Meditsinskiy sovet = Medical Council,
Год журнала:
2024,
Номер
5, С. 288 - 297
Опубликована: Май 13, 2024
A
growing
body
of
evidence
suggests
that
periodontal
pathology,
accompanied
by
oral
inflammation
and
pathological
changes
in
the
microbiome,
induces
gut
microbiome
(oral-gut
axis)
is
involved
pathogenesis
systemic
diseases.
This
review
focuses
on
published
literature,
with
an
emphasis
last
decade,
assessing
whether
disease,
primarily
periodontitis,
periodontopathic
bacteria
are
risk
factors
for
development
rheumatoid
arthritis.
The
examines
bilateral
connections
between
arthritis
highlights
main
links
this
connection.
Porphyromonas
gingivalis
other
may
contribute
to
inflammatory
diseases
remodeling
normally
benign
microbiota
into
a
dysbiotic
one.
expresses
endogenous
citrullinated
proteins
its
own
unique
bacterial
enzyme,
peptidyl
arginine
deminase,
leading
formation
cyclic
peptide
autoantibodies
impaired
immunotolerance
susceptible
patients.
Results
from
clinical
studies
suggest
people
periodontitis
infection
at
developing
arthritis,
supporting
findings
experimental
studies.
Non-surgical
treatment
likely
effective
controlling
reducing
disease
activity
(primarily
DAS28
ESR).
These
observations
highlight
importance
health
need
prevention
early
patients
Clinical and Experimental Dental Research,
Год журнала:
2025,
Номер
11(3)
Опубликована: Май 23, 2025
ABSTRACT
Objectives
Little
is
known
whether
the
number
of
systemic
medications,
indicating
worsened
general
health,
affects
dental
appointments
needed.
The
hypothesis
that
patients
purchasing
more
medications
would
have
an
increased
and
respective
need
for
treatments
than
who
do
not
purchase
as
many
medications.
Materials
Methods
Our
cohort
consists
1495
participants
from
Stockholm
area,
Sweden,
initially
examined
in
1985.
Using
national
population
patient
registers
(2005–2017),
association
between
medication
purchases
was
analyzed.
Anatomical
Therapeutic
Chemical
Classification
System
Medicines
(ATC)
used.
Descriptive
statistics,
chi‐square
tests,
logistic
regressions
were
used
with
several
covariates
like
gender
socioeconomic
status.
Results
Purchases
above
median
all
showed
a
statistically
significant
treatments.
Most
ATC
system's
main
drug
categories
significantly
associated
appointments,
even
when
adjusting
covariates.
32
different
subgroups
median.
Conclusion
In
group
adult
Swedes
studied,
it
found
nearly
types
drugs
study
years
2005–2017.
Diseases,
Год журнала:
2024,
Номер
12(1), С. 12 - 12
Опубликована: Янв. 1, 2024
The
aim
of
this
study
was
to
evaluate
the
impact
non-surgical
periodontal
treatment
(NS-PT)
on
parameters
and
inflammatory
biomarkers
in
concentration
level
calprotectin
(CLP)
women
with
periodontitis
rheumatoid
arthritis
(RA).
In
quasi-experimental
study,
we
evaluated
30
(mean
age:
52.0
±
5.8
years)
RA
who
had
been
diagnosed
treated
for
more
than
3
years
whose
activity
markers
remained
at
similar
values
without
significant
reduction
over
three
consecutive
months.
Patients
underwent
NS-PT,
which
included
plaque
control,
scaling,
root
planing.
Serum
saliva
samples,
indices,
markers,
Disease
Activity
Score-28
(DAS28),
erythrocyte
sedimentation
rate
(ESR),
C-reactive
protein
(CRP)
CLP
contents
were
measured
beginning
6
12
weeks
after
NS-PT.
Parametric
nonparametric
tests
used
analysis.
mean
age
years.
Compared
baseline
results,
all
indices
significantly
reduced
NS-PT
(p
<
0.001).
DAS28
also
0.0001).
