Periodontal disease and the incident risk of diabetes mellitus in Japanese men and women: a 12-year cohort study

Diabetology International, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

Язык: Английский

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Medication Purchases Are Associated With the Number of Dental Treatments

Clinical and Experimental Dental Research, Год журнала: 2025, Номер 11(3)

Опубликована: Май 23, 2025

ABSTRACT Objectives Little is known whether the number of systemic medications, indicating worsened general health, affects dental appointments needed. The hypothesis that patients purchasing more medications would have an increased and respective need for treatments than who do not purchase as many medications. Materials Methods Our cohort consists 1495 participants from Stockholm area, Sweden, initially examined in 1985. Using national population patient registers (2005–2017), association between medication purchases was analyzed. Anatomical Therapeutic Chemical Classification System Medicines (ATC) used. Descriptive statistics, chi‐square tests, logistic regressions were used with several covariates like gender socioeconomic status. Results Purchases above median all showed a statistically significant treatments. Most ATC system's main drug categories significantly associated appointments, even when adjusting covariates. 32 different subgroups median. Conclusion In group adult Swedes studied, it found nearly types drugs study years 2005–2017.

Язык: Английский

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Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study

Diseases, Год журнала: 2024, Номер 12(1), С. 12 - 12

Опубликована: Янв. 1, 2024

The aim of this study was to evaluate the impact non-surgical periodontal treatment (NS-PT) on parameters and inflammatory biomarkers in concentration level calprotectin (CLP) women with periodontitis rheumatoid arthritis (RA). In quasi-experimental study, we evaluated 30 (mean age: 52.0 ± 5.8 years) RA who had been diagnosed treated for more than 3 years whose activity markers remained at similar values without significant reduction over three consecutive months. Patients underwent NS-PT, which included plaque control, scaling, root planing. Serum saliva samples, indices, markers, Disease Activity Score-28 (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) CLP contents were measured beginning 6 12 weeks after NS-PT. Parametric nonparametric tests used analysis. mean age years. Compared baseline results, all indices significantly reduced NS-PT (p < 0.001). DAS28 also 0.0001). Similarly, serum decreased Of patients, 100% presented lower levels CRP ESR Overall, inflammation disease activity, highlighting importance oral health control systemic diseases such as confirming that effectively reduces plays a key role modulating activity. Therefore, should be considered an adjunct RA.

Язык: Английский

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Quercetin through miR-147–5p/Clip3 axis reducing Th17 cell differentiation to alleviate periodontitis

Regenerative Therapy, Год журнала: 2024, Номер 27, С. 496 - 505

Опубликована: Май 5, 2024

Quercetin (QU) plays an important role in treating periodontitis; however, the mechanism through which microRNAs regulate Th17 cell differentiation has not been determined. QU was administered intragastrically to periodontitis rats once a day for one month. The morphology of alveolar bone observed by micro-CT, gingival tissue structure HE staining, IL-6, TNF-α, IL-17A, RORγt, FOXP3 and IL-10 were detected immunohistochemical Treg cells peripheral blood flow cytometry. CD4+T induced differentiate into vitro. Cell viability determined CCK8, IL-17A RORγt qPCR. cytometry, microRNA sequencing bioinformatics analysis used screen key microRNAs, phenotypic changes after overexpressed via mimics. TargetScan database, situ hybridization, dual-luciferase reporter experiment predict prove target genes microRNAs. phenotype overexpression gene. Compared with group, distance from cementoenamel junction(CEJ) bone(AB) decreased, papilla improved, IL-17, downregulated, upregulated, proportion decreased increased treatment. mRNA levels significantly lower coculture group. MiR-147–5p low control upregulated downregulated intervention, it's eight bases inversely related 3′UTR Clip3, miR-147–5p Clip3 co-located periodontal tissue. those Th17-mimicsNC + cells, Th17-miR-147–5p cells. mimics inhibited luciferase activity WT but had no effect on Mut 3′UTR. miR-147–5p. Mimics transfected reversed decrease QU, while antagonized further reduced Moreover, decreases IL-17 treatment, pcDNA3.1 treatment RORγt. reducing inflammatory response promoting injury repair, closely relative inhibit downregulating promote activation Clip3.

