Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155597 - 155597
Опубликована: Сен. 23, 2024
Язык: Английский
Cell Proliferation, Год журнала: 2023, Номер 57(1)
Опубликована: Июль 11, 2023
Abstract Cardiovascular diseases (CVDs) are the primary drivers of growing public health epidemic and leading cause premature mortality economic burden worldwide. With decades research, CVDs have been proven to be associated with dysregulation inflammatory response, macrophages playing imperative roles in influencing prognosis CVDs. Autophagy is a conserved pathway that maintains cellular functions. Emerging evidence has revealed an intrinsic connection between autophagy macrophage This review focuses on role underlying mechanisms autophagy‐mediated regulation plasticity polarization, inflammasome activation, cytokine secretion, metabolism, phagocytosis, number macrophages. In addition, shown connect heart cells. It attributed specific substrate degradation or signalling activation by autophagy‐related proteins. Referring latest reports, applications targeting discussed CVDs, such as atherosclerosis, myocardial infarction, failure, myocarditis. describes novel approach for future CVD therapies.
Язык: Английский
Процитировано
21
Advanced Science, Год журнала: 2024, Номер 11(26)
Опубликована: Май 2, 2024
Abstract Atherosclerotic cardiovascular disease (ASCVD) has become the leading cause of death worldwide, and early diagnosis treatment atherosclerosis (AS) are crucial for reducing occurrence acute events. However, AS is challenging, oral anti‐AS drugs suffer from limitations like imprecise targeting low bioavailability. To overcome aforementioned shortcomings, Cur/MOF@DS developed, a nanoplatform integrating by loading curcumin (Cur) into metal−organic frameworks with nanozymes magnetic resonance imaging (MRI) properties. In addition, surface‐modification dextran sulfate (DS) enables PCN‐222(Mn) effectively target scavenger receptor class A in macrophages or foam cells within plaque region. This employs mechanisms that scavenge excessive reactive oxygen species microenvironment, promote macrophage autophagy regulate polarization to realize lipid regulation. vivo vitro experiments confirm this outstanding MRI performance effects, which may provide new option AS.
Язык: Английский
Процитировано
9
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(25), С. 17201 - 17210
Опубликована: Июнь 14, 2024
As one of the most lethal cardiovascular diseases, aortic dissection (AD) is initiated by overexpression reactive oxygen species (ROS) in aorta that damages vascular structure and finally leads to massive hemorrhage sudden death. Current drugs used clinics for AD treatment fail efficiently scavenge ROS a large extent, presenting undesirable therapeutic effect. In this work, nanocatalytic antioxidation concept has been proposed elevate efficacy constructing cobalt nanocatalyst with biomimetic can pathological an efficient sustainable manner. Theoretical calculations demonstrate reaction catalyzed redox transition between hydroxocobalt(III) oxo-hydroxocobalt(V) accompanied inner-sphere proton-coupled two-electron transfer, forming nonassociated activation catalytic cycle. The action region effectively alleviates oxidative stress, which further modulates inflammatory microenvironment promoting phenotype macrophages. Consequently, smooth muscle cells are also protected from inflammation meantime, suppressing progression. This study provides approach other diseases.
Язык: Английский
Процитировано
8
Applied Biochemistry and Biotechnology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
1
Cell Proliferation, Год журнала: 2024, Номер 57(8)
Опубликована: Март 19, 2024
Abstract Cardiovascular disease (CVD) is a group of diseases that primarily affect the heart or blood vessels, with high disability and mortality rates, posing serious threat to human health. The causative factors, pathogenesis, characteristics common CVD differ, but they all involve pathological processes such as inflammation, oxidative stress, fibrosis. S100A9 belongs S100 family calcium‐binding proteins, which are mainly secreted by myeloid cells bind Toll‐like receptor 4 for advanced glycation end products involved in regulating inflammatory response, fibrosis, vascular calcification, endothelial barrier function CVD. latest research has found key biomarker diagnosing predicting various Therefore, this article reviews progress on diagnostic predictive, therapeutic value inflammatory‐related atherosclerosis, myocardial infarction, arterial aneurysm summarizes its molecular mechanisms progression CVD, aiming explore new predictive methods identify potential intervention targets clinical practice.
Язык: Английский
Процитировано
6
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Дек. 18, 2024
Abstract Efferocytosis, the clearance of apoptotic cells, is a critical process that maintains tissue homeostasis and immune regulation. Defective efferocytosis linked to development chronic inflammatory conditions, including atherosclerosis, neurological disorders, autoimmune diseases. Moreover, interplay between autophagy crucial for inflammation control, as enhances ability phagocytic cells. Efficient efferocytosis, in turn, regulates autophagic pathways, fostering balanced cellular environment. Dysregulation this balance can contribute pathogenesis various disorders. Phytochemicals, bioactive compounds found plants, have emerged promising therapeutic agents owing their diverse pharmacological properties, antioxidant, anti-inflammatory, immunomodulatory effects. This review aims highlight pivotal role phytochemicals enhancing explore potential prevention treatment related study examines how influence key aspects cell activation, macrophage polarization, induction. The atherosclerosis diseases highlighted, emphasizing enhance reduce inflammation. also discusses innovative approaches, such nanoformulations combination therapies improve targeting bioavailability phytochemicals. Ultimately, inspires further research clinical applications phytochemical-mediated enhancement managing conditions.
Язык: Английский
Процитировано
5
Chinese Medicine, Год журнала: 2024, Номер 19(1)
Опубликована: Янв. 5, 2024
Abstract Background The synthetic liver X receptor ligand (LXR) T0901317 (T0) has been reported to attenuate atherosclerosis (AS) without hyperglyceridemia due innovative drug combination or nano-sized delivery. Given the key roles of mangiferin (MGF) in lipid metabolism and atherogenesis, it is critical investigate progression atherosclerotic lesion after combined treatment MGF T0. Methods Atherosclerotic plaque formation hepatic accumulation were compared Apoe −/− mice among T0 and/or treatment. vitro functions analyzed by Oil-red O staining, cholesterol efflux assay, transmission electron microscopy western blot analyses with acetylated low density lipoprotein. Results therapy are effective regulators for mice, upregulation ABCA1 ABCG1 induced LXR activation. Subsequently, we identified autophagy promoted establishes a positive feedback loop that increases efflux, resulted from LXRα Under atherogenic conditions, inhibitor CQ abolished enhancement effect on outflow Mechanically, promotes mTOR/AMPK signaling cascade macrophage, AMPK hepatocyte, leading metabolic homeostasis. Conclusions Altogether, our findings reveal engages AS side effects activating AMPK-dependent promote macrophage might serve as natural compound assist via targeting autophagy.
Язык: Английский
Процитировано
3
Journal of Integrative Medicine, Год журнала: 2024, Номер 22(2), С. 102 - 114
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
3
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 180, С. 117494 - 117494
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
3
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 13, 2025
Autophagy is responsible for maintaining cellular balance and ensuring survival. plays a crucial role in the development of diseases, particularly human cancers, with actions that can either promote survival or induce cell death. However, brain tumors contribute to high levels both mortality morbidity globally, resistance treatments being acquired due genetic mutations dysregulation molecular mechanisms, among other factors. Hence, having knowledge processes advancement enlightening, current review specifically examines autophagy. The discussion would focus on pathways control autophagy tumors, its dual as tumor suppressor supporter different types like glioblastoma, glioma, ependymoma, demonstrating potential treatment. mechanisms influence metastasis drug there complex interplay between responses stress hypoxia starvation. inhibit growth by promoting apoptosis. focusing could offer fresh perspectives creating successful treatments.
Язык: Английский
Процитировано
0