Similarly,
serum
decreased
Of
patients,
100%
presented
lower
levels
CRP
ESR
Overall,
inflammation
disease
activity,
highlighting
importance
oral
health
control
systemic
diseases
such
as
confirming
that
effectively
reduces
plays
a
key
role
modulating
activity.
Therefore,
should
be
considered
an
adjunct
RA.
Regenerative Therapy,
Год журнала:
2024,
Номер
27, С. 496 - 505
Опубликована: Май 5, 2024
Quercetin
(QU)
plays
an
important
role
in
treating
periodontitis;
however,
the
mechanism
through
which
microRNAs
regulate
Th17
cell
differentiation
has
not
been
determined.
QU
was
administered
intragastrically
to
periodontitis
rats
once
a
day
for
one
month.
The
morphology
of
alveolar
bone
observed
by
micro-CT,
gingival
tissue
structure
HE
staining,
IL-6,
TNF-α,
IL-17A,
RORγt,
FOXP3
and
IL-10
were
detected
immunohistochemical
Treg
cells
peripheral
blood
flow
cytometry.
CD4+T
induced
differentiate
into
vitro.
Cell
viability
determined
CCK8,
IL-17A
RORγt
qPCR.
cytometry,
microRNA
sequencing
bioinformatics
analysis
used
screen
key
microRNAs,
phenotypic
changes
after
overexpressed
via
mimics.
TargetScan
database,
situ
hybridization,
dual-luciferase
reporter
experiment
predict
prove
target
genes
microRNAs.
phenotype
overexpression
gene.
Compared
with
group,
distance
from
cementoenamel
junction(CEJ)
bone(AB)
decreased,
papilla
improved,
IL-17,
downregulated,
upregulated,
proportion
decreased
increased
treatment.
mRNA
levels
significantly
lower
coculture
group.
MiR-147–5p
low
control
upregulated
downregulated
intervention,
it's
eight
bases
inversely
related
3′UTR
Clip3,
miR-147–5p
Clip3
co-located
periodontal
tissue.
those
Th17-mimicsNC
+
cells,
Th17-miR-147–5p
cells.
mimics
inhibited
luciferase
activity
WT
but
had
no
effect
on
Mut
3′UTR.
miR-147–5p.
Mimics
transfected
reversed
decrease
QU,
while
antagonized
further
reduced
Moreover,
decreases
IL-17
treatment,
pcDNA3.1
treatment
RORγt.
reducing
inflammatory
response
promoting
injury
repair,
closely
relative
inhibit
downregulating
promote
activation
Clip3.
Journal Of Clinical Periodontology,
Год журнала:
2024,
Номер
51(9), С. 1157 - 1167
Опубликована: Май 27, 2024
Abstract
Aim
This
prospective
cohort
study
investigated
the
association
between
periodontal
diseases
(PDs)
and
all‐cause
cause‐specific
mortality.
Materials
Methods
We
utilized
adult
participants
recruited
from
six
National
Health
Nutrition
Examination
Survey
cycles
(1999–2014)
linked
mortality
data
Death
Index
up
to
December
2019.
Baseline
clinical
examinations
were
performed
by
trained
calibrated
examiners.
All‐cause
was
modelled
through
multivariable
Cox
proportional
hazards
Fine–Gray
models
account
for
competing
risks.
All
adjusted
demographic
lifestyle
variables,
measurements
comorbidities.
Results
Overall,
15,030
included,
with
a
median
length
of
follow‐up
9
years.
Risk
22%
greater
in
people
PD
than
control
group
(adjusted
hazard
ratio
[HR]:
1.22,
95%
confidence
interval
[CI]:
1.12–1.31).
Risks
cardiovascular
(CVD),
respiratory
disease
diabetes
highest
severe
(CVD—sub‐distribution
HR
[SHR]:
1.38,
CI:
1.16–1.64;
respiratory—SHR:
1.62,
1.07–2.45;
diabetes—SHR:
1.68,
1.12–2.53).
Conclusions
Severe
is
associated
among
US
adults
after
adjustment.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(22), С. 6631 - 6631
Опубликована: Ноя. 5, 2024
Objectives:
To
assess
the
prevalence
of
systemic
pathologies
associated
with
periodontal
diseases
to
determine
multimorbidity
patterns
and
risk
factors
for
care.