Язык: Английский

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All‐cause and cause‐specific mortality in US adults with periodontal diseases: A prospective cohort study

Journal Of Clinical Periodontology, Год журнала: 2024, Номер 51(9), С. 1157 - 1167

Опубликована: Май 27, 2024

Abstract Aim This prospective cohort study investigated the association between periodontal diseases (PDs) and all‐cause cause‐specific mortality. Materials Methods We utilized adult participants recruited from six National Health Nutrition Examination Survey cycles (1999–2014) linked mortality data Death Index up to December 2019. Baseline clinical examinations were performed by trained calibrated examiners. All‐cause was modelled through multivariable Cox proportional hazards Fine–Gray models account for competing risks. All adjusted demographic lifestyle variables, measurements comorbidities. Results Overall, 15,030 included, with a median length of follow‐up 9 years. Risk 22% greater in people PD than control group (adjusted hazard ratio [HR]: 1.22, 95% confidence interval [CI]: 1.12–1.31). Risks cardiovascular (CVD), respiratory disease diabetes highest severe (CVD—sub‐distribution HR [SHR]: 1.38, CI: 1.16–1.64; respiratory—SHR: 1.62, 1.07–2.45; diabetes—SHR: 1.68, 1.12–2.53). Conclusions Severe is associated among US adults after adjustment.

Язык: Английский

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Multimorbidity Patterns and Periodontal Diseases in a French Hospital-Based Dental School: A Retrospective Cross-Sectional Study

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(22), С. 6631 - 6631

Опубликована: Ноя. 5, 2024

Objectives: To assess the prevalence of systemic pathologies associated with periodontal diseases to determine multimorbidity patterns and risk factors for care. Methods: A single-center cross-sectional study analyzed patient records from 1 January 2019 31 December 2021 at Department Periodontology, part Dental Service a hospital-based dental school in Lyon, France. The anonymized data included patient-reported medical history (questionnaire) billing procedures. Data were compared between patients Periodontology Other Departments Service. association clinically relevant pathologies, as defined multimorbidity, admission assessed logistic regression. Prevalences chi-squared tests. Relationship among was described through correlation analysis. Statistical analyses conducted using R software significance level set p < 0.05. Results: This 20,945 1205 procedures performed Periodontology. Patients admitted care older mostly female (p-value 0.001). most frequent hypertension diabetes Hypertension pattern, while triad hypertension/diabetes/cardiac rhythm disorders. had 1.49 times higher likelihood (OR = [1.20; 1.86]), age also being significant factor but smaller effect size 1.02 [1.01; 1.03]). Conclusions: Within limitations this study, hypertension, diabetes, cardiac disorders, chronic renal insufficiency identified prevalent Multimorbidity including seems constitute requiring

Язык: Английский

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A randomised controlled trial to evaluate the effectiveness of personalised oral hygiene advice delivered via video technology

Journal of Dentistry, Год журнала: 2024, Номер 149, С. 105243 - 105243

Опубликована: Июль 15, 2024

To determine whether video-technology oral hygiene advice (OHA) improved clinical plaque and bleeding on probing (BOP) scores in individuals diagnosed with gingivitis, compared to conventional OHA after 3-months. This parallel, randomised 2-arm treatment, single-centre study, assessed Turesky Plaque Index (TPI) BOP at baseline 3-months adult participants mild-moderate gingivitis. Eligible smartphones were intervention (tailored video OHA), or control (conventional OHA). Oral (OH) habits/attitudes recorded a questionnaire. All used manual toothbrush anti-gingivitis toothpaste twice daily. 57 completed the study. Both groups had gingival health 3-months, change from being significantly greater group (12.21% vs 6.80 %, p < 0.05). TPI decreased more than group, but difference did not reach significance (1.15 0.92, = 0.079). OH habits attitudes similar few differences between observed however frequency of interdental brush use was increased, while self-rated as this timepoint (p The combination an individually tailored instructional appropriate toothbrushing using brush, participants' over brushing delivered general dental services. study demonstrates benefit changing behaviour delivering approach contemporary methodology. is usually verbally short time periods. technology individualised improves adherence empowers individuals, recipient receiving personal visual cues ability replay technique reiteration. real-world could be better utilised practice.

