Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 17, 2024
Despite
the
advanced
technologies
and
global
attention
on
cancer
treatment
strategies,
continues
to
claim
lives
adversely
affects
socio-economic
development.
Although
combination
therapies
were
anticipated
eradicate
this
disease,
resilient
restorative
nature
of
cancers
allows
them
proliferate
at
expense
host
immune
cells
energetically.
This
proliferation
is
driven
by
metabolic
profiles
specific
type
patient.
An
emerging
field
exploring
reprogramming
(MR)
predict
effective
treatments.
mini-review
discusses
recent
advancements
in
MR
that
have
contributed
predictive,
preventive,
precision
medicine.
Current
perspectives
mechanisms
various
types
prospects
for
personalized
medicine
are
essential
optimizing
outputs
necessary
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Окт. 11, 2023
The
role
of
tumor
interaction
with
stromal
components
during
carcinogenesis
is
crucial
for
the
design
efficient
cancer
treatment
approaches.
It
widely
admitted
that
hypoxic
stress
associated
aggressiveness
and
thus
impacts
susceptibility
resistance
to
different
types
treatments.
Notable
biological
processes
hypoxia
functions
in
include
its
regulation
heterogeneity
plasticity.
While
has
been
reported
as
a
major
player
survival
dissemination
regulation,
significance
inducible
factors
stem
cell
development
remains
poorly
understood.
Several
reports
indicate
emergence
cells
addition
their
phenotype
function
within
microenvironment
progression.
In
this
respect,
evidence
showed
are
key
elements
intratumoral
more
importantly
responsible
relapse
escape
This
paper
briefly
reviews
our
current
knowledge
between
stemness
acquisition
maintenance.
Our
review
extensively
covers
influence
on
formation
maintenance
discusses
potential
targeting
hypoxia-induced
alterations
expression
so
far
known
markers
therapy
We
believe
better
integrated
understanding
effect
might
lead
new
strategies
exploiting
hypoxia-associated
pathways
clinical
setting
order
overcome
mechanisms.
More
importantly,
at
present
time,
efforts
oriented
towards
innovative
therapeutical
approaches
specifically
target
cells.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 31, 2024
Lung
cancer
(LC)
is
one
of
the
most
common
worldwide.
Tumor-associated
macrophages
(TAMs)
are
important
component
tumor
microenvironment
(TME)
and
closely
related
to
stages
occurrence,
development,
metastasis.
Macrophages
plastic
can
differentiate
into
different
phenotypes
functions
under
influence
signaling
pathways
in
TME.
The
classically
activated
(M1-like)
alternatively
(M2-like)
represent
two
polarization
states
macrophages.
M1
exhibit
anti-tumor
functions,
while
M2
considered
support
cell
survival
Macrophage
involves
complex
pathways,
blocking
or
regulating
these
enhance
macrophages'
effects
has
become
a
research
hotspot
recent
years.
At
same
time,
there
have
been
new
discoveries
regarding
modulation
TAMs
towards
an
phenotype
by
synthetic
natural
drug
components.
Nanotechnology
better
achieve
combination
therapy
targeted
delivery
drugs,
maximizing
efficacy
drugs
minimizing
side
effects.
Up
now,
nanomedicines
targeting
various
active
substances
for
reprogramming
made
significant
progress.
In
this
review,
we
primarily
provided
comprehensive
overview
crosstalk
between
cells
LC
microenvironment.
Additionally,
latest
advancements
novel
nano-based
systems
(NDDSs)
that
target
were
also
reviewed.
Finally,
discussed
prospects
as
therapeutic
targets
barriers
clinical
translation.
The
fight
against
lung
adenocarcinoma
(LUAD)
is
challenged
by
tumor
microenvironment
(TME)-mediated
drug
resistance,
which
limits
effective
treatment.
This
study
examines
the
LUAD
TME
and
identifies
four
distinct
subtypes
through
multi-omics
profiling:
immune-rich,
immune-exhausted,
stromal-dominant,
TME-desert.
Each
subtype
has
unique
molecular
features,
diversity,
links
to
clinical
outcomes.
Immune-rich
respond
better
immune
checkpoint
inhibitors,
while
stromal-dominant
TME-desert
show
resistance
treatment
poor
prognosis.
Molecular
analysis
uncovers
subtype-specific
mutations,
chromosomal
instability,
altered
signaling
pathways,
pointing
potential
therapeutic
targets.
In
silico
screening
promising
treatments
for
resistant
subtypes.
These
findings,
validated
in
independent
cohorts,
highlight
critical
role
of
response,
providing
insights
personalized
strategies
LUAD.
Anti-Cancer Drugs,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Tumor-associated
macrophages
play
a
critical
role
in
regulating
the
progression
of
lung
adenocarcinoma
(LUAD).
Platelet-derived
protein
thrombospondin-2
(THBS2)
has
been
identified
as
tumor
marker
and
is
known
to
be
overexpressed
LUAD.
However,
specific
THBS2
M2
macrophage
polarization
within
LUAD
remains
unclear.
We
conducted
bioinformatics
analyses
assess
clinical
significance
expression
LUAD,
which
was
subsequently
validated
using
quantitative
PCR.
examined
relationship
between
infiltration.
A
coculture
system
cells
M0
established
investigate
influence
on
infiltration
through
immunofluorescence
ELISA.
explored
impact
fatty
acid
metabolism
(FAM)
oil
red
O
staining
relevant
kits
elucidated
proliferation
cell
counting
kit-8
(CCK-8)
colony
formation
assays.
Western
blot
employed
changes
Bax
Bcl-2.
highly
expressed
associated
with
poor
prognosis
patients.
In-vitro
experiments
demonstrated
that
silencing
significantly
inhibited
polarization.
primarily
activated
FAM
pathways,
inducing
promoting
proliferation.
enhanced
by
induce
These
findings
provide
theoretical
basis
for
targeting
novel
therapeutic
strategy