Methods:
A
single-center
cross-sectional
study
analyzed
patient
records
from
1
January
2019
31
December
2021
at
Department
Periodontology,
part
Dental
Service
a
hospital-based
dental
school
in
Lyon,
France.
The
anonymized
data
included
patient-reported
medical
history
(questionnaire)
billing
procedures.
Data
were
compared
between
patients
Periodontology
Other
Departments
Service.
association
clinically
relevant
pathologies,
as
defined
multimorbidity,
admission
assessed
logistic
regression.
Prevalences
chi-squared
tests.
Relationship
among
was
described
through
correlation
analysis.
Statistical
analyses
conducted
using
R
software
significance
level
set
p
<
0.05.
Results:
This
20,945
1205
procedures
performed
Periodontology.
Patients
admitted
care
older
mostly
female
(p-value
0.001).
most
frequent
hypertension
diabetes
Hypertension
pattern,
while
triad
hypertension/diabetes/cardiac
rhythm
disorders.
had
1.49
times
higher
likelihood
(OR
=
[1.20;
1.86]),
age
also
being
significant
factor
but
smaller
effect
size
1.02
[1.01;
1.03]).
Conclusions:
Within
limitations
this
study,
hypertension,
diabetes,
cardiac
disorders,
chronic
renal
insufficiency
identified
prevalent
Multimorbidity
including
seems
constitute
requiring
Journal of Dentistry,
Год журнала:
2024,
Номер
149, С. 105243 - 105243
Опубликована: Июль 15, 2024
To
determine
whether
video-technology
oral
hygiene
advice
(OHA)
improved
clinical
plaque
and
bleeding
on
probing
(BOP)
scores
in
individuals
diagnosed
with
gingivitis,
compared
to
conventional
OHA
after
3-months.
This
parallel,
randomised
2-arm
treatment,
single-centre
study,
assessed
Turesky
Plaque
Index
(TPI)
BOP
at
baseline
3-months
adult
participants
mild-moderate
gingivitis.
Eligible
smartphones
were
intervention
(tailored
video
OHA),
or
control
(conventional
OHA).
Oral
(OH)
habits/attitudes
recorded
a
questionnaire.
All
used
manual
toothbrush
anti-gingivitis
toothpaste
twice
daily.
57
completed
the
study.
Both
groups
had
gingival
health
3-months,
change
from
being
significantly
greater
group
(12.21%
vs
6.80
%,
p
<
0.05).
TPI
decreased
more
than
group,
but
difference
did
not
reach
significance
(1.15
0.92,
=
0.079).
OH
habits
attitudes
similar
few
differences
between
observed
however
frequency
of
interdental
brush
use
was
increased,
while
self-rated
as
this
timepoint
(p
The
combination
an
individually
tailored
instructional
appropriate
toothbrushing
using
brush,
participants'
over
brushing
delivered
general
dental
services.
study
demonstrates
benefit
changing
behaviour
delivering
approach
contemporary
methodology.
is
usually
verbally
short
time
periods.
technology
individualised
improves
adherence
empowers
individuals,
recipient
receiving
personal
visual
cues
ability
replay
technique
reiteration.
real-world
could
be
better
utilised
practice.
Periodontal
disease,
a
multifactorial
inflammatory
condition
affecting
the
supporting
structures
of
teeth,
has
been
increasingly
recognized
for
its
association
with
various
systemic
diseases.
Understanding
molecular
comorbidities
periodontal
disease
is
crucial
elucidating
shared
pathogenic
mechanisms
and
potential
therapeutic
targets.
In
this
study,
we
conducted
comprehensive
literature
biological
database
mining
utilizing
tools
such
as
DisGeNET2R,
Romin,
Rentrez
R
libraries
to
identify
diseases
sharing
associated
genes,
proteins,
or
pathways
periodontitis.
