Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 704, С. 149690 - 149690
Опубликована: Фев. 17, 2024
Язык: Английский
Experimental Cell Research, Год журнала: 2025, Номер 448(2), С. 114567 - 114567
Опубликована: Апрель 21, 2025
Язык: Английский
Процитировано
0
Critical Reviews in Eukaryotic Gene Expression, Год журнала: 2023, Номер 33(6), С. 73 - 86
Опубликована: Янв. 1, 2023
As a newly discovered mechanism of cell death, disulfidptosis is expected to help diagnose and treat bladder cancer patients. First, data obtained from public databases were analyzed using bioinformatics techniques. SVA packages used combine different remove batch effects. Then, the differential analysis COX regression ten disulfidptosis-related genes identified four prognostically relevant differentially expressed which subjected Lasso for further screening obtain model-related output model formulas. The predictive power prognostic was verified immunohistochemistry in HPA database. Pathway enrichment performed identify development progression. tumor microenvironment immune infiltration patients with risk scores personalize treatment. information IMvigor210 database predict responsiveness immunotherapy. oncoPredict package sensitivity at chemotherapy drugs, its results have some reference value guiding clinical use. After confirming that our could reliably prognosis patients, combined create nomogram accurately calculate patient survival rate. A containing three (NDUFA11, RPN1, SLC3A2) constructed. functional immune-related indicated high-risk group candidates drug susceptibility can guide more accurate treatment survival. NDUFA11, SLC3A2 are potential novel biomarkers diagnosis cancer. comprehensive profiles benefit
Язык: Английский
Процитировано
9
International Journal of Biological Sciences, Год журнала: 2023, Номер 19(15), С. 4915 - 4930
Опубликована: Янв. 1, 2023
Breast cancer is the most common affecting women worldwide.Investigating metabolism in breast may accelerate exploitation of new therapeutic options for immunotherapies.Metabolic reprogramming can confer cells (BCCs) with a survival advantage tumor microenvironment (TME) and metabolic alterations cancer, corresponding byproducts affect function tumor-associated macrophages (TAMs).Additionally, TAMs undergo response to signals present TME, which their progression.Here, we review crosstalk between BCCs terms glucose, lipids, amino acids, iron, adenosine metabolism.Summaries inhibitors that target metabolism-related processes or within have also served as valuable inspiration novel approaches fight against this disease.This provides perspectives on targeted anticancer therapies combine immunity metabolism.
Язык: Английский
Процитировано
9
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июль 31, 2024
Lung cancer (LC) is one of the most common worldwide. Tumor-associated macrophages (TAMs) are important component tumor microenvironment (TME) and closely related to stages occurrence, development, metastasis. Macrophages plastic can differentiate into different phenotypes functions under influence signaling pathways in TME. The classically activated (M1-like) alternatively (M2-like) represent two polarization states macrophages. M1 exhibit anti-tumor functions, while M2 considered support cell survival Macrophage involves complex pathways, blocking or regulating these enhance macrophages' effects has become a research hotspot recent years. At same time, there have been new discoveries regarding modulation TAMs towards an phenotype by synthetic natural drug components. Nanotechnology better achieve combination therapy targeted delivery drugs, maximizing efficacy drugs minimizing side effects. Up now, nanomedicines targeting various active substances for reprogramming made significant progress. In this review, we primarily provided comprehensive overview crosstalk between cells LC microenvironment. Additionally, latest advancements novel nano-based systems (NDDSs) that target were also reviewed. Finally, discussed prospects as therapeutic targets barriers clinical translation.
Язык: Английский
Процитировано
3
Heliyon, Год журнала: 2024, Номер 10(17), С. e36839 - e36839
Опубликована: Авг. 24, 2024
Tumor-associated macrophages play an important role in the tumor immune microenvironment, and regulating function of tumor-associated has therapeutic potential therapy. Mature could migrate to influencing multiple factors such as cell proliferation, invasion, metastasis, extracellular matrix remodeling, suppression, drug resistance. As a major component crosstalk with other cells. Currently, have garnered considerable attention therapy, broadening spectrum selection some extent, thereby aiding mitigating prevailing clinical resistance dilemma. This article summarizes recent advances concerning immunology, targeting mechanisms for treatment, new developments, existing challenges, offering insights future approaches. In addition, this paper summarized impact on current therapies, discussed advantages disadvantages targeted therapy compared predicted issues that need be focused on.
Язык: Английский
Процитировано
3
Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 29, 2024
Язык: Английский
Процитировано
3
Frontiers in Oncology, Год журнала: 2023, Номер 13
Опубликована: Окт. 11, 2023
The role of tumor interaction with stromal components during carcinogenesis is crucial for the design efficient cancer treatment approaches. It widely admitted that hypoxic stress associated aggressiveness and thus impacts susceptibility resistance to different types treatments. Notable biological processes hypoxia functions in include its regulation heterogeneity plasticity. While has been reported as a major player survival dissemination regulation, significance inducible factors stem cell development remains poorly understood. Several reports indicate emergence cells addition their phenotype function within microenvironment progression. In this respect, evidence showed are key elements intratumoral more importantly responsible relapse escape This paper briefly reviews our current knowledge between stemness acquisition maintenance. Our review extensively covers influence on formation maintenance discusses potential targeting hypoxia-induced alterations expression so far known markers therapy We believe better integrated understanding effect might lead new strategies exploiting hypoxia-associated pathways clinical setting order overcome mechanisms. More importantly, at present time, efforts oriented towards innovative therapeutical approaches specifically target cells.
Язык: Английский
Процитировано
8
Gene, Год журнала: 2023, Номер 895, С. 147975 - 147975
Опубликована: Ноя. 8, 2023
Язык: Английский
Процитировано
8
International Journal of General Medicine, Год журнала: 2023, Номер Volume 16, С. 1713 - 1733
Опубликована: Май 1, 2023
Non-small cell lung cancer (NSCLC) is currently a problem in the clinic and society. Tumor-related macrophages (TAMs) tumor microenvironment (TME) play vital role development of NSCLC.Bioinformatics was used to analyze Indoleamine 2,3-dioxygenase 1 (IDO1) NSCLC correlation its expression with CD163 expression. The IDO1 measured by immunohistochemistry, their colocalization assessed immunofluorescence. M2 macrophage polarization induced, coculture model cells established.Bioinformatics analysis showed that promoted metastasis differentiation inhibited DNA repair. Moreover, positively correlated We discovered related differentiation. In vitro, we increased invasion, proliferation, cells.In conclusion, determined can regulate TAMs promote progression NSCLC, which provides partial theoretical evidence for use inhibitors treatment NSCLC.
Язык: Английский
Процитировано
7
International Immunopharmacology, Год журнала: 2024, Номер 129, С. 111605 - 111605
Опубликована: Фев. 4, 2024
Язык: Английский
Процитировано
2