development novel methods based gene expression, metabolic peripheral urinary markers. More sophisticated modelling techniques, tracking symptom clusters objective illness, then longitudinally, required unpick direction causation phenomena. Increased coordinated global investment timely, lead genuine therapeutic

Language: Английский

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Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(1), P. e3001688 - e3001688

Published: Jan. 24, 2023

Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles observed human behavior and physiology, no study has measured the brain. Here, we identify transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times 3 PM/AM) dorsolateral prefrontal cortex, region involved cognition. Subjects with schizophrenia (SZ) lose genes associated unfolded protein response neuronal structural maintenance. Moreover, mitochondrial function translation, which normally transitions, instead SZ, suggesting suboptimal timing of these essential processes.

Language: Английский

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