Язык: Английский

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The Molecular Comorbidity Network of Periodontal Disease

Опубликована: Июль 25, 2024

Periodontal disease, a multifactorial inflammatory condition affecting the supporting structures of teeth, has been increasingly recognized for its association with various systemic diseases. Understanding molecular comorbidities periodontal disease is crucial elucidating shared pathogenic mechanisms and potential therapeutic targets. In this study, we conducted comprehensive literature biological database mining utilizing tools such as DisGeNET2R, Romin, Rentrez R libraries to identify diseases sharing associated genes, proteins, or pathways periodontitis. Our analysis revealed significant overlaps between several conditions, including cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, bowel Shared implicated in pathogenesis these periodontitis encompassed dysregulation mediators, immune response pathways, oxidative stress alterations extracellular matrix. Furthermore, network unveiled key hub genes proteins that play pivotal roles crosstalk comorbidities, offering targets intervention. Insights gained from integrative approach shed light on intricate interplay health well-being, emphasizing importance interdisciplinary collaboration developing personalized treatment strategies patients comorbidities.

Язык: Английский

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Explainable Deep Learning Approaches for Risk Screening of Periodontitis

Journal of Dental Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Several pieces of evidence have been reported regarding the association between periodontitis and systemic diseases. Despite emphasized significance prevention early diagnosis periodontitis, there is still a lack clinical tool for screening this condition. Therefore, study aims to use explainable artificial intelligence (XAI) technology facilitate periodontitis. This achieved by analyzing various features providing individualized risk assessment using XAI. We used 1,012 variables total 30,465 participants data from National Health Nutrition Examination Survey (NHANES). After preprocessing, 9,632 5,601 were left all age groups over 50 y group, respectively. They train deep learning machine models optimized opportunistic analysis based on Centers Disease Control Prevention/ American Academy Pediatrics case definition. Local interpretable model-agnostic explanations (LIME) applied evaluate potential associated factors, including demographic, lifestyle, medical, biochemical factors. The showed area under curve values 0.858 ± 0.011 0.865 0.008 diagnostic dataset, outperforming baselines. By LIME, we elicited important assessed combined impact interpretation each feature individual risk. Associated factors such as age, sex, diabetes status, tissue transglutaminase, smoking status emerged crucial that are about twice than other features, while arthritis, sleep disorders, high blood pressure, cholesterol levels, overweight also identified contributing contribution rankings generated with XAI offered insights align well clinically recognized These results highlight utility in learning-based factor detecting assistance developing detection strategies medical checkups.

Язык: Английский

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Diagnostic Accuracy of Novel Protein Biomarkers in Saliva to Detect Periodontitis Using Untargeted ‘SWATH’ Mass Spectrometry

Journal Of Clinical Periodontology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

ABSTRACT Aim To discover new salivary biomarkers to diagnose periodontitis and evaluate the impact of age smoking on predictive capacity. Material Methods Saliva samples were collected from 44 healthy periodontal individuals 41 with periodontitis. Samples analysed by sequential window acquisition all theoretical mass spectra (SWATH‐MS), proteins identified employing UniProt database. The diagnostic capacity molecules was determined generalized additive models. models obtained single‐protein unadjusted adjusted for status, besides two‐protein combinations. Results Eight single had a bias‐corrected accuracy (bc‐ACC) 78.8%–86.8% (bc‐sensitivity/bc‐specificity 62.5%–86.9%/60.9%–98.1%) Predictive increased more adjusting (bc‐ACC: 94.1%–98.2%; bc‐sensitivity/bc‐specificity: 90.2%–98.6%/93.6%–97.2%) than 83.9%–90.4%; 73.6%–89.9%/76.2%–96.4%). These keratin, type II cytoskeletal 1, protein S100‐A8, β‐2‐microglobulin, neutrophil defensin lysozyme C, ubiquitin‐60S ribosomal L40, isoform 2 tropomyosin α‐3 chain resistin. Two dual combinations showed bc‐sensitivity/bc‐specificity > 90%: β‐2‐microglobulin profilin‐1, C zymogen granule 16 homologue B. Conclusions New show good or excellent ability Age has significant influence smoking, results comparable

Язык: Английский

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