Our
analysis
revealed
significant
overlaps
between
several
conditions,
including
cardiovascular
diseases,
diabetes
mellitus,
rheumatoid
arthritis,
bowel
Shared
implicated
in
pathogenesis
these
periodontitis
encompassed
dysregulation
mediators,
immune
response
pathways,
oxidative
stress
alterations
extracellular
matrix.
Furthermore,
network
unveiled
key
hub
genes
proteins
that
play
pivotal
roles
crosstalk
comorbidities,
offering
targets
intervention.
Insights
gained
from
integrative
approach
shed
light
on
intricate
interplay
health
well-being,
emphasizing
importance
interdisciplinary
collaboration
developing
personalized
treatment
strategies
patients
comorbidities.
Journal of Dental Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Several
pieces
of
evidence
have
been
reported
regarding
the
association
between
periodontitis
and
systemic
diseases.
Despite
emphasized
significance
prevention
early
diagnosis
periodontitis,
there
is
still
a
lack
clinical
tool
for
screening
this
condition.
Therefore,
study
aims
to
use
explainable
artificial
intelligence
(XAI)
technology
facilitate
periodontitis.
This
achieved
by
analyzing
various
features
providing
individualized
risk
assessment
using
XAI.
We
used
1,012
variables
total
30,465
participants
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
After
preprocessing,
9,632
5,601
were
left
all
age
groups
over
50
y
group,
respectively.
They
train
deep
learning
machine
models
optimized
opportunistic
analysis
based
on
Centers
Disease
Control
Prevention/
American
Academy
Pediatrics
case
definition.
Local
interpretable
model-agnostic
explanations
(LIME)
applied
evaluate
potential
associated
factors,
including
demographic,
lifestyle,
medical,
biochemical
factors.
The
showed
area
under
curve
values
0.858
±
0.011
0.865
0.008
diagnostic
dataset,
outperforming
baselines.
By
LIME,
we
elicited
important
assessed
combined
impact
interpretation
each
feature
individual
risk.
Associated
factors
such
as
age,
sex,
diabetes
status,
tissue
transglutaminase,
smoking
status
emerged
crucial
that
are
about
twice
than
other
features,
while
arthritis,
sleep
disorders,
high
blood
pressure,
cholesterol
levels,
overweight
also
identified
contributing
contribution
rankings
generated
with
XAI
offered
insights
align
well
clinically
recognized
These
results
highlight
utility
in
learning-based
factor
detecting
assistance
developing
detection
strategies
medical
checkups.
Journal Of Clinical Periodontology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
ABSTRACT
Aim
To
discover
new
salivary
biomarkers
to
diagnose
periodontitis
and
evaluate
the
impact
of
age
smoking
on
predictive
capacity.
Material
Methods
Saliva
samples
were
collected
from
44
healthy
periodontal
individuals
41
with
periodontitis.
Samples
analysed
by
sequential
window
acquisition
all
theoretical
mass
spectra
(SWATH‐MS),
proteins
identified
employing
UniProt
database.
The
diagnostic
capacity
molecules
was
determined
generalized
additive
models.
models
obtained
single‐protein
unadjusted
adjusted
for
status,
besides
two‐protein
combinations.
Results
Eight
single
had
a
bias‐corrected
accuracy
(bc‐ACC)
78.8%–86.8%
(bc‐sensitivity/bc‐specificity
62.5%–86.9%/60.9%–98.1%)
Predictive
increased
more
adjusting
(bc‐ACC:
94.1%–98.2%;
bc‐sensitivity/bc‐specificity:
90.2%–98.6%/93.6%–97.2%)
than
83.9%–90.4%;
73.6%–89.9%/76.2%–96.4%).
These
keratin,
type
II
cytoskeletal
1,
protein
S100‐A8,
β‐2‐microglobulin,
neutrophil
defensin
lysozyme
C,
ubiquitin‐60S
ribosomal
L40,
isoform
2
tropomyosin
α‐3
chain
resistin.
Two
dual
combinations
showed
bc‐sensitivity/bc‐specificity
>
90%:
β‐2‐microglobulin
profilin‐1,
C
zymogen
granule
16
homologue
B.
Conclusions
New
show
good
or
excellent
ability
Age
has
significant
influence
smoking,
results
comparable